Eeig1 (estrogen-induced osteoclastogenesis regulator 1) - Rat Genome Database

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Gene: Eeig1 (estrogen-induced osteoclastogenesis regulator 1) Rattus norvegicus
Analyze
Symbol: Eeig1
Name: estrogen-induced osteoclastogenesis regulator 1
RGD ID: 1597535
Description: Predicted to be involved in positive regulation of osteoclast differentiation. Predicted to be located in cytoplasm; membrane raft; and nucleus. Orthologous to human EEIG1 (estrogen-induced osteoclastogenesis regulator 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fam102a; family with sequence similarity 102, member A; LOC687750; similar to early estrogen-induced gene 1 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,220,170 - 36,252,377 (+)NCBIGRCr8
mRatBN7.2315,822,441 - 15,854,651 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,823,144 - 15,854,643 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,891,228 - 18,923,318 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,476,235 - 27,508,325 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,726,984 - 25,759,060 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,554,084 - 11,586,315 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,554,457 - 11,586,303 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0316,904,780 - 16,936,721 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera310,562,181 - 10,594,377 (+)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
5-fluorouracil  (ISO)
afimoxifene  (ISO)
Aflatoxin B2 alpha  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
DDT  (ISO)
diethylstilbestrol  (ISO)
epoxiconazole  (ISO)
estriol  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
fluoranthene  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
iron dichloride  (ISO)
Licochalcone B  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
orphenadrine  (EXP)
paracetamol  (EXP)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercitrin  (ISO)
selenomethionine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetraphene  (ISO)
thiram  (ISO)
triphenyl phosphate  (EXP)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
membrane raft  (ISO)
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Eeig1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,220,170 - 36,252,377 (+)NCBIGRCr8
mRatBN7.2315,822,441 - 15,854,651 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,823,144 - 15,854,643 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,891,228 - 18,923,318 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,476,235 - 27,508,325 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,726,984 - 25,759,060 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,554,084 - 11,586,315 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,554,457 - 11,586,303 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0316,904,780 - 16,936,721 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera310,562,181 - 10,594,377 (+)NCBICelera
Cytogenetic Map3p11NCBI
EEIG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389127,940,582 - 127,980,989 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9127,940,582 - 127,980,989 (-)EnsemblGRCh38hg38GRCh38
GRCh379130,702,861 - 130,743,268 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,742,682 - 129,782,316 (-)NCBINCBI36Build 36hg18NCBI36
Celera9101,354,088 - 101,394,030 (-)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,319,806 - 100,359,690 (-)NCBIHuRef
CHM1_19130,855,162 - 130,895,087 (-)NCBICHM1_1
T2T-CHM13v2.09140,148,362 - 140,188,761 (-)NCBIT2T-CHM13v2.0
Eeig1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,425,344 - 32,459,763 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,425,344 - 32,459,768 (+)EnsemblGRCm39 Ensembl
GRCm38232,535,359 - 32,569,750 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,535,332 - 32,569,756 (+)EnsemblGRCm38mm10GRCm38
MGSCv37232,390,879 - 32,425,270 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36232,357,368 - 32,391,759 (+)NCBIMGSCv36mm8
Celera232,241,076 - 32,275,546 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Eeig1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955419707,847 - 736,339 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955419707,850 - 738,763 (+)NCBIChiLan1.0ChiLan1.0
EEIG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,372,435 - 11,412,569 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,374,803 - 11,414,917 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0999,061,030 - 99,101,144 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,731,243 - 127,771,098 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,731,243 - 127,771,098 (-)Ensemblpanpan1.1panPan2
EEIG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,449,384 - 55,483,472 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,449,627 - 55,480,653 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,643,422 - 54,677,588 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,371,383 - 56,405,562 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,371,666 - 56,405,562 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,131,405 - 55,165,573 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,446,129 - 55,480,283 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,537,322 - 55,571,509 (+)NCBIUU_Cfam_GSD_1.0
Eeig1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,801,202 - 195,832,975 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,572,309 - 15,601,411 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648715,569,729 - 15,601,508 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EEIG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11210,141,789 - 10,181,749 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1210,141,832 - 10,182,075 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660796,036,983 - 6,076,979 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eeig1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247607,601,860 - 7,634,014 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247607,601,507 - 7,636,446 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eeig1
195 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:75
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000073087
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat

Markers in Region
BM386928  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2315,843,161 - 15,843,311 (+)MAPPERmRatBN7.2
Rnor_6.0311,574,829 - 11,574,978NCBIRnor6.0
Rnor_5.0316,925,504 - 16,925,653UniSTSRnor5.0
Celera310,582,908 - 10,583,057UniSTS
RH 3.4 Map384.83UniSTS
BE105157  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2315,847,010 - 15,847,164 (+)MAPPERmRatBN7.2
Rnor_6.0311,578,678 - 11,578,831NCBIRnor6.0
Rnor_5.0316,929,353 - 16,929,506UniSTSRnor5.0
Celera310,586,757 - 10,586,910UniSTS
RH 3.4 Map381.7UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000073087   ⟹   ENSRNOP00000066467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,823,144 - 15,854,643 (+)Ensembl
Rnor_6.0 Ensembl311,554,457 - 11,586,303 (+)Ensembl
RefSeq Acc Id: NM_001399583   ⟹   NP_001386512
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,220,170 - 36,252,377 (+)NCBI
mRatBN7.2315,822,441 - 15,854,651 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001386512 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93230 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066467.1
Ensembl Acc Id: ENSRNOP00000066467   ⟸   ENSRNOT00000073087
RefSeq Acc Id: NP_001386512   ⟸   NM_001399583
- UniProtKB: M0RAC2 (UniProtKB/TrEMBL),   A6JU67 (UniProtKB/TrEMBL)
Protein Domains
C2 NT-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RAC2-F1-model_v2 AlphaFold M0RAC2 1-392 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597535 AgrOrtholog
BioCyc Gene G2FUF-50134 BioCyc
Ensembl Genes ENSRNOG00000050834 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073087.3 UniProtKB/TrEMBL
InterPro FAM102-like UniProtKB/TrEMBL
  NT-C2 UniProtKB/TrEMBL
NCBI Gene 687750 ENTREZGENE
PANTHER PROTEIN FAM102A UniProtKB/TrEMBL
  PTHR21456 UniProtKB/TrEMBL
Pfam NT-C2 UniProtKB/TrEMBL
PhenoGen Eeig1 PhenoGen
PROSITE C2_NT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050834 RatGTEx
UniProt A6JU67 ENTREZGENE, UniProtKB/TrEMBL
  M0RAC2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-09-30 Eeig1  estrogen-induced osteoclastogenesis regulator 1  Fam102a  family with sequence similarity 102, member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-16 Fam102a  family with sequence similarity 102, member A  LOC687750  similar to early estrogen-induced gene 1 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC687750  similar to early estrogen-induced gene 1 protein      Symbol and Name status set to provisional 70820 PROVISIONAL