Endog (endonuclease G) - Rat Genome Database
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Gene: Endog (endonuclease G) Rattus norvegicus
Analyze
Symbol: Endog
Name: endonuclease G
RGD ID: 1310763
Description: Exhibits deoxyribonuclease activity. Involved in several processes, including neuron death in response to oxidative stress; positive regulation of apoptotic DNA fragmentation; and positive regulation of hydrogen peroxide-mediated programmed cell death. Localizes to several cellular components, including cytosol; mitochondrion; and perikaryon. Biomarker of brain ischemia; congestive heart failure; muscular atrophy; and visual epilepsy. Orthologous to human ENDOG (endonuclease G); PARTICIPATES IN apoptotic cell death pathway; INTERACTS WITH acetamide; aldehydo-D-glucose; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: endonuclease G, mitochondrial; LOC362100
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2313,449,113 - 13,451,715 (+)NCBI
Rnor_6.0 Ensembl38,741,766 - 8,744,592 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.038,741,833 - 8,744,414 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0314,094,275 - 14,096,910 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.439,184,023 - 9,187,524 (+)NCBIRGSC3.4rn4RGSC3.4
Celera38,222,701 - 8,225,752 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
acetamide  (EXP)
aldehydo-D-glucose  (EXP,ISO)
amitrole  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
bisphenol A  (EXP,ISO)
bufalin  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
canertinib  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
casticin  (ISO)
chromium(6+)  (EXP,ISO)
chrysazin  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
ethanol  (ISO)
fisetin  (ISO)
folic acid  (ISO)
glucose  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
isoflavones  (ISO)
methotrexate  (ISO)
N-acetyl-L-cysteine  (ISO)
ochratoxin A  (EXP)
ouabain  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
tetrachloroethene  (ISO)
tetracycline  (ISO)
thapsigargin  (ISO)
thiomalic acid  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Davies AM, etal., Nucleic Acids Res. 2003 Feb 15;31(4):1364-73.
2. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA data from the GO Consortium
4. Ishihara Y and Shimamoto N, J Biol Chem. 2006 Mar 10;281(10):6726-33. Epub 2006 Jan 4.
5. Kapoor R, etal., Apoptosis. 2013 Jan;18(1):9-27. doi: 10.1007/s10495-012-0781-7.
6. Leeuwenburgh C, etal., Am J Physiol Regul Integr Comp Physiol. 2005 May;288(5):R1288-96. Epub 2005 Jan 13.
7. Li J, etal., Free Radic Biol Med. 2010 Aug 15;49(4):622-31. doi: 10.1016/j.freeradbiomed.2010.05.021. Epub 2010 Jun 1.
8. Liu W, etal., Neurol Res. 2012 Dec;34(10):915-22. doi: 10.1179/1743132812Y.0000000098. Epub 2012 Sep 20.
9. MGD data from the GO Consortium
10. Nielsen M, etal., Exp Brain Res. 2008 Sep;190(1):81-9. doi: 10.1007/s00221-008-1452-3. Epub 2008 Jun 21.
11. Pereira RT, etal., Mol Cell Endocrinol. 2014 Jan 25;382(1):227-33. doi: 10.1016/j.mce.2013.09.037. Epub 2013 Oct 9.
12. Pipeline to import KEGG annotations from KEGG into RGD
13. RGD automated data pipeline
14. RGD automated import pipeline for gene-chemical interactions
15. Singh BK, etal., PLoS One. 2012;7(4):e34200. doi: 10.1371/journal.pone.0034200. Epub 2012 Apr 3.
16. Siu PM, etal., J Mol Cell Cardiol. 2007 Mar;42(3):678-86. Epub 2007 Jan 9.
17. Teng BT, etal., J Physiol. 2011 Jul 1;589(Pt 13):3349-69. doi: 10.1113/jphysiol.2011.209619. Epub 2011 May 3.
18. Yu F, etal., J Neurotrauma. 2006 May;23(5):595-603.
19. Zhang Z, etal., Stroke. 2007 May;38(5):1606-13. Epub 2007 Mar 22.
20. Zhao S, etal., J Neurosci Res. 2010 Jun;88(8):1727-37. doi: 10.1002/jnr.22338.
Additional References at PubMed
PMID:14651853   PMID:14663139   PMID:16754658   PMID:16767516   PMID:16873557   PMID:17050806   PMID:18312415   PMID:18614015   PMID:19737385   PMID:21437288   PMID:21979051  


Genomics

Comparative Map Data
Endog
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2313,449,113 - 13,451,715 (+)NCBI
Rnor_6.0 Ensembl38,741,766 - 8,744,592 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.038,741,833 - 8,744,414 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0314,094,275 - 14,096,910 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.439,184,023 - 9,187,524 (+)NCBIRGSC3.4rn4RGSC3.4
Celera38,222,701 - 8,225,752 (+)NCBICelera
Cytogenetic Map3p12NCBI
ENDOG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9128,818,500 - 128,822,676 (+)EnsemblGRCh38hg38GRCh38
GRCh389128,818,402 - 128,822,676 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379131,580,779 - 131,584,955 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369130,620,600 - 130,624,776 (+)NCBINCBI36hg18NCBI36
Build 349128,660,332 - 128,664,509NCBI
Celera9102,231,564 - 102,235,740 (+)NCBI
Cytogenetic Map9q34.11NCBI
HuRef9101,189,778 - 101,193,954 (+)NCBIHuRef
CHM1_19131,731,780 - 131,735,956 (+)NCBICHM1_1
Endog
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39230,061,421 - 30,064,081 (+)NCBIGRCm39mm39
GRCm39 Ensembl230,061,505 - 30,064,081 (+)Ensembl
GRCm38230,171,408 - 30,174,069 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl230,171,493 - 30,174,069 (+)EnsemblGRCm38mm10GRCm38
MGSCv37230,027,044 - 30,029,589 (+)NCBIGRCm37mm9NCBIm37
MGSCv36229,993,533 - 29,996,078 (+)NCBImm8
Celera229,875,396 - 29,877,941 (+)NCBICelera
Cytogenetic Map2BNCBI
Endog
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555701,200,996 - 1,203,566 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555701,200,461 - 1,203,566 (+)NCBIChiLan1.0ChiLan1.0
ENDOG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19128,609,839 - 128,613,353 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0999,941,856 - 99,945,957 (+)NCBIMhudiblu_PPA_v0panPan3
ENDOG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1954,809,470 - 54,812,795 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl954,809,530 - 54,813,042 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,004,973 - 54,008,297 (-)NCBI
ROS_Cfam_1.0955,730,508 - 55,733,832 (-)NCBI
UMICH_Zoey_3.1954,491,141 - 54,494,468 (-)NCBI
UNSW_CanFamBas_1.0954,803,909 - 54,807,233 (-)NCBI
UU_Cfam_GSD_1.0954,897,321 - 54,900,646 (-)NCBI
Endog
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_ltri_2NW_024404947196,513,430 - 196,519,544 (+)NCBI
SpeTri2.0NW_00493648716,282,115 - 16,285,486 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENDOG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1269,154,090 - 269,157,788 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11269,153,955 - 269,157,789 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21303,170,007 - 303,173,838 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ENDOG
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,322,828 - 9,326,833 (-)NCBI
ChlSab1.1 Ensembl129,322,892 - 9,326,549 (-)Ensembl
Endog
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247606,193,168 - 6,196,209 (-)NCBI

Position Markers
RH134420  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.038,744,023 - 8,744,207NCBIRnor6.0
Rnor_5.0314,096,519 - 14,096,703UniSTSRnor5.0
RGSC_v3.439,187,133 - 9,187,317UniSTSRGSC3.4
Celera38,225,361 - 8,225,545UniSTS
RH 3.4 Map352.5UniSTS
Cytogenetic Map3p12UniSTS
BI278171  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.038,744,494 - 8,744,607NCBIRnor6.0
Rnor_5.0314,096,990 - 14,097,103UniSTSRnor5.0
RGSC_v3.439,187,604 - 9,187,717UniSTSRGSC3.4
Celera38,225,832 - 8,225,945UniSTS
RH 3.4 Map351.81UniSTS
Cytogenetic Map3p12UniSTS
RH124237  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.038,743,966 - 8,744,119NCBIRnor6.0
Rnor_5.0314,096,462 - 14,096,615UniSTSRnor5.0
RGSC_v3.439,187,076 - 9,187,229UniSTSRGSC3.4
Celera38,225,304 - 8,225,457UniSTS
Cytogenetic Map3p12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)3600074851687917Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)3600074851687917Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3128136884Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3328592928136884Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3128500807Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3128500807Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3128500807Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3125786001Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3139773425Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3263142133477544Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3128500807Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3132972944Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)3600086634394121Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)3600086634394121Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3600074834394365Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)3600086634394121Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3195176874Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3328592928136884Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3137891710Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3600074834394365Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3600074834394365Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)3565463925105730Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3263142148562146Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:77
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000021531
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43 2 2 2 8 11 18 20 3 8
Low 3 55 39 19 39 56 15 38 11
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021531   ⟹   ENSRNOP00000021531
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl38,741,766 - 8,744,592 (+)Ensembl
RefSeq Acc Id: NM_001034938   ⟹   NP_001030110
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2313,449,113 - 13,451,715 (+)NCBI
Rnor_6.038,741,833 - 8,744,414 (+)NCBI
Rnor_5.0314,094,275 - 14,096,910 (+)NCBI
RGSC_v3.439,184,023 - 9,187,524 (+)RGD
Celera38,222,701 - 8,225,752 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001030110 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAE44115 (Get FASTA)   NCBI Sequence Viewer  
  EDL93340 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001030110   ⟸   NM_001034938
- Peptide Label: precursor
- UniProtKB: Q3V5X8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021531   ⟸   ENSRNOT00000021531
Protein Domains
Endonuclease_NS   NUC

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691953
Promoter ID:EPDNEW_R2477
Type:multiple initiation site
Name:Endog_1
Description:endonuclease G
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.038,741,785 - 8,741,845EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310763 AgrOrtholog
Ensembl Genes ENSRNOG00000016033 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000021531 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021531 ENTREZGENE, UniProtKB/TrEMBL
InterPro DNA/RNA_endonuclease_AS UniProtKB/TrEMBL
  DNA/RNA_non-sp_Endonuclease UniProtKB/TrEMBL
  Extracellular_endonuc_su_A UniProtKB/TrEMBL
  Non-specific_endonuclease UniProtKB/TrEMBL
KEGG Report rno:362100 UniProtKB/TrEMBL
NCBI Gene 362100 ENTREZGENE
PANTHER PTHR13966 UniProtKB/TrEMBL
Pfam Endonuclease_NS UniProtKB/TrEMBL
PhenoGen Endog PhenoGen
PROSITE NUCLEASE_NON_SPEC UniProtKB/TrEMBL
SMART Endonuclease_NS UniProtKB/TrEMBL
  NUC UniProtKB/TrEMBL
UniProt Q3V5X8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Endog  endonuclease G  Endog_predicted  endonuclease G (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Endog_predicted  endonuclease G (predicted)      Symbol and Name status set to approved 70820 APPROVED