Slc2a8 (solute carrier family 2 member 8)

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Gene: Slc2a8 (solute carrier family 2 member 8) Rattus norvegicus

Analyze

Symbol:

Slc2a8

Name:

solute carrier family 2 member 8

RGD ID:

620611

Description:

Enables dehydroascorbic acid transmembrane transporter activity. Involved in dehydroascorbic acid transport and male meiosis I. Located in synaptic vesicle. Orthologous to human SLC2A8 (solute carrier family 2 member 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-deoxy-D-glucose; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

glucose transporter type 8; glucose transporter type X1; GLUT-8; Glut8; solute carrier family 2, (facilitated glucose transporter) member 8; solute carrier family 2, facilitated glucose transporter member 8

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC2A8 (solute carrier family 2 member 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Slc2a8 (solute carrier family 2, (facilitated glucose transporter), member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc2a8 (solute carrier family 2 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC2A8 (solute carrier family 2 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC2A8 (solute carrier family 2 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc2a8 (solute carrier family 2 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC2A8 (solute carrier family 2 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC2A8 (solute carrier family 2 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc2a8 (solute carrier family 2 member 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SLC2A8 (solute carrier family 2 member 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Slc2a8 (solute carrier family 2, (facilitated glucose transporter), member 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc2a8 (solute carrier family 2 member 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG10960	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	CG1213	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG14605	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG31100	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Tret1-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6484	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	Tret1-2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	sut4	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	CG4797	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	slc2a8	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	16,274,918 - 16,284,536 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	16,274,925 - 16,284,464 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	19,342,426 - 19,351,767 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	27,927,429 - 27,936,770 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	26,178,921 - 26,188,241 (-)	NCBI	Rnor_WKY
Rnor_6.0	3	12,020,227 - 12,029,920 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	12,020,229 - 12,029,877 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	17,356,860 - 17,366,549 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	11,962,570 - 11,972,115 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	11,858,949 - 11,868,471 (-)	NCBI
Celera	3	11,013,768 - 11,023,313 (-)	NCBI		Celera
Cytogenetic Map	3	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

developmental and epileptic encephalopathy (ISO)

developmental and epileptic encephalopathy 31 (ISO)

early infantile epileptic encephalopathy (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-acetamidofluorene (ISO)

2-deoxy-D-glucose (EXP,ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

avobenzone (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

C60 fullerene (EXP)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

clofibrate (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

D-mannitol (ISO)

decabromodiphenyl ether (ISO)

dehydroascorbic acid (EXP,ISO)

ethanol (ISO)

fulvestrant (ISO)

gallic acid (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

ivermectin (ISO)

L-dehydroascorbic acid (EXP,ISO)

leflunomide (ISO)

methyl methanesulfonate (ISO)

monosodium L-glutamate (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

quercetin (ISO)

Soman (EXP)

sunitinib (ISO)

temozolomide (ISO)

Tesaglitazar (EXP)

testosterone (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

trichloroethene (EXP)

triptonide (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

dehydroascorbic acid transport (IDA,ISO)

fructose transmembrane transport (ISO,ISS)

glucose transmembrane transport (IBA,ISO,ISS)

insulin receptor signaling pathway (ISO)

male meiosis I (IEP)

response to hypoxia (ISO)

transmembrane transport (IEA)

Cellular Component

cytoplasmic vesicle membrane (IEA)

membrane (IBA,IEA)

plasma membrane (ISO)

synaptic vesicle (IDA)

Molecular Function

dehydroascorbic acid transmembrane transporter activity (IDA,ISO)

fructose transmembrane transporter activity (ISO,ISS)

glucose binding (ISO)

glucose transmembrane transporter activity (IBA,ISO,ISS)

transmembrane transporter activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8.	Corpe CP, etal., J Biol Chem. 2013 Mar 29;288(13):9092-101. doi: 10.1074/jbc.M112.436790. Epub 2013 Feb 8.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Immunolocalization of GLUTX1 in the testis and to specific brain areas and vasopressin-containing neurons.	Ibberson M, etal., Endocrinology 2002 Jan;143(1):276-84.
5.	GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues.	Ibberson M, etal., J Biol Chem 2000 Feb 18;275(7):4607-12.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	Peripheral glucose administration stimulates the translocation of GLUT8 glucose transporter to the endoplasmic reticulum in the rat hippocampus.	Piroli GG, etal., J Comp Neurol 2002 Oct 14;452(2):103-14.
9.	GLUT8 glucose transporter is localized to excitatory and inhibitory neurons in the rat hippocampus.	Reagan LP, etal., Brain Res 2002 Apr 5;932(1-2):129-34.
10.	GOA pipeline	RGD automated data pipeline
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:10821868	PMID:10860996	PMID:11689004	PMID:15811071	PMID:16109784	PMID:17897319	PMID:19194835	PMID:24382486

Genomics

Comparative Map Data

Slc2a8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	16,274,918 - 16,284,536 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	16,274,925 - 16,284,464 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	19,342,426 - 19,351,767 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	27,927,429 - 27,936,770 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	26,178,921 - 26,188,241 (-)	NCBI	Rnor_WKY
Rnor_6.0	3	12,020,227 - 12,029,920 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	12,020,229 - 12,029,877 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	17,356,860 - 17,366,549 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	11,962,570 - 11,972,115 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	11,858,949 - 11,868,471 (-)	NCBI
Celera	3	11,013,768 - 11,023,313 (-)	NCBI		Celera
Cytogenetic Map	3	p11	NCBI

SLC2A8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	127,397,169 - 127,407,898 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	9	127,397,138 - 127,408,424 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	130,159,448 - 130,170,177 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	129,199,286 - 129,209,988 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	127,239,018 - 127,249,715	NCBI
Celera	9	100,814,105 - 100,824,801 (+)	NCBI		Celera
Cytogenetic Map	9	q33.3	NCBI
HuRef	9	99,775,055 - 99,785,815 (+)	NCBI		HuRef
CHM1_1	9	130,310,083 - 130,320,879 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	139,603,648 - 139,615,379 (+)	NCBI		T2T-CHM13v2.0

Slc2a8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	32,862,993 - 32,872,095 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	32,863,002 - 32,872,095 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	32,972,981 - 32,982,083 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	32,972,990 - 32,982,083 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	32,828,509 - 32,837,576 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	32,794,998 - 32,804,065 (-)	NCBI		MGSCv36	mm8
Celera	2	32,679,974 - 32,689,041 (-)	NCBI		Celera
Cytogenetic Map	2	B	NCBI
cM Map	2	22.09	NCBI

Slc2a8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	1,177,059 - 1,187,110 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955419	1,177,752 - 1,187,157 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC2A8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	9	11,946,837 - 11,959,128 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	98,517,880 - 98,534,333 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	127,171,671 - 127,183,478 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	127,171,671 - 127,182,460 (+)	Ensembl	panpan1.1		panPan2

SLC2A8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	55,921,635 - 55,928,753 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	55,921,635 - 55,928,753 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	55,125,406 - 55,132,524 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	56,842,917 - 56,850,266 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	56,842,923 - 56,850,266 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	55,602,890 - 55,610,006 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	55,917,939 - 55,925,055 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	56,008,864 - 56,015,980 (-)	NCBI		UU_Cfam_GSD_1.0

Slc2a8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	195,386,156 - 195,396,547 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936487	15,154,641 - 15,165,870 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936487	15,154,712 - 15,164,615 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC2A8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	267,925,193 - 267,937,038 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	267,925,184 - 267,934,096 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	301,835,694 - 301,844,621 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC2A8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	10,720,266 - 10,731,196 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666079	5,483,909 - 5,494,978 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc2a8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	8,054,391 - 8,066,784 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	8,057,892 - 8,066,804 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc2a8
61 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	79
Count of miRNA genes:	75
Interacting mature miRNAs:	75
Transcripts:	ENSRNOT00000022327
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70202	Alc19	Alcohol consumption QTL 19	2.5		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	3	1	27494778	Rat
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	1	31158234	Rat
631831	Alc8	Alcohol consumption QTL 8	2.7		consumption behavior trait (VT:0002069)	calculated ethanol drink intake rate (CMO:0001615)	3	1	33230976	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	diastolic blood pressure (CMO:0000005)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	pulse pressure (CMO:0000292)	3	1	33278763	Rat
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
4889966	Bss95	Bone structure and strength QTL 95	4.4		tibia area (VT:1000281)	tibia-fibula cross-sectional area (CMO:0001718)	3	1	36847613	Rat
2312664	Scl62	Serum cholesterol level QTL 62		0.05	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	1	38710544	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	39874793	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1298526	Arunc3	Aerobic running capacity QTL 3	2.2		exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	8227194	33703538	Rat
10401810	Kidm53	Kidney mass QTL 53			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	8227194	47233430	Rat
70203	Gcr2	Gastric cancer resistance QTL 2	2.6		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	3	8658162	27494778	Rat
1358357	Srcrtb1	Stress Responsive Cort Basal QTL 1	6.36	0.002	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	8658162	27494778	Rat
6893355	Bw101	Body weight QTL 101	0.4	0.38	body mass (VT:0001259)	body weight (CMO:0000012)	3	10778704	30357018	Rat
6893363	Bw105	Body weight QTL 105	2.6	0.0036	body mass (VT:0001259)	body weight (CMO:0000012)	3	10778704	30357018	Rat
1558654	Bw56	Body weight QTL 56	4.5	0.0000171	body mass (VT:0001259)	body weight (CMO:0000012)	3	10778704	30357018	Rat
70191	BpQTLcluster4	Blood pressure QTL cluster 4	3		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	3	10778704	50302886	Rat
70191	BpQTLcluster4	Blood pressure QTL cluster 4	3		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	3	10778704	50302886	Rat
1558647	Cm46	Cardiac mass QTL 46	5.4	0.0000055	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	10778823	30356773	Rat
1558650	Cm48	Cardiac mass QTL 48	4	0.0001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	3	10778823	30356773	Rat
1558657	Cm43	Cardiac mass QTL 43	6.6	0.0000000293	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	10778823	30356773	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10861912	89878372	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
2298542	Neuinf11	Neuroinflammation QTL 11	3.9		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	3	15005422	76927699	Rat

Markers in Region

RH129995

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	16,274,970 - 16,275,161 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	12,020,280 - 12,020,470	NCBI	Rnor6.0
Rnor_5.0	3	17,356,913 - 17,357,103	UniSTS	Rnor5.0
RGSC_v3.4	3	11,962,623 - 11,962,813	UniSTS	RGSC3.4
Celera	3	11,013,821 - 11,014,011	UniSTS
RH 3.4 Map	3	76.2	UniSTS
Cytogenetic Map	3	p11	UniSTS

RH143490

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	16,284,535 - 16,284,683 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	12,029,949 - 12,030,096	NCBI	Rnor6.0
Rnor_5.0	3	17,366,582 - 17,366,729	UniSTS	Rnor5.0
RGSC_v3.4	3	11,972,187 - 11,972,334	UniSTS	RGSC3.4
Celera	3	11,023,385 - 11,023,532	UniSTS
RH 3.4 Map	3	83.1	UniSTS
Cytogenetic Map	3	p11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		14			3			2	68	23	35	11
Low	3	29	57	41	16	41	8	9	6	12	6		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053494	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761779	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105998	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105999	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039106000	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AJ245935	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BU759499	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000022327 ⟹ ENSRNOP00000022326

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	16,274,925 - 16,284,464 (-)	Ensembl
Rnor_6.0 Ensembl	3	12,020,229 - 12,029,877 (-)	Ensembl

RefSeq Acc Id:

NM_053494 ⟹ NP_445946

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	16,274,918 - 16,284,464 (-)	NCBI
Rnor_6.0	3	12,020,227 - 12,029,877 (-)	NCBI
Rnor_5.0	3	17,356,860 - 17,366,549 (-)	NCBI
RGSC_v3.4	3	11,962,570 - 11,972,115 (-)	RGD
Celera	3	11,013,768 - 11,023,313 (-)	RGD

Sequence:

show sequence

CGACAGTTCGCGGGTCAGACCCTGTTGACATGTCGCCCGAGGACCCCCAGGAAACACAGCCGCT
GTTGCGGTCGCCGGGCGCCAGGGCTCCCGGCGGCCGCCGGGTCTTCCTTGCCACCTTCGCCGCC
GCCCTGGGCCCGCTCAGCTTCGGCTTCGCGCTTGGCTACAGCTCCCCCGCCATCCCCAGCCTGC
GGCGCACCGCACCCCCTGCCCTACGCCTCGGAGACACTGCGGCCTCCTGGTTCGGGGCCGTCGT
GACCCTGGGCGCTGCGGCAGGGGGCGTGCTGGGCGGCTGGCTCCTGGACCGTGCAGGGCGCAAG
CTGAGCCTCCTGCTCTGCACCGTGCCCTTCGTGACCGGTTTTGCTGTCATCACCGCGGCCCGGG
ATGTGTGGATGCTGCTCGGAGGCCGCCTCCTCACCGGCCTAGCCTGCGGAGTCGCCTCATTAGT
GGCACCGGTCTATATCTCGGAAATCGCCTACCCAGCCGTTCGAGGACTGCTCGGCTCCTGTGTG
CAGCTGATGGTTGTCACTGGCATCCTCTTGGCCTACGTGGCAGGCTGGGTCCTAGAATGGCGCT
GGTTGGCTGTGCTGGGCTGTGTGCCCCCCACCCTCATGCTGCTGCTCATGTGCTACATGCCCGA
GACCCCACGCTTCCTCCTGACGCAACACCAGTACCAGGAGGCCATGGCTGCCCTGCGCTTCCTG
TGGGGCTCTGAGGAGGGCTGGGAAGAGCCCCCTGTTGGGGCTGAGCACCAGGGCTTCCAGCTGG
CTATGCTGAGGCGCCCTGGTGTCCACAAGCCCCTCATCATCGGCATTTGCCTCATGGTCTTCCA
GCAGCTGTCAGGGGTCAACGCCATCATGTTCTATGCCAACACCATCTTTGAGGAGGCCAAGTTC
AAGGACAGCAGCCTGGCCTCGGTCACTGTGGGCATCATCCAGGTTCTGTTCACTGCTGTGGCGG
CCCTCATCATGGACAGAGCAGGGCGAAAACTGCTTCTGGCCTTGTCGGGTGTGATCATGGTTTT
CAGCATGAGCGCCTTTGGTACCTACTTCAAACTGACCCAGAGTGGCCCCAGCAACTCCTCCCAT
GTAGGCCTCCTGGTGCCCATCTCCGCAGAGCCTGCTGATGTTCACCTGGGGCTGGCCTGGCTGG
CTGTAGGCAGCATGTGCCTCTTCATCGCTGGTTTTGCAGTAGGCTGGGGACCCATCCCCTGGCT
CCTCATGTCAGAGATCTTCCCTCTGCACATCAAGGGTGTGGCTACCGGCGTCTGTGTCCTCACC
AACTGGTTCATGGCCTTTCTGGTGACCAAAGAGTTTAACAGCATCATGGAGATCCTCAGACCCT
ACGGCGCCTTCTGGCTCACCGCTGCCTTCTGTATCCTCAGCGTCCTTTTCACGCTCACCTTTGT
CCCTGAGACTAAAGGCAGGACTCTGGAACAAATCACAGCCCATTTCGAGGGACGGTGACGGACC
CTTTCTGTGACTGGCAGCCCTGAGCTGAGCTGGCTTCGGGTTTCAAAAGGAGTGGAGTGGCCTC
AGTGACCACAGTTTGAGCCCAGGGGCCCCCTGACTCCTCAGATCTCCGGGCCAGCTTTGTCCAG
ATCTCAACCCAGATCCACACCATGAGCTTCACCAGATTCTGAGGCTCTGCAGCCTGCTGCACAC
ACAACACATCTGCGGAGCCATGCAGTCTCGCCTAACCCACGGGTCTCCTTCCTAAGACTAAAGC
AACTGACGAGACTGCGGGCTCCTGGCTCTAGTGCTCTGGCTGGGCATCTTTGGGGTGCTTGGTC
CTAAGCAACTGCCCATACCTCACTTGACTGGGGGATGAGAAAGGGACTTAGCCACATAAGATTT
GGGCTCAGAAACAAGGTCAGGTGAGTCCAGGAAGAAAAGAGAATGTTCTTGTCTTGTCAACCAA
GTCCTTCTCAGAGTGCCCAGAGACCTCCGGATTCACCTTGGGGTTAGCCAGCTTACCCATCACT
TACAGGTTCTCTCCAGCTCTTCCCTGGTCTCAGTGTCCTGGATCATTAGTCACCAGGTCTTGTT
GAGTTTCAGAAAATAAAAGGCCTCTTTCCGTTCAACTTTAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_008761779 ⟹ XP_008760001

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	16,274,918 - 16,284,435 (-)	NCBI
Rnor_6.0	3	12,020,227 - 12,029,920 (-)	NCBI

Sequence:

show sequence

CCATTGGTCACTCCTGCCGCGGAGGCCGCGCTCGCCCGAGCCGCGACAGTTCGCGGGTCAGACC
CTGTTGACATGTCGCCCGAGGACCCCCAGGAAACACAGCCGCTGTTGCGGTCGCCGGGCGCCAG
GGCTCCCGGCGGCCGCCGGGTCTTCCTTGCCACCTTCGCCGCCGCCCTGGGCCCGCTCAGCTTC
GGCTTCGCGCTTGGCTACAGCTCCCCCGCCATCCCCAGCCTGCGGCGCACCGCACCCCCTGCCC
TACGCCTCGGAGACACTGCGGCCTCCTGGTTCGGGGCCGTCGTGACCCTGGGCGCTGCGGCAGG
GGGCGTGCTGGGCGGCTGGCTCCTGGACCGTGCAGGGCGCAAGCTGAGCCTCCTGCTCTGCACC
GTGCCCTTCGTGACCGGTTTTGCTGTCATCACCGCGGCCCGGGATGTGTGGATGCTGCTCGGAG
GCCGCCTCCTCACCGGCCTAGCCTGCGGAGTCGCCTCATTAGTGGCACCGGTCTATATCTCGGA
AATCGCCTACCCAGCCGTTCGAGGACTGCTCGGCTCCTGTGTGCAGCTGATGGTTGTCACTGGC
ATCCTCTTGGCCTACGTGGCAGGCTGGGTCCTAGAATGGCGCTGGTTGGCTGTGCTGGGCTGTG
TGCCCCCCACCCTCATGCTGCTGCTCATGTGCTACATGCCCGAGACCCCACGCTTCCTCCTGAC
GCAACACCAGTACCAGGAGGCCATGGCTGCCCTGCGCTTCCTGTGGGGCTCTGAGGAGGGCTGG
GAAGAGCCCCCTGTTGGGGCTGAGCACCAGGGCTTCCAGCTGGCTATGCTGAGGCGCCCTGGTG
TCCACAAGCCCCTCATCATCGGCATTTGCCTCATGGTCTTCCAGCAGCTGTCAGGGGTCAACGC
CATCATGTTCTATGCCAACACCATCTTTGAGGAGGCCAAGTTCAAGGACAGCAGCCTGGCCTCG
GTCACTGTGGGCATCATCCAGGTTCTGTTCACTGCTGTGGCGGCCCTCATCATGGACAGAGCAG
GGCGAAAACTGCTTCTGGCCTTGTCGGGTTTTGCAGTAGGCTGGGGACCCATCCCCTGGCTCCT
CATGTCAGAGATCTTCCCTCTGCACATCAAGGGTGTGGCTACCGGCGTCTGTGTCCTCACCAAC
TGGTTCATGGCCTTTCTGGTGACCAAAGAGTTTAACAGCATCATGGAGATCCTCAGACCCTACG
GCGCCTTCTGGCTCACCGCTGCCTTCTGTATCCTCAGCGTCCTTTTCACGCTCACCTTTGTCCC
TGAGACTAAAGGCAGGACTCTGGAACAAATCACAGCCCATTTCGAGGGACGGTGACGGACCCTT
TCTGTGACTGGCAGCCCTGAGCTGAGCTGGCTTCGGGTTTCAAAAGGAGTGGAGTGGCCTCAGT
GACCACAGTTTGAGCCCAGGGGCCCCCTGACTCCTCAGATCTCCGGGCCAGCTTTGTCCAGATC
TCAACCCAGATCCACACCATGAGCTTCACCAGATTCTGAGGCTCTGCAGCCTGCTGCACACACA
ACACATCTGCGGAGCCATGCAGTCTCGCCTAACCCACGGGTCTCCTTCCTAAGACTAAAGCAAC
TGACGAGACTGCGGGCTCCTGGCTCTAGTGCTCTGGCTGGGCATCTTTGGGGTGCTTGGTCCTA
AGCAACTGCCCATACCTCACTTGACTGGGGGATGAGAAAGGGACTTAGCCACATAAGATTTGGG
CTCAGAAACAAGGTCAGGTGAGTCCAGGAAGAAAAGAGAATGTTCTTGTCTTGTCAACCAAGTC
CTTCTCAGAGTGCCCAGAGACCTCCGGATTCACCTTGGGGTTAGCCAGCTTACCCATCACTTAC
AGGTTCTCTCCAGCTCTTCCCTGGTCTCAGTGTCCTGGATCATTAGTCACCAGGTCTTGTTGAG
TTTCAGAAAATAAAAGGCCTCTTTCCGTTCAACTTTAA

hide sequence

RefSeq Acc Id:

XM_039105998 ⟹ XP_038961926

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	16,276,743 - 16,284,435 (-)	NCBI

RefSeq Acc Id:

XM_039105999 ⟹ XP_038961927

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	16,277,245 - 16,284,435 (-)	NCBI

RefSeq Acc Id:

XM_039106000 ⟹ XP_038961928

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	16,278,199 - 16,284,536 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_445946	(Get FASTA)	NCBI Sequence Viewer
	XP_008760001	(Get FASTA)	NCBI Sequence Viewer
	XP_038961926	(Get FASTA)	NCBI Sequence Viewer
	XP_038961927	(Get FASTA)	NCBI Sequence Viewer
	XP_038961928	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAB75729	(Get FASTA)	NCBI Sequence Viewer
	EDL93196	(Get FASTA)	NCBI Sequence Viewer
	EDL93197	(Get FASTA)	NCBI Sequence Viewer
	Q9JJZ1	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_445946 ⟸ NM_053494

- UniProtKB:

Q9JMA6 (UniProtKB/Swiss-Prot), Q9JJZ1 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MSPEDPQETQPLLRSPGARAPGGRRVFLATFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRL
GDTAASWFGAVVTLGAAAGGVLGGWLLDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRL
LTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPP
TLMLLLMCYMPETPRFLLTQHQYQEAMAALRFLWGSEEGWEEPPVGAEHQGFQLAMLRRPGVHK
PLIIGICLMVFQQLSGVNAIMFYANTIFEEAKFKDSSLASVTVGIIQVLFTAVAALIMDRAGRK
LLLALSGVIMVFSMSAFGTYFKLTQSGPSNSSHVGLLVPISAEPADVHLGLAWLAVGSMCLFIA
GFAVGWGPIPWLLMSEIFPLHIKGVATGVCVLTNWFMAFLVTKEFNSIMEILRPYGAFWLTAAF
CILSVLFTLTFVPETKGRTLEQITAHFEGR

hide sequence

RefSeq Acc Id:

XP_008760001 ⟸ XM_008761779

- Peptide Label:

isoform X1

- Sequence:

show sequence

MSPEDPQETQPLLRSPGARAPGGRRVFLATFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRL
GDTAASWFGAVVTLGAAAGGVLGGWLLDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRL
LTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPP
TLMLLLMCYMPETPRFLLTQHQYQEAMAALRFLWGSEEGWEEPPVGAEHQGFQLAMLRRPGVHK
PLIIGICLMVFQQLSGVNAIMFYANTIFEEAKFKDSSLASVTVGIIQVLFTAVAALIMDRAGRK
LLLALSGFAVGWGPIPWLLMSEIFPLHIKGVATGVCVLTNWFMAFLVTKEFNSIMEILRPYGAF
WLTAAFCILSVLFTLTFVPETKGRTLEQITAHFEGR

hide sequence

RefSeq Acc Id:

ENSRNOP00000022326 ⟸ ENSRNOT00000022327

RefSeq Acc Id:	XP_038961926 ⟸ XM_039105998
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038961927 ⟸ XM_039105999
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038961928 ⟸ XM_039106000
- Peptide Label:	isoform X4

Protein Domains

Major facilitator superfamily (MFS) profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9JJZ1-F1-model_v2	AlphaFold	Q9JJZ1	1-478	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691999

Promoter ID:

EPDNEW_R2524

Type:

initiation region

Name:

Slc2a8_1

Description:

solute carrier family 2 member 8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	12,029,911 - 12,029,971	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620611	AgrOrtholog
BioCyc Gene	G2FUF-50112	BioCyc
Ensembl Genes	ENSRNOG00000022274	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000022326	ENTREZGENE
	ENSRNOP00000022326.3	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000022327	ENTREZGENE
	ENSRNOT00000022327.4	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1250.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	MFS_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MFS_sugar_transport-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MFS_trans_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sugar/inositol_transpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sugar_transporter_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:85256	UniProtKB/Swiss-Prot
NCBI Gene	85256	ENTREZGENE
PANTHER	PTHR48021	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 8	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Sugar_tr	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Slc2a8	PhenoGen
PRINTS	SUGRTRNSPORT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	MFS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SUGAR_TRANSPORT_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SUGAR_TRANSPORT_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF103473	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs	TIGR00879	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8L2QBS5_RAT	UniProtKB/TrEMBL
	GTR8_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q9JMA6	ENTREZGENE
UniProt Secondary	Q9JMA6	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-24	Slc2a8	solute carrier family 2 member 8	Slc2a8	solute carrier family 2, (facilitated glucose transporter) member 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-02-26	Slc2a8	solute carrier family 2, (facilitated glucose transporter) member 8			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Slc2a8	solute carrier family 2, (facilitated glucose transporter) member 8			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	located in synaptic vesicles and hormone granules	70577
gene_disease	associated with type 2 diabetes	70600
gene_domains	contains 12 putative transmembrane segments, glucose transporter sequence motifs characteristic of glucose transporters, a short extracellular loop between transmembrane domain (TM), TM1 and TM2, a long extracellular loop between TM9 and TM10 that contain	70600
gene_drugs	transport activity was inhibited by cytochalasin B and partly competed by D-fructose and D-galactose	70600
gene_expression	abundant in testis and brain	70577
gene_expression	localized mainly to archi- and paleocortex in brain; also found in hypothalamus, hippocampal and dentate gyrus neurons	70577
gene_expression	expressed in high levels in testis, moderate levels in cerebellum, brain stem, hippocampus, hypothalamus, adrenal gland, liver, spleen, brown adipose tissue and lung, low levels in white adipose tissue, muscle, kidney and tongue and not expressed in thyro	70600
gene_function	transporter	70600
gene_mutations_overexpression	mutation of the dileucine internalization motif induced cell surface expression	70600
gene_process	facilitates glucose transport	70577
gene_process	mediates glucose transport	70600
gene_product	member of hexose transporter family	70600
gene_regulation	surface expression may be initiated by hormone or other stimulus	70600

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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