Coq4 (coenzyme Q4) - Rat Genome Database

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Gene: Coq4 (coenzyme Q4) Rattus norvegicus
Analyze
Symbol: Coq4
Name: coenzyme Q4
RGD ID: 1304638
Description: Predicted to be involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be part of ubiquinone biosynthesis complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 7. Orthologous to human COQ4 (coenzyme Q4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; chlormequat chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: coenzyme Q biosynthesis protein 4 homolog; coenzyme Q4 homolog; coenzyme Q4 homolog (S. cerevisiae); coenzyme Q4 homolog (yeast); LOC366013; MGC116264; ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8333,457,834 - 33,468,387 (+)NCBIGRCr8
mRatBN7.2313,060,054 - 13,070,502 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl313,060,455 - 13,068,799 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx316,135,246 - 16,143,579 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0324,720,207 - 24,728,540 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0322,971,360 - 22,979,697 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.038,349,386 - 8,357,719 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl38,349,185 - 8,357,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0313,692,575 - 13,700,908 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.438,775,412 - 8,783,745 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.138,775,712 - 8,784,085 (+)NCBI
Celera37,838,136 - 7,846,469 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:18614015   PMID:25152161  


Genomics

Comparative Map Data
Coq4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8333,457,834 - 33,468,387 (+)NCBIGRCr8
mRatBN7.2313,060,054 - 13,070,502 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl313,060,455 - 13,068,799 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx316,135,246 - 16,143,579 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0324,720,207 - 24,728,540 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0322,971,360 - 22,979,697 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.038,349,386 - 8,357,719 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl38,349,185 - 8,357,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0313,692,575 - 13,700,908 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.438,775,412 - 8,783,745 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.138,775,712 - 8,784,085 (+)NCBI
Celera37,838,136 - 7,846,469 (+)NCBICelera
Cytogenetic Map3p12NCBI
COQ4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389128,322,839 - 128,334,072 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9128,322,544 - 128,334,072 (+)EnsemblGRCh38hg38GRCh38
GRCh379131,085,118 - 131,096,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369130,124,636 - 130,136,172 (+)NCBINCBI36Build 36hg18NCBI36
Build 349128,164,368 - 128,175,905NCBI
Celera9101,735,695 - 101,747,255 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,697,662 - 100,709,174 (+)NCBIHuRef
CHM1_19131,235,826 - 131,247,386 (+)NCBICHM1_1
T2T-CHM13v2.09140,529,941 - 140,541,174 (+)NCBIT2T-CHM13v2.0
Coq4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39229,677,505 - 29,687,947 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl229,677,505 - 29,687,947 (+)EnsemblGRCm39 Ensembl
GRCm38229,787,493 - 29,797,935 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl229,787,493 - 29,797,935 (+)EnsemblGRCm38mm10GRCm38
MGSCv37229,643,783 - 29,653,263 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36229,610,272 - 29,619,752 (+)NCBIMGSCv36mm8
Celera229,495,338 - 29,504,818 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map220.62NCBI
Coq4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955570837,216 - 846,653 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955570837,216 - 846,653 (+)NCBIChiLan1.0ChiLan1.0
COQ4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,017,109 - 11,029,707 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,019,458 - 11,032,056 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0999,444,414 - 99,457,281 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19128,111,957 - 128,124,918 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9128,111,957 - 128,124,918 (+)Ensemblpanpan1.1panPan2
COQ4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,182,919 - 55,194,048 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,183,354 - 55,194,006 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,378,354 - 54,389,250 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,105,495 - 56,116,394 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,104,611 - 56,116,046 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1954,865,091 - 54,876,010 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,179,328 - 55,190,227 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,271,260 - 55,282,157 (-)NCBIUU_Cfam_GSD_1.0
COQ4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,756,685 - 268,768,343 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,756,690 - 268,768,355 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,747,002 - 302,758,980 (+)NCBISscrofa10.2Sscrofa10.2susScr3
COQ4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,796,284 - 9,808,156 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660796,427,970 - 6,439,513 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Coq4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247606,548,228 - 6,557,212 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247606,545,040 - 6,557,291 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Coq4
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:46
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000038602
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat

Markers in Region
RH131626  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2313,068,600 - 13,068,782 (+)MAPPERmRatBN7.2
Rnor_6.038,357,516 - 8,357,697NCBIRnor6.0
Rnor_5.0313,700,705 - 13,700,886UniSTSRnor5.0
RGSC_v3.438,783,542 - 8,783,723UniSTSRGSC3.4
Celera37,846,266 - 7,846,447UniSTS
RH 3.4 Map20493.62UniSTS
Cytogenetic Map3p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 60 25 27 2
Low 1 43 57 41 19 41 8 11 14 10 14 9 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000038602   ⟹   ENSRNOP00000038869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl313,060,455 - 13,068,799 (+)Ensembl
Rnor_6.0 Ensembl38,349,185 - 8,357,871 (+)Ensembl
RefSeq Acc Id: NM_001031662   ⟹   NP_001026832
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,458,352 - 33,466,685 (+)NCBI
mRatBN7.2313,060,471 - 13,068,804 (+)NCBI
Rnor_6.038,349,386 - 8,357,719 (+)NCBI
Rnor_5.0313,692,575 - 13,700,908 (+)NCBI
RGSC_v3.438,775,412 - 8,783,745 (+)RGD
Celera37,838,136 - 7,846,469 (+)RGD
Sequence:
RefSeq Acc Id: XM_039105582   ⟹   XP_038961510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,458,289 - 33,468,387 (+)NCBI
mRatBN7.2313,060,054 - 13,070,502 (+)NCBI
RefSeq Acc Id: XM_063284260   ⟹   XP_063140330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,457,834 - 33,468,387 (+)NCBI
RefSeq Acc Id: XR_010064672
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8333,458,289 - 33,468,387 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001026832 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961510 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140330 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH99123 (Get FASTA)   NCBI Sequence Viewer  
  EDL93374 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038869
  ENSRNOP00000038869.4
GenBank Protein Q4FZU1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001026832   ⟸   NM_001031662
- Peptide Label: precursor
- UniProtKB: Q4FZU1 (UniProtKB/Swiss-Prot),   A0A0H2UHW2 (UniProtKB/TrEMBL),   A6JTS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038869   ⟸   ENSRNOT00000038602
RefSeq Acc Id: XP_038961510   ⟸   XM_039105582
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063140330   ⟸   XM_063284260
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4FZU1-F1-model_v2 AlphaFold Q4FZU1 1-265 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304638 AgrOrtholog
BioCyc Gene G2FUF-50254 BioCyc
Ensembl Genes ENSRNOG00000026691 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038602 ENTREZGENE
  ENSRNOT00000038602.6 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7462864 IMAGE-MGC_LOAD
InterPro Coq4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Coq4_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:366013 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116264 IMAGE-MGC_LOAD
NCBI Gene 366013 ENTREZGENE
PANTHER PTHR12922 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Coq4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Coq4 PhenoGen
RatGTEx ENSRNOG00000026691 RatGTEx
UniProt A0A0H2UHW2 ENTREZGENE, UniProtKB/TrEMBL
  A6JTS3 ENTREZGENE, UniProtKB/TrEMBL
  COQ4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-11 Coq4  coenzyme Q4  Coq4  coenzyme Q4 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-15 Coq4  coenzyme Q4 homolog (S. cerevisiae)  Coq4  coenzyme Q4 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Coq4  coenzyme Q4 homolog (yeast)  Coq4_predicted  coenzyme Q4 homolog (yeast) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Coq4_predicted  coenzyme Q4 homolog (yeast) (predicted)      Symbol and Name status set to approved 70820 APPROVED