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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:20993
Term: aldehydo-D-glucosamine
Definition: The open-chain form of D-glucosamine.
Chemical ID: MESH:D005944
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5increases expressionEXP 6480464CTDGlucosamine results in increased expression of HSPA5 mRNAPMID:20165829
Hspa5multiple interactionsEXP 6480464CTD4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]; ursodoxicoltaurine inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]PMID:20165829
Hspa5decreases expressionISOHspa5 (Mus musculus)6480464CTDGlucosamine results in decreased expression of HSPA5 mRNAPMID:17178593
Hspa5increases expressionISOHspa5 (Mus musculus)6480464CTDGlucosamine results in increased expression of HSPA5 mRNA; Glucosamine results in increased expression of HSPA5 proteinPMID:30602124
Hspa5increases expressionISOHSPA5 (Homo sapiens)6480464CTDGlucosamine results in increased expression of HSPA5 mRNA; Glucosamine results in increased expression of HSPA5 proteinPMID:15618547 PMID:16380481 PMID:19383982 PMID:20165829 PMID:22020377 PMID:33812996
Hspa5multiple interactionsISOHspa5 (Mus musculus)6480464CTD4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 protein]PMID:30602124
Hspa5multiple interactionsISOHSPA5 (Homo sapiens)6480464CTD4-phenylbutyric acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]; NUS1 protein inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]; NUS1 protein inhibits the reaction [Glucosamine results in increased expression of HSPA5 protein]; ursodoxicoltaurine inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]PMID:20165829 PMID:33812996
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