Gene: Ezh2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) Mus musculus
Analyze
Symbol:
Ezh2
Name:
enhancer of zeste 2 polycomb repressive complex 2 subunit
Description:
Exhibits several functions, including nucleic acid binding activity; protein methyltransferase activity; and transcription corepressor activity. Involved in several processes, including macromolecule methylation; negative regulation of cell differentiation; and regulation of transcription, DNA-templated. Localizes to the ESC/E(Z) complex and pronucleus. Colocalizes with the nuclear chromatin. Used to study Weaver syndrome and acute lymphocytic leukemia. Human ortholog(s) of this gene implicated in Weaver syndrome; glioblastoma multiforme; hematologic cancer (multiple); and stomach cancer. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and sensory organ. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
enhancer of zeste homolog 2; Enx-1; Enx1h; histone-lysine N-methyltransferase EZH2; KIAA4065; KMT6; MGC90723; mKIAA4065
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):
Ezh2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Ezh2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ezh2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Rattus norvegicus (Norway rat):
Ezh2 (enhancer of zeste 2 polycomb repressive complex 2 subunit)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, TreeFam)
Danio rerio (zebrafish):
ezh2 (enhancer of zeste 2 polycomb repressive complex 2 subunit)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam, ZFIN)
Drosophila melanogaster (fruit fly):
E(z)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
mes-2
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 6 47,530,274 - 47,595,270 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 6 47,480,273 - 47,545,029 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 6 47,459,867 - 47,524,606 (-) NCBI mm8 Celera 6 47,385,379 - 47,451,063 (-) NCBI Celera Cytogenetic Map 6 B2.3 NCBI cM Map 6 22.92 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
genetic disease ISO RGD:1312683 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:22177091 more ... lymphoma ISO RGD:1312683 8554872 ClinVar Annotator: match by term: Lymphoma ClinVar PMID:23023262 more ... lymphoma ISO RGD:1312683 8554872 ClinVar Annotator: match by term: Lymphoma ClinVar PMID:23023262 , PMID:26619011 lymphoma ISO RGD:1312683 8554872 ClinVar Annotator: match by term: Lymphoma ClinVar PMID:23023262 melanoma ISO RGD:1312683 8554872 ClinVar Annotator: match by term: MELANOMA, MALIGNANT, SOMATIC ClinVar PMID:26619011 melanoma ISO RGD:1312683 8554872 ClinVar Annotator: match by term: MELANOMA, MALIGNANT, SOMATIC ClinVar PMID:23023262 , PMID:26619011 melanoma ISO RGD:1312683 8554872 ClinVar Annotator: match by term: MELANOMA, MALIGNANT, SOMATIC ClinVar PMID:23023262 more ... non-Hodgkin lymphoma ISO RGD:1312683 8554872 ClinVar Annotator: match by term: Familial non-Hodgkin lymphoma ClinVar PMID:26619011 non-Hodgkin lymphoma ISO RGD:1312683 8554872 ClinVar Annotator: match by term: Familial non-Hodgkin lymphoma ClinVar PMID:23023262 , PMID:26619011 non-Hodgkin lymphoma ISO RGD:1312683 8554872 ClinVar Annotator: match by term: Familial non-Hodgkin lymphoma ClinVar PMID:23023262 more ... Weaver syndrome ISO RGD:1312683 8554872 ClinVar Annotator: match by term: Weaver syndrome ClinVar PMID:18414213 more ... Weaver syndrome ISO RGD:1312683 8554872 ClinVar Annotator: match by term: Weaver syndrome ClinVar PMID:24728327 , PMID:28492532 Weaver syndrome ISO RGD:1312683 8554872 ClinVar Annotator: match by term: Weaver syndrome ClinVar PMID:24728327 Weaver syndrome ISO RGD:1312683 8554872 ClinVar Annotator: match by term: Weaver syndrome ClinVar PMID:18414213 more ... Weaver syndrome ISO RGD:1312683 8554872 ClinVar Annotator: match by term: Weaver syndrome ClinVar PMID:18414213 , PMID:28492532 Weaver syndrome ISO RGD:1312683 8554872 ClinVar Annotator: match by term: Weaver syndrome ClinVar PMID:25741868 , PMID:28492532 Weaver syndrome ISO RGD:1312683 8554872 ClinVar Annotator: match by term: Weaver syndrome ClinVar PMID:24728327 more ... Weaver syndrome ISO RGD:1312683 8554872 ClinVar Annotator: match by term: Weaver syndrome ClinVar PMID:18414213 , PMID:25741868 Weaver syndrome ISO RGD:1312683 8554872 ClinVar Annotator: match by OMIM:277590 ClinVar PMID:26380986 Weaver syndrome ISO RGD:1312683 8554872 ClinVar Annotator: match by null ClinVar PMID:22177091 , PMID:4366187 Weaver syndrome ISO RGD:1312683 8554872 ClinVar Annotator: match by OMIM:277590 ClinVar PMID:22177091 Weaver syndrome ISO RGD:1312683 8554872 ClinVar Annotator: match by OMIM:277590 ClinVar Weaver syndrome ISO RGD:1312683 8554872 ClinVar Annotator: match by term: Weaver syndrome ClinVar PMID:25741868 Weaver syndrome ISO RGD:1312683 8554872 ClinVar Annotator: match by OMIM:277590 ClinVar PMID:24214728 Weaver syndrome ISO RGD:1312683 8554872 ClinVar Annotator: match by OMIM:277590 ClinVar PMID:18414213 Weaver syndrome ISO RGD:1312683 8554872 ClinVar Annotator: match by term: Weaver syndrome ClinVar PMID:18414213 more ... Weaver syndrome ISO RGD:1312683 8554872 ClinVar Annotator: match by term: Weaver syndrome ClinVar PMID:28492532
Imported Annotations - CTD
Breast Neoplasms ISO RGD:1312683 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21903722 Chromosome Breakage ISO RGD:1312683 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29391238 craniosynostosis ISO RGD:1312683 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26424790 diffuse large B-cell lymphoma ISO RGD:1312683 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20081860 Endometrial Neoplasms ISO RGD:1312683 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21903722 follicular lymphoma ISO RGD:1312683 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24362818 hepatocellular carcinoma ISO RGD:1312683 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28284560 juvenile myelomonocytic leukemia ISO RGD:1312683 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26457647 Megakaryoblastic Leukemia of Down Syndrome ISO RGD:1312683 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24056718 myelodysplastic syndrome ISO RGD:1312683 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20601954 myelodysplastic/myeloproliferative neoplasm ISO RGD:1312683 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20601953 myelofibrosis ISO RGD:1312683 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20601953 Neoplastic Cell Transformation ISO RGD:1312683 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29391238 osteosarcoma ISO RGD:1312683 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14767549 Prostatic Neoplasms ISO RGD:1312683 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17003774 more ... Upper Extremity Deformities, Congenital ISO RGD:1312683 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:26424790 Weight Gain ISO RGD:1312683 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:30971429 Imported Annotations - MGI
acute lymphocytic leukemia IEA 13592920 OMIM:247640 more ... MouseDO Weaver syndrome IEA 13592920 OMIM:277590 MouseDO Imported Annotations - OMIM
Weaver syndrome ISO RGD:1312683 7240710 OMIM
(+)-Eudesmin decreases expression ISO RGD:1312683 6480464 eudesmin results in decreased expression of EZH2 mRNA, eudesmin results in decreased expression of EZH2 protein CTD PMID:31026422 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE multiple interactions ISO RGD:1595860 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of EZH2 mRNA CTD PMID:25729387 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE decreases expression ISO RGD:1595860 6480464 Topotecan results in decreased expression of EZH2 mRNA CTD PMID:25729387 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE affects response to substance ISO RGD:1312683 6480464 EZH2 protein affects the susceptibility to Topotecan CTD PMID:16217747 1,1-dichloroethene increases expression EXP 6480464 vinylidene chloride results in increased expression of EZH2 mRNA CTD PMID:26682919 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EZH2 mRNA CTD PMID:17942748 17beta-estradiol multiple interactions ISO RGD:1312683 6480464 Estradiol promotes the reaction [CREBBP protein binds to EZH2 promoter] more ... CTD PMID:25088689 17beta-estradiol increases expression ISO RGD:1595860 6480464 Estradiol results in increased expression of EZH2 mRNA, Estradiol results in increased expression of EZH2 protein CTD PMID:25088689 17beta-estradiol increases methylation ISO RGD:1312683 6480464 Estradiol results in increased methylation of EZH2 promoter CTD PMID:25088689 17beta-estradiol increases expression ISO RGD:1312683 6480464 Estradiol results in increased expression of EZH2 mRNA, Estradiol results in increased expression of EZH2 protein CTD PMID:25088689 17beta-estradiol multiple interactions ISO RGD:1595860 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of EZH2 mRNA more ... CTD PMID:25088689 17beta-estradiol increases acetylation ISO RGD:1312683 6480464 Estradiol results in increased acetylation of EZH2 promoter CTD PMID:25088689 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EZH2 mRNA, [Tetrachlorodibenzodioxin results in decreased expression of MIR101A] which results in increased expression of EZH2 protein CTD PMID:17942748 , PMID:21602190 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1312683 6480464 Tetrachlorodibenzodioxin affects the expression of EZH2 mRNA CTD PMID:22574217 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of EZH2 mRNA CTD PMID:21570461 2-methylcholine affects expression ISO RGD:1312683 6480464 beta-methylcholine affects the expression of EZH2 mRNA CTD PMID:21179406 6-propyl-2-thiouracil increases expression ISO RGD:1595860 6480464 Propylthiouracil results in increased expression of EZH2 mRNA CTD PMID:24780913 8-bromo-3',5'-cyclic AMP multiple interactions ISO RGD:1312683 6480464 [8-Bromo Cyclic Adenosine Monophosphate co-treated with Medroxyprogesterone Acetate] results in decreased expression of EZH2 mRNA more ... CTD PMID:21903722 8-bromo-3',5'-cyclic AMP decreases expression ISO RGD:1312683 6480464 8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of EZH2 mRNA, 8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of EZH2 protein CTD PMID:21903722 acrylamide increases expression ISO RGD:1595860 6480464 Acrylamide results in increased expression of EZH2 mRNA CTD PMID:28959563 aflatoxin B1 affects expression ISO RGD:1312683 6480464 Aflatoxin B1 affects the expression of EZH2 protein CTD PMID:20106945 aflatoxin B2 increases methylation ISO RGD:1312683 6480464 aflatoxin B2 results in increased methylation of EZH2 intron CTD PMID:30157460 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of EZH2 mRNA CTD PMID:17198874 all-trans-retinoic acid decreases expression ISO RGD:1312683 6480464 Tretinoin results in decreased expression of EZH2 mRNA CTD PMID:22906706 andrographolide multiple interactions ISO RGD:1312683 6480464 andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein], IL6 protein promotes the reaction [andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein]] CTD PMID:31128153 andrographolide multiple interactions EXP 6480464 andrographolide inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EZH2 protein] CTD PMID:31128153 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:1312683 6480464 pyrazolanthrone inhibits the reaction [Arsenicals results in increased phosphorylation of EZH2 protein] CTD PMID:23255093 arsane multiple interactions EXP 6480464 [[Arsenic results in decreased expression of IGF1 mRNA] co-treated with [Arsenic affects the localization of and results in increased expression of EZH2 protein]] results in decreased expression of MYOG more ... CTD PMID:22426358 arsane multiple interactions ISO RGD:1312683 6480464 Acetylcysteine inhibits the reaction [Arsenic analog results in increased phosphorylation of EZH2 protein], Arsenic analog results in increased phosphorylation of and affects the localization of EZH2 protein CTD PMID:24582688 arsane increases expression EXP 6480464 Arsenic results in increased expression of EZH2 protein CTD PMID:22426358 , PMID:22843710 arsane affects localization EXP 6480464 Arsenic affects the localization of EZH2 protein CTD PMID:22426358 arsenic atom affects localization EXP 6480464 Arsenic affects the localization of EZH2 protein CTD PMID:22426358 arsenic atom multiple interactions ISO RGD:1312683 6480464 Acetylcysteine inhibits the reaction [Arsenic analog results in increased phosphorylation of EZH2 protein], Arsenic analog results in increased phosphorylation of and affects the localization of EZH2 protein CTD PMID:24582688 arsenic atom increases expression EXP 6480464 Arsenic results in increased expression of EZH2 protein CTD PMID:22426358 , PMID:22843710 arsenic atom multiple interactions EXP 6480464 [[Arsenic results in decreased expression of IGF1 mRNA] co-treated with [Arsenic affects the localization of and results in increased expression of EZH2 protein]] results in decreased expression of MYOG more ... CTD PMID:22426358 arsenic(3+) multiple interactions ISO RGD:1312683 6480464 Acetylcysteine inhibits the reaction [Arsenic analog results in increased phosphorylation of EZH2 protein], Arsenic analog results in increased phosphorylation of and affects the localization of EZH2 protein CTD PMID:24582688 arsenic(3+) affects localization EXP 6480464 Arsenic affects the localization of EZH2 protein CTD PMID:22426358 arsenic(3+) multiple interactions EXP 6480464 [[Arsenic results in decreased expression of IGF1 mRNA] co-treated with [Arsenic affects the localization of and results in increased expression of EZH2 protein]] results in decreased expression of MYOG more ... CTD PMID:22426358 arsenic(3+) increases expression EXP 6480464 Arsenic results in increased expression of EZH2 protein CTD PMID:22426358 , PMID:22843710 azathioprine decreases expression ISO RGD:1312683 6480464 Azathioprine results in decreased expression of EZH2 mRNA CTD PMID:22623647 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of EZH2 mRNA CTD PMID:17942131 benzo[a]pyrene affects methylation ISO RGD:1312683 6480464 Benzo(a)pyrene affects the methylation of EZH2 intron CTD PMID:30157460 benzo[a]pyrene decreases expression ISO RGD:1312683 6480464 Benzo(a)pyrene results in decreased expression of EZH2 mRNA CTD PMID:21632981 , PMID:22316170 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1312683 6480464 7 more ... CTD PMID:20382639 benzo[e]pyrene increases methylation ISO RGD:1312683 6480464 benzo(e)pyrene results in increased methylation of EZH2 intron CTD PMID:30157460 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of EZH2 protein CTD PMID:21761357 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of EZH2 mRNA CTD PMID:30015891 bisphenol A decreases expression ISO RGD:1312683 6480464 bisphenol A results in decreased expression of EZH2 mRNA CTD PMID:29275510 bisphenol A affects expression ISO RGD:1312683 6480464 bisphenol A affects the expression of EZH2 mRNA CTD PMID:28765096 bisphenol A increases methylation ISO RGD:1312683 6480464 bisphenol A results in increased methylation of EZH2 promoter CTD PMID:25088689 bisphenol A increases expression ISO RGD:1595860 6480464 bisphenol A results in increased expression of EZH2 mRNA, bisphenol A results in increased expression of EZH2 protein CTD PMID:25088689 more ... bisphenol A multiple interactions ISO RGD:1595860 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of EZH2 mRNA, [bisphenol A co-treated with Estradiol] results in increased expression of EZH2 protein CTD PMID:25088689 bisphenol A increases expression ISO RGD:1312683 6480464 bisphenol A results in increased expression of EZH2 mRNA, bisphenol A results in increased expression of EZH2 protein CTD PMID:21761357 , PMID:25088689 bisphenol A increases acetylation ISO RGD:1312683 6480464 bisphenol A results in increased acetylation of EZH2 promoter CTD PMID:25088689 bisphenol A multiple interactions ISO RGD:1312683 6480464 bisphenol A promotes the reaction [CREBBP protein binds to EZH2 promoter] more ... CTD PMID:25088689 buta-1,3-diene increases expression EXP 6480464 1, 3-butadiene results in increased expression of EZH2 mRNA CTD PMID:25237060 cadmium dichloride increases expression ISO RGD:1312683 6480464 Cadmium Chloride results in increased expression of EZH2 mRNA CTD PMID:26472689 calcitriol decreases expression ISO RGD:1312683 6480464 Calcitriol results in decreased expression of EZH2 mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:1312683 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of EZH2 mRNA CTD PMID:21592394 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon analog results in increased expression of EZH2 mRNA, Nanotubes, Carbon results in increased expression of EZH2 mRNA CTD PMID:25554681 carmustine decreases expression ISO RGD:1312683 6480464 Carmustine results in decreased expression of EZH2 mRNA CTD PMID:15980968 cisplatin increases expression ISO RGD:1312683 6480464 Cisplatin results in increased expression of EZH2 mRNA CTD PMID:27594783 clorgyline decreases expression ISO RGD:1312683 6480464 Clorgyline results in decreased expression of EZH2 mRNA CTD PMID:19691856 cobalt dichloride multiple interactions ISO RGD:1312683 6480464 EZH2 mRNA promotes the reaction [cobaltous chloride deficiency results in decreased expression of DICER1 mRNA] CTD PMID:25351418 cobalt dichloride decreases expression ISO RGD:1312683 6480464 cobaltous chloride results in decreased expression of EZH2 mRNA CTD PMID:19320972 copper atom increases expression ISO RGD:1595860 6480464 Copper results in increased expression of EZH2 mRNA CTD PMID:30556269 copper(0) increases expression ISO RGD:1595860 6480464 Copper results in increased expression of EZH2 mRNA CTD PMID:30556269 copper(2+) increases expression ISO RGD:1595860 6480464 Copper results in increased expression of EZH2 mRNA CTD PMID:30556269 corticosterone decreases expression ISO RGD:1595860 6480464 Corticosterone results in decreased expression of EZH2 mRNA CTD PMID:15755911 coumestrol increases expression ISO RGD:1312683 6480464 Coumestrol results in increased expression of EZH2 mRNA CTD PMID:19167446 coumestrol multiple interactions ISO RGD:1312683 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 cyclosporin A increases expression ISO RGD:1312683 6480464 Cyclosporine results in increased expression of EZH2 mRNA CTD PMID:20106945 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of EZH2 mRNA CTD PMID:17942131 dexamethasone multiple interactions ISO RGD:1312683 6480464 [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of EZH2 mRNA more ... CTD PMID:26424790 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of EZH2 mRNA CTD PMID:21266533 dibutyl phthalate decreases expression ISO RGD:1595860 6480464 Dibutyl Phthalate results in decreased expression of EZH2 mRNA CTD PMID:21266533 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of EZH2 mRNA, Diethylstilbestrol results in increased expression of EZH2 protein CTD PMID:21761357 diethylstilbestrol increases methylation ISO RGD:1312683 6480464 Diethylstilbestrol results in increased methylation of EZH2 promoter CTD PMID:25088689 diethylstilbestrol increases expression ISO RGD:1312683 6480464 Diethylstilbestrol results in increased expression of EZH2 mRNA, Diethylstilbestrol results in increased expression of EZH2 protein CTD PMID:21761357 , PMID:25088689 diethylstilbestrol multiple interactions ISO RGD:1312683 6480464 Diethylstilbestrol promotes the reaction [CREBBP protein binds to EZH2 promoter] more ... CTD PMID:25088689 diethylstilbestrol multiple interactions ISO RGD:1595860 6480464 [Diethylstilbestrol co-treated with Estradiol] results in increased expression of EZH2 mRNA, [Diethylstilbestrol co-treated with Estradiol] results in increased expression of EZH2 protein CTD PMID:25088689 diethylstilbestrol increases expression ISO RGD:1595860 6480464 Diethylstilbestrol results in increased expression of EZH2 mRNA, Diethylstilbestrol results in increased expression of EZH2 protein CTD PMID:25088689 diethylstilbestrol increases acetylation ISO RGD:1312683 6480464 Diethylstilbestrol results in increased acetylation of EZH2 promoter CTD PMID:25088689 dioxygen multiple interactions ISO RGD:1312683 6480464 Oxygen deficiency promotes the reaction [EZH2 protein binds to DICER1 promoter] CTD PMID:25351418 doxorubicin affects response to substance ISO RGD:1312683 6480464 EZH2 protein affects the susceptibility to Doxorubicin CTD PMID:16217747 doxorubicin affects expression ISO RGD:1312683 6480464 Doxorubicin affects the expression of EZH2 mRNA CTD PMID:29803840 endosulfan increases expression ISO RGD:1312683 6480464 Endosulfan results in increased expression of EZH2 mRNA CTD PMID:29054638 endosulfan decreases expression ISO RGD:1595860 6480464 Endosulfan results in decreased expression of EZH2 mRNA CTD PMID:29391264 endosulfan multiple interactions ISO RGD:1312683 6480464 Endosulfan results in increased expression of and results in increased activity of EZH2 protein CTD PMID:29054638 Enterolactone multiple interactions ISO RGD:1312683 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of EZH2 mRNA CTD PMID:19167446 ethanol affects expression EXP 6480464 Ethanol affects the expression of EZH2 mRNA CTD PMID:30319688 formaldehyde increases expression ISO RGD:1312683 6480464 Formaldehyde results in increased expression of EZH2 mRNA CTD PMID:23649840 genistein increases phosphorylation ISO RGD:1595860 6480464 Genistein results in increased phosphorylation of EZH2 protein CTD PMID:22504913 geraniol decreases expression ISO RGD:1312683 6480464 geraniol results in decreased expression of EZH2 mRNA CTD PMID:27683099 glycerol 2-phosphate multiple interactions ISO RGD:1312683 6480464 [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of EZH2 mRNA more ... CTD PMID:26424790 heptachlor increases expression ISO RGD:1595860 6480464 Heptachlor results in increased expression of EZH2 mRNA CTD PMID:23153324 hydrogen peroxide affects expression ISO RGD:1312683 6480464 Hydrogen Peroxide affects the expression of EZH2 mRNA CTD PMID:20044591 , PMID:21179406 hydrogen peroxide multiple interactions ISO RGD:1312683 6480464 Acetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of EZH2 protein], Hydrogen Peroxide results in increased phosphorylation of and affects the localization of EZH2 protein CTD PMID:24582688 hydroquinone decreases expression ISO RGD:1312683 6480464 hydroquinone results in decreased expression of EZH2 protein CTD PMID:27979589 ibuprofen increases expression ISO RGD:1595860 6480464 Ibuprofen results in increased expression of EZH2 mRNA CTD PMID:29665328 ketamine decreases expression ISO RGD:1595860 6480464 Ketamine results in decreased expression of EZH2 mRNA CTD PMID:20080153 L-ascorbic acid multiple interactions ISO RGD:1312683 6480464 [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of EZH2 mRNA more ... CTD PMID:26424790 lead(0) affects expression ISO RGD:1312683 6480464 Lead affects the expression of EZH2 mRNA CTD PMID:28903495 lead(0) multiple interactions ISO RGD:1595860 6480464 EZH2 protein inhibits the reaction [Lead results in increased expression of HDAC2 mRNA], EZH2 protein inhibits the reaction [Lead results in increased expression of HDAC2 protein] CTD PMID:29301062 lead(0) decreases expression ISO RGD:1595860 6480464 Lead results in decreased expression of EZH2 protein CTD PMID:29301062 lead(2+) affects expression ISO RGD:1312683 6480464 Lead affects the expression of EZH2 mRNA CTD PMID:28903495 lead(2+) decreases expression ISO RGD:1595860 6480464 Lead results in decreased expression of EZH2 protein CTD PMID:29301062 lead(2+) multiple interactions ISO RGD:1595860 6480464 EZH2 protein inhibits the reaction [Lead results in increased expression of HDAC2 mRNA], EZH2 protein inhibits the reaction [Lead results in increased expression of HDAC2 protein] CTD PMID:29301062 lucanthone decreases expression ISO RGD:1312683 6480464 Lucanthone results in decreased expression of EZH2 mRNA CTD PMID:21148553 medroxyprogesterone acetate decreases expression ISO RGD:1312683 6480464 Medroxyprogesterone Acetate results in decreased expression of EZH2 mRNA, Medroxyprogesterone Acetate results in decreased expression of EZH2 protein CTD PMID:21903722 medroxyprogesterone acetate multiple interactions ISO RGD:1312683 6480464 [8-Bromo Cyclic Adenosine Monophosphate co-treated with Medroxyprogesterone Acetate] results in decreased expression of EZH2 mRNA more ... CTD PMID:21903722 menadione affects expression ISO RGD:1312683 6480464 Vitamin K 3 affects the expression of EZH2 mRNA CTD PMID:20044591 methapyrilene increases methylation ISO RGD:1312683 6480464 Methapyrilene results in increased methylation of EZH2 intron CTD PMID:30157460 methotrexate decreases expression ISO RGD:1312683 6480464 Methotrexate results in decreased expression of EZH2 protein CTD PMID:21114963 methyl methanesulfonate increases expression ISO RGD:1312683 6480464 Methyl Methanesulfonate results in increased expression of EZH2 mRNA CTD PMID:23649840 methylazoxymethanol increases expression EXP 6480464 methylazoxymethanol results in increased expression of EZH2 mRNA CTD PMID:17107856 morphine multiple interactions ISO RGD:1595860 6480464 Morphine promotes the reaction [EZH2 protein binds to BDNF promoter] CTD PMID:25643298 myo-inositol hexakisphosphate multiple interactions EXP 6480464 Phytic Acid inhibits the reaction [Urethane results in increased expression of EZH2 mRNA], Phytic Acid inhibits the reaction [Urethane results in increased expression of EZH2 protein] CTD PMID:25168426 N-acetyl-L-cysteine multiple interactions ISO RGD:1312683 6480464 Acetylcysteine inhibits the reaction [Arsenic analog results in increased phosphorylation of EZH2 protein], Acetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of EZH2 protein] CTD PMID:24582688 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of EZH2 mRNA CTD PMID:17854601 N-nitrosodiethylamine multiple interactions EXP 6480464 RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of EZH2 mRNA] CTD PMID:17854601 oxaliplatin decreases expression ISO RGD:1595860 6480464 oxaliplatin results in decreased expression of EZH2 mRNA CTD PMID:25729387 oxaliplatin multiple interactions ISO RGD:1595860 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of EZH2 mRNA CTD PMID:25729387 palbociclib decreases expression ISO RGD:1312683 6480464 palbociclib results in decreased expression of EZH2 mRNA, palbociclib results in decreased expression of EZH2 protein CTD PMID:20948315 more ... paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of EZH2 mRNA CTD PMID:17942131 paracetamol increases expression ISO RGD:1595860 6480464 Acetaminophen results in increased expression of EZH2 mRNA CTD PMID:29665328 paracetamol affects expression ISO RGD:1312683 6480464 Acetaminophen affects the expression of EZH2 mRNA CTD PMID:25458485 paracetamol increases expression ISO RGD:1312683 6480464 Acetaminophen results in increased expression of EZH2 mRNA CTD PMID:21420995 more ... pentachlorophenol increases expression EXP 6480464 Pentachlorophenol results in increased expression of EZH2 mRNA CTD PMID:23892564 perfluorooctane-1-sulfonic acid increases expression EXP 6480464 perfluorooctane sulfonic acid results in increased expression of EZH2 mRNA, perfluorooctane sulfonic acid results in increased expression of EZH2 protein CTD PMID:25510869 piroxicam decreases expression ISO RGD:1312683 6480464 Piroxicam results in decreased expression of EZH2 mRNA CTD PMID:21858171 potassium dichromate increases expression ISO RGD:1312683 6480464 Potassium Dichromate results in increased expression of EZH2 protein CTD PMID:29391238 potassium dichromate multiple interactions ISO RGD:1312683 6480464 EZH2 protein promotes the reaction [Potassium Dichromate results in increased expression of H2AX protein modified form] CTD PMID:29391238 progesterone increases expression ISO RGD:1312683 6480464 Progesterone results in increased expression of EZH2 mRNA CTD PMID:18070364 resveratrol multiple interactions ISO RGD:1312683 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of EZH2 mRNA more ... CTD PMID:19167446 , PMID:26934322 resveratrol increases expression ISO RGD:1312683 6480464 resveratrol results in increased expression of EZH2 mRNA, resveratrol results in increased expression of EZH2 protein CTD PMID:26934322 resveratrol increases response to substance ISO RGD:1312683 6480464 EZH2 mRNA results in increased susceptibility to resveratrol CTD PMID:26934322 resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of EZH2 protein CTD PMID:25505154 resveratrol multiple interactions EXP 6480464 MIR137 mRNA affects the reaction [resveratrol results in decreased expression of EZH2 protein] CTD PMID:25505154 sodium dichromate affects expression ISO RGD:1595860 6480464 sodium bichromate affects the expression of EZH2 mRNA CTD PMID:22110744 Soman increases expression ISO RGD:1595860 6480464 Soman results in increased expression of EZH2 mRNA CTD PMID:19281266 stattic multiple interactions ISO RGD:1312683 6480464 stattic inhibits the reaction [Arsenicals results in increased phosphorylation of EZH2 protein] CTD PMID:23255093 streptozocin multiple interactions EXP 6480464 [Streptozocin co-treated with Dietary Fats] results in increased expression of EZH2 mRNA, [Streptozocin co-treated with Dietary Fats] results in increased expression of EZH2 protein CTD PMID:29127188 tamoxifen multiple interactions ISO RGD:1312683 6480464 [EZH2 protein results in decreased expression of ESR1 protein] which results in decreased susceptibility to Tamoxifen CTD PMID:20306127 tert-butyl hydroperoxide decreases expression ISO RGD:1312683 6480464 tert-Butylhydroperoxide results in decreased expression of EZH2 mRNA CTD PMID:15336504 testosterone decreases expression ISO RGD:1312683 6480464 Testosterone results in decreased expression of EZH2 mRNA CTD PMID:21592394 testosterone multiple interactions ISO RGD:1312683 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of EZH2 mRNA CTD PMID:21592394 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of EZH2 mRNA CTD PMID:17484886 , PMID:27339419 topotecan multiple interactions ISO RGD:1595860 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of EZH2 mRNA CTD PMID:25729387 topotecan affects response to substance ISO RGD:1312683 6480464 EZH2 protein affects the susceptibility to Topotecan CTD PMID:16217747 topotecan decreases expression ISO RGD:1595860 6480464 Topotecan results in decreased expression of EZH2 mRNA CTD PMID:25729387 Tributyltin oxide decreases expression EXP 6480464 bis(tri-n-butyltin)oxide results in decreased expression of EZH2 mRNA CTD PMID:17942131 trimellitic anhydride increases expression EXP 6480464 trimellitic anhydride results in increased expression of EZH2 mRNA CTD PMID:19042947 Triptolide decreases expression ISO RGD:1312683 6480464 triptolide results in decreased expression of EZH2 protein CTD PMID:19879315 troglitazone decreases expression ISO RGD:1312683 6480464 troglitazone results in decreased expression of EZH2 mRNA CTD PMID:19140230 urethane increases expression EXP 6480464 Urethane results in increased expression of EZH2 mRNA, Urethane results in increased expression of EZH2 protein CTD PMID:25168426 urethane increases expression ISO RGD:1312683 6480464 Urethane results in increased expression of EZH2 mRNA CTD PMID:28818685 urethane multiple interactions EXP 6480464 Phytic Acid inhibits the reaction [Urethane results in increased expression of EZH2 mRNA], Phytic Acid inhibits the reaction [Urethane results in increased expression of EZH2 protein] CTD PMID:25168426 valproic acid increases expression ISO RGD:1312683 6480464 Valproic Acid results in increased expression of EZH2 mRNA CTD PMID:29154799 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of EZH2 mRNA CTD PMID:17963808 valproic acid affects expression ISO RGD:1312683 6480464 Valproic Acid affects the expression of EZH2 mRNA CTD PMID:25979313 vemurafenib multiple interactions ISO RGD:1312683 6480464 [(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of EZH2 mRNA CTD PMID:27169980 vorinostat decreases expression ISO RGD:1312683 6480464 vorinostat results in decreased expression of EZH2 protein CTD PMID:21114963
Biological Process cardiac muscle hypertrophy in response to stress IDA 2290270 (MGI:MGI:5576864, PMID:24137001) MGI MGI:MGI:5576864 , PMID:24137001 cellular response to hydrogen peroxide IDA 2290270 (MGI:MGI:5496352, PMID:20808772) MGI MGI:MGI:5496352 , PMID:20808772 cellular response to trichostatin A IMP 2290270 (MGI:MGI:5576864, PMID:24137001) MGI MGI:MGI:5576864 , PMID:24137001 cerebellar cortex development IMP MGI:MGI:2661097 2290270 (MGI:MGI:4833736, PMID:20798045) MGI MGI:MGI:4833736 , PMID:20798045 chromatin organization IEA UniProtKB-KW:KW-0156 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 chromatin silencing at telomere ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 DNA methylation IMP 2290270 (MGI:MGI:5522578, PMID:24105743) MGI MGI:MGI:5522578 , PMID:24105743 G1 to G0 transition IMP MGI:MGI:2661097 2290270 (MGI:MGI:3846264, PMID:19303854) MGI MGI:MGI:3846264 , PMID:19303854 hepatocyte homeostasis IGI MGI:MGI:1097695 2290270 (MGI:MGI:5637451, PMID:25477280) MGI MGI:MGI:5637451 , PMID:25477280 histone H3-K27 methylation IMP MGI:MGI:1858961 2290270 (MGI:MGI:3788959, PMID:18311137) MGI MGI:MGI:3788959 , PMID:18311137 histone H3-K27 methylation IMP 2290270 (MGI:MGI:3694308, PMID:16717091) UniProtKB MGI:MGI:3694308 , PMID:16717091 histone H3-K27 methylation ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 histone H3-K27 methylation ISO RGD:1595860 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 histone H3-K27 methylation IMP MGI:MGI:2661097 2290270 (MGI:MGI:4833736, PMID:20798045) MGI MGI:MGI:4833736 , PMID:20798045 histone H3-K27 trimethylation IGI MGI:MGI:1097695 2290270 (MGI:MGI:5637451, PMID:25477280) MGI MGI:MGI:5637451 , PMID:25477280 histone methylation IDA 2290270 (MGI:MGI:2668801, PMID:12900441) MGI MGI:MGI:2668801 , PMID:12900441 histone methylation ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 liver regeneration IGI MGI:MGI:1097695 2290270 (MGI:MGI:5637451, PMID:25477280) MGI MGI:MGI:5637451 , PMID:25477280 methylation IEA UniProtKB-KW:KW-0489 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 negative regulation of DNA-binding transcription factor activity IGI MGI:MGI:102858 2290270 (MGI:MGI:5617064, PMID:25547114) MGI MGI:MGI:5617064 , PMID:25547114 negative regulation of epidermal cell differentiation IMP MGI:MGI:2661097 2290270 (MGI:MGI:3846264, PMID:19303854) MGI MGI:MGI:3846264 , PMID:19303854 negative regulation of G1/S transition of mitotic cell cycle IMP MGI:MGI:2661097 2290270 (MGI:MGI:3846264, PMID:19303854) MGI MGI:MGI:3846264 , PMID:19303854 negative regulation of gene expression ISO RGD:1595860 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 negative regulation of gene expression, epigenetic ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of retinoic acid receptor signaling pathway ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of striated muscle cell differentiation IDA 2290270 (MGI:MGI:3057067, PMID:15520282) MGI MGI:MGI:3057067 , PMID:15520282 negative regulation of transcription by RNA polymerase II IDA 2290270 (MGI:MGI:5522578, PMID:24105743) MGI MGI:MGI:5522578 , PMID:24105743 negative regulation of transcription by RNA polymerase II ISO RGD:1595860 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 negative regulation of transcription by RNA polymerase II ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of transcription elongation from RNA polymerase II promoter IMP MGI:MGI:2661097 2290270 (MGI:MGI:3846264, PMID:19303854) MGI MGI:MGI:3846264 , PMID:19303854 negative regulation of transcription, DNA-templated ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of cell cycle G1/S phase transition ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of cell population proliferation ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of dendrite development ISO RGD:1595860 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of epithelial to mesenchymal transition ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of GTPase activity ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of MAP kinase activity ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of protein serine/threonine kinase activity ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein localization to chromatin IMP MGI:MGI:3805309 2290270 (MGI:MGI:3788959, PMID:18311137) MGI MGI:MGI:3788959 , PMID:18311137 regulation of cell population proliferation IMP MGI:MGI:2661097 2290270 (MGI:MGI:3846264, PMID:19303854) MGI MGI:MGI:3846264 , PMID:19303854 regulation of circadian rhythm ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of circadian rhythm IMP 2290270 (MGI:MGI:3694308, PMID:16717091) UniProtKB MGI:MGI:3694308 , PMID:16717091 regulation of gene expression IMP MGI:MGI:2661097 2290270 (MGI:MGI:4833736, PMID:20798045) MGI MGI:MGI:4833736 , PMID:20798045 regulation of gene expression IMP 2290270 (MGI:MGI:5576864, PMID:24137001) MGI MGI:MGI:5576864 , PMID:24137001 regulation of gliogenesis IMP MGI:MGI:2661097 2290270 (MGI:MGI:4833736, PMID:20798045) MGI MGI:MGI:4833736 , PMID:20798045 regulation of neurogenesis IMP MGI:MGI:2661097 2290270 (MGI:MGI:4833736, PMID:20798045) MGI MGI:MGI:4833736 , PMID:20798045 regulation of protein phosphorylation IMP MGI:MGI:2661097 2290270 (MGI:MGI:3846264, PMID:19303854) MGI MGI:MGI:3846264 , PMID:19303854 regulation of transcription by RNA polymerase II IMP MGI:MGI:2661097 , MGI:MGI:3574960 2290270 (MGI:MGI:4950630, PMID:21498568) MGI MGI:MGI:4950630 , PMID:21498568 response to tetrachloromethane IGI MGI:MGI:1097695 2290270 (MGI:MGI:5637451, PMID:25477280) MGI MGI:MGI:5637451 , PMID:25477280 rhythmic process IEA UniProtKB-KW:KW-0090 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IMP MGI:MGI:2661097 , MGI:MGI:3574960 2290270 (MGI:MGI:4950630, PMID:21498568) MGI MGI:MGI:4950630 , PMID:21498568 Cellular Component chromosome IEA UniProtKB-KW:KW-0158 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 chromosome, telomeric region ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 cytoplasm ISO RGD:1595860 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 ESC/E(Z) complex ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 ESC/E(Z) complex IDA 2290270 (MGI:MGI:3820717 more ... UniProt MGI:MGI:3820717 more ... nuclear chromatin colocalizes_with IDA 2290270 (MGI:MGI:5444773, PMID:23046516) MGI MGI:MGI:5444773 , PMID:23046516 nuclear chromatin ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleus IDA 2290270 (MGI:MGI:1203943 more ... MGI MGI:MGI:1203943 more ... nucleus ISO RGD:1595860 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nucleus ISO UniProtKB:Q15910 2290270 (MGI:MGI:3845989, PMID:19144645) MGI MGI:MGI:3845989 , PMID:19144645 pronucleus IDA 2290270 (MGI:MGI:2668801, PMID:12900441) MGI MGI:MGI:2668801 , PMID:12900441 Molecular Function chromatin binding ISO RGD:1595860 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 chromatin binding IDA 2290270 (MGI:MGI:3057067 more ... MGI MGI:MGI:3057067 more ... chromatin binding ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 chromatin DNA binding IDA 2290270 (MGI:MGI:3789777 more ... MGI MGI:MGI:3789777 more ... chromatin DNA binding ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 histone methyltransferase activity IDA 2290270 (MGI:MGI:2668801, PMID:12900441) MGI MGI:MGI:2668801 , PMID:12900441 histone methyltransferase activity ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 histone methyltransferase activity (H3-K27 specific) ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 histone-lysine N-methyltransferase activity ISO UniProtKB:Q15910 2290270 (MGI:MGI:3845989, PMID:19144645) MGI MGI:MGI:3845989 , PMID:19144645 methyltransferase activity IEA UniProtKB-KW:KW-0489 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 primary miRNA binding IDA 2290270 (MGI:MGI:5576864, PMID:24137001) MGI MGI:MGI:5576864 , PMID:24137001 promoter-specific chromatin binding ISO UniProtKB:Q15910 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein binding IPI UniProtKB:P97462 2290270 (MGI:MGI:1203943, PMID:9584197) MGI MGI:MGI:1203943 , PMID:9584197 protein binding IPI UniProtKB:Q62315 more ... 2290270 (MGI:MGI:4431292 more ... IntAct MGI:MGI:4431292 more ... protein binding IPI UniProtKB:Q02395 2290270 (MGI:MGI:4436818, PMID:20064376) IntAct MGI:MGI:4436818 , PMID:20064376 protein binding IPI UniProtKB:Q80U70 2290270 (MGI:MGI:5499261 more ... IntAct MGI:MGI:5499261 more ... protein binding IPI UniProtKB:P38398 2290270 (MGI:MGI:5499261, PMID:23624935) IntAct MGI:MGI:5499261 , PMID:23624935 protein binding IPI UniProtKB:O08785 more ... 2290270 (MGI:MGI:3694308, PMID:16717091) UniProtKB MGI:MGI:3694308 , PMID:16717091 protein binding IPI UniProtKB:O09106 , UniProtKB:P97462 2290270 (MGI:MGI:2668801, PMID:12900441) MGI MGI:MGI:2668801 , PMID:12900441 protein binding IPI UniProtKB:Q921E6 2290270 (MGI:MGI:3703096 more ... MGI MGI:MGI:3703096 more ... protein binding IPI UniProtKB:Q80U70 , UniProtKB:Q9CWR8 2290270 (MGI:MGI:5553039, PMID:24074865) IntAct MGI:MGI:5553039 , PMID:24074865 protein binding IPI UniProtKB:P59598 2290270 (MGI:MGI:5529751, PMID:24216483) MGI MGI:MGI:5529751 , PMID:24216483 protein binding IPI UniProtKB:Q62315 2290270 (MGI:MGI:5286758, PMID:21811233) IntAct MGI:MGI:5286758 , PMID:21811233 protein-lysine N-methyltransferase activity IDA 2290270 (MGI:MGI:5617064, PMID:25547114) MGI MGI:MGI:5617064 , PMID:25547114 ribonucleoprotein complex binding IDA 2290270 (MGI:MGI:4881870, PMID:21172659) MGI MGI:MGI:4881870 , PMID:21172659 RNA binding IPI RefSeq:NR_047528 2290270 (MGI:MGI:4867320, PMID:21123648) MGI MGI:MGI:4867320 , PMID:21123648 RNA binding IPI 2290270 (MGI:MGI:5694641 more ... MGI MGI:MGI:5694641 more ... RNA binding IPI EMBL:DQ059755 2290270 (MGI:MGI:5439212, PMID:22911650) MGI MGI:MGI:5439212 , PMID:22911650 RNA binding IDA 2290270 (MGI:MGI:5294273, PMID:21936910) MGI MGI:MGI:5294273 , PMID:21936910 RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 2290270 (MGI:MGI:5576864, PMID:24137001) MGI MGI:MGI:5576864 , PMID:24137001 RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP 2290270 (MGI:MGI:3694308, PMID:16717091) UniProtKB MGI:MGI:3694308 , PMID:16717091 RNA polymerase II core promoter sequence-specific DNA binding IMP 2290270 (MGI:MGI:3694308, PMID:16717091) MGI MGI:MGI:3694308 , PMID:16717091 RNA polymerase II core promoter sequence-specific DNA binding IDA 2290270 (MGI:MGI:4833736, PMID:20798045) MGI MGI:MGI:4833736 , PMID:20798045 sequence-specific DNA binding IDA 2290270 (MGI:MGI:4838928, PMID:20956546) MGI MGI:MGI:4838928 , PMID:20956546 transcription corepressor activity IDA 2290270 (MGI:MGI:3820717, PMID:19026781) ARUK-UCL MGI:MGI:3820717 , PMID:19026781 transcription regulatory region DNA binding ISO RGD:1595860 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 transferase activity IEA UniProtKB-KW:KW-0808 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194
Gene-Chemical Interaction Annotations
