Ezh2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) - Rat Genome Database

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Gene: Ezh2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) Mus musculus
Analyze
Symbol: Ezh2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
RGD ID: 1312684
MGI Page MGI
Description: Enables several functions, including histone H3K27 methyltransferase activity; nucleic acid binding activity; and transcription corepressor activity. Involved in B cell differentiation; facultative heterochromatin formation; and regulation of circadian rhythm. Acts upstream of or within several processes, including cardiac muscle hypertrophy in response to stress; negative regulation of cell differentiation; and negative regulation of macromolecule biosynthetic process. Located in pronucleus. Part of ESC/E(Z) complex; chromatin silencing complex; and pericentric heterochromatin. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Used to study B-cell lymphoma; Weaver syndrome; and acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Weaver syndrome; gastrointestinal system cancer (multiple); glioblastoma; hematologic cancer (multiple); and renal Wilms' tumor. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: enhancer of zeste homolog 2; Enx-; Enx-1; Enx1; Enx1h; histone-lysine N-methyltransferase EZH2; KIAA4065; KMT6; MGC90723; mKIAA4065
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39647,507,208 - 47,613,843 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl647,507,073 - 47,572,275 (-)EnsemblGRCm39 Ensembl
GRCm38647,530,274 - 47,595,270 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl647,530,139 - 47,595,341 (-)EnsemblGRCm38mm10GRCm38
MGSCv37647,480,273 - 47,545,029 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36647,459,867 - 47,524,606 (-)NCBIMGSCv36mm8
Celera647,385,379 - 47,451,063 (-)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map622.92NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acute lymphoblastic leukemia  (IAGP)
acute megakaryocytic leukemia  (ISO)
acute myeloid leukemia  (IMP,ISO)
B-cell lymphoma  (IAGP,IMP,ISO)
Breast Neoplasms  (ISO)
cholangiocarcinoma  (ISO)
Chromosome Breakage  (ISO)
chronic myeloid leukemia  (ISO)
chronic myelomonocytic leukemia  (ISO)
colon cancer  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal adenoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
Congenital Upper Extremity Deformities  (ISO)
congestive heart failure  (ISO)
cortical dysplasia-focal epilepsy syndrome  (ISO)
COVID-19  (ISO)
craniosynostosis  (ISO)
diffuse large B-cell lymphoma  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Colitis  (IMP)
Experimental Diabetes Mellitus  (ISO)
follicular lymphoma  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
invasive ductal carcinoma  (ISO)
juvenile myelomonocytic leukemia  (ISO)
Kidney Reperfusion Injury  (IEP)
Left Ventricular Hypertrophy  (ISO)
leiomyoma  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung non-small cell carcinoma  (ISO)
lymphoma  (ISO)
malignant pleural mesothelioma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
myelodysplastic syndrome  (ISO)
myelodysplastic/myeloproliferative neoplasm  (IMP,ISO)
myelofibrosis  (ISO)
myeloid leukemia associated with Down Syndrome  (ISO)
myeloid neoplasm  (IMP)
nasopharynx carcinoma  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
Neurodevelopmental Disorders  (ISO)
non-Hodgkin lymphoma  (ISO)
oral squamous cell carcinoma  (ISO)
osteosarcoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
Peritoneal Adhesions  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
renal Wilms' tumor  (ISO)
skin melanoma  (ISO)
stomach cancer  (ISO)
T-cell acute lymphoblastic leukemia  (IMP)
Transplant Rejection  (ISO)
urinary bladder cancer  (ISO)
Weaver syndrome  (IAGP,ISO)
Weight Gain  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Eudesmin  (ISO)
1,1-dichloroethene  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (ISO)
andrographolide  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bucladesine  (ISO)
buta-1,3-diene  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
carmustine  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
clorgyline  (ISO)
clothianidin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
doxycycline  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
enzalutamide  (ISO)
ethanol  (EXP,ISO)
fenvalerate  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (ISO)
geraniol  (ISO)
glycerol 2-phosphate  (ISO)
GSK343  (ISO)
heptachlor  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
ketamine  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lucanthone  (ISO)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylazoxymethanol  (EXP)
methylmercury chloride  (ISO)
morphine  (EXP,ISO)
myo-inositol hexakisphosphate  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
oxaliplatin  (ISO)
ozone  (EXP)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
piroxicam  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
Soman  (ISO)
sorafenib  (ISO)
stattic  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
topotecan  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP)
urethane  (EXP,ISO)
valproic acid  (EXP,ISO)
vemurafenib  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell differentiation  (IMP)
cardiac muscle hypertrophy in response to stress  (IDA)
cellular response to hydrogen peroxide  (IDA)
cellular response to trichostatin A  (IMP)
cerebellar cortex development  (IMP)
chromatin organization  (IEA)
chromatin remodeling  (IEA)
DNA methylation-dependent heterochromatin formation  (IMP)
epidermal cell differentiation  (IMP)
facultative heterochromatin formation  (IDA)
G1 to G0 transition  (IMP)
G1/S transition of mitotic cell cycle  (IMP)
hemopoiesis  (IMP)
hepatocyte homeostasis  (IGI)
heterochromatin formation  (IBA)
hippocampus development  (ISO)
immunoglobulin heavy chain V-D-J recombination  (TAS)
keratinocyte differentiation  (IMP)
liver regeneration  (IGI)
methylation  (IEA)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of DNA-binding transcription factor activity  (IGI)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of epidermal cell differentiation  (IMP)
negative regulation of G1/S transition of mitotic cell cycle  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of gene expression, epigenetic  (ISO)
negative regulation of keratinocyte differentiation  (IMP)
negative regulation of retinoic acid receptor signaling pathway  (ISO)
negative regulation of stem cell differentiation  (IMP)
negative regulation of striated muscle cell differentiation  (IDA)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
negative regulation of transcription elongation by RNA polymerase II  (IMP)
positive regulation of cell cycle G1/S phase transition  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of dendrite development  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of protein serine/threonine kinase activity  (ISO)
protein localization to chromatin  (IMP)
protein modification process  (ISO)
regulation of cell population proliferation  (IMP)
regulation of circadian rhythm  (IMP,ISO)
regulation of gene expression  (IMP)
regulation of gliogenesis  (IMP)
regulation of kidney development  (ISO)
regulation of neurogenesis  (IMP)
regulation of protein phosphorylation  (IMP)
regulation of transcription by RNA polymerase II  (IMP)
regulatory ncRNA-mediated heterochromatin formation  (ISO)
response to estradiol  (ISO)
response to tetrachloromethane  (IGI)
rhythmic process  (IEA)
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration  (IMP)
stem cell differentiation  (IMP)
subtelomeric heterochromatin formation  (ISO)
synaptic transmission, GABAergic  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell differentiation  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal endometrial gland morphology  (IAGP)
abnormal endometrium morphology  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal hair follicle infundibulum morphology  (IAGP)
abnormal hair follicle outer root sheath morphology  (IAGP)
abnormal hair growth  (IAGP)
abnormal immunoglobulin V(D)J recombination  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal oligodendrocyte morphology  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal parturition  (IAGP)
abnormal pro-B cell morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal spleen white pulp morphology  (IAGP)
abnormal uterine epithelium development  (IAGP)
absent gastric milk in neonates  (IAGP)
absent inner cell mass proliferation  (IAGP)
cleft palate  (IAGP)
decreased B cell proliferation  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased germinal center B cell number  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG3 level  (IAGP)
decreased immature B cell number  (IAGP)
decreased litter size  (IAGP)
decreased pre-B cell number  (IAGP)
decreased spleen germinal center number  (IAGP)
decreased spleen germinal center size  (IAGP)
decreased thymocyte number  (IAGP)
decreased uterine NK cell number  (IAGP)
dysmyelination  (IAGP)
dystocia  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality between somite formation and embryo turning, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
endometrium hyperplasia  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
enlarged uterine horn  (IAGP)
epidermal hyperplasia  (IAGP)
failure to gastrulate  (IAGP)
hair follicle degeneration  (IAGP)
increased B cell derived lymphoma incidence  (IAGP)
increased body weight  (IAGP)
increased circulating triglyceride level  (IEA)
increased double-negative T cell number  (IAGP)
increased endometrial gland number  (IAGP)
increased femur compact bone thickness  (IAGP)
increased growth rate  (IAGP)
increased hair follicle apoptosis  (IAGP)
increased heart weight  (IAGP)
increased internal diameter of femur  (IAGP)
increased kidney weight  (IAGP)
increased leukemia incidence  (IAGP)
increased mean corpuscular hemoglobin  (IEA)
increased melanoma incidence  (IAGP)
increased sacral vertebrae number  (IEA)
increased spleen weight  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
myocardial ventricular hypertrabeculation  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
primary atelectasis  (IAGP)
reduced female fertility  (IAGP)
small hair follicles  (IAGP)
thin myocardium compact layer  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Modified Adenovirus Reduces De Novo Peritoneal Adhesions in Rats and Limits Off-Target Transfection. Role of EZH2 in Adhesion Formation. Atta HM, etal., J Invest Surg. 2017 Apr;30(2):78-87. doi: 10.1080/08941939.2016.1229366. Epub 2016 Oct 3.
2. EZH2 protein expression associates with the early pathogenesis, tumor progression, and prognosis of non-small cell lung carcinoma. Behrens C, etal., Clin Cancer Res. 2013 Dec 1;19(23):6556-65. doi: 10.1158/1078-0432.CCR-12-3946. Epub 2013 Oct 4.
3. Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes. Bejar R, etal., J Clin Oncol. 2012 Sep 20;30(27):3376-82. doi: 10.1200/JCO.2011.40.7379. Epub 2012 Aug 6.
4. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, etal., Mol Cell. 2012 Nov 30;48(4):491-507. doi: 10.1016/j.molcel.2012.11.006.
5. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. Bracken AP, etal., EMBO J. 2003 Oct 15;22(20):5323-35.
6. EZH2 promotes malignant phenotypes and is a predictor of oral cancer development in patients with oral leukoplakia. Cao W, etal., Cancer Prev Res (Phila). 2011 Nov;4(11):1816-24. doi: 10.1158/1940-6207.CAPR-11-0130. Epub 2011 Jun 22.
7. EZH2 promotes malignant behaviors via cell cycle dysregulation and its mRNA level associates with prognosis of patient with non-small cell lung cancer. Cao W, etal., PLoS One. 2012;7(12):e52984. doi: 10.1371/journal.pone.0052984. Epub 2012 Dec 31.
8. Enhancer of zeste homolog 2 expression is associated with tumor cell proliferation and metastasis in gastric cancer. Choi JH, etal., APMIS. 2010 Mar;118(3):196-202. doi: 10.1111/j.1600-0463.2009.02579.x.
9. An EZH2 polymorphism is associated with clinical outcome in metastatic colorectal cancer patients. Crea F, etal., Ann Oncol. 2012 May;23(5):1207-1213. doi: 10.1093/annonc/mdr387. Epub 2011 Sep 16.
10. Expression of EZH2 and Ki-67 in colorectal cancer and associations with treatment response and prognosis. Fluge Ø, etal., Br J Cancer. 2009 Oct 20;101(8):1282-9. doi: 10.1038/sj.bjc.6605333. Epub 2009 Sep 22.
11. RAS oncogenic signal upregulates EZH2 in pancreatic cancer. Fujii S, etal., Biochem Biophys Res Commun. 2012 Jan 20;417(3):1074-9. doi: 10.1016/j.bbrc.2011.12.099. Epub 2011 Dec 26.
12. Environmental estrogens differentially engage the histone methyltransferase EZH2 to increase risk of uterine tumorigenesis. Greathouse KL, etal., Mol Cancer Res. 2012 Apr;10(4):546-57. doi: 10.1158/1541-7786.MCR-11-0605.
13. Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevance. Grossmann V, etal., Leukemia. 2011 May;25(5):877-9. doi: 10.1038/leu.2011.10. Epub 2011 Feb 22.
14. EZH2 mutational status predicts poor survival in myelofibrosis. Guglielmelli P, etal., Blood. 2011 Nov 10;118(19):5227-34. doi: 10.1182/blood-2011-06-363424. Epub 2011 Sep 14.
15. Age-associated alteration of gene expression patterns in mouse oocytes. Hamatani T, etal., Hum Mol Genet 2004 Oct 1;13(19):2263-78. Epub 2004 Aug 18.
16. Targeting protein lysine methylation and demethylation in cancers. He Y, etal., Acta Biochim Biophys Sin (Shanghai). 2012 Jan;44(1):70-9. doi: 10.1093/abbs/gmr109.
17. Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease. Herrera-Merchan A, etal., Nat Commun. 2012 Jan 10;3:623. doi: 10.1038/ncomms1623.
18. SET for life: biochemical activities and biological functions of SET domain-containing proteins. Herz HM, etal., Trends Biochem Sci. 2013 Dec;38(12):621-39. doi: 10.1016/j.tibs.2013.09.004. Epub 2013 Oct 20.
19. Enhancer of zeste homolog 2 overexpression in nasopharyngeal carcinoma: an independent poor prognosticator that enhances cell growth. Hwang CF, etal., Int J Radiat Oncol Biol Phys. 2012 Feb 1;82(2):597-604. doi: 10.1016/j.ijrobp.2010.11.062. Epub 2011 Feb 6.
20. Polycomb repressor complex-2 is a novel target for mesothelioma therapy. Kemp CD, etal., Clin Cancer Res. 2012 Jan 1;18(1):77-90. doi: 10.1158/1078-0432.CCR-11-0962. Epub 2011 Oct 25.
21. Full spectrum of clonal haematopoiesis-driver mutations in chronic heart failure and their associations with mortality. Kiefer KC, etal., ESC Heart Fail. 2021 Jun;8(3):1873-1884. doi: 10.1002/ehf2.13297. Epub 2021 Mar 28.
22. Epigenetic changes in renal genes dysregulated in mouse and rat models of type 1 diabetes. Komers R, etal., Lab Invest. 2013 May;93(5):543-52. doi: 10.1038/labinvest.2013.47. Epub 2013 Mar 18.
23. The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway. Kurihara H, etal., Oncotarget. 2016 Mar 15;7(11):12704-17. doi: 10.18632/oncotarget.7260.
24. Polycomb repressive complex 2 (PRC2) suppresses Emu-myc lymphoma. Lee SC, etal., Blood. 2013 Oct 10;122(15):2654-63. doi: 10.1182/blood-2013-02-484055. Epub 2013 Aug 27.
25. DAB2IP Expression in Abdominal Aortic Aneurysm: EZH2 and mir-363-3p as Potential Mediators. Legaki E, etal., In Vivo. 2019 May-Jun;33(3):737-742. doi: 10.21873/invivo.11533.
26. Inhibition of histone methyltransferase EZH2 ameliorates early acute renal allograft rejection in rats. Li L, etal., BMC Immunol. 2016 Oct 26;17(1):41. doi: 10.1186/s12865-016-0179-3.
27. EZH2 overexpression in primary gastrointestinal diffuse large B-cell lymphoma and its association with the clinicopathological features. Liu Y, etal., Hum Pathol. 2017 Jun;64:213-221. doi: 10.1016/j.humpath.2017.04.011. Epub 2017 Apr 22.
28. Discovery of EBI-2511: A Highly Potent and Orally Active EZH2 Inhibitor for the Treatment of Non-Hodgkin's Lymphoma. Lu B, etal., ACS Med Chem Lett. 2018 Jan 29;9(2):98-102. doi: 10.1021/acsmedchemlett.7b00437. eCollection 2018 Feb 8.
29. Enhancer of zeste homolog 2 silencing inhibits tumor growth and lung metastasis in osteosarcoma. Lv YF, etal., Sci Rep. 2015 Aug 12;5:12999. doi: 10.1038/srep12999.
30. Expression of the enhancer of zeste homolog 2 is correlated with poor prognosis in human gastric cancer. Matsukawa Y, etal., Cancer Sci. 2006 Jun;97(6):484-91. doi: 10.1111/j.1349-7006.2006.00203.x.
31. Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes. Metsuyanim S, etal., Stem Cells. 2008 Jul;26(7):1808-17. doi: 10.1634/stemcells.2007-0322. Epub 2008 May 8.
32. MGDs mouse GO annotations MGD data from the GO Consortium
33. MGD IEA MGD IEA
34. Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders. Muto T, etal., J Exp Med. 2013 Nov 18;210(12):2627-39. doi: 10.1084/jem.20131144. Epub 2013 Nov 11.
35. DNMT1 and EZH2 mediated methylation silences the microRNA-200b/a/429 gene and promotes tumor progression. Ning X, etal., Cancer Lett. 2015 Apr 10;359(2):198-205. doi: 10.1016/j.canlet.2015.01.005. Epub 2015 Jan 13.
36. BCR/ABL increases EZH2 levels which regulates XIAP expression via miRNA-219 in chronic myeloid leukemia cells. Nishioka C, etal., Leuk Res. 2016 Jun;45:24-32. doi: 10.1016/j.leukres.2016.03.012. Epub 2016 Apr 1.
37. Increased EZH2 expression during the adenoma-carcinoma sequence in colorectal cancer. Ohuchi M, etal., Oncol Lett. 2018 Oct;16(4):5275-5281. doi: 10.3892/ol.2018.9240. Epub 2018 Jul 31.
38. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
39. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
40. A single nucleotide polymorphism in EZH2 predicts overall survival rate in patients with cholangiocarcinoma. Paolicchi E, etal., Oncol Lett. 2013 Nov;6(5):1487-1491. doi: 10.3892/ol.2013.1559. Epub 2013 Sep 2.
41. Mouse MP Annotation Import Pipeline RGD automated import pipeline
42. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
43. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
44. Inhibition of Histone Methyltransferase EZH2 Suppresses Endometriotic Vesicle Development in a Rat Model of Endometriosis. Seguinot-Tarafa I, etal., Reprod Sci. 2020 Sep;27(9):1812-1820. doi: 10.1007/s43032-020-00257-9. Epub 2020 Jul 10.
45. Aberrant expression of EZH2 is associated with pathological findings and P53 alteration. Shiogama S, etal., Anticancer Res. 2013 Oct;33(10):4309-17.
46. A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia. Simon C, etal., Genes Dev. 2012 Apr 1;26(7):651-6. doi: 10.1101/gad.186411.111. Epub 2012 Mar 19.
47. Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Simon JA and Kingston RE, Mol Cell. 2013 Mar 7;49(5):808-24. doi: 10.1016/j.molcel.2013.02.013.
48. Effects of EZH2 promoter polymorphisms and methylation status on oral squamous cell carcinoma susceptibility and pathology. Su KJ, etal., Am J Cancer Res. 2015 Oct 15;5(11):3475-84. eCollection 2015.
49. Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker. Takawa M, etal., Cancer Sci. 2011 Jul;102(7):1298-305. doi: 10.1111/j.1349-7006.2011.01958.x. Epub 2011 May 26.
50. Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia. Tanaka S, etal., Blood. 2012 Aug 2;120(5):1107-17. doi: 10.1182/blood-2011-11-394932. Epub 2012 Jun 7.
51. Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features. van Leenders GJ, etal., Eur Urol. 2007 Aug;52(2):455-63. Epub 2006 Nov 17.
52. EZH2 down-regulation exacerbates lipid accumulation and inflammation in in vitro and in vivo NAFLD. Vella S, etal., Int J Mol Sci. 2013 Dec 12;14(12):24154-68. doi: 10.3390/ijms141224154.
53. [Expression of enhancer of zeste homolog 2 in esophageal squamous cell carcinoma and its prognostic value in postoperative patients]. Wang HR, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2015 Jan;35(1):99-102.
54. TET2, ASXL1 and EZH2 mutations in Chinese with myelodysplastic syndromes. Wang J, etal., Leuk Res. 2013 Mar;37(3):305-11. doi: 10.1016/j.leukres.2012.10.004. Epub 2012 Oct 23.
55. Mutual regulation between CHD5 and EZH2 in hepatocellular carcinoma. Xie CR, etal., Oncotarget. 2015 Dec 1;6(38):40940-52. doi: 10.18632/oncotarget.5724.
56. Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring. Xu F, etal., Ann Hematol. 2011 Jun;90(6):643-53. doi: 10.1007/s00277-010-1128-5. Epub 2010 Dec 2.
57. MicroRNA-101 inhibits human hepatocellular carcinoma progression through EZH2 downregulation and increased cytostatic drug sensitivity. Xu L, etal., J Hepatol. 2014 Mar;60(3):590-8. doi: 10.1016/j.jhep.2013.10.028. Epub 2013 Nov 6.
58. Aberrant expression of EZH2 is associated with a poor outcome and P53 alteration in squamous cell carcinoma of the esophagus. Yamada A, etal., Int J Oncol. 2011 Feb;38(2):345-53. doi: 10.3892/ijo.2010.868. Epub 2010 Dec 9.
59. MicroRNA-214 provokes cardiac hypertrophy via repression of EZH2. Yang T, etal., Biochem Biophys Res Commun. 2013 Jul 12;436(4):578-84. doi: 10.1016/j.bbrc.2013.05.079. Epub 2013 May 29.
60. Genetic polymorphisms in the polycomb group gene EZH2 and the risk of lung cancer. Yoon KA, etal., J Thorac Oncol. 2010 Jan;5(1):10-6. doi: 10.1097/JTO.0b013e3181c422d9.
61. The landscape of somatic mutations in Down syndrome-related myeloid disorders. Yoshida K, etal., Nat Genet. 2013 Nov;45(11):1293-9. doi: 10.1038/ng.2759. Epub 2013 Sep 22.
62. Effects of EZH2 polymorphisms on susceptibility to and pathological development of hepatocellular carcinoma. Yu YL, etal., PLoS One. 2013 Sep 10;8(9):e74870. doi: 10.1371/journal.pone.0074870. eCollection 2013.
63. Aberrant upregulation of 14-3-3σ and EZH2 expression serves as an inferior prognostic biomarker for hepatocellular carcinoma. Zhang Y, etal., PLoS One. 2014 Sep 16;9(9):e107251. doi: 10.1371/journal.pone.0107251. eCollection 2014.
64. Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation. Zhou J, etal., Nat Commun. 2019 Jun 3;10(1):2427. doi: 10.1038/s41467-019-10176-2.
65. EZH2 genetic variants affect risk of gastric cancer in the Chinese Han population. Zhou Y, etal., Mol Carcinog. 2014 Aug;53(8):589-97. doi: 10.1002/mc.21871. Epub 2012 Jan 6.
Additional References at PubMed
PMID:8861097   PMID:8921387   PMID:9176491   PMID:9214638   PMID:9473645   PMID:9584197   PMID:9742080   PMID:10051331   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861  
PMID:11217851   PMID:11287189   PMID:11390661   PMID:12123576   PMID:12477932   PMID:12496962   PMID:12520002   PMID:12589020   PMID:12900441   PMID:12904583   PMID:14610273   PMID:14671313  
PMID:14681479   PMID:15077161   PMID:15385962   PMID:15520282   PMID:15536069   PMID:15596546   PMID:15733677   PMID:15741177   PMID:15782199   PMID:15882624   PMID:16009709   PMID:16025120  
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Genomics

Comparative Map Data
Ezh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39647,507,208 - 47,613,843 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl647,507,073 - 47,572,275 (-)EnsemblGRCm39 Ensembl
GRCm38647,530,274 - 47,595,270 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl647,530,139 - 47,595,341 (-)EnsemblGRCm38mm10GRCm38
MGSCv37647,480,273 - 47,545,029 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36647,459,867 - 47,524,606 (-)NCBIMGSCv36mm8
Celera647,385,379 - 47,451,063 (-)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map622.92NCBI
EZH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387148,807,383 - 148,884,291 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7148,807,257 - 148,884,321 (-)EnsemblGRCh38hg38GRCh38
GRCh377148,504,475 - 148,581,383 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367148,135,408 - 148,212,347 (-)NCBINCBI36Build 36hg18NCBI36
Build 347147,942,122 - 148,019,062NCBI
Celera7143,174,898 - 143,251,832 (-)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7142,583,460 - 142,659,958 (-)NCBIHuRef
CHM1_17148,512,861 - 148,589,845 (-)NCBICHM1_1
T2T-CHM13v2.07149,989,157 - 150,066,070 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27147,842,417 - 147,919,393 (-)NCBI
Ezh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8477,624,223 - 77,698,598 (-)NCBIGRCr8
mRatBN7.2476,624,399 - 76,687,362 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl476,624,399 - 76,687,362 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx481,590,638 - 81,653,503 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0477,503,983 - 77,566,865 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0475,884,156 - 75,947,036 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0477,284,404 - 77,347,011 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl477,284,404 - 77,347,011 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04141,955,864 - 142,018,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4475,709,959 - 75,773,279 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera471,429,142 - 71,492,047 (-)NCBICelera
Cytogenetic Map4q24NCBI
Ezh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554914,215,298 - 4,292,235 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554914,215,353 - 4,292,229 (-)NCBIChiLan1.0ChiLan1.0
EZH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26185,392,512 - 185,468,679 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1737,402,774 - 37,478,924 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07140,536,962 - 140,613,104 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17153,017,590 - 153,059,726 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7153,017,590 - 153,059,726 (-)Ensemblpanpan1.1panPan2
EZH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1161,926,443 - 1,991,995 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl161,925,956 - 1,991,838 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha163,025,322 - 3,090,857 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0161,730,910 - 1,796,671 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl161,754,174 - 1,796,670 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1161,717,683 - 1,783,294 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0161,577,046 - 1,642,624 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0161,581,164 - 1,646,809 (+)NCBIUU_Cfam_GSD_1.0
Ezh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051187,804,044 - 7,879,353 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365275,024,068 - 5,063,939 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365275,024,077 - 5,069,152 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EZH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9109,385,015 - 109,450,941 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19109,384,976 - 109,450,943 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29120,322,804 - 120,388,754 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EZH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121117,380,518 - 117,515,224 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21117,380,361 - 117,421,573 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607213,330,068 - 13,407,159 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ezh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248006,802,901 - 6,874,196 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248006,781,848 - 6,874,221 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ezh2
2583 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1355
Count of miRNA genes:582
Interacting mature miRNAs:691
Transcripts:ENSMUST00000081721, ENSMUST00000092648, ENSMUST00000114616, ENSMUST00000114618, ENSMUST00000133043, ENSMUST00000164006, ENSMUST00000165492, ENSMUST00000167278, ENSMUST00000169889, ENSMUST00000170311, ENSMUST00000170327, ENSMUST00000171614
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
1301266Lmr4_mleishmaniasis resistance 4 (mouse)Not determined64209335876093500Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
12910785Pwgrq16_mpost-weaning growth rate QTL 16 (mouse)64380374777788506Mouse
11252142Mom12_mModifier of Min 12 (mouse)63387226167872400Mouse
12910798Pwgrq5_mpre-weaning growth rate QTL 5 (mouse)64380374777788506Mouse
1300767Aliq4_macute lung injury QTL 4 (mouse)Not determined63627333270273435Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
14746995Manh60_mmandible shape 60 (mouse)63720266271202662Mouse
12910807Pwbwq11_mpost-weaning body weight QTL 11 (mouse)64380374777788506Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
12910802Pwbwq12_mpost-weaning body weight QTL 12 (mouse)64380374777788506Mouse
4141094Hrtr1_mheart rate 1 (mouse)Not determined3674146370741463Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64529099387403016Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2829099362291115Mouse
12910809Pwbwq10_mpost-weaning body weight QTL 10 (mouse)64380374777788506Mouse
12910820Ogrq3_moverall growth rate QTL 3 (mouse)64380374777788506Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3170349965703611Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63387226167872400Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
1301326Trbv4c2_mT cell receptor beta variable 4 (mouse)Not determined64086823071356155Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3282758578215957Mouse
12880424V25Dq4_mvitamin D inactive form serum level QTL 4 (mouse)64157698575576985Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63267698066676980Mouse
11040600Lmr4c_mleishmaniasis resistance 4c (mouse)64209335876093500Mouse
11040601Lmr4a_mleishmaniasis resistance 4a (mouse)64209335876093500Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
11533915Mts4_mmammary tumor susceptibility 4 (mouse)64209335876093500Mouse
10043885Cia6c_mcollagen induced arthritis QTL 6c (mouse)Not determined64444280571096451Mouse
1357539Bsbob3_mBSB obesity 3 (mouse)Not determined63644845670448576Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse

Markers in Region
AW554728  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38647,530,506 - 47,530,593UniSTSGRCm38
MGSCv37647,480,505 - 47,480,592UniSTSGRCm37
Celera647,385,610 - 47,385,697UniSTS
Cytogenetic Map6BUniSTS
cM Map619.2UniSTS
Whitehead/MRC_RH6445.33UniSTS
U52951  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38647,530,326 - 47,530,476UniSTSGRCm38
MGSCv37647,480,325 - 47,480,475UniSTSGRCm37
Celera647,385,430 - 47,385,580UniSTS
Cytogenetic Map6BUniSTS
cM Map619.2UniSTS
Whitehead_YAC6 UniSTS
D6Mit351  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38647,574,728 - 47,574,837UniSTSGRCm38
MGSCv37647,524,727 - 47,524,836UniSTSGRCm37
Celera647,429,501 - 47,429,614UniSTS
Cytogenetic Map6BUniSTS
cM Map620.4UniSTS
Whitehead Genetic610.9UniSTS
Whitehead_YAC6 UniSTS
RH125972  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38647,585,266 - 47,585,457UniSTSGRCm38
GRCm38729,174,563 - 29,175,430UniSTSGRCm38
MGSCv37647,535,265 - 47,535,456UniSTSGRCm37
MGSCv37729,959,582 - 29,960,449UniSTSGRCm37
Celera723,744,632 - 23,745,499UniSTS
Celera647,440,040 - 47,440,231UniSTS
Cytogenetic Map6BUniSTS
Cytogenetic Map7B1UniSTS
cM Map619.2UniSTS
PMC108938P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,192,437 - 101,192,953UniSTSGRCm38
MGSCv3711101,053,751 - 101,054,267UniSTSGRCm37
Celera11112,488,553 - 112,489,069UniSTS
Cytogenetic Map11C-DUniSTS
Cytogenetic Map6BUniSTS
cM Map619.2UniSTS
PMC87093P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38647,554,329 - 47,554,729UniSTSGRCm38
MGSCv37647,504,328 - 47,504,728UniSTSGRCm37
Celera647,409,317 - 47,409,717UniSTS
Cytogenetic Map6BUniSTS
cM Map619.2UniSTS
Ezh2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38647,545,791 - 47,546,001UniSTSGRCm38
MGSCv37647,495,790 - 47,496,000UniSTSGRCm37
Celera647,400,784 - 47,400,994UniSTS
Cytogenetic Map6BUniSTS
cM Map619.2UniSTS
Ezh2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38647,530,349 - 47,530,473UniSTSGRCm38
MGSCv37647,480,348 - 47,480,472UniSTSGRCm37
Celera647,385,453 - 47,385,577UniSTS
Cytogenetic Map6BUniSTS
cM Map619.2UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001146689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_176898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_176899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_176900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_176901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_176902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_176903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006505527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030255155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC154015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC155652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF104359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U52951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000081721   ⟹   ENSMUSP00000080419
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl647,507,073 - 47,571,964 (-)Ensembl
GRCm38.p6 Ensembl647,530,139 - 47,595,030 (-)Ensembl
Ensembl Acc Id: ENSMUST00000092648   ⟹   ENSMUSP00000090318
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl647,507,475 - 47,554,594 (-)Ensembl
GRCm38.p6 Ensembl647,530,541 - 47,577,660 (-)Ensembl
Ensembl Acc Id: ENSMUST00000114616   ⟹   ENSMUSP00000110263
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl647,507,073 - 47,571,964 (-)Ensembl
GRCm38.p6 Ensembl647,530,139 - 47,595,030 (-)Ensembl
Ensembl Acc Id: ENSMUST00000114618   ⟹   ENSMUSP00000110265
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl647,507,073 - 47,571,964 (-)Ensembl
GRCm38.p6 Ensembl647,530,139 - 47,595,030 (-)Ensembl
Ensembl Acc Id: ENSMUST00000133043   ⟹   ENSMUSP00000118663
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl647,529,320 - 47,572,275 (-)Ensembl
GRCm38.p6 Ensembl647,552,386 - 47,595,341 (-)Ensembl
Ensembl Acc Id: ENSMUST00000164006   ⟹   ENSMUSP00000133195
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl647,517,777 - 47,528,695 (-)Ensembl
GRCm38.p6 Ensembl647,540,843 - 47,551,761 (-)Ensembl
Ensembl Acc Id: ENSMUST00000165492
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl647,510,676 - 47,522,817 (-)Ensembl
GRCm38.p6 Ensembl647,533,742 - 47,545,883 (-)Ensembl
Ensembl Acc Id: ENSMUST00000167278   ⟹   ENSMUSP00000128542
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl647,520,940 - 47,528,695 (-)Ensembl
GRCm38.p6 Ensembl647,544,006 - 47,551,761 (-)Ensembl
Ensembl Acc Id: ENSMUST00000169889   ⟹   ENSMUSP00000126481
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl647,522,717 - 47,531,148 (-)Ensembl
GRCm38.p6 Ensembl647,545,783 - 47,554,214 (-)Ensembl
Ensembl Acc Id: ENSMUST00000170311
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl647,509,564 - 47,517,643 (-)Ensembl
GRCm38.p6 Ensembl647,532,630 - 47,540,709 (-)Ensembl
Ensembl Acc Id: ENSMUST00000170327
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl647,532,964 - 47,554,944 (-)Ensembl
GRCm38.p6 Ensembl647,556,030 - 47,578,010 (-)Ensembl
Ensembl Acc Id: ENSMUST00000171614
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl647,508,944 - 47,512,059 (-)Ensembl
GRCm38.p6 Ensembl647,532,010 - 47,535,125 (-)Ensembl
Ensembl Acc Id: ENSMUST00000203857
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl647,507,253 - 47,509,050 (-)Ensembl
GRCm38.p6 Ensembl647,530,319 - 47,532,116 (-)Ensembl
Ensembl Acc Id: ENSMUST00000204243   ⟹   ENSMUSP00000144781
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl647,507,073 - 47,517,669 (-)Ensembl
GRCm38.p6 Ensembl647,530,139 - 47,540,735 (-)Ensembl
Ensembl Acc Id: ENSMUST00000204798   ⟹   ENSMUSP00000144780
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl647,522,770 - 47,571,992 (-)Ensembl
GRCm38.p6 Ensembl647,545,836 - 47,595,058 (-)Ensembl
RefSeq Acc Id: NM_001146689   ⟹   NP_001140161
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,964 (-)NCBI
GRCm38647,530,274 - 47,595,030 (-)NCBI
MGSCv37647,480,273 - 47,545,029 (-)RGD
Celera647,385,379 - 47,451,063 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001409810   ⟹   NP_001396739
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,572,328 (-)NCBI
RefSeq Acc Id: NM_001409811   ⟹   NP_001396740
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,717 (-)NCBI
RefSeq Acc Id: NM_001409812   ⟹   NP_001396741
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,964 (-)NCBI
RefSeq Acc Id: NM_001409813   ⟹   NP_001396742
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,717 (-)NCBI
RefSeq Acc Id: NM_001409814   ⟹   NP_001396743
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,572,328 (-)NCBI
RefSeq Acc Id: NM_001409815   ⟹   NP_001396744
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,613,843 (-)NCBI
RefSeq Acc Id: NM_001409816   ⟹   NP_001396745
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,613,843 (-)NCBI
RefSeq Acc Id: NM_001409817   ⟹   NP_001396746
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,964 (-)NCBI
RefSeq Acc Id: NM_001409818   ⟹   NP_001396747
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,964 (-)NCBI
RefSeq Acc Id: NM_001409819   ⟹   NP_001396748
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,572,328 (-)NCBI
RefSeq Acc Id: NM_001409820   ⟹   NP_001396749
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,613,843 (-)NCBI
RefSeq Acc Id: NM_001409821   ⟹   NP_001396750
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,613,843 (-)NCBI
RefSeq Acc Id: NM_001409822   ⟹   NP_001396751
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,964 (-)NCBI
RefSeq Acc Id: NM_001409823   ⟹   NP_001396752
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,717 (-)NCBI
RefSeq Acc Id: NM_001409824   ⟹   NP_001396753
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,613,843 (-)NCBI
RefSeq Acc Id: NM_001409825   ⟹   NP_001396754
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,613,843 (-)NCBI
RefSeq Acc Id: NM_001409826   ⟹   NP_001396755
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,572,328 (-)NCBI
RefSeq Acc Id: NM_001409827   ⟹   NP_001396756
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,964 (-)NCBI
RefSeq Acc Id: NM_001409828   ⟹   NP_001396757
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,964 (-)NCBI
RefSeq Acc Id: NM_001409829   ⟹   NP_001396758
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,964 (-)NCBI
RefSeq Acc Id: NM_001409830   ⟹   NP_001396759
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,964 (-)NCBI
RefSeq Acc Id: NM_001409831   ⟹   NP_001396760
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,964 (-)NCBI
RefSeq Acc Id: NM_007971   ⟹   NP_031997
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,964 (-)NCBI
GRCm38647,530,274 - 47,595,030 (-)NCBI
MGSCv37647,480,273 - 47,545,029 (-)RGD
Celera647,385,379 - 47,451,063 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_176898
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,964 (-)NCBI
RefSeq Acc Id: NR_176899
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,964 (-)NCBI
RefSeq Acc Id: NR_176900
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,964 (-)NCBI
RefSeq Acc Id: NR_176901
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,964 (-)NCBI
RefSeq Acc Id: NR_176902
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,964 (-)NCBI
RefSeq Acc Id: NR_176903
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,964 (-)NCBI
RefSeq Acc Id: XM_006505527   ⟹   XP_006505590
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,919 (-)NCBI
GRCm38647,530,274 - 47,594,985 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030255155   ⟹   XP_030111015
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,919 (-)NCBI
GRCm38647,530,274 - 47,594,985 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165817   ⟹   XP_036021710
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,217 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165818   ⟹   XP_036021711
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,568,525 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165819   ⟹   XP_036021712
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,556,168 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165820   ⟹   XP_036021713
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,568,525 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165822   ⟹   XP_036021715
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,556,171 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165823   ⟹   XP_036021716
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,714 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165827   ⟹   XP_036021720
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,904 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165828   ⟹   XP_036021721
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,958 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165829   ⟹   XP_036021722
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,572,002 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165831   ⟹   XP_036021724
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,714 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165832   ⟹   XP_036021725
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39647,507,208 - 47,571,921 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001140161 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396739 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396740 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396741 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396742 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396743 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396744 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396745 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396746 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396747 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396748 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396749 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396750 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396751 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396752 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396753 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396754 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396755 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396756 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396757 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396758 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396759 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396760 (Get FASTA)   NCBI Sequence Viewer  
  NP_031997 (Get FASTA)   NCBI Sequence Viewer  
  XP_006505590 (Get FASTA)   NCBI Sequence Viewer  
  XP_030111015 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021710 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021711 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021712 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021713 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021715 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021716 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021720 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021721 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021722 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021724 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021725 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52655 (Get FASTA)   NCBI Sequence Viewer  
  AAD54020 (Get FASTA)   NCBI Sequence Viewer  
  AAH03772 (Get FASTA)   NCBI Sequence Viewer  
  AAH16391 (Get FASTA)   NCBI Sequence Viewer  
  AAH79538 (Get FASTA)   NCBI Sequence Viewer  
  BAC40432 (Get FASTA)   NCBI Sequence Viewer  
  BAD90359 (Get FASTA)   NCBI Sequence Viewer  
  BAE32205 (Get FASTA)   NCBI Sequence Viewer  
  BAE34232 (Get FASTA)   NCBI Sequence Viewer  
  EDL13435 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000080419
  ENSMUSP00000080419.7
  ENSMUSP00000090318
  ENSMUSP00000090318.7
  ENSMUSP00000110263.2
  ENSMUSP00000110265
  ENSMUSP00000110265.2
  ENSMUSP00000118663.2
  ENSMUSP00000126481.2
  ENSMUSP00000128542.2
  ENSMUSP00000133195.2
  ENSMUSP00000144780.2
  ENSMUSP00000144781.2
GenBank Protein Q61188 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_031997   ⟸   NM_007971
- Peptide Label: isoform 1
- UniProtKB: Q99L74 (UniProtKB/Swiss-Prot),   Q9R090 (UniProtKB/Swiss-Prot),   Q61188 (UniProtKB/Swiss-Prot),   Q3TZH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001140161   ⟸   NM_001146689
- Peptide Label: isoform 2
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL),   Q6AXH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006505590   ⟸   XM_006505527
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_030111015   ⟸   XM_030255155
- Peptide Label: isoform X13
Ensembl Acc Id: ENSMUSP00000144781   ⟸   ENSMUST00000204243
Ensembl Acc Id: ENSMUSP00000133195   ⟸   ENSMUST00000164006
Ensembl Acc Id: ENSMUSP00000118663   ⟸   ENSMUST00000133043
Ensembl Acc Id: ENSMUSP00000090318   ⟸   ENSMUST00000092648
Ensembl Acc Id: ENSMUSP00000144780   ⟸   ENSMUST00000204798
Ensembl Acc Id: ENSMUSP00000080419   ⟸   ENSMUST00000081721
Ensembl Acc Id: ENSMUSP00000110265   ⟸   ENSMUST00000114618
Ensembl Acc Id: ENSMUSP00000110263   ⟸   ENSMUST00000114616
Ensembl Acc Id: ENSMUSP00000128542   ⟸   ENSMUST00000167278
Ensembl Acc Id: ENSMUSP00000126481   ⟸   ENSMUST00000169889
RefSeq Acc Id: XP_036021722   ⟸   XM_036165829
- Peptide Label: isoform X10
- UniProtKB: D3Z774 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036021721   ⟸   XM_036165828
- Peptide Label: isoform X9
- UniProtKB: D3Z774 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036021725   ⟸   XM_036165832
- Peptide Label: isoform X11
RefSeq Acc Id: XP_036021720   ⟸   XM_036165827
- Peptide Label: isoform X8
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036021716   ⟸   XM_036165823
- Peptide Label: isoform X3
- UniProtKB: Q6AXH7 (UniProtKB/TrEMBL),   Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036021724   ⟸   XM_036165831
- Peptide Label: isoform X11
RefSeq Acc Id: XP_036021710   ⟸   XM_036165817
- Peptide Label: isoform X1
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036021713   ⟸   XM_036165820
- Peptide Label: isoform X2
- UniProtKB: Q99L74 (UniProtKB/Swiss-Prot),   Q61188 (UniProtKB/Swiss-Prot),   Q9R090 (UniProtKB/Swiss-Prot),   Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036021711   ⟸   XM_036165818
- Peptide Label: isoform X1
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036021715   ⟸   XM_036165822
- Peptide Label: isoform X2
- UniProtKB: Q99L74 (UniProtKB/Swiss-Prot),   Q61188 (UniProtKB/Swiss-Prot),   Q9R090 (UniProtKB/Swiss-Prot),   Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036021712   ⟸   XM_036165819
- Peptide Label: isoform X1
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396750   ⟸   NM_001409821
- Peptide Label: isoform 4
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396753   ⟸   NM_001409824
- Peptide Label: isoform 6
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396745   ⟸   NM_001409816
- Peptide Label: isoform 1
- UniProtKB: Q99L74 (UniProtKB/Swiss-Prot),   Q61188 (UniProtKB/Swiss-Prot),   Q9R090 (UniProtKB/Swiss-Prot),   Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396749   ⟸   NM_001409820
- Peptide Label: isoform 4
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396754   ⟸   NM_001409825
- Peptide Label: isoform 6
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396744   ⟸   NM_001409815
- Peptide Label: isoform 1
- UniProtKB: Q99L74 (UniProtKB/Swiss-Prot),   Q61188 (UniProtKB/Swiss-Prot),   Q9R090 (UniProtKB/Swiss-Prot),   Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396748   ⟸   NM_001409819
- Peptide Label: isoform 4
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396755   ⟸   NM_001409826
- Peptide Label: isoform 6
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396743   ⟸   NM_001409814
- Peptide Label: isoform 1
- UniProtKB: Q99L74 (UniProtKB/Swiss-Prot),   Q61188 (UniProtKB/Swiss-Prot),   Q9R090 (UniProtKB/Swiss-Prot),   Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396739   ⟸   NM_001409810
- Peptide Label: isoform 3
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396759   ⟸   NM_001409830
- Peptide Label: isoform 8
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396747   ⟸   NM_001409818
- Peptide Label: isoform 4
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396758   ⟸   NM_001409829
- Peptide Label: isoform 7
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396760   ⟸   NM_001409831
- Peptide Label: isoform 9
- UniProtKB: D3Z774 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396757   ⟸   NM_001409828
- Peptide Label: isoform 6
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396751   ⟸   NM_001409822
- Peptide Label: isoform 5
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396741   ⟸   NM_001409812
- Peptide Label: isoform 3
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396756   ⟸   NM_001409827
- Peptide Label: isoform 6
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396746   ⟸   NM_001409817
- Peptide Label: isoform 1
- UniProtKB: Q99L74 (UniProtKB/Swiss-Prot),   Q61188 (UniProtKB/Swiss-Prot),   Q9R090 (UniProtKB/Swiss-Prot),   Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396752   ⟸   NM_001409823
- Peptide Label: isoform 6
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396742   ⟸   NM_001409813
- Peptide Label: isoform 1
- UniProtKB: Q99L74 (UniProtKB/Swiss-Prot),   Q61188 (UniProtKB/Swiss-Prot),   Q9R090 (UniProtKB/Swiss-Prot),   Q3TZH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396740   ⟸   NM_001409811
- Peptide Label: isoform 3
- UniProtKB: Q3TZH6 (UniProtKB/TrEMBL)
Protein Domains
CXC   EZH1/2 MCSS   Polycomb repressive complex 2 subunit EZH1/EZH2 tri-   SET

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61188-F1-model_v2 AlphaFold Q61188 1-746 view protein structure

Promoters
RGD ID:6839277
Promoter ID:MM_KWN:45853
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000114616,   ENSMUST00000114618,   ENSMUST00000114623,   OTTMUST00000050207,   OTTMUST00000050208
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36647,544,819 - 47,545,319 (-)MPROMDB
RGD ID:6889564
Promoter ID:EPDNEW_M8233
Type:initiation region
Name:Ezh2_1
Description:Mus musculus enhancer of zeste 2 polycomb repressive complex2 subunit , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38647,594,995 - 47,595,055EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107940 AgrOrtholog
Ensembl Genes ENSMUSG00000029687 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000081721 ENTREZGENE
  ENSMUST00000081721.13 UniProtKB/Swiss-Prot
  ENSMUST00000092648 ENTREZGENE
  ENSMUST00000092648.13 UniProtKB/Swiss-Prot
  ENSMUST00000114616.8 UniProtKB/TrEMBL
  ENSMUST00000114618 ENTREZGENE
  ENSMUST00000114618.8 UniProtKB/TrEMBL
  ENSMUST00000133043.3 UniProtKB/TrEMBL
  ENSMUST00000164006.8 UniProtKB/TrEMBL
  ENSMUST00000167278.8 UniProtKB/TrEMBL
  ENSMUST00000169889.3 UniProtKB/TrEMBL
  ENSMUST00000204243.3 UniProtKB/TrEMBL
  ENSMUST00000204798.3 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.1880 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.170.270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CXC_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EZH1/2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EZH1/2_MCSS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EZH1/EZH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EZH2_SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRC2_HTH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pre-SET_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SANT/Myb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tesmin/TSO1-like_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14056 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:107940 ENTREZGENE
NCBI Gene 14056 ENTREZGENE
PANTHER HISTONE-LYSINE N-METHYLTRANSFERASE EZH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45747 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ezh2_MCSS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EZH2_WD-Binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRC2_HTH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  preSET_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ezh2 PhenoGen
PROSITE CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SANT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF82199 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SUQ7_MOUSE UniProtKB/TrEMBL
  A0A0N4SUQ8_MOUSE UniProtKB/TrEMBL
  D3Z774 ENTREZGENE, UniProtKB/TrEMBL
  E9PWK3_MOUSE UniProtKB/TrEMBL
  EZH2_MOUSE UniProtKB/Swiss-Prot
  F6T3Z0_MOUSE UniProtKB/TrEMBL
  F7AQX0_MOUSE UniProtKB/TrEMBL
  F7CW38_MOUSE UniProtKB/TrEMBL
  Q3TZH6 ENTREZGENE, UniProtKB/TrEMBL
  Q3U575_MOUSE UniProtKB/TrEMBL
  Q571L5_MOUSE UniProtKB/TrEMBL
  Q61188 ENTREZGENE
  Q6AXH7 ENTREZGENE, UniProtKB/TrEMBL
  Q99L74 ENTREZGENE
  Q9R090 ENTREZGENE
UniProt Secondary Q99L74 UniProtKB/Swiss-Prot
  Q9R090 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-17 Ezh2  enhancer of zeste 2 polycomb repressive complex 2 subunit    enhancer of zeste homolog 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED