Hdac7 (histone deacetylase 7) - Rat Genome Database

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Gene: Hdac7 (histone deacetylase 7) Rattus norvegicus
Analyze
Symbol: Hdac7
Name: histone deacetylase 7
RGD ID: 619982
Description: Predicted to enable several functions, including 14-3-3 protein binding activity; protein kinase C binding activity; and transcription corepressor activity. Involved in cellular response to mechanical stimulus; neuron apoptotic process; and neuron differentiation. Predicted to be located in cytosol. Predicted to be part of histone deacetylase complex. Predicted to be active in nucleus. Orthologous to human HDAC7 (histone deacetylase 7); PARTICIPATES IN histone modification pathway; hypoxia inducible factor pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: HD7; HD7a; Hdac7a; histone deacetylase 7A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87130,803,013 - 130,841,181 (-)NCBIGRCr8
mRatBN7.27128,923,918 - 128,961,926 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7128,923,920 - 128,962,072 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.07139,280,396 - 139,319,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7139,281,187 - 139,318,455 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07139,471,977 - 139,510,581 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47136,501,738 - 136,523,073 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17136,593,467 - 136,597,288 (-)NCBI
Celera7125,415,230 - 125,435,773 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
alpha-pinene  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzylpenicillin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumarin  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
doxorubicin  (EXP)
ethanol  (EXP)
folic acid  (ISO)
FR900359  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lithium chloride  (ISO)
methamphetamine  (ISO)
mifepristone  (EXP,ISO)
Muraglitazar  (EXP)
nickel dichloride  (EXP)
nicotine  (ISO)
ozone  (ISO)
paraquat  (EXP)
pelargonidin  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenytoin  (ISO)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
saccharin  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tauroursodeoxycholic acid  (EXP)
tert-butyl hydroperoxide  (ISO)
thiram  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO,ISS,TAS)
cytosol  (IEA,ISO)
histone deacetylase complex  (TAS)
nucleus  (IEA,ISO,ISS,TAS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Upregulation of class II histone deacetylases mRNA during neural differentiation of cultured rat hippocampal progenitor cells. Ajamian F, etal., Neurosci Lett 2003 Jul 31;346(1-2):57-60.
2. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Kao HY, etal., Genes Dev 2000 Jan 1;14(1):55-66.
3. Neuroprotection by histone deacetylase-7 (HDAC7) occurs by inhibition of c-jun expression through a deacetylase-independent mechanism. Ma C and D'Mello SR, J Biol Chem. 2011 Feb 11;286(6):4819-28. doi: 10.1074/jbc.M110.146860. Epub 2010 Nov 30.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure. Stypula-Cyrus Y, etal., PLoS One. 2013 May 28;8(5):e64600. doi: 10.1371/journal.pone.0064600. Print 2013.
13. Class II histone deacetylases: versatile regulators. Verdin E, etal., Trends Genet. 2003 May;19(5):286-93.
14. Histone deacetylases modulate vascular smooth muscle cell migration induced by cyclic mechanical strain. Yan ZQ, etal., J Biomech. 2009 May 11;42(7):945-8. doi: 10.1016/j.jbiomech.2009.01.012. Epub 2009 Mar 3.
15. Abnormal epigenetic modifications in peripheral blood mononuclear cells from patients with alopecia areata. Zhao M, etal., Br J Dermatol. 2012 Feb;166(2):226-73. doi: 10.1111/j.1365-2133.2011.10646.x. Epub 2012 Jan 9.
Additional References at PubMed
PMID:16109736   PMID:16260608   PMID:16873063   PMID:16980613   PMID:17360565   PMID:17997710   PMID:19351956   PMID:20188095   PMID:20590529   PMID:25411248   PMID:25916381   PMID:30538141  
PMID:32106109  


Genomics

Comparative Map Data
Hdac7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87130,803,013 - 130,841,181 (-)NCBIGRCr8
mRatBN7.27128,923,918 - 128,961,926 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7128,923,920 - 128,962,072 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.07139,280,396 - 139,319,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7139,281,187 - 139,318,455 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07139,471,977 - 139,510,581 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47136,501,738 - 136,523,073 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17136,593,467 - 136,597,288 (-)NCBI
Celera7125,415,230 - 125,435,773 (-)NCBICelera
Cytogenetic Map7q36NCBI
HDAC7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381247,782,722 - 47,821,344 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1247,782,722 - 47,833,132 (-)EnsemblGRCh38hg38GRCh38
GRCh371248,176,505 - 48,213,686 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361246,462,772 - 46,499,924 (-)NCBINCBI36Build 36hg18NCBI36
Build 341246,462,775 - 46,479,190NCBI
Celera1246,974,055 - 47,011,314 (-)NCBICelera
Cytogenetic Map12q13.11NCBI
HuRef1245,207,665 - 45,244,811 (-)NCBIHuRef
CHM1_11248,142,408 - 48,179,666 (-)NCBICHM1_1
T2T-CHM13v2.01247,744,115 - 47,782,739 (-)NCBIT2T-CHM13v2.0
Hdac7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391597,690,542 - 97,742,383 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1597,690,545 - 97,742,383 (-)EnsemblGRCm39 Ensembl
GRCm381597,792,661 - 97,844,502 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1597,792,664 - 97,844,502 (-)EnsemblGRCm38mm10GRCm38
MGSCv371597,623,112 - 97,662,102 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361597,620,715 - 97,659,705 (-)NCBIMGSCv36mm8
Celera1599,920,309 - 99,939,192 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1553.79NCBI
Hdac7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555006,693,668 - 6,709,864 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555006,692,656 - 6,707,453 (-)NCBIChiLan1.0ChiLan1.0
HDAC7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21046,347,359 - 46,384,891 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11246,344,312 - 46,381,649 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01240,913,301 - 40,950,542 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11241,788,202 - 41,825,123 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1241,789,367 - 41,825,123 (+)Ensemblpanpan1.1panPan2
HDAC7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1276,941,287 - 6,968,370 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl276,929,829 - 6,979,317 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2739,338,114 - 39,375,845 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0276,998,714 - 7,036,476 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl276,997,822 - 7,036,540 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1276,935,774 - 6,973,459 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0276,971,287 - 7,008,847 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02739,626,577 - 39,664,313 (-)NCBIUU_Cfam_GSD_1.0
Hdac7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494567,447,349 - 67,482,511 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365125,682,490 - 5,697,869 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365125,680,564 - 5,701,182 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HDAC7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl578,150,561 - 78,186,072 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1578,150,554 - 78,186,051 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2581,388,011 - 81,393,534 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HDAC7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11144,002,616 - 44,040,766 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1144,003,736 - 44,039,902 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037202,340,868 - 202,378,940 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hdac7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248164,441,849 - 4,475,437 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248164,441,543 - 4,476,520 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hdac7
207 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:318
Count of miRNA genes:88
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000011159, ENSRNOT00000011322, ENSRNOT00000071974, ENSRNOT00000072948
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
D7Rat117  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87130,819,165 - 130,819,291 (+)Marker Load Pipeline
mRatBN7.27128,940,074 - 128,940,200 (+)MAPPERmRatBN7.2
Rnor_6.07139,296,547 - 139,296,672NCBIRnor6.0
Rnor_5.07139,488,296 - 139,488,421UniSTSRnor5.0
RGSC_v3.47136,519,125 - 136,519,250UniSTSRGSC3.4
RGSC_v3.47136,625,917 - 136,626,043RGDRGSC3.4
RGSC_v3.47136,519,124 - 136,519,250RGDRGSC3.4
RGSC_v3.47136,625,918 - 136,626,043UniSTSRGSC3.4
RGSC_v3.17136,702,355 - 136,702,480RGD
RH 3.4 Map71096.1UniSTS
RH 3.4 Map71096.1RGD
RH 2.0 Map7778.4RGD
SHRSP x BN Map786.2099RGD
Cytogenetic Map7q36UniSTS
RH130958  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27128,923,707 - 128,923,900 (+)MAPPERmRatBN7.2
Rnor_6.07139,280,183 - 139,280,375NCBIRnor6.0
Rnor_5.07139,471,765 - 139,471,957UniSTSRnor5.0
RGSC_v3.47136,500,906 - 136,501,098UniSTSRGSC3.4
Celera7125,415,017 - 125,415,209UniSTS
RH 3.4 Map71096.1UniSTS
Cytogenetic Map7q36UniSTS
MARC_6513-6514:996689732:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87130,806,355 - 130,807,140 (+)Marker Load Pipeline
mRatBN7.27128,927,261 - 128,928,046 (+)MAPPERmRatBN7.2
Rnor_6.07139,283,736 - 139,284,520NCBIRnor6.0
Rnor_5.07139,475,318 - 139,476,102UniSTSRnor5.0
RGSC_v3.47136,504,459 - 136,505,243UniSTSRGSC3.4
Celera7125,418,570 - 125,419,354UniSTS
Cytogenetic Map7q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001419534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC121206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF321135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000092029   ⟹   ENSRNOP00000073744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7128,923,920 - 128,962,072 (-)Ensembl
Rnor_6.0 Ensembl7139,281,187 - 139,318,455 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094130   ⟹   ENSRNOP00000086506
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7128,923,920 - 128,941,801 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100053   ⟹   ENSRNOP00000096380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7128,923,920 - 128,942,587 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106809   ⟹   ENSRNOP00000089609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7128,923,920 - 128,962,072 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118593   ⟹   ENSRNOP00000084448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7128,923,920 - 128,941,801 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119709   ⟹   ENSRNOP00000080988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7128,925,137 - 128,944,545 (-)Ensembl
RefSeq Acc Id: NM_001419534   ⟹   NP_001406463
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87130,803,013 - 130,841,017 (-)NCBI
mRatBN7.27128,923,918 - 128,961,926 (-)NCBI
RefSeq Acc Id: XM_006242364   ⟹   XP_006242426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87130,803,013 - 130,841,111 (-)NCBI
mRatBN7.27128,923,918 - 128,943,938 (-)NCBI
Rnor_6.07139,280,396 - 139,301,009 (-)NCBI
Rnor_5.07139,471,977 - 139,510,581 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242365   ⟹   XP_006242427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87130,803,013 - 130,841,116 (-)NCBI
mRatBN7.27128,923,918 - 128,943,938 (-)NCBI
Rnor_6.07139,280,396 - 139,301,009 (-)NCBI
Rnor_5.07139,471,977 - 139,510,581 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242366   ⟹   XP_006242428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87130,803,013 - 130,841,108 (-)NCBI
mRatBN7.27128,923,918 - 128,943,938 (-)NCBI
Rnor_6.07139,280,396 - 139,301,009 (-)NCBI
Rnor_5.07139,471,977 - 139,510,581 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242367   ⟹   XP_006242429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87130,803,013 - 130,841,113 (-)NCBI
mRatBN7.27128,923,918 - 128,943,938 (-)NCBI
Rnor_6.07139,280,396 - 139,301,009 (-)NCBI
Rnor_5.07139,471,977 - 139,510,581 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080355   ⟹   XP_038936283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87130,810,808 - 130,841,157 (-)NCBI
mRatBN7.27128,931,714 - 128,943,938 (-)NCBI
RefSeq Acc Id: XM_063264340   ⟹   XP_063120410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87130,803,013 - 130,841,181 (-)NCBI
RefSeq Acc Id: XM_063264341   ⟹   XP_063120411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87130,803,013 - 130,841,106 (-)NCBI
RefSeq Acc Id: XM_063264342   ⟹   XP_063120412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87130,803,013 - 130,841,181 (-)NCBI
RefSeq Acc Id: XM_063264343   ⟹   XP_063120413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87130,803,013 - 130,841,181 (-)NCBI
RefSeq Acc Id: XP_006242427   ⟸   XM_006242365
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ASC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242426   ⟸   XM_006242364
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ASC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242429   ⟸   XM_006242367
- Peptide Label: isoform X4
- UniProtKB: A6KC44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242428   ⟸   XM_006242366
- Peptide Label: isoform X3
- UniProtKB: A6KC44 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073744   ⟸   ENSRNOT00000092029
RefSeq Acc Id: XP_038936283   ⟸   XM_039080355
- Peptide Label: isoform X9
Ensembl Acc Id: ENSRNOP00000096380   ⟸   ENSRNOT00000100053
Ensembl Acc Id: ENSRNOP00000080988   ⟸   ENSRNOT00000119709
Ensembl Acc Id: ENSRNOP00000086506   ⟸   ENSRNOT00000094130
Ensembl Acc Id: ENSRNOP00000084448   ⟸   ENSRNOT00000118593
Ensembl Acc Id: ENSRNOP00000089609   ⟸   ENSRNOT00000106809
RefSeq Acc Id: NP_001406463   ⟸   NM_001419534
- UniProtKB: A0A8I6ASC9 (UniProtKB/TrEMBL),   A0A0G2K6B1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120413   ⟸   XM_063264343
- Peptide Label: isoform X8
- UniProtKB: A6KC44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120412   ⟸   XM_063264342
- Peptide Label: isoform X7
- UniProtKB: A6KC44 (UniProtKB/TrEMBL),   A0A8I6ACZ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120410   ⟸   XM_063264340
- Peptide Label: isoform X5
- UniProtKB: A0A8I6ASC9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120411   ⟸   XM_063264341
- Peptide Label: isoform X6
- UniProtKB: A0A8I6ASC9 (UniProtKB/TrEMBL)
Protein Domains
Histone deacetylase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99P96-F1-model_v2 AlphaFold Q99P96 1-238 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695631
Promoter ID:EPDNEW_R6142
Type:initiation region
Name:Hdac7_1
Description:histone deacetylase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07139,318,400 - 139,318,460EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619982 AgrOrtholog
BioCyc Gene G2FUF-32175 BioCyc
Ensembl Genes ENSRNOG00000055597 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000092029.2 UniProtKB/TrEMBL
  ENSRNOT00000094130.1 UniProtKB/TrEMBL
  ENSRNOT00000100053 ENTREZGENE
  ENSRNOT00000100053.1 UniProtKB/TrEMBL
  ENSRNOT00000106809 ENTREZGENE
  ENSRNOT00000106809.1 UniProtKB/TrEMBL
  ENSRNOT00000118593.1 UniProtKB/TrEMBL
  ENSRNOT00000119709.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.800.20 UniProtKB/TrEMBL
InterPro HDAC4/5/7/9 UniProtKB/TrEMBL
  HDAC_PDAC UniProtKB/TrEMBL
  His_deacetylse UniProtKB/TrEMBL
  His_deacetylse_dom UniProtKB/TrEMBL
  His_deacetylse_dom_sf UniProtKB/TrEMBL
  Ureohydrolase_domain UniProtKB/TrEMBL
NCBI Gene 84582 ENTREZGENE
PANTHER HISTONE DEACETYLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HISTONE DEACETYLASE 7 UniProtKB/TrEMBL
  HISTONE DEACETYLASE 9-RELATED UniProtKB/TrEMBL
  HISTONE DEACETYLASE HDAC1-RELATED UniProtKB/TrEMBL
  PTHR45364 UniProtKB/Swiss-Prot
Pfam Hist_deacetyl UniProtKB/TrEMBL
PhenoGen Hdac7 PhenoGen
PIRSF HDAC_II_euk UniProtKB/TrEMBL
PRINTS HDASUPER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055597 RatGTEx
Superfamily-SCOP SSF52768 UniProtKB/TrEMBL
UniProt A0A0G2K6B1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZS13_RAT UniProtKB/TrEMBL
  A0A8I6A3X5_RAT UniProtKB/TrEMBL
  A0A8I6ACZ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASC9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GAE4_RAT UniProtKB/TrEMBL
  A6KC44 ENTREZGENE, UniProtKB/TrEMBL
  HDAC7_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-04-14 Hdac7  histone deacetylase 7  Hdac7a  histone deacetylase 7A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Hdac7a  histone deacetylase 7A    histone deacetylase 7  Name updated 1299863 APPROVED
2004-09-10 Hdac7a  histone deacetylase 7  Hdac7    Symbol and Name updated 1299863 APPROVED
2002-08-07 Hdac7  histone deacetylase 7      Symbol and Name status set to provisional 70820 PROVISIONAL