C5 (complement C5) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: C5 (complement C5) Rattus norvegicus
Analyze
Symbol: C5
Name: complement C5
RGD ID: 2237
Description: Exhibits C5a anaphylatoxin chemotactic receptor binding activity. Involved in several processes, including glucose homeostasis; leukocyte migration involved in inflammatory response; and negative regulation of catecholamine secretion. Localizes to extracellular space. Used to study adult respiratory distress syndrome; asthma; and neutropenia. Biomarker of brain edema. Human ortholog(s) of this gene implicated in several diseases, including complement component 5 deficiency; liver cirrhosis; neutropenia; paroxysmal nocturnal hemoglobinuria; and pneumonia. Orthologous to human C5 (complement C5); PARTICIPATES IN coagulation cascade pathway; complement system pathway; prion disease pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: anaphylatoxin; C5a; complement component 5; Hc; RGD1561905
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2318,270,696 - 18,361,994 (-)NCBI
Rnor_6.0 Ensembl314,049,995 - 14,229,080 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0314,206,466 - 14,229,141 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0314,049,993 - 14,113,931 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0319,525,468 - 19,547,636 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0319,369,981 - 19,432,948 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4314,011,115 - 14,102,744 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1313,962,273 - 13,963,756 (-)NCBI
Celera312,987,748 - 13,080,508 (-)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (EXP)
Actein  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chondroitin sulfate  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cytochalasin B  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dithionite(2-)  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ethylene glycol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
flutamide  (EXP)
furan  (EXP)
genistein  (ISO)
glafenine  (EXP)
glutathione  (EXP)
heparin  (ISO)
indometacin  (ISO)
isoprenaline  (EXP)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (EXP)
leukotriene B4  (ISO)
levofloxacin  (EXP)
manganese(II) chloride  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N,N-dimethylsphingosine  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
olanzapine  (ISO)
paracetamol  (ISO)
parthenolide  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
poly(styrene)  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
tributylstannane  (EXP)
trichloroethene  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Abe M, etal., J Immunol. 2001 Oct 15;167(8):4651-60.
2. Akatsu H, etal., Microbiol Immunol 1997;41(7):575-80.
3. Arumugam TV, etal., J Hepatol. 2004 Jun;40(6):934-41.
4. Bhatia M, etal., Am J Physiol Gastrointest Liver Physiol. 2001 May;280(5):G974-8.
5. Bora NS, etal., J Immunol. 2006 Aug 1;177(3):1872-8.
6. Bowser C, etal., Ann Allergy Asthma Immunol. 2010 Jan;104(1):42-9.
7. Chudwin DS, etal., Clin Immunol Immunopathol. 1985 Oct;37(1):93-7.
8. Cugno M, etal., J Allergy Clin Immunol. 2020 May 14. pii: S0091-6749(20)30650-3. doi: 10.1016/j.jaci.2020.05.006.
9. Cui L, etal., Protein Sci. 1994 Aug;3(8):1169-77.
10. Daveau M, etal., J Immunol. 2004 Sep 1;173(5):3418-24.
11. Dromer F, etal., Clin Exp Immunol. 1989 Dec;78(3):412-7.
12. Fick RB Jr, etal., Pediatr Res. 1986 Dec;20(12):1258-68.
13. Flierl MA, etal., PLoS One. 2008 Jul 2;3(7):e2560.
14. Fowler SR, etal., Am Rev Respir Dis. 1987 Sep;136(3):691-7.
15. GOA data from the GO Consortium
16. Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89
17. Hasegawa K, etal., Hum Genet. 2004 Sep;115(4):295-301.
18. Hillebrandt S, etal., Nat Genet. 2005 Aug;37(8):835-43. Epub 2005 Jul 3.
19. Karp CL, etal., Nat Immunol. 2000 Sep;1(3):221-6.
20. Kelly KJ, etal., Am J Nephrol. 2015;41(1):48-56. doi: 10.1159/000371426. Epub 2015 Jan 30.
21. Kondo C, etal., Clin Exp Immunol. 2001 May;124(2):323-9.
22. Lajoie S, etal., Nat Immunol. 2010 Oct;11(10):928-35. Epub 2010 Aug 29.
23. Langlois PF and Gawryl MS, Am Rev Respir Dis. 1988 Aug;138(2):368-75.
24. Marc MM, etal., Scand J Immunol. 2010 May;71(5):386-91.
25. Melendi GA, etal., J Virol. 2007 Jan;81(2):991-9. Epub 2006 Nov 1.
26. MGD data from the GO Consortium
27. Mulligan MS, etal., J Clin Invest. 1996 Jul 15;98(2):503-12.
28. Nandakumar KS, etal., PLoS One. 2010 Oct 20;5(10):e13511.
29. Nauta AJ, etal., Eur J Immunol 2002 Mar;32(3):783-92.
30. NCBI rat LocusLink and RefSeq merged data July 26, 2002
31. OMIM Disease Annotation Pipeline
32. Piccolo MT, etal., Exp Mol Pathol. 1999 Aug;66(3):220-6.
33. Pierangeli SS, etal., Arthritis Rheum. 2005 Jul;52(7):2120-4.
34. Pipeline to import KEGG annotations from KEGG into RGD
35. RGD automated data pipeline
36. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. RGD automated import pipeline for gene-chemical interactions
38. Rhein LM, etal., Am J Respir Cell Mol Biol. 2008 Apr;38(4):401-6. Epub 2007 Nov 1.
39. Riedemann NC, etal., FASEB J. 2004 Feb;18(2):370-2. Epub 2003 Dec 19.
40. Riedemann NC, etal., J Immunol 2002 Feb 15;168(4):1919-25.
41. Robbins RA, etal., Am Rev Respir Dis. 1987 Mar;135(3):651-8.
42. Rothermel E, etal., Biochim Biophys Acta 1997 Mar 20;1351(1-2):9-12.
43. Rubins JB, etal., J Clin Invest. 1995 Jan;95(1):142-50.
44. Schieferdecker HL, etal., Hepatology. 1999 Aug;30(2):454-61.
45. Schlaf G, etal., Lab Invest. 1999 Oct;79(10):1287-97.
46. Schmid E, etal., Inflammation. 1997 Jun;21(3):325-33.
47. Short A, etal., Br J Pharmacol. 1999 Feb;126(3):551-4.
48. Short AJ, etal., Br J Pharmacol. 1999 Oct;128(3):511-4.
49. Strachan AJ, etal., J Immunol. 2000 Jun 15;164(12):6560-5.
50. Tang K, etal., Can J Physiol Pharmacol. 2012 Oct;90(10):1394-402. doi: 10.1139/y2012-114. Epub 2012 Oct 15.
51. Tvedten HW, etal., Am J Pathol. 1985 Apr;119(1):92-100.
52. Vakeva AP, etal., Circulation. 1998 Jun 9;97(22):2259-67.
53. Verroust F, etal., J Clin Lab Immunol. 1981 Sep;6(2):127-30.
54. Walter L, etal., Immunogenetics 2002 Jul;54(4):268-75. Epub 2002 Jun 14.
55. Wilken HC, etal., J Immunol Methods. 1999 Jun 24;226(1-2):139-45.
56. Woodruff TM, etal., Arthritis Rheum. 2002 Sep;46(9):2476-85.
57. Xi G, etal., Stroke. 2001 Jan;32(1):162-7.
Additional References at PubMed
PMID:11877299   PMID:12218141   PMID:12637249   PMID:14566334   PMID:14732352   PMID:16452172   PMID:16769899   PMID:16780818   PMID:17068344   PMID:17389734   PMID:17621257   PMID:17703884  
PMID:18084313   PMID:18178252   PMID:18947875   PMID:19056867   PMID:19196477   PMID:19285573   PMID:21148255   PMID:22537900   PMID:22832194   PMID:23237573   PMID:23533145   PMID:24344329  
PMID:25385326   PMID:27437704   PMID:29956782   PMID:30092352   PMID:31624141  


Genomics

Candidate Gene Status
C5 is a candidate Gene for QTL Cia11
Comparative Map Data
C5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2318,270,696 - 18,361,994 (-)NCBI
Rnor_6.0 Ensembl314,049,995 - 14,229,080 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0314,206,466 - 14,229,141 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0314,049,993 - 14,113,931 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0319,525,468 - 19,547,636 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0319,369,981 - 19,432,948 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4314,011,115 - 14,102,744 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1313,962,273 - 13,963,756 (-)NCBI
Celera312,987,748 - 13,080,508 (-)NCBICelera
Cytogenetic Map3p11NCBI
C5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9120,952,335 - 121,050,275 (-)EnsemblGRCh38hg38GRCh38
GRCh389120,952,335 - 121,074,865 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379123,714,613 - 123,837,143 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369122,754,434 - 122,852,375 (-)NCBINCBI36hg18NCBI36
Build 349120,794,168 - 120,892,108NCBI
Celera994,363,035 - 94,461,011 (-)NCBI
Cytogenetic Map9q33.2NCBI
HuRef993,332,095 - 93,430,452 (-)NCBIHuRef
CHM1_19123,861,740 - 123,984,460 (-)NCBICHM1_1
Hc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39234,873,341 - 34,958,518 (-)NCBIGRCm39mm39
GRCm39 Ensembl234,873,343 - 34,951,450 (-)Ensembl
GRCm38234,983,329 - 35,068,506 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl234,983,331 - 35,061,438 (-)EnsemblGRCm38mm10GRCm38
MGSCv37234,838,851 - 34,916,961 (-)NCBIGRCm37mm9NCBIm37
MGSCv36234,805,340 - 34,883,405 (-)NCBImm8
Celera234,677,654 - 34,755,968 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map223.22NCBI
C5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19120,416,256 - 120,548,366 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9120,426,354 - 120,523,856 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0992,069,574 - 92,202,513 (-)NCBIMhudiblu_PPA_v0panPan3
C5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11173,953,727 - 74,029,919 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1173,953,727 - 74,029,851 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1172,364,536 - 72,439,848 (-)NCBI
ROS_Cfam_1.01175,089,862 - 75,165,511 (-)NCBI
UMICH_Zoey_3.11173,598,023 - 73,673,494 (-)NCBI
UNSW_CanFamBas_1.01173,629,460 - 73,704,118 (-)NCBI
UU_Cfam_GSD_1.01174,367,743 - 74,443,207 (-)NCBI
C5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947189,622,879 - 189,804,753 (-)NCBI
SpeTri2.0NW_0049364879,391,774 - 9,474,168 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,995,662 - 261,133,483 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,995,662 - 261,088,868 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21293,077,418 - 293,163,277 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q2.13NCBI
C5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11218,525,855 - 18,624,048 (+)NCBI
ChlSab1.1 Ensembl1218,525,880 - 18,623,636 (+)Ensembl
Vero_WHO_p1.0NW_02366603524,390,627 - 24,506,352 (-)NCBI

Position Markers
D3Rat52  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,311,454 - 18,311,610 (+)MAPPER
Rnor_6.0314,090,411 - 14,090,566NCBIRnor6.0
Rnor_5.0319,410,399 - 19,410,554UniSTSRnor5.0
RGSC_v3.4314,051,872 - 14,052,028RGDRGSC3.4
RGSC_v3.4314,051,873 - 14,052,028UniSTSRGSC3.4
RGSC_v3.1313,948,245 - 13,948,400RGD
Celera313,028,531 - 13,028,700UniSTS
RH 3.4 Map3157.8RGD
RH 3.4 Map3157.8UniSTS
RH 2.0 Map347.5RGD
SHRSP x BN Map34.6298RGD
Cytogenetic Map3p11UniSTS
D3Cebr7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,278,158 - 18,278,369 (+)MAPPER
Rnor_6.0314,057,455 - 14,057,665NCBIRnor6.0
Rnor_5.0319,377,443 - 19,377,653UniSTSRnor5.0
RGSC_v3.4314,018,577 - 14,018,787UniSTSRGSC3.4
Celera312,995,210 - 12,995,413UniSTS
Cytogenetic Map3p11UniSTS
RH143462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,357,646 - 18,357,794 (+)MAPPER
Rnor_6.0314,224,793 - 14,224,940NCBIRnor6.0
Rnor_5.0319,543,310 - 19,543,457UniSTSRnor5.0
RGSC_v3.4314,098,470 - 14,098,617UniSTSRGSC3.4
Celera313,076,161 - 13,076,308UniSTS
RH 3.4 Map3164.3UniSTS
Cytogenetic Map3p11UniSTS
RH131515  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,326,070 - 18,326,264 (+)MAPPER
Rnor_6.0314,105,149 - 14,105,342NCBIRnor6.0
Rnor_5.0319,425,137 - 19,425,330UniSTSRnor5.0
RGSC_v3.4314,067,044 - 14,067,237UniSTSRGSC3.4
Celera313,044,868 - 13,045,061UniSTS
RH 3.4 Map3161.8UniSTS
Cytogenetic Map3p11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3125786001Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3128136884Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3128500807Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3128500807Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3128500807Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3128500807Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3132972944Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3137891710Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3139773425Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3195176874Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3263142133477544Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3263142148562146Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3328592928136884Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3328592928136884Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)3565463925105730Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3600074834394365Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3600074834394365Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3600074834394365Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)3600074851687917Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)3600074851687917Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)3600086634394121Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)3600086634394121Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)3600086634394121Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31009408193415837Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31011931879772001Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat
11528620Bss113Bone structure and strength QTL 1139.750.00000000017femur morphology trait (VT:0000559)femoral neck width (CMO:0001695)31223622115217668Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31312691436600143Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31312691436600143Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31312691436600143Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31312691436600143Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31312691436600143Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31312691436600143Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31312691436600143Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31312691436600143Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31312691441510346Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31409041129084626Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31409041148562146Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31409041148562146Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31409041148562146Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31409041148562146Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31409041148562146Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31409041148562146Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31409041148562146Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:47
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000025534
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 37 37 37 19 2 9
Low 2 14 2 14 2 3 3 3 16 17 2 3
Below cutoff 3 24 6 2 5 2 5 6 59 22 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025534   ⟹   ENSRNOP00000025534
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl314,050,357 - 14,229,067 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092736   ⟹   ENSRNOP00000076004
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl314,049,995 - 14,112,851 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092865   ⟹   ENSRNOP00000075982
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl314,207,044 - 14,229,080 (-)Ensembl
RefSeq Acc Id: NM_053020   ⟹   NP_444179
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2318,270,696 - 18,361,994 (-)NCBI
RefSeq Acc Id: XM_001079130   ⟹   XP_001079130
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera312,987,748 - 13,080,508 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003749455   ⟹   XP_003749503
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0314,206,466 - 14,229,141 (-)NCBI
Rnor_5.0319,525,468 - 19,547,636 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761798   ⟹   XP_008760020
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0314,049,993 - 14,113,931 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_444179 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA62994 (Get FASTA)   NCBI Sequence Viewer  
  P08650 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_001079130   ⟸   XM_001079130
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_003749503   ⟸   XM_003749455
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008760020   ⟸   XM_008761798
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000076004   ⟸   ENSRNOT00000092736
RefSeq Acc Id: ENSRNOP00000075982   ⟸   ENSRNOT00000092865
RefSeq Acc Id: ENSRNOP00000025534   ⟸   ENSRNOT00000025534
RefSeq Acc Id: NP_444179   ⟸   NM_053020
- Peptide Label: precursor
Protein Domains
Anaphylatoxin-like   MG1   MG2   MG3   NTR

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692014
Promoter ID:EPDNEW_R2538
Type:initiation region
Name:C5_1
Description:complement C5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0314,229,122 - 14,229,182EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2237 AgrOrtholog
Ensembl Genes ENSRNOG00000018899 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000025534 UniProtKB/TrEMBL
  ENSRNOP00000075982 UniProtKB/TrEMBL
  ENSRNOP00000076004 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025534 UniProtKB/TrEMBL
  ENSRNOT00000092736 UniProtKB/TrEMBL
  ENSRNOT00000092865 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.120 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  2.60.40.690 UniProtKB/TrEMBL
InterPro A-macroglobulin_rcpt-bd UniProtKB/TrEMBL
  A-macroglobulin_rcpt-bd_sf UniProtKB/TrEMBL
  A2M_comp UniProtKB/TrEMBL
  A2M_N UniProtKB/TrEMBL
  A2M_N_2 UniProtKB/TrEMBL
  Anaphylatoxin/fibulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anaphylatoxin_comp_syst UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anaphylatoxn_comp_syst_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C3/4/5_MG1 UniProtKB/TrEMBL
  Complement_C5 UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Macroglobln_a2 UniProtKB/TrEMBL
  MG3 UniProtKB/TrEMBL
  MG4 UniProtKB/TrEMBL
  Netrin_domain UniProtKB/TrEMBL
  Netrin_module_non-TIMP UniProtKB/TrEMBL
  Terpenoid_cyclase/PrenylTrfase UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/TrEMBL
NCBI Gene 362119 ENTREZGENE
PANTHER PTHR11412:SF83 UniProtKB/TrEMBL
Pfam A2M UniProtKB/TrEMBL
  A2M_comp UniProtKB/TrEMBL
  A2M_N UniProtKB/TrEMBL
  A2M_N_2 UniProtKB/TrEMBL
  A2M_recep UniProtKB/TrEMBL
  ANATO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG1 UniProtKB/TrEMBL
  MG3 UniProtKB/TrEMBL
  MG4 UniProtKB/TrEMBL
  NTR UniProtKB/TrEMBL
PhenoGen C5 PhenoGen
PRINTS ANAPHYLATOXN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANAPHYLATOXIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANAPHYLATOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTR UniProtKB/TrEMBL
SMART A2M UniProtKB/TrEMBL
  A2M_N_2 UniProtKB/TrEMBL
  A2M_recep UniProtKB/TrEMBL
  ANATO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C345C UniProtKB/TrEMBL
Superfamily-SCOP SSF47686 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48239 UniProtKB/TrEMBL
  SSF49410 UniProtKB/TrEMBL
  SSF50242 UniProtKB/TrEMBL
UniProt A0A096P6L9_RAT UniProtKB/TrEMBL
  A0A1B0GWQ4_RAT UniProtKB/TrEMBL
  A0A1B0GWS5_RAT UniProtKB/TrEMBL
  CO5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q63078 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 C5  complement C5  C5  complement component 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 C5  Complement component 5      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds to alveolar epithelial cells 61066
gene_function binds to alveolar epithelial cells 70320
gene_process enhances inflamatory response in lung by increasing expression of C5a receptor and pro-inflamatory mediators 61066
gene_process enhances inflamatory response in lung by increasing expression of C5a receptor and pro-inflamatory mediators 70320
gene_regulation binding to alveolar epithelial cells is increased by LPS, Il-6, and Tnf 61066
gene_regulation binding to alveolar epithelial cells is increased by LPS, Il-6, and Tnf 70320