Ezh2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) - Rat Genome Database
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Gene: Ezh2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) Mus musculus
Analyze
Symbol: Ezh2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
RGD ID: 1312684
MGI Page MGI
Description: Exhibits several functions, including nucleic acid binding activity; protein methyltransferase activity; and transcription corepressor activity. Involved in several processes, including animal organ development; macromolecule methylation; and regulation of transcription, DNA-templated. Localizes to ESC/E(Z) complex; chromatin silencing complex; and pronucleus. Colocalizes with nuclear chromatin. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study B-cell lymphoma; Weaver syndrome; and acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in Weaver syndrome; glioblastoma multiforme; hematologic cancer (multiple); and stomach cancer. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: enhancer of zeste homolog 2; Enx-; Enx-1; Enx1; Enx1h; histone-lysine N-methyltransferase EZH2; KIAA4065; KMT6; MGC90723; mKIAA4065
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39647,507,208 - 47,572,309 (-)NCBIGRCm39mm39
GRCm38647,530,274 - 47,595,270 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl647,530,139 - 47,595,341 (-)EnsemblGRCm38mm10GRCm38
MGSCv37647,480,273 - 47,545,029 (-)NCBIGRCm37mm9NCBIm37
MGSCv36647,459,867 - 47,524,606 (-)NCBImm8
Celera647,385,379 - 47,451,063 (-)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map622.92NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Eudesmin  (ISO)
1,1-dichloroethene  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (EXP,ISO)
andrographolide  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
chlordecone  (EXP)
cisplatin  (ISO)
clorgyline  (ISO)
clothianidin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
coumestrol  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
ethanol  (EXP)
formaldehyde  (ISO)
genistein  (ISO)
geraniol  (ISO)
glycerol 2-phosphate  (ISO)
heptachlor  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
ketamine  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lucanthone  (ISO)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylazoxymethanol  (EXP)
morphine  (ISO)
myo-inositol hexakisphosphate  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
oxaliplatin  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
piroxicam  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
resveratrol  (EXP,ISO)
sodium dichromate  (ISO)
Soman  (ISO)
stattic  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
topotecan  (ISO)
Tributyltin oxide  (EXP)
trimellitic anhydride  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
urethane  (EXP,ISO)
valproic acid  (EXP,ISO)
vemurafenib  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell differentiation  (IMP)
cardiac muscle hypertrophy in response to stress  (IDA)
cell development  (IMP)
cellular response to hydrogen peroxide  (IDA)
cellular response to trichostatin A  (IMP)
cerebellar cortex development  (IMP)
chromatin organization  (IEA)
chromatin silencing at telomere  (ISO)
DNA methylation  (IMP)
G1 to G0 transition  (IMP)
hepatocyte homeostasis  (IGI)
hippocampus development  (ISO)
histone H3-K27 methylation  (IMP,ISO)
histone H3-K27 trimethylation  (IGI)
histone methylation  (IDA,ISO)
immunoglobulin heavy chain V-D-J recombination  (TAS)
liver regeneration  (IGI)
methylation  (IEA)
negative regulation of DNA-binding transcription factor activity  (IGI)
negative regulation of epidermal cell differentiation  (IMP)
negative regulation of G1/S transition of mitotic cell cycle  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of gene expression, epigenetic  (ISO)
negative regulation of retinoic acid receptor signaling pathway  (ISO)
negative regulation of striated muscle cell differentiation  (IDA)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
negative regulation of transcription elongation from RNA polymerase II promoter  (IMP)
negative regulation of transcription, DNA-templated  (ISO)
positive regulation of cell cycle G1/S phase transition  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of dendrite development  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of protein serine/threonine kinase activity  (ISO)
protein localization to chromatin  (IMP)
regulation of cell population proliferation  (IMP)
regulation of circadian rhythm  (IMP,ISO)
regulation of gene expression  (IMP)
regulation of gliogenesis  (IMP)
regulation of neurogenesis  (IMP)
regulation of protein phosphorylation  (IMP)
regulation of transcription by RNA polymerase II  (IMP)
response to estradiol  (ISO)
response to tetrachloromethane  (IGI)
rhythmic process  (IEA)
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell differentiation  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal hair follicle infundibulum morphology  (IAGP)
abnormal hair follicle outer root sheath morphology  (IAGP)
abnormal hair growth  (IAGP)
abnormal immunoglobulin V(D)J recombination  (IAGP)
abnormal myocardial trabeculae morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal oligodendrocyte morphology  (IAGP)
abnormal pro-B cell morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal spleen white pulp morphology  (IAGP)
absent gastric milk in neonates  (IAGP)
absent inner cell mass proliferation  (IAGP)
decreased B cell proliferation  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased germinal center B cell number  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG3 level  (IAGP)
decreased immature B cell number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased spleen germinal center number  (IAGP)
decreased spleen germinal center size  (IAGP)
decreased thymocyte number  (IAGP)
dysmyelination  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality between somite formation and embryo turning, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
epidermal hyperplasia  (IAGP)
failure to gastrulate  (IAGP)
hair follicle degeneration  (IAGP)
increased B cell derived lymphoma incidence  (IAGP)
increased body weight  (IAGP)
increased circulating triglyceride level  (IEA)
increased double-negative T cell number  (IAGP)
increased growth rate  (IAGP)
increased hair follicle apoptosis  (IAGP)
increased heart weight  (IAGP)
increased kidney weight  (IAGP)
increased leukemia incidence  (IAGP)
increased mean corpuscular hemoglobin  (IEA)
increased melanoma incidence  (IAGP)
increased sacral vertebrae number  (IEA)
increased spleen weight  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
primary atelectasis  (IAGP)
small hair follicles  (IAGP)
thin myocardium compact layer  (IAGP)
References

References - curated
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2. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
3. Bracken AP, etal., EMBO J. 2003 Oct 15;22(20):5323-35.
4. Fujii S, etal., Biochem Biophys Res Commun. 2012 Jan 20;417(3):1074-9. doi: 10.1016/j.bbrc.2011.12.099. Epub 2011 Dec 26.
5. Greathouse KL, etal., Mol Cancer Res. 2012 Apr;10(4):546-57. doi: 10.1158/1541-7786.MCR-11-0605.
6. Grossmann V, etal., Leukemia. 2011 May;25(5):877-9. doi: 10.1038/leu.2011.10. Epub 2011 Feb 22.
7. Guglielmelli P, etal., Blood. 2011 Nov 10;118(19):5227-34. doi: 10.1182/blood-2011-06-363424. Epub 2011 Sep 14.
8. Hamatani T, etal., Hum Mol Genet 2004 Oct 1;13(19):2263-78. Epub 2004 Aug 18.
9. He Y, etal., Acta Biochim Biophys Sin (Shanghai). 2012 Jan;44(1):70-9. doi: 10.1093/abbs/gmr109.
10. Herrera-Merchan A, etal., Nat Commun. 2012 Jan 10;3:623. doi: 10.1038/ncomms1623.
11. Herz HM, etal., Trends Biochem Sci. 2013 Dec;38(12):621-39. doi: 10.1016/j.tibs.2013.09.004. Epub 2013 Oct 20.
12. Komers R, etal., Lab Invest. 2013 May;93(5):543-52. doi: 10.1038/labinvest.2013.47. Epub 2013 Mar 18.
13. Lee SC, etal., Blood. 2013 Oct 10;122(15):2654-63. doi: 10.1182/blood-2013-02-484055. Epub 2013 Aug 27.
14. MGD data from the GO Consortium
15. MGD IEA
16. Muto T, etal., J Exp Med. 2013 Nov 18;210(12):2627-39. doi: 10.1084/jem.20131144. Epub 2013 Nov 11.
17. Ning X, etal., Cancer Lett. 2015 Apr 10;359(2):198-205. doi: 10.1016/j.canlet.2015.01.005. Epub 2015 Jan 13.
18. Nishioka C, etal., Leuk Res. 2016 Jun;45:24-32. doi: 10.1016/j.leukres.2016.03.012. Epub 2016 Apr 1.
19. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
20. OMIM Disease Annotation Pipeline
21. RGD automated import pipeline
22. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. RGD automated import pipeline for gene-chemical interactions
24. Simon C, etal., Genes Dev. 2012 Apr 1;26(7):651-6. doi: 10.1101/gad.186411.111. Epub 2012 Mar 19.
25. Simon JA and Kingston RE, Mol Cell. 2013 Mar 7;49(5):808-24. doi: 10.1016/j.molcel.2013.02.013.
26. Tanaka S, etal., Blood. 2012 Aug 2;120(5):1107-17. doi: 10.1182/blood-2011-11-394932. Epub 2012 Jun 7.
27. van Leenders GJ, etal., Eur Urol. 2007 Aug;52(2):455-63. Epub 2006 Nov 17.
28. Vella S, etal., Int J Mol Sci. 2013 Dec 12;14(12):24154-68. doi: 10.3390/ijms141224154.
29. Wang J, etal., Leuk Res. 2013 Mar;37(3):305-11. doi: 10.1016/j.leukres.2012.10.004. Epub 2012 Oct 23.
30. Xu F, etal., Ann Hematol. 2011 Jun;90(6):643-53. doi: 10.1007/s00277-010-1128-5. Epub 2010 Dec 2.
31. Xu L, etal., J Hepatol. 2014 Mar;60(3):590-8. doi: 10.1016/j.jhep.2013.10.028. Epub 2013 Nov 6.
32. Yang T, etal., Biochem Biophys Res Commun. 2013 Jul 12;436(4):578-84. doi: 10.1016/j.bbrc.2013.05.079. Epub 2013 May 29.
33. Yoshida K, etal., Nat Genet. 2013 Nov;45(11):1293-9. doi: 10.1038/ng.2759. Epub 2013 Sep 22.
Additional References at PubMed
PMID:8861097   PMID:8921387   PMID:9176491   PMID:9214638   PMID:9473645   PMID:9584197   PMID:9742080   PMID:10051331   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861  
PMID:11217851   PMID:11287189   PMID:11390661   PMID:12123576   PMID:12477932   PMID:12496962   PMID:12520002   PMID:12589020   PMID:12900441   PMID:12904583   PMID:14610273   PMID:14671313  
PMID:14681479   PMID:15077161   PMID:15385962   PMID:15520282   PMID:15536069   PMID:15596546   PMID:15733677   PMID:15741177   PMID:15782199   PMID:15882624   PMID:16009709   PMID:16025120  
PMID:16141072   PMID:16141073   PMID:16717091   PMID:17107999   PMID:17344414   PMID:17804093   PMID:17937919   PMID:17996646   PMID:17997413   PMID:18022353   PMID:18281287   PMID:18287559  
PMID:18311137   PMID:18416604   PMID:18483221   PMID:18687996   PMID:18713946   PMID:18799693   PMID:18848501   PMID:18974356   PMID:19026780   PMID:19026781   PMID:19079346   PMID:19144645  
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PMID:29789597   PMID:29891551   PMID:29898397   PMID:29899112   PMID:29905573   PMID:29959321   PMID:29967448   PMID:30005706   PMID:30008323   PMID:30022044   PMID:30051352   PMID:30080177  
PMID:30080881   PMID:30169530   PMID:30197001   PMID:30213970   PMID:30222957   PMID:30295189   PMID:30305391   PMID:30327434   PMID:30341286   PMID:30510991   PMID:30522506   PMID:30539787  
PMID:30541888   PMID:30566000   PMID:30575739   PMID:30689973   PMID:30705058   PMID:30705065   PMID:30795863   PMID:30820607   PMID:30851295   PMID:30872457   PMID:30890554   PMID:30954472  
PMID:30971429   PMID:31154015   PMID:31160593   PMID:31201420   PMID:31243262   PMID:31259687   PMID:31273598   PMID:31281901   PMID:31340157   PMID:31345937   PMID:31347330   PMID:31361780  
PMID:31363169   PMID:31408621   PMID:31431463   PMID:31451685   PMID:31523200   PMID:31534051   PMID:31579944   PMID:31597089   PMID:31704972   PMID:31735087   PMID:31748268   PMID:31815666  
PMID:31841397   PMID:31871160   PMID:31916627   PMID:32094206   PMID:32181346   PMID:32325033   PMID:32380038   PMID:32428001   PMID:32554463   PMID:32907838   PMID:32999031  


Genomics

Comparative Map Data
Ezh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39647,507,208 - 47,572,309 (-)NCBIGRCm39mm39
GRCm38647,530,274 - 47,595,270 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl647,530,139 - 47,595,341 (-)EnsemblGRCm38mm10GRCm38
MGSCv37647,480,273 - 47,545,029 (-)NCBIGRCm37mm9NCBIm37
MGSCv36647,459,867 - 47,524,606 (-)NCBImm8
Celera647,385,379 - 47,451,063 (-)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map622.92NCBI
EZH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7148,807,383 - 148,884,321 (-)EnsemblGRCh38hg38GRCh38
GRCh387148,807,374 - 148,884,344 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377148,504,464 - 148,581,441 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh377148,504,475 - 148,581,383 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367148,135,408 - 148,212,347 (-)NCBINCBI36hg18NCBI36
Build 347147,942,122 - 148,019,062NCBI
Celera7143,174,898 - 143,251,832 (-)NCBI
Cytogenetic Map7q36.1NCBI
HuRef7142,583,460 - 142,659,958 (-)NCBIHuRef
CHM1_17148,512,861 - 148,589,845 (-)NCBICHM1_1
CRA_TCAGchr7v27147,842,417 - 147,919,393 (-)NCBI
Ezh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2476,624,399 - 76,687,362 (-)NCBI
Rnor_6.0 Ensembl477,284,404 - 77,347,011 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0477,284,404 - 77,347,011 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04141,955,864 - 142,018,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4475,709,959 - 75,773,279 (-)NCBIRGSC3.4rn4RGSC3.4
Celera471,429,142 - 71,492,047 (-)NCBICelera
Cytogenetic Map4q24NCBI
Ezh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554914,215,298 - 4,292,235 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554914,215,353 - 4,292,229 (-)NCBIChiLan1.0ChiLan1.0
EZH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17153,017,590 - 153,059,726 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7153,017,590 - 153,059,726 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07140,536,962 - 140,613,104 (-)NCBIMhudiblu_PPA_v0panPan3
EZH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl161,925,956 - 1,991,838 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1161,926,443 - 1,991,995 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ezh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365275,024,077 - 5,069,152 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EZH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9109,384,995 - 109,450,941 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19109,384,976 - 109,450,943 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29120,322,804 - 120,388,754 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EZH2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121117,380,518 - 117,515,224 (-)NCBI
ChlSab1.1 Ensembl21117,380,361 - 117,421,573 (-)Ensembl
Ezh2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248006,781,848 - 6,874,221 (+)NCBI

Position Markers
AW554728  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38647,530,506 - 47,530,593UniSTSGRCm38
MGSCv37647,480,505 - 47,480,592UniSTSGRCm37
Celera647,385,610 - 47,385,697UniSTS
Cytogenetic Map6BUniSTS
cM Map619.2UniSTS
Whitehead/MRC_RH6445.33UniSTS
U52951  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38647,530,326 - 47,530,476UniSTSGRCm38
MGSCv37647,480,325 - 47,480,475UniSTSGRCm37
Celera647,385,430 - 47,385,580UniSTS
Cytogenetic Map6BUniSTS
cM Map619.2UniSTS
Whitehead_YAC6 UniSTS
D6Mit351  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38647,574,728 - 47,574,837UniSTSGRCm38
MGSCv37647,524,727 - 47,524,836UniSTSGRCm37
Celera647,429,501 - 47,429,614UniSTS
Cytogenetic Map6BUniSTS
cM Map620.4UniSTS
Whitehead Genetic610.9UniSTS
Whitehead_YAC6 UniSTS
RH125972  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38647,585,266 - 47,585,457UniSTSGRCm38
GRCm38729,174,563 - 29,175,430UniSTSGRCm38
MGSCv37647,535,265 - 47,535,456UniSTSGRCm37
MGSCv37729,959,582 - 29,960,449UniSTSGRCm37
Celera723,744,632 - 23,745,499UniSTS
Celera647,440,040 - 47,440,231UniSTS
Cytogenetic Map6BUniSTS
Cytogenetic Map7B1UniSTS
cM Map619.2UniSTS
PMC108938P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,192,437 - 101,192,953UniSTSGRCm38
MGSCv3711101,053,751 - 101,054,267UniSTSGRCm37
Celera11112,488,553 - 112,489,069UniSTS
Cytogenetic Map11C-DUniSTS
Cytogenetic Map6BUniSTS
cM Map619.2UniSTS
PMC87093P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38647,554,329 - 47,554,729UniSTSGRCm38
MGSCv37647,504,328 - 47,504,728UniSTSGRCm37
Celera647,409,317 - 47,409,717UniSTS
Cytogenetic Map6BUniSTS
cM Map619.2UniSTS
Ezh2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38647,545,791 - 47,546,001UniSTSGRCm38
MGSCv37647,495,790 - 47,496,000UniSTSGRCm37
Celera647,400,784 - 47,400,994UniSTS
Cytogenetic Map6BUniSTS
cM Map619.2UniSTS
Ezh2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38647,530,349 - 47,530,473UniSTSGRCm38
MGSCv37647,480,348 - 47,480,472UniSTSGRCm37
Celera647,385,453 - 47,385,577UniSTS
Cytogenetic Map6BUniSTS
cM Map619.2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348726677Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348726677Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348726677Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080600000Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61770000053500000Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61773466351734784Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1773466351734784Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61773466351734784Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414873387692Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61963941153639411Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61963941153639411Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61963941153639411Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268671322775Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62007289554072895Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62380000057800000Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62500000080000000Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2831405962314181Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3172656565726677Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63270000066700000Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3285065078238974Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63389528167895420Mouse
11252142Mom12_mModifier of Min 12 (mouse)63389528167895420Mouse
1300767Aliq4_macute lung injury QTL 4 (mouse)Not determined63629634770296450Mouse
1357539Bsbob3_mBSB obesity 3 (mouse)Not determined63647147170471591Mouse
4141094Hrtr1_mheart rate 1 (mouse)Not determined3676447870764478Mouse
14746995Manh60_mmandible shape 60 (mouse)63722567771225677Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1301326Trbv4c2_mT cell receptor beta variable 4 (mouse)Not determined64089129671379171Mouse
12880424V25Dq4_mvitamin D inactive form serum level QTL 4 (mouse)64160000075600000Mouse
1301266Lmr4_mleishmaniasis resistance 4 (mouse)Not determined64211637376116515Mouse
11040600Lmr4c_mleishmaniasis resistance 4c (mouse)64211637376116515Mouse
11040601Lmr4a_mleishmaniasis resistance 4a (mouse)64211637376116515Mouse
11533915Mts4_mmammary tumor susceptibility 4 (mouse)64211637376116515Mouse
12910785Pwgrq16_mpost-weaning growth rate QTL 16 (mouse)64382681377811523Mouse
12910798Pwgrq5_mpre-weaning growth rate QTL 5 (mouse)64382681377811523Mouse
12910802Pwbwq12_mpost-weaning body weight QTL 12 (mouse)64382681377811523Mouse
12910807Pwbwq11_mpost-weaning body weight QTL 11 (mouse)64382681377811523Mouse
12910809Pwbwq10_mpost-weaning body weight QTL 10 (mouse)64382681377811523Mouse
12910820Ogrq3_moverall growth rate QTL 3 (mouse)64382681377811523Mouse
10043885Cia6c_mcollagen induced arthritis QTL 6c (mouse)Not determined64446587171119467Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mirlet7a-1mmu-let-7a-5pOncomiRDBexternal_infoNANA22442719
Mirlet7f-2mmu-let-7f-5pOncomiRDBexternal_infoNANA22442719
Mir26a-1mmu-miR-26a-5pMirtarbaseexternal_infoqRT-PCR//Western blot//Reporter assay;Western blotFunctional MTI18281287
Mir26a-1mmu-miR-26a-5pTarbaseexternal_infoReporter GenePOSITIVE
Mir26a-1mmu-miR-26a-5pTarbaseexternal_infoqPCRPOSITIVE
Mir26a-1mmu-miR-26a-5pTarbaseexternal_infoWesternblitPOSITIVE
Mir26a-1mmu-miR-26a-5pOncomiRDBexternal_infoNANA21368858
Mir26a-1mmu-miR-26a-5pOncomiRDBexternal_infoNANA21199804
Mir26a-1mmu-miR-26a-5pOncomiRDBexternal_infoNANA18713946
Mirlet7c-2mmu-let-7c-5pOncomiRDBexternal_infoNANA22442719
Mir98mmu-miR-98-5pOncomiRDBexternal_infoNANA21368858
Mirlet7a-2mmu-let-7a-5pOncomiRDBexternal_infoNANA22442719
Mirlet7gmmu-let-7g-5pOncomiRDBexternal_infoNANA22442719
Mirlet7bmmu-let-7b-5pOncomiRDBexternal_infoNANA22442719
Mir26a-2mmu-miR-26a-5pOncomiRDBexternal_infoNANA18713946
Mir138-1mmu-miR-138-5pOncomiRDBexternal_infoNANA23343715
Mir138-2mmu-miR-138-5pOncomiRDBexternal_infoNANA23343715
Mir214mmu-miR-214-3pMirtarbaseexternal_infoReporter assay;OtherFunctional MTI19818710
Mir214mmu-miR-214-3pTarbaseexternal_infoReporter GenePOSITIVE
Mir214mmu-miR-214-3pTarbaseexternal_infoOtherPOSITIVE
Mir214mmu-miR-214-3pOncomiRDBexternal_infoNANA22962603
Mir214mmu-miR-214-3pOncomiRDBexternal_infoNANA21828058
Mir137mmu-miR-137-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20368621
Mir31mmu-miR-31-5pOncomiRDBexternal_infoNANA22948084
Mirlet7dmmu-let-7d-5pOncomiRDBexternal_infoNANA22442719
Mir30dmmu-miR-30d-5pOncomiRDBexternal_infoNANA22399519
Mirlet7immu-let-7i-5pOncomiRDBexternal_infoNANA22442719
Mir26a-2mmu-miR-26a-5pMirtarbaseexternal_infoqRT-PCR//Western blot//Reporter assay;Western blotFunctional MTI18281287
Mir26a-2mmu-miR-26a-5pTarbaseexternal_infoReporter GenePOSITIVE
Mir26a-2mmu-miR-26a-5pTarbaseexternal_infoqPCRPOSITIVE
Mir26a-2mmu-miR-26a-5pTarbaseexternal_infoWesternblitPOSITIVE
Mir26a-2mmu-miR-26a-5pOncomiRDBexternal_infoNANA21368858
Mir26a-2mmu-miR-26a-5pOncomiRDBexternal_infoNANA21199804
Mirlet7emmu-let-7e-5pOncomiRDBexternal_infoNANA22442719
Mir25mmu-miR-25-3pOncomiRDBexternal_infoNANA22399519
Mirlet7c-1mmu-let-7c-5pOncomiRDBexternal_infoNANA22442719

Predicted Target Of
Summary Value
Count of predictions:1355
Count of miRNA genes:582
Interacting mature miRNAs:691
Transcripts:ENSMUST00000081721, ENSMUST00000092648, ENSMUST00000114616, ENSMUST00000114618, ENSMUST00000133043, ENSMUST00000164006, ENSMUST00000165492, ENSMUST00000167278, ENSMUST00000169889, ENSMUST00000170311, ENSMUST00000170327, ENSMUST00000171614
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001146689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006505520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006505521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006505523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006505524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006505525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006505526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006505527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006505529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030255150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030255151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030255152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030255155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC154015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC155652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF104359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U52951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000081721   ⟹   ENSMUSP00000080419
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl647,530,139 - 47,595,030 (-)Ensembl
RefSeq Acc Id: ENSMUST00000092648   ⟹   ENSMUSP00000090318
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl647,530,541 - 47,577,660 (-)Ensembl
RefSeq Acc Id: ENSMUST00000114616   ⟹   ENSMUSP00000110263
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl647,530,139 - 47,595,030 (-)Ensembl
RefSeq Acc Id: ENSMUST00000114618   ⟹   ENSMUSP00000110265
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl647,530,139 - 47,595,030 (-)Ensembl
RefSeq Acc Id: ENSMUST00000133043   ⟹   ENSMUSP00000118663
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl647,552,386 - 47,595,341 (-)Ensembl
RefSeq Acc Id: ENSMUST00000164006   ⟹   ENSMUSP00000133195
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl647,540,843 - 47,551,761 (-)Ensembl
RefSeq Acc Id: ENSMUST00000165492
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl647,533,742 - 47,545,883 (-)Ensembl
RefSeq Acc Id: ENSMUST00000167278   ⟹   ENSMUSP00000128542
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl647,544,006 - 47,551,761 (-)Ensembl
RefSeq Acc Id: ENSMUST00000169889   ⟹   ENSMUSP00000126481
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl647,545,783 - 47,554,214 (-)Ensembl
RefSeq Acc Id: ENSMUST00000170311
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl647,532,630 - 47,540,709 (-)Ensembl
RefSeq Acc Id: ENSMUST00000170327
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl647,556,030 - 47,578,010 (-)Ensembl
RefSeq Acc Id: ENSMUST00000171614
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl647,532,010 - 47,535,125 (-)Ensembl
RefSeq Acc Id: ENSMUST00000203857
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl647,530,319 - 47,532,116 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204243   ⟹   ENSMUSP00000144781
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl647,530,139 - 47,540,735 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204798   ⟹   ENSMUSP00000144780
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl647,545,836 - 47,595,058 (-)Ensembl
RefSeq Acc Id: NM_001146689   ⟹   NP_001140161
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,964 (-)NCBI
GRCm38647,530,274 - 47,595,030 (-)NCBI
MGSCv37647,480,273 - 47,545,029 (-)RGD
Celera647,385,379 - 47,451,063 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_007971   ⟹   NP_031997
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,964 (-)NCBI
GRCm38647,530,274 - 47,595,030 (-)NCBI
MGSCv37647,480,273 - 47,545,029 (-)RGD
Celera647,385,379 - 47,451,063 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006505520   ⟹   XP_006505583
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,907 (-)NCBI
GRCm38647,530,274 - 47,594,947 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006505521   ⟹   XP_006505584
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,572,309 (-)NCBI
GRCm38647,530,274 - 47,595,270 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006505523   ⟹   XP_006505586
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,996 (-)NCBI
GRCm38647,530,274 - 47,595,062 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006505524   ⟹   XP_006505587
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,995 (-)NCBI
GRCm38647,530,274 - 47,595,063 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006505525   ⟹   XP_006505588
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,996 (-)NCBI
GRCm38647,530,274 - 47,595,062 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006505526   ⟹   XP_006505589
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,997 (-)NCBI
GRCm38647,530,274 - 47,595,068 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006505527   ⟹   XP_006505590
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,919 (-)NCBI
GRCm38647,530,274 - 47,594,985 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006505529   ⟹   XP_006505592
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,972 (-)NCBI
GRCm38647,530,274 - 47,594,985 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030255150   ⟹   XP_030111010
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,907 (-)NCBI
GRCm38647,530,274 - 47,594,938 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030255151   ⟹   XP_030111011
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,907 (-)NCBI
GRCm38647,530,274 - 47,594,938 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030255152   ⟹   XP_030111012
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,572,128 (-)NCBI
GRCm38647,530,274 - 47,595,194 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030255155   ⟹   XP_030111015
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,919 (-)NCBI
GRCm38647,530,274 - 47,594,985 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165817   ⟹   XP_036021710
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,217 (-)NCBI
RefSeq Acc Id: XM_036165818   ⟹   XP_036021711
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,568,525 (-)NCBI
RefSeq Acc Id: XM_036165819   ⟹   XP_036021712
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,556,168 (-)NCBI
RefSeq Acc Id: XM_036165820   ⟹   XP_036021713
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,568,525 (-)NCBI
RefSeq Acc Id: XM_036165821   ⟹   XP_036021714
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,572,309 (-)NCBI
RefSeq Acc Id: XM_036165822   ⟹   XP_036021715
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,556,171 (-)NCBI
RefSeq Acc Id: XM_036165823   ⟹   XP_036021716
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,714 (-)NCBI
RefSeq Acc Id: XM_036165825   ⟹   XP_036021718
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,572,280 (-)NCBI
RefSeq Acc Id: XM_036165826   ⟹   XP_036021719
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,996 (-)NCBI
RefSeq Acc Id: XM_036165827   ⟹   XP_036021720
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,904 (-)NCBI
RefSeq Acc Id: XM_036165828   ⟹   XP_036021721
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,958 (-)NCBI
RefSeq Acc Id: XM_036165829   ⟹   XP_036021722
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,572,002 (-)NCBI
RefSeq Acc Id: XM_036165831   ⟹   XP_036021724
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,714 (-)NCBI
RefSeq Acc Id: XM_036165832   ⟹   XP_036021725
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,921 (-)NCBI
RefSeq Acc Id: XM_036165833   ⟹   XP_036021726
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,921 (-)NCBI
RefSeq Acc Id: XM_036165834   ⟹   XP_036021727
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,919 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001140161 (Get FASTA)   NCBI Sequence Viewer  
  NP_031997 (Get FASTA)   NCBI Sequence Viewer  
  XP_006505583 (Get FASTA)   NCBI Sequence Viewer  
  XP_006505584 (Get FASTA)   NCBI Sequence Viewer  
  XP_006505586 (Get FASTA)   NCBI Sequence Viewer  
  XP_006505587 (Get FASTA)   NCBI Sequence Viewer  
  XP_006505588 (Get FASTA)   NCBI Sequence Viewer  
  XP_006505589 (Get FASTA)   NCBI Sequence Viewer  
  XP_006505590 (Get FASTA)   NCBI Sequence Viewer  
  XP_006505592 (Get FASTA)   NCBI Sequence Viewer  
  XP_030111010 (Get FASTA)   NCBI Sequence Viewer  
  XP_030111011 (Get FASTA)   NCBI Sequence Viewer  
  XP_030111012 (Get FASTA)   NCBI Sequence Viewer  
  XP_030111015 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021710 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021711 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021712 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021713 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021714 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021715 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021716 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021718 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021719 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021720 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021721 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021722 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021724 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021725 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021726 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021727 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52655 (Get FASTA)   NCBI Sequence Viewer  
  AAD54020 (Get FASTA)   NCBI Sequence Viewer  
  AAH03772 (Get FASTA)   NCBI Sequence Viewer  
  AAH16391 (Get FASTA)   NCBI Sequence Viewer  
  AAH79538 (Get FASTA)   NCBI Sequence Viewer  
  BAC40432 (Get FASTA)   NCBI Sequence Viewer  
  BAD90359 (Get FASTA)   NCBI Sequence Viewer  
  BAE32205 (Get FASTA)   NCBI Sequence Viewer  
  BAE34232 (Get FASTA)   NCBI Sequence Viewer  
  EDL13435 (Get FASTA)   NCBI Sequence Viewer  
  Q61188 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_031997   ⟸   NM_007971
- Peptide Label: isoform 1
- UniProtKB: Q61188 (UniProtKB/Swiss-Prot),   Q3TZH6 (UniProtKB/TrEMBL),   Q571L5 (UniProtKB/TrEMBL),   Q6AXH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001140161   ⟸   NM_001146689
- Peptide Label: isoform 2
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL),   Q571L5 (UniProtKB/TrEMBL),   Q6AXH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006505584   ⟸   XM_006505521
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006505589   ⟸   XM_006505526
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006505588   ⟸   XM_006505525
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_006505586   ⟸   XM_006505523
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006505587   ⟸   XM_006505524
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006505592   ⟸   XM_006505529
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_006505590   ⟸   XM_006505527
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_006505583   ⟸   XM_006505520
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_030111012   ⟸   XM_030255152
- Peptide Label: isoform X6
RefSeq Acc Id: XP_030111015   ⟸   XM_030255155
- Peptide Label: isoform X13
RefSeq Acc Id: XP_030111011   ⟸   XM_030255151
- Peptide Label: isoform X6
RefSeq Acc Id: XP_030111010   ⟸   XM_030255150
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000144781   ⟸   ENSMUST00000204243
RefSeq Acc Id: ENSMUSP00000133195   ⟸   ENSMUST00000164006
RefSeq Acc Id: ENSMUSP00000118663   ⟸   ENSMUST00000133043
RefSeq Acc Id: ENSMUSP00000090318   ⟸   ENSMUST00000092648
RefSeq Acc Id: ENSMUSP00000144780   ⟸   ENSMUST00000204798
RefSeq Acc Id: ENSMUSP00000080419   ⟸   ENSMUST00000081721
RefSeq Acc Id: ENSMUSP00000110265   ⟸   ENSMUST00000114618
RefSeq Acc Id: ENSMUSP00000110263   ⟸   ENSMUST00000114616
RefSeq Acc Id: ENSMUSP00000128542   ⟸   ENSMUST00000167278
RefSeq Acc Id: ENSMUSP00000126481   ⟸   ENSMUST00000169889
RefSeq Acc Id: XP_036021714   ⟸   XM_036165821
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036021718   ⟸   XM_036165825
- Peptide Label: isoform X4
RefSeq Acc Id: XP_036021722   ⟸   XM_036165829
- Peptide Label: isoform X10
RefSeq Acc Id: XP_036021719   ⟸   XM_036165826
- Peptide Label: isoform X7
RefSeq Acc Id: XP_036021721   ⟸   XM_036165828
- Peptide Label: isoform X9
RefSeq Acc Id: XP_036021726   ⟸   XM_036165833
- Peptide Label: isoform X12
RefSeq Acc Id: XP_036021725   ⟸   XM_036165832
- Peptide Label: isoform X11
RefSeq Acc Id: XP_036021727   ⟸   XM_036165834
- Peptide Label: isoform X14
RefSeq Acc Id: XP_036021720   ⟸   XM_036165827
- Peptide Label: isoform X8
RefSeq Acc Id: XP_036021716   ⟸   XM_036165823
- Peptide Label: isoform X3
RefSeq Acc Id: XP_036021724   ⟸   XM_036165831
- Peptide Label: isoform X11
RefSeq Acc Id: XP_036021710   ⟸   XM_036165817
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036021713   ⟸   XM_036165820
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036021711   ⟸   XM_036165818
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036021715   ⟸   XM_036165822
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036021712   ⟸   XM_036165819
- Peptide Label: isoform X1
Protein Domains
CXC   PRC2_HTH_1   SET

Promoters
RGD ID:6839277
Promoter ID:MM_KWN:45853
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000114616,   ENSMUST00000114618,   ENSMUST00000114623,   OTTMUST00000050207,   OTTMUST00000050208
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36647,544,819 - 47,545,319 (-)MPROMDB
RGD ID:6889564
Promoter ID:EPDNEW_M8233
Type:initiation region
Name:Ezh2_1
Description:Mus musculus enhancer of zeste 2 polycomb repressive complex2 subunit , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38647,594,995 - 47,595,055EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107940 AgrOrtholog
Ensembl Genes ENSMUSG00000029687 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000080419 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000090318 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000110263 UniProtKB/TrEMBL
  ENSMUSP00000110265 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000118663 UniProtKB/TrEMBL
  ENSMUSP00000126481 UniProtKB/TrEMBL
  ENSMUSP00000128542 UniProtKB/TrEMBL
  ENSMUSP00000133195 UniProtKB/TrEMBL
  ENSMUSP00000144780 UniProtKB/TrEMBL
  ENSMUSP00000144781 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000081721 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000092648 UniProtKB/Swiss-Prot
  ENSMUST00000114616 UniProtKB/TrEMBL
  ENSMUST00000114618 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000133043 UniProtKB/TrEMBL
  ENSMUST00000164006 UniProtKB/TrEMBL
  ENSMUST00000167278 UniProtKB/TrEMBL
  ENSMUST00000169889 UniProtKB/TrEMBL
  ENSMUST00000204243 UniProtKB/TrEMBL
  ENSMUST00000204798 UniProtKB/TrEMBL
InterPro CXC_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EZH1/EZH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRC2_HTH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pre-SET_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SANT/Myb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tesmin/TSO1-like_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14056 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:107940 ENTREZGENE
NCBI Gene 14056 ENTREZGENE
Pfam EZH2_WD-Binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRC2_HTH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  preSET_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ezh2 PhenoGen
PROSITE CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SANT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SUQ7_MOUSE UniProtKB/TrEMBL
  A0A0N4SUQ8_MOUSE UniProtKB/TrEMBL
  D3Z774_MOUSE UniProtKB/TrEMBL
  E9PWK3_MOUSE UniProtKB/TrEMBL
  EZH2_MOUSE UniProtKB/Swiss-Prot
  F6T3Z0_MOUSE UniProtKB/TrEMBL
  F7AQX0_MOUSE UniProtKB/TrEMBL
  F7CW38_MOUSE UniProtKB/TrEMBL
  Q3TZH6 ENTREZGENE, UniProtKB/TrEMBL
  Q3U575_MOUSE UniProtKB/TrEMBL
  Q571L5 ENTREZGENE, UniProtKB/TrEMBL
  Q61188 ENTREZGENE
  Q6AXH7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q99L74 UniProtKB/Swiss-Prot
  Q9R090 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-17 Ezh2  enhancer of zeste 2 polycomb repressive complex 2 subunit    enhancer of zeste homolog 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED