Dab2ip (DAB2 interacting protein) - Rat Genome Database

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Pathways
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Gene: Dab2ip (DAB2 interacting protein) Chinchilla lanigera
Analyze
Symbol: Dab2ip
Name: DAB2 interacting protein
RGD ID: 9021239
Description: ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); death receptor binding (ortholog); GTPase activator activity (ortholog); INVOLVED IN cell motility involved in cerebral cortex radial glia guided migration (ortholog); cellular response to epidermal growth factor stimulus (ortholog); cellular response to interleukin-1 (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); atherosclerosis (ortholog); carotid artery occlusion (ortholog); FOUND IN AIP1-IRE1 complex (ortholog); axon (ortholog); cerebellar mossy fiber (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554196,228,591 - 6,416,402 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554196,229,437 - 6,416,619 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell motility involved in cerebral cortex radial glia guided migration  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
intracellular signal transduction  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
layer formation in cerebral cortex  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of endothelial cell migration  (ISO)
negative regulation of epidermal growth factor receptor signaling pathway  (ISO)
negative regulation of epithelial cell migration  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of G0 to G1 transition  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of Ras protein signal transduction  (ISO)
negative regulation of toll-like receptor 4 signaling pathway  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vascular endothelial growth factor receptor signaling pathway  (ISO)
negative regulation of vascular endothelial growth factor signaling pathway  (ISO)
neuron projection morphogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of dendrite development  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of neuron migration  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of proteasomal protein catabolic process  (ISO)
positive regulation of protein catabolic process  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of synapse maturation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein catabolic process  (ISO)
regulation of canonical NF-kappaB signal transduction  (ISO)
regulation of cell cycle  (ISO)
regulation of p38MAPK cascade  (ISO)
regulation of protein-containing complex assembly  (ISO)
tube formation  (ISO)
vascular endothelial growth factor receptor-2 signaling pathway  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Dab2ip
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554196,228,591 - 6,416,402 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554196,229,437 - 6,416,619 (-)NCBIChiLan1.0ChiLan1.0
DAB2IP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389121,567,074 - 121,785,530 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9121,567,057 - 121,785,530 (+)EnsemblGRCh38hg38GRCh38
GRCh379124,329,353 - 124,547,809 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369123,369,220 - 123,587,630 (+)NCBINCBI36Build 36hg18NCBI36
Build 349121,584,617 - 121,624,486NCBI
Celera994,977,959 - 95,196,365 (+)NCBICelera
Cytogenetic Map9q33.2NCBI
HuRef993,947,187 - 94,165,205 (+)NCBIHuRef
CHM1_19124,476,692 - 124,695,048 (+)NCBICHM1_1
T2T-CHM13v2.09133,763,089 - 133,981,519 (+)NCBIT2T-CHM13v2.0
Dab2ip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39235,448,285 - 35,621,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl235,448,278 - 35,621,006 (+)EnsemblGRCm39 Ensembl
GRCm38235,558,446 - 35,730,994 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl235,558,266 - 35,730,994 (+)EnsemblGRCm38mm10GRCm38
MGSCv37235,413,978 - 35,586,514 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36235,514,003 - 35,553,001 (+)NCBIMGSCv36mm8
Celera235,262,708 - 35,435,145 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map223.74NCBI
Dab2ip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8339,312,745 - 39,483,730 (+)NCBIGRCr8
mRatBN7.2318,915,290 - 19,086,282 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl318,915,290 - 19,086,280 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx321,993,857 - 22,164,973 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0330,578,777 - 30,749,893 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0328,824,966 - 28,996,227 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0314,889,263 - 15,060,286 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl314,889,510 - 15,060,286 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0320,200,937 - 20,371,268 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4314,667,700 - 14,840,625 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1314,665,957 - 14,736,995 (+)NCBI
Celera313,627,572 - 13,799,395 (+)NCBICelera
Cytogenetic Map3p11NCBI
DAB2IP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21117,559,459 - 17,775,392 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1917,561,808 - 17,777,742 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0992,696,798 - 92,912,425 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19121,206,211 - 121,254,336 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9121,143,457 - 121,254,336 (+)Ensemblpanpan1.1panPan2
DAB2IP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1960,725,887 - 60,918,242 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl960,726,809 - 60,918,139 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha959,923,807 - 60,112,921 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0961,652,013 - 61,841,403 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl961,649,556 - 61,841,557 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1960,418,457 - 60,607,676 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0960,735,047 - 60,780,893 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0960,826,819 - 60,947,231 (-)NCBIUU_Cfam_GSD_1.0
Dab2ip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947190,288,527 - 190,474,488 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648710,145,278 - 10,243,174 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648710,056,809 - 10,243,021 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAB2IP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1261,659,660 - 261,859,022 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11261,732,280 - 261,859,833 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21293,998,983 - 294,126,953 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DAB2IP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11217,802,030 - 18,017,648 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1217,801,831 - 17,830,890 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603525,028,520 - 25,243,744 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dab2ip
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476013,472,672 - 13,657,930 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476013,472,500 - 13,658,070 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005382543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005382544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005382545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005382546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005382549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005382553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005382554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005382555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013513228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGCD01019852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01019853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01019854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01019855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01019856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01019857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01019858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBDF01128674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCLAT00000023747   ⟹   ENSCLAP00000023524
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554196,228,591 - 6,416,402 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000023748   ⟹   ENSCLAP00000023525
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554196,228,591 - 6,393,039 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000023749   ⟹   ENSCLAP00000023526
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554196,229,437 - 6,353,499 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000023750   ⟹   ENSCLAP00000023527
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554196,229,437 - 6,274,327 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000023751   ⟹   ENSCLAP00000023528
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554196,231,619 - 6,353,362 (-)Ensembl
RefSeq Acc Id: XM_005382543   ⟹   XP_005382600
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554196,229,437 - 6,353,498 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005382544   ⟹   XP_005382601
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554196,229,437 - 6,353,498 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005382545   ⟹   XP_005382602
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554196,229,437 - 6,416,619 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005382546   ⟹   XP_005382603
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554196,229,437 - 6,353,499 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005382549   ⟹   XP_005382606
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554196,229,437 - 6,274,327 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005382553   ⟹   XP_005382610
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554196,229,437 - 6,268,468 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005382554   ⟹   XP_005382611
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554196,229,437 - 6,288,537 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005382555   ⟹   XP_005382612
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554196,229,437 - 6,393,039 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013513228   ⟹   XP_013368682
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554196,229,437 - 6,274,484 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005382602   ⟸   XM_005382545
- Peptide Label: isoform X3
- UniProtKB: A0A8C2W0U0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005382612   ⟸   XM_005382555
- Peptide Label: isoform X7
- UniProtKB: A0A8C2W0W4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005382600   ⟸   XM_005382543
- Peptide Label: isoform X1
- UniProtKB: A0A8C2W1C7 (UniProtKB/TrEMBL),   A0A8C2YU54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005382603   ⟸   XM_005382546
- Peptide Label: isoform X4
- UniProtKB: A0A8C2W0U0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005382601   ⟸   XM_005382544
- Peptide Label: isoform X2
- UniProtKB: A0A8C2YU54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005382611   ⟸   XM_005382554
- Peptide Label: isoform X6
- UniProtKB: A0A8C2W0W4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005382606   ⟸   XM_005382549
- Peptide Label: isoform X5
- UniProtKB: A0A8C2YU59 (UniProtKB/TrEMBL),   A0A8C2W0W4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005382610   ⟸   XM_005382553
- Peptide Label: isoform X6
- UniProtKB: A0A8C2W0W4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013368682   ⟸   XM_013513228
- Peptide Label: isoform X6
- UniProtKB: A0A8C2W0W4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000023527   ⟸   ENSCLAT00000023750
RefSeq Acc Id: ENSCLAP00000023528   ⟸   ENSCLAT00000023751
RefSeq Acc Id: ENSCLAP00000023524   ⟸   ENSCLAT00000023747
RefSeq Acc Id: ENSCLAP00000023525   ⟸   ENSCLAT00000023748
RefSeq Acc Id: ENSCLAP00000023526   ⟸   ENSCLAT00000023749
Protein Domains
C2   PH   Ras-GAP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016135 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000023747 ENTREZGENE
  ENSCLAT00000023747.1 UniProtKB/TrEMBL
  ENSCLAT00000023748.1 UniProtKB/TrEMBL
  ENSCLAT00000023749 ENTREZGENE
  ENSCLAT00000023749.1 UniProtKB/TrEMBL
  ENSCLAT00000023750 ENTREZGENE
  ENSCLAT00000023750.1 UniProtKB/TrEMBL
  ENSCLAT00000023751.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  DUF3498 UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Ras_GTPase UniProtKB/TrEMBL
  RasGAP_CS UniProtKB/TrEMBL
  RasGAP_dom UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
NCBI Gene Dab2ip ENTREZGENE
PANTHER PTHR10194 UniProtKB/TrEMBL
  PTHR10194:SF26 UniProtKB/TrEMBL
Pfam DUF3498 UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  RasGAP UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_1 UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_2 UniProtKB/TrEMBL
SMART RasGAP UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48350 UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
UniProt A0A8C2W0U0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2W0W4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2W1C7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YU54 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YU59 ENTREZGENE, UniProtKB/TrEMBL