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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:8273
Term: plumbagin
Definition: A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 2 and 5 are substituted by methyl and hydroxy groups, respectively.
Chemical ID: MESH:C014758
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5increases expressionISOHSPA5 (Homo sapiens)6480464CTDplumbagin results in increased expression of HSPA5 proteinPMID:31276663
Hspa5multiple interactionsISOHSPA5 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [plumbagin results in increased expression of HSPA5 protein]; Cycloheximide inhibits the reaction [plumbagin results in increased expression of HSPA5 protein]PMID:31276663
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