RGD Reference Report - Urinary excretion of aquaporin-2 water channel in diabetic ketoacidosis. - Rat Genome Database

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Urinary excretion of aquaporin-2 water channel in diabetic ketoacidosis.

Authors: Kusaka, I  Saito, T  Nakamura, T  Nagasaka, S  Ishibashi, S  Ishikawa, SE 
Citation: Kusaka I, etal., Nephron. 2002 May;91(1):167-9.
RGD ID: 2314345
Pubmed: (View Article at PubMed) PMID:12021537
DOI: Full-text: DOI:57622

We studied the changes in plasma arginine vasopressin (AVP) and urinary excretion of aquaporin-2 (UAQP-2) water channel in 3 patients with diabetic ketoacidosis. They had marked hyperglycemia of 27.9 +/- 2.8 mmol/l (mean +/- SEM), and elevated hemoglobin A1c of 8.8 +/- 1.4%. Circulatory blood volume was decreased by approximately 25%, which was determined by the changes in hematocrit. Plasma AVP levels were elevated to 10.3 +/- 3.0 pmol/l and UAQP-2, 578 +/- 200 fmol/mg creatinine (normal, 153 +/- 28) at the hospitalization. When hyperglycemia was improved by the intravenous infusion of a small dose of insulin plus fluid administration, both plasma AVP and UAQP-2 promptly decreased to 1.2 +/- 0.2 pmol/l and 252 +/- 29 fmol/mg creatinine on day 7, respectively. These alterations were concomitant with the recovery of circulatory blood volume. In the present study, UAQP-2, in addition to plasma AVP, indicates circulatory blood volume depletion, and the changes in UAQP-2 estimates the AVP-dependent recovery of circulatory blood volume during the therapeutic period in the patients with diabetic ketoacidosis.


Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Aqp2  (aquaporin 2)

Genes (Mus musculus)
Aqp2  (aquaporin 2)

Genes (Homo sapiens)
AQP2  (aquaporin 2)

Additional Information