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Gene: C5 (complement C5) Rattus norvegicus
Symbol: C5
Name: complement C5
Description: Exhibits C5a anaphylatoxin chemotactic receptor binding activity. Involved in several processes, including glucose homeostasis; leukocyte migration involved in inflammatory response; and negative regulation of catecholamine secretion. Localizes to extracellular space. Used to study adult respiratory distress syndrome; asthma; and neutropenia. Biomarker of brain edema. Human ortholog(s) of this gene implicated in several diseases, including asthma; complement component 5 deficiency; liver cirrhosis; neutropenia; and paroxysmal nocturnal hemoglobinuria. Orthologous to human C5 (complement C5); PARTICIPATES IN coagulation cascade pathway; complement system pathway; prion disease pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: anaphylatoxin; C5a; complement component 5; Hc; RGD1561905
Homo sapiens (human) : C5 (complement C5)  HGNC  Alliance
Mus musculus (house mouse) : Hc (hemolytic complement)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : C5 (complement C5)
Canis lupus familiaris (dog) : C5 (complement C5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101959685 (complement C5)
Sus scrofa (pig) : C5 (complement C5)
Chlorocebus sabaeus (African green monkey) : C5 (complement C5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0314,206,466 - 14,229,141 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0314,049,993 - 14,113,931 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl314,049,995 - 14,229,080 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0319,525,468 - 19,547,636 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0319,369,981 - 19,432,948 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4314,011,115 - 14,102,744 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1313,962,273 - 13,963,756 (-)NCBI
Celera312,987,748 - 13,080,508 (-)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on C5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2237
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.