Cel (carboxyl ester lipase) - Rat Genome Database

Name: Cel
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Cel (carboxyl ester lipase) Rattus norvegicus

Analyze

Symbol:

Cel

Name:

carboxyl ester lipase

RGD ID:

2331

Description:

Enables carboxylic ester hydrolase activity and glycosphingolipid binding activity. Predicted to be involved in ceramide catabolic process; intestinal cholesterol absorption; and pancreatic juice secretion. Located in extracellular space and zymogen granule. Part of protein-containing complex. Human ortholog(s) of this gene implicated in lipomatosis; maturity-onset diabetes of the young type 8; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human CEL (carboxyl ester lipase); PARTICIPATES IN glycerolipid metabolic pathway; steroid biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-ethoxyethanol; 2-methoxyethanol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Bal; bile salt-activated lipase; bile salt-stimulated lipase; Bssl; cholesterol esterase; pancreatic lysophospholipase; sterol esterase

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CEL (carboxyl ester lipase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Cel (carboxyl ester lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cel (carboxyl ester lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CEL (carboxyl ester lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CEL (carboxyl ester lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cel (carboxyl ester lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CEL (carboxyl ester lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CEL (carboxyl ester lipase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Cel (carboxyl ester lipase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CEL (carboxyl ester lipase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cel.2 (carboxyl ester lipase, tandem duplicate 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cel.1 (carboxyl ester lipase, tandem duplicate 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG10339	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	cel.2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	11,883,532 - 11,891,035 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	11,883,532 - 11,891,035 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	14,955,824 - 14,963,304 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	23,540,779 - 23,548,259 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	21,795,231 - 21,802,711 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	7,134,021 - 7,141,522 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	7,134,021 - 7,141,522 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	12,485,038 - 12,492,645 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	7,541,127 - 7,549,245 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	7,541,429 - 7,549,545 (-)	NCBI
Celera	3	6,664,206 - 6,672,217 (-)	NCBI		Celera
Cytogenetic Map	3	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chronic Pancreatitis (ISO)

developmental and epileptic encephalopathy 14 (ISO)

diabetes mellitus (ISO)

Ehlers-Danlos syndrome classic type 1 (ISO)

Experimental Diabetes Mellitus (IEP)

genetic disease (ISO)

Leigh disease (ISO)

lipomatosis (ISO)

maturity-onset diabetes of the young type 1 (ISO)

maturity-onset diabetes of the young type 8 (ISO)

primary coenzyme Q10 deficiency 7 (ISO)

Rafiq syndrome (ISO)

transient neonatal diabetes mellitus (ISO)

tuberous sclerosis 1 (ISO)

type 1 diabetes mellitus (ISO)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4,6-trinitrobenzenesulfonic acid (ISO)

2-ethoxyethanol (EXP)

2-methoxyethanol (EXP)

3,3',4,4',5-pentachlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (ISO)

4-nitrophenyl acetate (ISO)

actinomycin D (ISO)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

antimycin A (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

azoxystrobin (ISO)

benzo[a]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

cerium trichloride (ISO)

cisplatin (ISO)

cocaine (EXP)

cyclophosphamide (ISO)

deguelin (ISO)

dextran sulfate (ISO)

dihydroxyacetone (ISO)

dorsomorphin (ISO)

elemental selenium (ISO)

endosulfan (EXP)

ethyl methanesulfonate (ISO)

etoposide (ISO)

fenpyroximate (ISO)

ferroheme b (EXP)

flavonoids (EXP)

folic acid (ISO)

formaldehyde (ISO)

heme b (EXP)

hydralazine (ISO)

irinotecan (ISO)

iron atom (EXP)

iron(0) (EXP)

isotretinoin (ISO)

Lasiocarpine (ISO)

lead diacetate (ISO)

methyl methanesulfonate (ISO)

N-methyl-N-nitrosourea (ISO)

Nor-9-carboxy-delta9-THC (ISO)

orlistat (ISO)

p-chloromercuribenzoic acid (ISO)

paracetamol (ISO)

perfluorononanoic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

picoxystrobin (ISO)

pirinixic acid (ISO)

pyrimidifen (ISO)

quercetin (ISO)

resveratrol (EXP,ISO)

rotenone (ISO)

SB 431542 (ISO)

selenium atom (ISO)

senecionine (ISO)

silver atom (ISO)

silver(0) (ISO)

sunitinib (ISO)

taurocholic acid (ISO)

tebufenpyrad (ISO)

testosterone (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

valproic acid (ISO)

zinc atom (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

ceramide catabolic process (IBA,IEA,ISO)

intestinal cholesterol absorption (IEA,ISO)

pancreatic juice secretion (IBA,IEA,ISO)

retinol metabolic process (IEA)

Cellular Component

cytoplasm (IDA)

endoplasmic reticulum (ISO)

extracellular space (IDA)

Golgi apparatus (ISO)

protein-containing complex (IDA)

zymogen granule (IDA)

Molecular Function

acetylesterase activity (IEA)

carboxylic ester hydrolase activity (IEA)

glycosphingolipid binding (IDA)

lysophospholipase activity (IDA)

protein binding (ISO)

protein-containing complex binding (IDA)

retinyl-palmitate esterase activity (IBA,IDA)

sterol esterase activity (IBA,IDA)

triglyceride lipase activity (IBA,IDA)

Molecular Pathway Annotations Click to see Annotation Detail View

glycerolipid metabolic pathway (IEA)

steroid biosynthetic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	The combinatorial extension method reveals a sphingolipid binding domain on pancreatic bile salt-dependent lipase: role in secretion.	Aubert-Jousset E, etal., Structure. 2004 Aug;12(8):1437-47.
2.	Participation of GRP94-related protein in secretion of pancreatic bile salt-dependent lipase and in its internalization by the intestinal epithelium.	Bruneau N, etal., J Cell Sci. 1998 Sep;111 ( Pt 17):2665-79.
3.	Pancreatic bile-salt-dependent lipase activity in serum of diabetic patients: is there a relationship with glycation?	Caillol N, etal., Clin Sci (Lond). 1998 Feb;94(2):181-8.
4.	Identity of a cytosolic neutral cholesterol esterase in rat liver with the bile salt stimulated cholesterol esterase in pancreas.	Camulli ED, etal., Biochim Biophys Acta. 1989 Sep 25;1005(2):177-82.
5.	Site-specific mutagenesis of an essential histidine residue in pancreatic cholesterol esterase.	DiPersio LP, etal., J Biol Chem 1991 Mar 5;266(7):4033-6.
6.	Decrease in contents of pancreatic carboxyl ester lipase, phospholipase A2, and lingual lipase in rats with streptozotocin-induced diabetes.	Duan RD and Sternby B, Scand J Gastroenterol. 1993 Mar;28(3):256-60.
7.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
9.	Isolation of full-length putative rat lysophospholipase cDNA using improved methods for mRNA isolation and cDNA cloning.	Han JH, etal., Biochemistry 1987 Mar 24;26(6):1617-25.
10.	Size of the catalytically active unit of rat hepatic carboxylester lipase in the presence and absence of bile salt.	Harrison EH, etal., Biochim Biophys Acta. 1997 Aug 16;1347(2-3):177-82.
11.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
12.	Molecular cloning and expression of cDNA for rat pancreatic cholesterol esterase.	Kissel JA, etal., Biochim Biophys Acta 1989 Nov 28;1006(2):227-36.
13.	Impairment of bile salt-dependent lipase secretion in AR4-2J rat pancreatic cells induces its degradation by the proteasome.	Le Petit-Thevenin J, etal., Biochim Biophys Acta. 2001 Feb 26;1530(2-3):184-98.
14.	Importance of arginines 63 and 423 in modulating the bile salt-dependent and bile salt-independent hydrolytic activities of rat carboxyl ester lipase.	Liang Y, etal., J Biol Chem. 2000 Aug 4;275(31):24040-6.
15.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
16.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
17.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
18.	Circulating antibodies against an exocrine pancreatic enzyme in type 1 diabetes.	Panicot L, etal., Diabetes. 1999 Dec;48(12):2316-23.
19.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
20.	Pancreatic lipomatosis is a structural marker in nondiabetic children with mutations in carboxyl-ester lipase.	Raeder H, etal., Diabetes. 2007 Feb;56(2):444-9.
21.	Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction.	Raeder H, etal., Nat Genet. 2006 Jan;38(1):54-62. Epub 2005 Dec 20.
22.	GOA pipeline	RGD automated data pipeline
23.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
25.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:1854805	PMID:2069957	PMID:2211595	PMID:9160047	PMID:11733511	PMID:12031288	PMID:15265857	PMID:16502470	PMID:17805199	PMID:23376485	PMID:23533145

Genomics

Comparative Map Data

Cel
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	11,883,532 - 11,891,035 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	11,883,532 - 11,891,035 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	14,955,824 - 14,963,304 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	23,540,779 - 23,548,259 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	21,795,231 - 21,802,711 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	7,134,021 - 7,141,522 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	7,134,021 - 7,141,522 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	12,485,038 - 12,492,645 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	7,541,127 - 7,549,245 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	7,541,429 - 7,549,545 (-)	NCBI
Celera	3	6,664,206 - 6,672,217 (-)	NCBI		Celera
Cytogenetic Map	3	p12	NCBI

CEL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	133,061,981 - 133,071,861 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	133,061,981 - 133,071,861 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	135,937,368 - 135,947,248 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	134,927,186 - 134,937,069 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	132,966,918 - 132,976,801	NCBI
Celera	9	106,479,095 - 106,504,472 (+)	NCBI		Celera
Cytogenetic Map	9	q34.13	NCBI
HuRef	9	105,431,068 - 105,440,909 (+)	NCBI		HuRef
CHM1_1	9	136,087,941 - 136,097,924 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	145,276,137 - 145,285,985 (+)	NCBI		T2T-CHM13v2.0

Cel
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	28,445,831 - 28,453,415 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	28,445,807 - 28,453,415 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	28,555,819 - 28,563,403 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	28,555,795 - 28,563,403 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	28,411,339 - 28,418,882 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	28,377,828 - 28,385,371 (-)	NCBI		MGSCv36	mm8
Celera	2	28,259,995 - 28,267,538 (-)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	19.38	NCBI

Cel
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955513	2,324,025 - 2,382,877 (+)	NCBI	ChiLan1.0	ChiLan1.0

CEL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	9	6,287,257 - 6,297,627 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	104,180,310 - 104,191,434 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	132,809,606 - 132,821,010 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	132,810,986 - 132,821,010 (+)	Ensembl	panpan1.1		panPan2

CEL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	51,337,205 - 51,345,284 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	51,337,187 - 51,362,422 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	50,600,407 - 50,608,486 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	52,230,487 - 52,238,498 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	52,230,540 - 52,255,656 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	51,009,024 - 51,017,035 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	51,333,616 - 51,341,559 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	51,412,863 - 51,420,943 (-)	NCBI		UU_Cfam_GSD_1.0

Cel
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	199,691,971 - 199,702,102 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936487	19,463,182 - 19,469,900 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936487	19,463,219 - 19,472,029 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CEL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	272,763,003 - 272,770,255 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	272,763,203 - 272,770,259 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	306,719,658 - 306,726,753 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CEL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	5,053,817 - 5,077,487 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	5,066,882 - 5,077,227 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666079	10,574,982 - 10,585,407 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Cel
24 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	47
Count of miRNA genes:	42
Interacting mature miRNAs:	47
Transcripts:	ENSRNOT00000014572
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70202	Alc19	Alcohol consumption QTL 19	2.5		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	3	1	27494778	Rat
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	1	31158234	Rat
631831	Alc8	Alcohol consumption QTL 8	2.7		consumption behavior trait (VT:0002069)	calculated ethanol drink intake rate (CMO:0001615)	3	1	33230976	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	diastolic blood pressure (CMO:0000005)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	pulse pressure (CMO:0000292)	3	1	33278763	Rat
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
4889966	Bss95	Bone structure and strength QTL 95	4.4		tibia area (VT:1000281)	tibia-fibula cross-sectional area (CMO:0001718)	3	1	36847613	Rat
2312664	Scl62	Serum cholesterol level QTL 62		0.05	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	1	38710544	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	39874793	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1298526	Arunc3	Aerobic running capacity QTL 3	2.2		exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	8227194	33703538	Rat
10401810	Kidm53	Kidney mass QTL 53			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	8227194	47233430	Rat
70203	Gcr2	Gastric cancer resistance QTL 2	2.6		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	3	8658162	27494778	Rat
1358357	Srcrtb1	Stress Responsive Cort Basal QTL 1	6.36	0.002	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	8658162	27494778	Rat
6893355	Bw101	Body weight QTL 101	0.4	0.38	body mass (VT:0001259)	body weight (CMO:0000012)	3	10778704	30357018	Rat
6893363	Bw105	Body weight QTL 105	2.6	0.0036	body mass (VT:0001259)	body weight (CMO:0000012)	3	10778704	30357018	Rat
1558654	Bw56	Body weight QTL 56	4.5	0.0000171	body mass (VT:0001259)	body weight (CMO:0000012)	3	10778704	30357018	Rat
70191	BpQTLcluster4	Blood pressure QTL cluster 4	3		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	3	10778704	50302886	Rat
70191	BpQTLcluster4	Blood pressure QTL cluster 4	3		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	3	10778704	50302886	Rat
1558647	Cm46	Cardiac mass QTL 46	5.4	0.0000055	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	10778823	30356773	Rat
1558650	Cm48	Cardiac mass QTL 48	4	0.0001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	3	10778823	30356773	Rat
1558657	Cm43	Cardiac mass QTL 43	6.6	0.0000000293	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	10778823	30356773	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10861912	89878372	Rat

Markers in Region

D3Wox12

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	11,884,712 - 11,884,828 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	7,135,202 - 7,135,317	NCBI	Rnor6.0
Rnor_5.0	3	12,486,219 - 12,486,334	UniSTS	Rnor5.0
RGSC_v3.4	3	7,542,304 - 7,542,420	RGD	RGSC3.4
RGSC_v3.4	3	7,542,305 - 7,542,420	UniSTS	RGSC3.4
RGSC_v3.1	3	7,542,604 - 7,542,720	RGD
Celera	3	6,666,010 - 6,666,125	UniSTS
RH 3.4 Map	3	21.8	UniSTS
RH 3.4 Map	3	21.8	RGD
Cytogenetic Map	3	p12	UniSTS

D3Arb3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	3	7,140,238 - 7,140,570	NCBI	Rnor6.0
Rnor_5.0	3	12,491,255 - 12,491,693	UniSTS	Rnor5.0
RGSC_v3.4	3	7,547,341 - 7,548,297	UniSTS	RGSC3.4
Celera	3	6,671,047 - 6,671,265	UniSTS
RH 3.4 Map	3	21.9	RGD
RH 3.4 Map	3	21.9	UniSTS
SHRSP x BN Map	3	2.2899	UniSTS
SHRSP x BN Map	3	2.2899	RGD
Cytogenetic Map	3	p12	UniSTS

RH132776

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	11,885,366 - 11,885,686 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	7,135,856 - 7,136,175	NCBI	Rnor6.0
Rnor_5.0	3	12,486,873 - 12,487,192	UniSTS	Rnor5.0
RGSC_v3.4	3	7,542,959 - 7,543,278	UniSTS	RGSC3.4
Celera	3	6,666,664 - 6,666,984	UniSTS
RH 3.4 Map	3	21.8	UniSTS
Cytogenetic Map	3	p12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High					2
Medium			7	6	7	6
Low	2	11	17	5	9	5	5	6	52	18	32	11	5
Below cutoff	1	32	33	30	1	30	3	5	22	17	7		3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_016997	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC129847	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M15893	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M69157	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X16054	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	Z22803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000014572 ⟹ ENSRNOP00000014572

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	11,883,532 - 11,891,035 (-)	Ensembl
Rnor_6.0 Ensembl	3	7,134,021 - 7,141,522 (-)	Ensembl

RefSeq Acc Id:

NM_016997 ⟹ NP_058693

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	11,883,532 - 11,891,035 (-)	NCBI
Rnor_6.0	3	7,134,021 - 7,141,522 (-)	NCBI
Rnor_5.0	3	12,485,038 - 12,492,645 (-)	NCBI
RGSC_v3.4	3	7,541,127 - 7,549,245 (-)	RGD
Celera	3	6,664,206 - 6,672,217 (-)	NCBI

Sequence:

show sequence

GCCTAGAGGCAGACACTCACTATGGGGCGCCTGGAGGTTCTGTTTCTTGGCCTCACCTGCTGCT
TGGCAGCTGCTTGTGCTGCAAAGTTGGGTGCTGTGTACACAGAAGGCGGTTTTGTGGAGGGCGT
CAACAAGAAACTCAGTCTCTTGGGTGGTGACTCTGTTGACATCTTCAAGGGCATCCCCTTTGCT
ACCGCCAAGACCCTGGAGAATCCTCAGCGTCACCCTGGCTGGCAAGGGACACTGAAGGCTACAG
ACTTCAAGAAACGATGTCTACAAGCCACCATCACCCAGGATGATACCTATGGGCAAGAAGACTG
CCTCTATCTCAACATCTGGGTCCCTCAGGGCAGGAAGCAAGTGTCTCATGACCTGCCTGTGATG
GTCTGGATCTATGGAGGTGCCTTCCTCATGGGGTCTGGCCAGGGAGCCAATTTTCTCAAGAATT
ACCTGTATGATGGGGAAGAGATCGCCACTAGAGGCAATGTCATTGTGGTCACCTTCAACTACCG
TGTCGGACCCTTGGGTTTCCTTAGCACCGGAGATGCTAACCTTCCAGGTAACTTTGGACTTCGA
GATCAGCACATGGCTATTGCCTGGGTGAAGAGGAACATTGCAGCCTTTGGAGGAGACCCCGATA
ACATCACCATCTTTGGGGAATCTGCTGGAGCTGCCAGTGTCTCTCTGCAGACCCTCTCCCCATA
CAACAAGGGCCTCATCCGGCGAGCCATCAGTCAGAGTGGTGTGGCACTGAGCCCCTGGGCCATC
CAGGAGAATCCACTTTTCTGGGCCAAAACGATCGCTAAGAAGGTGGGATGCCCCACAGAGGATA
CCGCCAAGATGGCTGGGTGTCTGAAGATCACAGATCCCCGAGCCTTGACACTGGCCTATAGGTT
GCCCTTGAAAAGCCAGGAGTACCCCATTGTGCACTACCTGGCCTTCATCCCTGTCGTCGATGGT
GACTTCATTCCTGATGATCCCATCAACCTGTACGACAACGCTGCTGACATTGACTACTTAGCGG
GTATTAATGACATGGATGGCCACCTGTTTGCTACAGTTGACGTGCCCGCCATCGACAAGGCCAA
GCAGGATGTCACAGAGGAGGACTTCTACAGGCTAGTCAGTGGACACACTGTCGCCAAGGGGCTT
AAAGGCACCCAAGCCACCTTTGACATCTACACTGAGTCCTGGGCCCAGGACCCGTCCCAGGAGA
ACATGAAGAAGACAGTGGTGGCCTTTGAGACTGACATACTCTTCCTGATCCCCACAGAGATGGC
TCTGGCCCAGCACAGAGCCCATGCCAAGAGTGCCAAGACCTACTCTTACCTGTTTTCCCACCCT
TCACGAATGCCTATCTACCCAAAATGGATGGGGGCAGACCACGCTGATGACCTCCAGTACGTCT
TTGGGAAGCCCTTTGCCACCCCACTGGGCTACCGGGCCCAAGACAGGACTGTCTCCAAGGCCAT
GATTGCCTACTGGACCAACTTTGCCAAGAGTGGGGACCCCAACATGGGCAACTCACCCGTGCCC
ACACACTGGTACCCTTATACCACGGAGAATGGTAACTACCTGGACATCAATAAGAAAATAACCA
GCACCTCCATGAAGGAGCACCTAAGGGAAAAGTTCCTCAAGTTCTGGGCTGTGACATTCGAGAT
GCTGCCCACTGTGGTTGGTGACCACACTCCCCCTGAGGATGACTCAGAGGCTGCCCCCGTCCCA
CCTACAGACGACTCCCAGGTTGTTCCTGTCCCACCTACAGATGACTCTCAGACAACACCGGTGC
CCCCAACAGACAACTCTCAGGCTGGTGACTCTGTGGAGGCTCAGATGCCTGTCGCCATTGGCTT
CTAAAGTCCTATAAACCGGGGCTAGAGATGGCTCAGGAGCTAAGAGCTCTTCTTCCACTGTTCT
TCTGAAGGTCCTGTGTTCAATTCCCAGCACCCACATTGCTGCTTACAGCTGTCTGATTCCGTCT
ACTGGTGTGCAGATGTACACGCAGACAAAGCGCCTATATATAGAAAATTCATACATAAATAAAG
TCTTATAAGCCTTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_058693	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41540	(Get FASTA)	NCBI Sequence Viewer
	AAB46376	(Get FASTA)	NCBI Sequence Viewer
	CAA34189	(Get FASTA)	NCBI Sequence Viewer
	CAA80460	(Get FASTA)	NCBI Sequence Viewer
	EDL93407	(Get FASTA)	NCBI Sequence Viewer
	EDL93408	(Get FASTA)	NCBI Sequence Viewer
	P07882	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_058693 ⟸ NM_016997
- Peptide Label:	precursor
- UniProtKB:	P14722 (UniProtKB/Swiss-Prot), P07882 (UniProtKB/Swiss-Prot), G3V7G2 (UniProtKB/TrEMBL), A6JTP0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGRLEVLFLGLTCCLAAACAAKLGAVYTEGGFVEGVNKKLSLLGGDSVDIFKGIPFATAKTLEN PQRHPGWQGTLKATDFKKRCLQATITQDDTYGQEDCLYLNIWVPQGRKQVSHDLPVMVWIYGGA FLMGSGQGANFLKNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNFGLRDQHMAIA WVKRNIAAFGGDPDNITIFGESAGAASVSLQTLSPYNKGLIRRAISQSGVALSPWAIQENPLFW AKTIAKKVGCPTEDTAKMAGCLKITDPRALTLAYRLPLKSQEYPIVHYLAFIPVVDGDFIPDDP INLYDNAADIDYLAGINDMDGHLFATVDVPAIDKAKQDVTEEDFYRLVSGHTVAKGLKGTQATF DIYTESWAQDPSQENMKKTVVAFETDILFLIPTEMALAQHRAHAKSAKTYSYLFSHPSRMPIYP KWMGADHADDLQYVFGKPFATPLGYRAQDRTVSKAMIAYWTNFAKSGDPNMGNSPVPTHWYPYT TENGNYLDINKKITSTSMKEHLREKFLKFWAVTFEMLPTVVGDHTPPEDDSEAAPVPPTDDSQV VPVPPTDDSQTTPVPPTDNSQAGDSVEAQMPVAIGF hide sequence

RefSeq Acc Id:

ENSRNOP00000014572 ⟸ ENSRNOT00000014572

Protein Domains

Carboxylesterase type B

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P07882-F1-model_v2	AlphaFold	P07882	1-612	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2331	AgrOrtholog
BioCyc Gene	G2FUF-50278	BioCyc
Ensembl Genes	ENSRNOG00000010406	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000014572	ENTREZGENE
	ENSRNOP00000014572.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000014572	ENTREZGENE
	ENSRNOT00000014572.5	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1820	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	AB_hydrolase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CarbesteraseB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Carboxylesterase_B_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Carboxylesterase_B_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:24254	UniProtKB/TrEMBL
NCBI Gene	24254	ENTREZGENE
PANTHER	NEUROLIGIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR43903:SF1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	COesterase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Cel	PhenoGen
PROSITE	CARBOXYLESTERASE_B_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CARBOXYLESTERASE_B_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53474	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6JTN9_RAT	UniProtKB/TrEMBL
	A6JTP0	ENTREZGENE, UniProtKB/TrEMBL
	CEL_RAT	UniProtKB/Swiss-Prot
	G3V7G2	ENTREZGENE, UniProtKB/TrEMBL
	P07882	ENTREZGENE
	P14722	ENTREZGENE
UniProt Secondary	P14722	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Cel	Carboxyl ester lipase			Symbol and Name status set to approved	70586	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)