Cutal (cutA divalent cation tolerance homolog-like) - Rat Genome Database

Send us a Message



Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Grant Resources Citing RGD About Us Contact Us
Search by Genomic Position Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quantitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cutal (cutA divalent cation tolerance homolog-like) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cutal
Name: cutA divalent cation tolerance homolog-like
RGD ID: 1564854
Description: Predicted to enable copper ion binding activity. Predicted to be involved in response to metal ion; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC502617; LOC502617; RGD1564854; similar to divalent cation tolerant protein CUTA; uncharacterized protein LOC502617
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8338,551,790 - 38,571,209 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl338,551,731 - 38,571,208 (+)EnsemblGRCr8
mRatBN7.2318,154,300 - 18,174,957 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl318,154,300 - 18,173,796 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx321,222,454 - 21,241,855 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0329,807,476 - 29,826,879 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0328,061,333 - 28,080,739 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd336,098,507 - 36,117,960 (+)NCBI
Lyon_Normotensive343,063,231 - 43,082,680 (+)NCBI
Lyon_Hypertensive334,962,001 - 34,981,453 (+)NCBI
F344_StmMcwi316,169,126 - 16,188,574 (+)NCBI
Rnor_6.0313,936,709 - 13,955,651 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl313,936,783 - 13,955,651 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.0319,256,171 - 19,275,220 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4313,882,427 - 13,901,917 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera312,875,259 - 12,894,713 (+)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Cutal
212 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:284
Count of miRNA genes:170
Interacting mature miRNAs:193
Transcripts:ENSRNOT00000025501
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
11528620Bss113Bone structure and strength QTL 1139.752e-10femur morphology trait (VT:0000559)femoral neck width (CMO:0001695)33688834239639105Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)33777225855937853Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)33083238444921701Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)33779691953640235Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)33779691947904329Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)33779691959119581Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
217 153 159 682 2099 1001 1719 71 871 140 853 145 3345 1191 196 1964 19 1357 621 879 97 95

Sequence


Ensembl Acc Id: ENSRNOT00000025501   ⟹   ENSRNOP00000025501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl318,154,300 - 18,173,796 (+)Ensembl
Rnor_6.0 Ensembl313,936,783 - 13,955,651 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102877   ⟹   ENSRNOP00000094648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl338,551,731 - 38,569,419 (+)Ensembl
mRatBN7.2 Ensembl318,154,300 - 18,171,932 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000148582   ⟹   ENSRNOP00000103291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl338,551,731 - 38,571,208 (+)Ensembl
RefSeq Acc Id: NM_001395619   ⟹   NP_001382548
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8338,551,790 - 38,571,209 (+)NCBI
mRatBN7.2318,154,300 - 18,173,724 (+)NCBI
Dahl_SR_JrHsd336,098,507 - 36,117,960 (+)NCBI
Lyon_Normotensive343,063,231 - 43,082,680 (+)NCBI
Lyon_Hypertensive334,962,001 - 34,981,453 (+)NCBI
F344_StmMcwi316,169,126 - 16,188,574 (+)NCBI
RefSeq Acc Id: XM_039105724   ⟹   XP_038961652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8338,552,009 - 38,571,209 (+)NCBI
mRatBN7.2318,154,512 - 18,174,957 (+)NCBI
RefSeq Acc Id: XM_063284398   ⟹   XP_063140468
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8338,551,856 - 38,571,209 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001382548 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961652 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140468 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93159 (Get FASTA)   NCBI Sequence Viewer  
  EDL93160 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000094648.1
  ENSRNOP00000103291
  ENSRNOP00000103291.1
Ensembl Acc Id: ENSRNOP00000025501   ⟸   ENSRNOT00000025501
RefSeq Acc Id: XP_038961652   ⟸   XM_039105724
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000094648   ⟸   ENSRNOT00000102877
RefSeq Acc Id: NP_001382548   ⟸   NM_001395619
- UniProtKB: A0ABK0LDD5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140468   ⟸   XM_063284398
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000103291   ⟸   ENSRNOT00000148582

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZY56-F1-model_v2 AlphaFold D3ZY56 1-157 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692009
Promoter ID:EPDNEW_R2534
Type:initiation region
Name:RGD1564854_1
Description:similar to divalent cation tolerant protein CUTA
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0313,936,817 - 13,936,877EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564854 AgrOrtholog
BioCyc Gene G2FUF-50074 BioCyc
Ensembl Genes ENSRNOG00000018832 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000102877.2 UniProtKB/TrEMBL
  ENSRNOT00000148582 ENTREZGENE
  ENSRNOT00000148582.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.120 UniProtKB/TrEMBL
InterPro Ion_tolerance_CutA1 UniProtKB/TrEMBL
  N-reg_PII-like_a/b UniProtKB/TrEMBL
  N-reg_PII/ATP_PRibTrfase_C UniProtKB/TrEMBL
NCBI Gene 502617 ENTREZGENE
PANTHER CUTA DIVALENT CATION TOLERANCE HOMOLOG-LIKE UniProtKB/TrEMBL
  Ion_tolerance_CutA1 UniProtKB/TrEMBL
Pfam CutA1 UniProtKB/TrEMBL
PhenoGen Cutal PhenoGen
RatGTEx ENSRNOG00000018832 RatGTEx
Superfamily-SCOP N-reg_PII-like_a/b UniProtKB/TrEMBL
UniProt A0A8I6ANK7_RAT UniProtKB/TrEMBL
  A0ABK0LDD5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Cutal  cutA divalent cation tolerance homolog-like  RGD1564854  similar to divalent cation tolerant protein CUTA  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1564854  similar to divalent cation tolerant protein CUTA   RGD1564854_predicted  similar to divalent cation tolerant protein CUTA (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564854_predicted  similar to divalent cation tolerant protein CUTA (predicted)  LOC502617  similar to divalent cation tolerant protein CUTA  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC502617  similar to divalent cation tolerant protein CUTA      Symbol and Name status set to provisional 70820 PROVISIONAL