Ptges (prostaglandin E synthase) - Rat Genome Database

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Gene: Ptges (prostaglandin E synthase) Rattus norvegicus
Analyze
Symbol: Ptges
Name: prostaglandin E synthase
RGD ID: 62076
Description: Enables prostaglandin-D synthase activity and prostaglandin-E synthase activity. Involved in several processes, including prostaglandin biosynthetic process; response to lipopolysaccharide; and response to retinoic acid. Located in perinuclear region of cytoplasm. Biomarker of Barrett's esophagus; ischemia; papilloma; peptic esophagitis; and transitional cell carcinoma. Orthologous to human PTGES (prostaglandin E synthase); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutathione peroxidase PTGES; glutathione transferase PTGES; inducible prostaglandin E synthase; MGC124930; microsomal prostaglandin E synthase 1; mPGES-1; Pges
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8334,575,643 - 34,586,987 (-)NCBIGRCr8
mRatBN7.2314,177,892 - 14,189,236 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx317,250,209 - 17,261,554 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0325,835,203 - 25,846,550 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0324,082,580 - 24,093,932 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.039,727,408 - 9,738,752 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl39,727,408 - 9,738,752 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0315,086,726 - 15,098,070 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.439,946,194 - 9,957,538 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.139,841,561 - 9,852,906 (-)NCBI
Celera38,938,064 - 8,949,408 (-)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
26-hydroxycholesterol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7alpha-hydroxycholesterol  (ISO)
[6]-Shogaol  (ISO)
Acetaminophen cystein  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (EXP,ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (ISO)
beta-hexachlorocyclohexane  (ISO)
bifenthrin  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (EXP)
calciol  (ISO)
carbon nanotube  (ISO)
carrageenan  (EXP)
celecoxib  (EXP,ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chondroitin sulfate  (ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clomiphene  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cumene  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
D-gluconic acid  (EXP)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenzofuran  (EXP)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
Garcinol  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gingerol  (ISO)
graphite  (EXP)
Heptachlor epoxide  (ISO)
hexestrol  (ISO)
irinotecan  (ISO)
isobutanol  (ISO)
isorhamnetin  (ISO)
kaempferol  (ISO)
levonorgestrel  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
lupeol  (ISO)
mancozeb  (ISO)
mesalamine  (ISO)
mestranol  (ISO)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
naphthalenes  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
o-anisidine  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parthenolide  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
prostaglandin E2  (EXP,ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium fluoride  (ISO)
sodium hydrogensulfite  (EXP)
sodium sulfite  (EXP)
Soman  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
terephthalic acid  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone undecanoate  (ISO)
tetrachloroethene  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Global analyses of gene expression in early experimental osteoarthritis. Appleton CT, etal., Arthritis Rheum. 2007 Jun;56(6):1854-68.
2. Inhibition of prostaglandin E2 synthesis by SC-560 is independent of cyclooxygenase 1 inhibition. Brenneis C, etal., FASEB J. 2006 Jul;20(9):1352-60.
3. Key enzymes for renal prostaglandin synthesis: site-specific expression in rodent kidney (rat, mouse). Campean V, etal., Am J Physiol Renal Physiol 2003 Jul;285(1):F19-32. Epub 2003 Mar 25.
4. Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia. Candelario-Jalil E, etal., J Neuroinflammation. 2007 Oct 10;4:25.
5. Expression of inducible microsomal prostaglandin E synthase in local lesions of endometriosis patients. Chishima F, etal., Am J Reprod Immunol. 2007 Mar;57(3):218-26.
6. Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis model. Claveau D, etal., J Immunol. 2003 May 1;170(9):4738-44.
7. Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: evidence for uncoupled regulation of mPGES-1 and COX-2. de Oliveira AC, etal., Glia. 2008 Jun;56(8):844-55.
8. A histopathologic investigation of PGE(2) pathways as predictors of proliferation and invasion in urothelial carcinomas of the bladder. Eschwege P, etal., Eur Urol. 2003 Oct;44(4):435-41.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are overexpressed in squamous cell carcinoma of the penis. Golijanin D, etal., Clin Cancer Res. 2004 Feb 1;10(3):1024-31.
12. Carrageenan-induced paw edema in rat elicits a predominant prostaglandin E2 (PGE2) response in the central nervous system associated with the induction of microsomal PGE2 synthase-1. Guay J, etal., J Biol Chem. 2004 Jun 4;279(23):24866-72. Epub 2004 Mar 24.
13. Roles of cyclooxygenase 2 and microsomal prostaglandin E synthase 1 in rat acid reflux oesophagitis. Hayakawa T, etal., Gut. 2006 Apr;55(4):450-6. Epub 2005 Oct 6.
14. Prostanoids as regulators of innate and adaptive immunity. Hirata T and Narumiya S, Adv Immunol. 2012;116:143-74. doi: 10.1016/B978-0-12-394300-2.00005-3.
15. Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury. Ikeda-Matsuo Y, etal., Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11790-5. Epub 2006 Jul 24.
16. Prostaglandin E(2)-synthesizing enzymes in fever: differential transcriptional regulation. Ivanov AI, etal., Am J Physiol Regul Integr Comp Physiol 2002 Nov;283(5):R1104-17.
17. Expression of COX-2 and PGE synthase and synthesis of PGE(2)in endometrial adenocarcinoma: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors. Jabbour HN, etal., Br J Cancer. 2001 Sep 28;85(7):1023-31.
18. Expression of cyclooxygenase 2, microsomal prostaglandin E synthase 1, and EP receptors is increased in rat oesophageal squamous cell dysplasia and Barrett's metaplasia induced by duodenal contents reflux. Jang TJ, etal., Gut. 2004 Jan;53(1):27-33.
19. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
20. Retinoic acid enhances prostaglandin E2 production through increased expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in rat brain microglia. Kim B, etal., J Neurosci Res. 2008 May 1;86(6):1353-60.
21. Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. Majed BH and Khalil RA, Pharmacol Rev. 2012 Jul;64(3):540-82. doi: 10.1124/pr.111.004770. Epub 2012 Jun 7.
22. Cloning, expression, and up-regulation of inducible rat prostaglandin e synthase during lipopolysaccharide-induced pyresis and adjuvant-induced arthritis. Mancini JA, etal., J Biol Chem 2001 Feb 9;276(6):4469-75.
23. Microsomal prostaglandin E2 synthase-1 in breast cancer: a potential target for therapy. Mehrotra S, etal., J Pathol. 2006 Feb;208(3):356-63.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2. Murakami M, etal., J Biol Chem 2000 Oct 20;275(42):32783-92.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. CREB-dependent cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression is mediated by protein kinase C and calcium. Pham H, etal., J Cell Biochem. 2006 Aug 15;98(6):1653-66.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
30. Ovarian epithelial cancer: a role for PGE2-synthesis and signalling in malignant transformation and progression. Rask K, etal., Mol Cancer. 2006 Nov 16;5:62.
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Expression of prostaglandin E synthase mRNA is induced in beta-amyloid treated rat astrocytes. Satoh K, etal., Neurosci Lett 2000 Apr 14;283(3):221-3.
33. Elevated prostaglandin E2 level via cPLA2--COX-2--mPGES-1 pathway involved in bladder carcinogenesis induced by terephthalic acid-calculi in Wistar rats. Shi Y, etal., Prostaglandins Leukot Essent Fatty Acids. 2006 May;74(5):309-15. Epub 2006 Apr 18.
34. Expression of cyclooxygenase 2 and prostaglandin E synthase after renal ischemia-reperfusion. Slimane MA, etal., Transplant Proc. 2002 Nov;34(7):2841-2.
35. Intracellular-specific colocalization of prostaglandin E2 synthases and cyclooxygenases in the brain. Vazquez-Tello A, etal., Am J Physiol Regul Integr Comp Physiol. 2004 Nov;287(5):R1155-63. Epub 2004 Jul 29.
36. Co-overexpression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 adversely affects the postoperative survival in non-small cell lung cancer. Wu YC, etal., J Thorac Oncol. 2010 Aug;5(8):1167-74.
Additional References at PubMed
PMID:11795891   PMID:12021206   PMID:12477932   PMID:14555660   PMID:15358613   PMID:16574649   PMID:18485889   PMID:18682561   PMID:19692487   PMID:21075851   PMID:21226556   PMID:21945087  
PMID:22387750   PMID:22822059   PMID:23284082   PMID:25726376   PMID:26543101   PMID:29891860   PMID:39417702  


Genomics

Comparative Map Data
Ptges
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8334,575,643 - 34,586,987 (-)NCBIGRCr8
mRatBN7.2314,177,892 - 14,189,236 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx317,250,209 - 17,261,554 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0325,835,203 - 25,846,550 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0324,082,580 - 24,093,932 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.039,727,408 - 9,738,752 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl39,727,408 - 9,738,752 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0315,086,726 - 15,098,070 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.439,946,194 - 9,957,538 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.139,841,561 - 9,852,906 (-)NCBI
Celera38,938,064 - 8,949,408 (-)NCBICelera
Cytogenetic Map3p12NCBI
PTGES
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389129,738,349 - 129,753,042 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9129,738,331 - 129,753,042 (-)EnsemblGRCh38hg38GRCh38
GRCh379132,500,628 - 132,515,321 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369131,540,433 - 131,555,165 (-)NCBINCBI36Build 36hg18NCBI36
Build 349129,580,165 - 129,594,898NCBI
Celera9103,151,433 - 103,166,162 (-)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9102,099,772 - 102,114,492 (-)NCBIHuRef
CHM1_19132,649,284 - 132,663,955 (-)NCBICHM1_1
T2T-CHM13v2.09141,942,947 - 141,957,638 (-)NCBIT2T-CHM13v2.0
Ptges
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39230,779,483 - 30,793,309 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl230,779,483 - 30,819,875 (-)EnsemblGRCm39 Ensembl
GRCm38230,889,471 - 30,931,020 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl230,889,471 - 30,929,863 (-)EnsemblGRCm38mm10GRCm38
MGSCv37230,744,991 - 30,758,817 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36230,711,480 - 30,725,306 (-)NCBIMGSCv36mm8
Celera230,594,839 - 30,608,694 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map221.75NCBI
Ptges
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544510,053,745 - 10,056,981 (+)NCBIChiLan1.0ChiLan1.0
PTGES
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2119,572,006 - 9,611,010 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan199,574,355 - 9,613,375 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09100,865,702 - 100,880,408 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19129,522,547 - 129,537,020 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9129,522,547 - 129,537,020 (-)Ensemblpanpan1.1panPan2
PTGES
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1954,071,472 - 54,082,232 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl954,071,472 - 54,082,232 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha953,267,891 - 53,278,651 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0954,966,888 - 54,977,655 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl954,966,888 - 54,977,655 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1953,745,854 - 53,756,539 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0954,065,785 - 54,076,457 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0954,159,043 - 54,169,736 (+)NCBIUU_Cfam_GSD_1.0
Ptges
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947197,190,736 - 197,200,389 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648716,959,231 - 16,968,922 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648716,959,263 - 16,968,909 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGES
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1269,911,789 - 269,924,462 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11269,911,785 - 269,924,481 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21303,779,651 - 303,792,393 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTGES
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1128,393,462 - 8,408,441 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl128,393,550 - 8,408,435 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660797,033,845 - 7,048,827 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptges
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247605,643,501 - 5,654,475 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247605,643,549 - 5,653,747 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptges
66 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:120
Count of miRNA genes:84
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000045993
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat

Markers in Region
D3Chm40  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2314,189,701 - 14,189,875 (+)MAPPERmRatBN7.2
Rnor_6.039,739,220 - 9,739,393NCBIRnor6.0
Rnor_5.0315,098,536 - 15,098,709UniSTSRnor5.0
RGSC_v3.439,958,004 - 9,958,177UniSTSRGSC3.4
RGSC_v3.439,958,003 - 9,958,177RGDRGSC3.4
Celera38,949,874 - 8,950,047UniSTS
Cytogenetic Map3p12UniSTS
D3Chm41  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2314,190,045 - 14,190,218 (+)MAPPERmRatBN7.2
Rnor_6.039,739,564 - 9,739,736NCBIRnor6.0
Rnor_5.0315,098,880 - 15,099,052UniSTSRnor5.0
RGSC_v3.439,958,348 - 9,958,520UniSTSRGSC3.4
RGSC_v3.439,958,347 - 9,958,520RGDRGSC3.4
Celera38,950,218 - 8,950,392UniSTS
Cytogenetic Map3p12UniSTS
RH129128  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2314,177,887 - 14,178,073 (+)MAPPERmRatBN7.2
Rnor_6.039,727,404 - 9,727,589NCBIRnor6.0
Rnor_5.0315,086,722 - 15,086,907UniSTSRnor5.0
RGSC_v3.439,946,190 - 9,946,375UniSTSRGSC3.4
Celera38,938,060 - 8,938,245UniSTS
RH 3.4 Map349.8UniSTS
Cytogenetic Map3p12UniSTS
RH134815  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2314,178,124 - 14,178,328 (+)MAPPERmRatBN7.2
Rnor_6.039,727,641 - 9,727,844NCBIRnor6.0
Rnor_5.0315,086,959 - 15,087,162UniSTSRnor5.0
RGSC_v3.439,946,427 - 9,946,630UniSTSRGSC3.4
Celera38,938,297 - 8,938,500UniSTS
RH 3.4 Map348.5UniSTS
Cytogenetic Map3p12UniSTS
AU048497  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2314,180,493 - 14,180,885 (+)MAPPERmRatBN7.2
Rnor_6.039,730,010 - 9,730,401NCBIRnor6.0
Rnor_5.0315,089,328 - 15,089,719UniSTSRnor5.0
RGSC_v3.439,948,796 - 9,949,187UniSTSRGSC3.4
Celera38,940,666 - 8,941,057UniSTS
Cytogenetic Map3p12UniSTS
AU049847  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2314,184,839 - 14,184,946 (+)MAPPERmRatBN7.2
Rnor_6.039,734,356 - 9,734,462NCBIRnor6.0
Rnor_5.0315,093,674 - 15,093,780UniSTSRnor5.0
RGSC_v3.439,953,142 - 9,953,248UniSTSRGSC3.4
Celera38,945,012 - 8,945,118UniSTS
Cytogenetic Map3p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 47 113 68 67 36 25 36 6 193 95 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000045993   ⟹   ENSRNOP00000044191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl39,727,408 - 9,738,752 (-)Ensembl
RefSeq Acc Id: NM_021583   ⟹   NP_067594
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8334,575,643 - 34,586,987 (-)NCBI
mRatBN7.2314,177,892 - 14,189,236 (-)NCBI
Rnor_6.039,727,408 - 9,738,752 (-)NCBI
Rnor_5.0315,086,726 - 15,098,070 (-)NCBI
RGSC_v3.439,946,194 - 9,957,538 (-)RGD
Celera38,938,064 - 8,949,408 (-)RGD
Sequence:
RefSeq Acc Id: NP_067594   ⟸   NM_021583
- UniProtKB: Q9JHF3 (UniProtKB/TrEMBL),   Q5I0P8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044191   ⟸   ENSRNOT00000045993

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHF3-F1-model_v2 AlphaFold Q9JHF3 1-153 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691968
Promoter ID:EPDNEW_R2493
Type:multiple initiation site
Name:Ptges_1
Description:prostaglandin E synthase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.039,738,749 - 9,738,809EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62076 AgrOrtholog
BioCyc Gene G2FUF-50192 BioCyc
BioCyc Pathway PWY66-374 [C20 prostanoid biosynthesis] BioCyc
BioCyc Pathway Image PWY66-374 BioCyc
Ensembl Genes ENSRNOG00000006320 Ensembl
  ENSRNOG00055007207 UniProtKB/Swiss-Prot
  ENSRNOG00065021085 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00055011957 UniProtKB/Swiss-Prot
  ENSRNOT00065035852 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7378919 IMAGE-MGC_LOAD
  IMAGE:7456259 IMAGE-MGC_LOAD
InterPro MAPEG-like_dom UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Membr-assoc_MAPEG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MGST1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59103 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108548 IMAGE-MGC_LOAD
  MGC:124930 IMAGE-MGC_LOAD
NCBI Gene 59103 ENTREZGENE
PANTHER PROSTAGLANDIN E SYNTHASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MAPEG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PTGES RGD
PhenoGen Ptges PhenoGen
RatGTEx ENSRNOG00000006320 RatGTEx
  ENSRNOG00055007207 RatGTEx
  ENSRNOG00065021085 RatGTEx
Superfamily-SCOP SSF161084 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt PTGES_RAT UniProtKB/Swiss-Prot
  Q5I0P8 ENTREZGENE, UniProtKB/TrEMBL
  Q9JHF3 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ptges  prostaglandin E synthase       Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression after LPS (lipopoylsaccharide) challenge, mRNA level increased in lung, colon, brain, heart, testis, spleen, and seminal vesicles; highest induction was seen in lung and in the adjuvant-treated paw 61719
gene_expression after LPS (lipopoylsaccharide) challenge, mRNA level increased in lung, colon, brain, heart, testis, spleen, and seminal vesicles; highest induction was seen in lung and in the adjuvant-treated paw 67929
gene_expression expressed in the liver 628462
gene_function catalyzes the conversion of PGH2 to PGE2. 61719
gene_function catalyzes the conversion of PGH2 to PGE2. 67929
gene_process major mediator of the febrile response 628462
gene_regulation enzymatic activity is modulated through two major mechanisms, transcriptional upregulation and posttranslational modification 628462