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Gene: AQP2 (aquaporin 2) Homo sapiens
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Symbol: AQP2
Name: aquaporin 2
Description: Exhibits glycerol transmembrane transporter activity and water channel activity. Involved in several processes, including cellular response to metal ion; protein homotetramerization; and renal water homeostasis. Localizes to apical plasma membrane; extracellular exosome; and integral component of plasma membrane. Implicated in nephrogenic diabetes insipidus. Biomarker of diabetic ketoacidosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADH water channel; AQP-2; AQP-CD; aquaporin 2 (collecting duct); aquaporin-2; aquaporin-CD; collecting duct water channel protein; MGC34501; water channel protein for renal collecting duct; water-channel aquaporin 2; WCH-CD
Orthologs:
Mus musculus (house mouse) : Aqp2 (aquaporin 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Aqp2 (aquaporin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aqp2 (aquaporin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : AQP2 (aquaporin 2)
Canis lupus familiaris (dog) : AQP2 (aquaporin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aqp2 (aquaporin 2)
Sus scrofa (pig) : AQP2 (aquaporin 2)
Chlorocebus sabaeus (African green monkey) : AQP2 (aquaporin 2)
Heterocephalus glaber (naked mole-rat) : Aqp2 (aquaporin 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1249,950,741 - 49,958,881 (+)EnsemblGRCh38hg38GRCh38
GRCh381249,950,737 - 49,958,878 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371250,344,524 - 50,352,664 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361248,630,796 - 48,638,931 (+)NCBINCBI36hg18NCBI36
Build 341248,630,795 - 48,638,929NCBI
Celera1249,140,628 - 49,148,768 (+)NCBI
Cytogenetic Map12q13.12NCBI
HuRef1247,376,094 - 47,384,234 (+)NCBIHuRef
CHM1_11250,310,689 - 50,318,825 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on AQP2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 70370
Created: 2002-03-20
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.