Slc2a8 (solute carrier family 2 member 8) - Rat Genome Database

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Gene: Slc2a8 (solute carrier family 2 member 8) Rattus norvegicus
Analyze
Symbol: Slc2a8
Name: solute carrier family 2 member 8
RGD ID: 620611
Description: Enables dehydroascorbic acid transmembrane transporter activity. Involved in dehydroascorbic acid transport and male meiosis I. Located in synaptic vesicle. Orthologous to human SLC2A8 (solute carrier family 2 member 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-deoxy-D-glucose; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glucose transporter type 8; glucose transporter type X1; GLUT-8; Glut8; solute carrier family 2, (facilitated glucose transporter) member 8; solute carrier family 2, facilitated glucose transporter member 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2316,274,918 - 16,284,536 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl316,274,925 - 16,284,464 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx319,342,426 - 19,351,767 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0327,927,429 - 27,936,770 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0326,178,921 - 26,188,241 (-)NCBIRnor_WKY
Rnor_6.0312,020,227 - 12,029,920 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl312,020,229 - 12,029,877 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0317,356,860 - 17,366,549 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,962,570 - 11,972,115 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1311,858,949 - 11,868,471 (-)NCBI
Celera311,013,768 - 11,023,313 (-)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8. Corpe CP, etal., J Biol Chem. 2013 Mar 29;288(13):9092-101. doi: 10.1074/jbc.M112.436790. Epub 2013 Feb 8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Immunolocalization of GLUTX1 in the testis and to specific brain areas and vasopressin-containing neurons. Ibberson M, etal., Endocrinology 2002 Jan;143(1):276-84.
5. GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. Ibberson M, etal., J Biol Chem 2000 Feb 18;275(7):4607-12.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Peripheral glucose administration stimulates the translocation of GLUT8 glucose transporter to the endoplasmic reticulum in the rat hippocampus. Piroli GG, etal., J Comp Neurol 2002 Oct 14;452(2):103-14.
9. GLUT8 glucose transporter is localized to excitatory and inhibitory neurons in the rat hippocampus. Reagan LP, etal., Brain Res 2002 Apr 5;932(1-2):129-34.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10821868   PMID:10860996   PMID:11689004   PMID:15811071   PMID:16109784   PMID:17897319   PMID:19194835   PMID:24382486  


Genomics

Comparative Map Data
Slc2a8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2316,274,918 - 16,284,536 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl316,274,925 - 16,284,464 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx319,342,426 - 19,351,767 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0327,927,429 - 27,936,770 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0326,178,921 - 26,188,241 (-)NCBIRnor_WKY
Rnor_6.0312,020,227 - 12,029,920 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl312,020,229 - 12,029,877 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0317,356,860 - 17,366,549 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,962,570 - 11,972,115 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1311,858,949 - 11,868,471 (-)NCBI
Celera311,013,768 - 11,023,313 (-)NCBICelera
Cytogenetic Map3p11NCBI
SLC2A8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389127,397,169 - 127,407,898 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9127,397,138 - 127,408,424 (+)EnsemblGRCh38hg38GRCh38
GRCh379130,159,448 - 130,170,177 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,199,286 - 129,209,988 (+)NCBINCBI36Build 36hg18NCBI36
Build 349127,239,018 - 127,249,715NCBI
Celera9100,814,105 - 100,824,801 (+)NCBICelera
Cytogenetic Map9q33.3NCBI
HuRef999,775,055 - 99,785,815 (+)NCBIHuRef
CHM1_19130,310,083 - 130,320,879 (+)NCBICHM1_1
T2T-CHM13v2.09139,603,648 - 139,614,377 (+)NCBIT2T-CHM13v2.0
Slc2a8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,862,993 - 32,872,095 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,863,002 - 32,872,095 (-)EnsemblGRCm39 Ensembl
GRCm38232,972,981 - 32,982,083 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,972,990 - 32,982,083 (-)EnsemblGRCm38mm10GRCm38
MGSCv37232,828,509 - 32,837,576 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36232,794,998 - 32,804,065 (-)NCBIMGSCv36mm8
Celera232,679,974 - 32,689,041 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Slc2a8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554191,177,059 - 1,187,110 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554191,177,752 - 1,187,157 (-)NCBIChiLan1.0ChiLan1.0
SLC2A8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19127,171,671 - 127,183,478 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,171,671 - 127,182,460 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0998,517,880 - 98,534,333 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SLC2A8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,921,635 - 55,928,753 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,921,635 - 55,928,753 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha955,125,406 - 55,132,524 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,842,917 - 56,850,266 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,842,923 - 56,850,266 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,602,890 - 55,610,006 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,917,939 - 55,925,055 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0956,008,864 - 56,015,980 (-)NCBIUU_Cfam_GSD_1.0
Slc2a8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,386,156 - 195,396,547 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,154,641 - 15,165,870 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493648715,154,712 - 15,164,615 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC2A8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1267,925,193 - 267,937,038 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11267,925,184 - 267,934,096 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21301,835,694 - 301,844,621 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC2A8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11210,720,266 - 10,731,196 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660795,483,909 - 5,494,978 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc2a8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247608,054,391 - 8,066,784 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247608,057,892 - 8,066,804 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc2a8
61 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:75
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000022327
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat

Markers in Region
RH129995  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2316,274,970 - 16,275,161 (+)MAPPERmRatBN7.2
Rnor_6.0312,020,280 - 12,020,470NCBIRnor6.0
Rnor_5.0317,356,913 - 17,357,103UniSTSRnor5.0
RGSC_v3.4311,962,623 - 11,962,813UniSTSRGSC3.4
Celera311,013,821 - 11,014,011UniSTS
RH 3.4 Map376.2UniSTS
Cytogenetic Map3p11UniSTS
RH143490  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2316,284,535 - 16,284,683 (+)MAPPERmRatBN7.2
Rnor_6.0312,029,949 - 12,030,096NCBIRnor6.0
Rnor_5.0317,366,582 - 17,366,729UniSTSRnor5.0
RGSC_v3.4311,972,187 - 11,972,334UniSTSRGSC3.4
Celera311,023,385 - 11,023,532UniSTS
RH 3.4 Map383.1UniSTS
Cytogenetic Map3p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 14 3 2 68 23 35 11
Low 3 29 57 41 16 41 8 9 6 12 6 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022327   ⟹   ENSRNOP00000022326
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl316,274,925 - 16,284,464 (-)Ensembl
Rnor_6.0 Ensembl312,020,229 - 12,029,877 (-)Ensembl
RefSeq Acc Id: NM_053494   ⟹   NP_445946
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2316,274,918 - 16,284,464 (-)NCBI
Rnor_6.0312,020,227 - 12,029,877 (-)NCBI
Rnor_5.0317,356,860 - 17,366,549 (-)NCBI
RGSC_v3.4311,962,570 - 11,972,115 (-)RGD
Celera311,013,768 - 11,023,313 (-)RGD
Sequence:
RefSeq Acc Id: XM_008761779   ⟹   XP_008760001
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2316,274,918 - 16,284,435 (-)NCBI
Rnor_6.0312,020,227 - 12,029,920 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105998   ⟹   XP_038961926
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2316,276,743 - 16,284,435 (-)NCBI
RefSeq Acc Id: XM_039105999   ⟹   XP_038961927
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2316,277,245 - 16,284,435 (-)NCBI
RefSeq Acc Id: XM_039106000   ⟹   XP_038961928
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2316,278,199 - 16,284,536 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_445946   ⟸   NM_053494
- UniProtKB: Q9JMA6 (UniProtKB/Swiss-Prot),   Q9JJZ1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008760001   ⟸   XM_008761779
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000022326   ⟸   ENSRNOT00000022327
RefSeq Acc Id: XP_038961926   ⟸   XM_039105998
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038961927   ⟸   XM_039105999
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038961928   ⟸   XM_039106000
- Peptide Label: isoform X4
Protein Domains
MFS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJZ1-F1-model_v2 AlphaFold Q9JJZ1 1-478 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691999
Promoter ID:EPDNEW_R2524
Type:initiation region
Name:Slc2a8_1
Description:solute carrier family 2 member 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0312,029,911 - 12,029,971EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620611 AgrOrtholog
BioCyc Gene G2FUF-50112 BioCyc
Ensembl Genes ENSRNOG00000022274 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000022326 ENTREZGENE
  ENSRNOP00000022326.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022327 ENTREZGENE
  ENSRNOT00000022327.4 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_sugar_transport-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar/inositol_transpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:85256 UniProtKB/Swiss-Prot
NCBI Gene 85256 ENTREZGENE
Pfam Sugar_tr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc2a8 PhenoGen
PRINTS SUGRTRNSPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR_TRANSPORT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs TIGR00879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QBS5_RAT UniProtKB/TrEMBL
  GTR8_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9JMA6 ENTREZGENE
UniProt Secondary Q9JMA6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc2a8  solute carrier family 2 member 8  Slc2a8  solute carrier family 2, (facilitated glucose transporter) member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Slc2a8  solute carrier family 2, (facilitated glucose transporter) member 8      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Slc2a8  solute carrier family 2, (facilitated glucose transporter) member 8      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization located in synaptic vesicles and hormone granules 70577
gene_disease associated with type 2 diabetes 70600
gene_domains contains 12 putative transmembrane segments, glucose transporter sequence motifs characteristic of glucose transporters, a short extracellular loop between transmembrane domain (TM), TM1 and TM2, a long extracellular loop between TM9 and TM10 that contain 70600
gene_drugs transport activity was inhibited by cytochalasin B and partly competed by D-fructose and D-galactose 70600
gene_expression abundant in testis and brain 70577
gene_expression localized mainly to archi- and paleocortex in brain; also found in hypothalamus, hippocampal and dentate gyrus neurons 70577
gene_expression expressed in high levels in testis, moderate levels in cerebellum, brain stem, hippocampus, hypothalamus, adrenal gland, liver, spleen, brown adipose tissue and lung, low levels in white adipose tissue, muscle, kidney and tongue and not expressed in thyro 70600
gene_function transporter 70600
gene_mutations_overexpression mutation of the dileucine internalization motif induced cell surface expression 70600
gene_process facilitates glucose transport 70577
gene_process mediates glucose transport 70600
gene_product member of hexose transporter family 70600
gene_regulation surface expression may be initiated by hormone or other stimulus 70600