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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5increases expressionEXP 6480464CTDParaquat results in increased expression of HSPA5 mRNA; Paraquat results in increased expression of HSPA5 proteinPMID:17935786 PMID:18198484 PMID:22245251 PMID:22678742 PMID:24912635
Hspa5multiple interactionsEXP 6480464CTDMinocycline inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]; NFE2L2 mutant form inhibits the reaction [Paraquat results in increased expression of HSPA5 mRNA]; NFE2L2 mutant form inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]PMID:22245251 PMID:22678742
Hspa5increases expressionISOHspa5 (Mus musculus)6480464CTDParaquat results in increased expression of HSPA5 proteinPMID:27442881
Hspa5increases expressionISOHSPA5 (Homo sapiens)6480464CTDParaquat results in increased expression of HSPA5 mRNA; Paraquat results in increased expression of HSPA5 proteinPMID:19735704 PMID:20883675 PMID:28986289 PMID:30185695
Hspa5multiple interactionsISOHspa5 (Mus musculus)6480464CTD[Paraquat co-treated with Maneb] results in increased expression of HSPA5 mRNAPMID:18386188
Hspa5multiple interactionsISOHSPA5 (Homo sapiens)6480464CTDEIF2S1 protein promotes the reaction [salubrinal inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]; salubrinal inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]PMID:19735704 PMID:28986289 PMID:30185695
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