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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:379896
Term: 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one
Definition: A synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.
Chemical ID: MESH:D015741
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5affects localizationISOHSPA5 (Homo sapiens)6480464CTDMetribolone affects the localization of HSPA5 proteinPMID:17440980
Hspa5increases expressionISOHSPA5 (Homo sapiens)6480464CTDMetribolone results in increased expression of HSPA5 proteinPMID:17152098
Hspa5multiple interactionsISOHSPA5 (Homo sapiens)6480464CTDMetribolone promotes the reaction [NDRG1 protein binds to HSPA5 protein]PMID:17220478
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