Arid2 (AT-rich interaction domain 2) - Rat Genome Database

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Gene: Arid2 (AT-rich interaction domain 2) Rattus norvegicus
Analyze
Symbol: Arid2
Name: AT-rich interaction domain 2
RGD ID: 1311105
Description: Predicted to enable DNA binding activity. Predicted to be involved in several processes, including negative regulation of cell migration; nucleosome disassembly; and positive regulation of double-strand break repair via homologous recombination. Predicted to act upstream of or within embryonic organ development; heart development; and homeostatic process. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of SWI/SNF complex and brahma complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 6; colorectal cancer; and hepatocellular carcinoma. Orthologous to human ARID2 (AT-rich interaction domain 2); PARTICIPATES IN SWI/SNF family mediated chromatin remodeling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AT rich interactive domain 2 (Arid-rfx like); AT-rich interactive domain-containing protein 2; LOC366980
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87129,326,371 - 129,443,813 (+)NCBIGRCr8
mRatBN7.27127,447,192 - 127,565,987 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7127,447,278 - 127,563,512 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.07137,680,564 - 137,798,329 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7137,680,530 - 137,795,655 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07137,312,585 - 137,430,353 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47134,959,992 - 135,077,477 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17135,036,399 - 135,153,718 (+)NCBI
Celera7123,951,414 - 124,071,020 (+)NCBICelera
Cytogenetic Map7q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Arid2Ratcolorectal cancer exacerbatesISORGD:1322383150429650 RGD 
Arid2Rathepatocellular carcinoma disease_progressionISORGD:1322383150340708 RGD 
Arid2Rathepatocellular carcinoma  ISORGD:1322383150340712associated with hepatitis B;protein:decreased expression:liverRGD 
Arid2Rathepatocellular carcinoma exacerbatesISORGD:1322383150340711 RGD 
Arid2Rathepatocellular carcinoma disease_progressionISORGD:1322383150429631 RGD 
Arid2Ratlung metastasis exacerbatesISORGD:1322383150340708associated with hepatocellular carcinoma,RGD 
Arid2Ratoral squamous cell carcinoma disease_progressionISORGD:1322383150340710 RGD 
Arid2Ratstomach cancer onsetISORGD:13223839068941protein:decreased expression:stomach (human)RGDPMID:26637902|REF_RGD_ID:126848744
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Original Reference(s)
Arid2Ratautism spectrum disorder  ISORGD:13223838554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:25741868
Arid2RatCoffin-Siris syndrome 1  ISORGD:13223838554872ClinVar Annotator: match by term: Coffin-Siris syndrome 1ClinVarPMID:25741868
Arid2RatCoffin-Siris syndrome 6  ISORGD:13223838554872ClinVar Annotator: match by term: ARID2-related condition | ClinVar Annotator: match by term: Coffin-Siris syndrome more ...ClinVarPMID:24728327|PMID:25741868|PMID:26238514|PMID:28124119|PMID:28492532|PMID:28884947|PMID:29698805|PMID:30838730
Arid2Ratdesmoplastic/nodular medulloblastoma  ISORGD:13223838554872ClinVar Annotator: match by term: Desmoplastic/nodular medulloblastomaClinVarPMID:26580448
Arid2RatDevelopmental Disease  ISORGD:13223838554872ClinVar Annotator: match by term: Developmental disorderClinVarPMID:25741868
Arid2RatDiarrhea 9  ISORGD:13223838554872ClinVar Annotator: match by term: Chronic diarrheaClinVarPMID:25741868
Arid2Ratgenetic disease  ISORGD:13223838554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:24728327|PMID:25741868|PMID:28492532
Arid2Ratmicrocephaly  ISORGD:13223838554872ClinVar Annotator: match by term: MicrocephalyClinVarPMID:24728327|PMID:25741868|PMID:28492532
Arid2Ratmulticentric Castleman disease  ISORGD:13223838554872ClinVar Annotator: match by term: TAFRO syndromeClinVar 
Arid2RatNeurodevelopmental Disorders  ISORGD:13223838554872ClinVar Annotator: match by term: Neurodevelopmental abnormality | ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
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Original Reference(s)
Arid2Rathepatocellular carcinoma  ISORGD:132238311554173CTD Direct Evidence: marker/mechanismCTDPMID:21822264|PMID:22634756
Arid2RatProstatic Neoplasms  ISORGD:132238311554173CTD Direct Evidence: marker/mechanismCTDPMID:29610475
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Original Reference(s)
Arid2RatCoffin-Siris syndrome 6  ISORGD:13223837240710 OMIM 

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Original Reference(s)
Arid2Rat(-)-demecolcine increases expressionISORGD:13223836480464Demecolcine results in increased expression of ARID2 mRNACTDPMID:23649840
Arid2Rat1,2-dichloroethane increases expressionISORGD:13223846480464ethylene dichloride results in increased expression of ARID2 mRNACTDPMID:28960355
Arid2Rat1,2-dimethylhydrazine decreases expressionISORGD:132238464804641,2-Dimethylhydrazine results in decreased expression of ARID2 mRNACTDPMID:22206623
Arid2Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of ARID2 mRNACTDPMID:32145629
Arid2Rat2,3',4,4',5-Pentachlorobiphenyl increases expressionISORGD:132238464804642,3',4,4',5-pentachlorobiphenyl results in increased expression of ARID2 mRNACTDPMID:31388691
Arid2Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:13223846480464[Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in increased expression of ARID2 mRNACTDPMID:19465110
Arid2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of ARID2 mRNACTDPMID:33387578
Arid2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of ARID2 mRNACTDPMID:32109520
Arid2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:13223846480464Tetrachlorodibenzodioxin affects the expression of ARID2 mRNACTDPMID:21570461
Arid2Rat2,4-dinitrotoluene affects expressionEXP 64804642,4-dinitrotoluene affects the expression of ARID2 mRNACTDPMID:21346803
Arid2Rat2,6-dinitrotoluene affects expressionEXP 64804642,6-dinitrotoluene affects the expression of ARID2 mRNACTDPMID:21346803
Arid2Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISORGD:13223836480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ...CTDPMID:28628672
Arid2Rat4,4'-sulfonyldiphenol decreases expressionISORGD:13223846480464bisphenol S results in decreased expression of ARID2 mRNACTDPMID:39298647
Arid2Rat4,4'-sulfonyldiphenol affects methylationISORGD:13223846480464bisphenol S affects the methylation of ARID2 geneCTDPMID:31683443
Arid2Ratacetazolamide increases expressionISORGD:13223846480464Acetazolamide results in increased expression of ARID2 mRNACTDPMID:19274763
Arid2Rataflatoxin B1 decreases methylationISORGD:13223836480464Aflatoxin B1 results in decreased methylation of ARID2 geneCTDPMID:27153756
Arid2Rataflatoxin B1 increases methylationISORGD:13223836480464Aflatoxin B1 results in increased methylation of ARID2 intronCTDPMID:30157460
Arid2RatAflatoxin B2 alpha affects methylationISORGD:13223836480464aflatoxin B2 affects the methylation of ARID2 intronCTDPMID:30157460
Arid2Ratamphetamine decreases expressionEXP 6480464Amphetamine results in decreased expression of ARID2 mRNACTDPMID:30779732
Arid2Rataristolochic acid A decreases expressionISORGD:13223836480464aristolochic acid I results in decreased expression of ARID2 mRNA; aristolochic acid I results in more ...CTDPMID:33212167

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Biological Process
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Arid2Ratbiological_process  ND 159840710/2014: no relevant rat dataRGD 
Arid2Ratcardiac muscle cell proliferation acts_upstream_of_or_withinISORGD:13223841624291MGI:4433303 PMID:25299188RGDPMID:25299188
Arid2Ratcardiac muscle cell proliferation acts_upstream_of_or_withinIEAUniProtKB:E9Q7E2|ensembl:ENSMUSP000000939691600115GO_REF:0000107EnsemblGO_REF:0000107
Arid2Ratchromatin remodeling involved_inIBAFB:FBgn0042085|PANTHER:PTN008586427|SGD:S0000045961600115GO_REF:0000033GO_CentralGO_REF:0000033
Arid2Ratcirculatory system development acts_upstream_of_or_withinISORGD:13223841624291MGI:4433303 PMID:25299188RGDPMID:25299188
Arid2Ratcirculatory system development acts_upstream_of_or_withinIEAUniProtKB:E9Q7E2|ensembl:ENSMUSP000000939691600115GO_REF:0000107EnsemblGO_REF:0000107
Arid2Ratcoronary artery morphogenesis acts_upstream_of_or_withinIEAUniProtKB:E9Q7E2|ensembl:ENSMUSP000000939691600115GO_REF:0000107EnsemblGO_REF:0000107
Arid2Ratcoronary artery morphogenesis acts_upstream_of_or_withinISORGD:13223841624291MGI:4433303 PMID:25299188RGDPMID:25299188
Arid2Ratembryonic organ development acts_upstream_of_or_withinISORGD:13223841624291MGI:4433303 PMID:25299188RGDPMID:25299188
Arid2Ratembryonic organ development acts_upstream_of_or_withinIEAUniProtKB:E9Q7E2|ensembl:ENSMUSP000000939691600115GO_REF:0000107EnsemblGO_REF:0000107
Arid2Ratheart morphogenesis acts_upstream_of_or_withinIEAUniProtKB:E9Q7E2|ensembl:ENSMUSP000000939691600115GO_REF:0000107EnsemblGO_REF:0000107
Arid2Ratheart morphogenesis acts_upstream_of_or_withinISORGD:13223841624291MGI:4433303 PMID:25299188RGDPMID:25299188
Arid2Rathomeostatic process acts_upstream_of_or_withinIEAUniProtKB:E9Q7E2|ensembl:ENSMUSP000000939691600115GO_REF:0000107EnsemblGO_REF:0000107
Arid2Rathomeostatic process acts_upstream_of_or_withinISORGD:13223841624291MGI:4433303 PMID:25299188RGDPMID:25299188
Arid2Ratnegative regulation of cell migration involved_inISORGD:13223831624291 PMID:26169693RGDPMID:26169693
Arid2Ratnegative regulation of cell migration involved_inIEAUniProtKB:Q68CP9|ensembl:ENSP000003350441600115GO_REF:0000107EnsemblGO_REF:0000107
Arid2Ratnegative regulation of cell population proliferation involved_inISORGD:13223831624291 PMID:26169693RGDPMID:26169693
Arid2Ratnegative regulation of cell population proliferation involved_inIEAUniProtKB:Q68CP9|ensembl:ENSP000003350441600115GO_REF:0000107EnsemblGO_REF:0000107
Arid2Ratnucleosome disassembly involved_inISORGD:13223831624291 PMID:8895581RGDPMID:8895581
Arid2Ratnucleosome disassembly involved_inIEAUniProtKB:Q68CP9|ensembl:ENSP000003350441600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component

  
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Original Reference(s)
Arid2Ratbrahma complex part_ofIBAFB:FBgn0042085|PANTHER:PTN0011218801600115GO_REF:0000033GO_CentralGO_REF:0000033
Arid2Ratnucleoplasm located_inIEAUniProtKB:Q68CP9|ensembl:ENSP000003350441600115GO_REF:0000107EnsemblGO_REF:0000107
Arid2Ratnucleoplasm located_inISORGD:1322383|UniProtKB:Q68CP9-11624291 RGDGO_REF:0000052
Arid2Ratplasma membrane located_inISORGD:1322383|UniProtKB:Q68CP9-11624291 RGDGO_REF:0000052
Arid2Ratplasma membrane located_inIEAUniProtKB:Q68CP9|ensembl:ENSP000003350441600115GO_REF:0000107EnsemblGO_REF:0000107
Arid2RatSWI/SNF complex part_ofISORGD:13223831624291 PMID:8895581RGDPMID:8895581
Arid2RatSWI/SNF complex part_ofIEAUniProtKB:Q68CP9|ensembl:ENSP000003350441600115GO_REF:0000107EnsemblGO_REF:0000107

Molecular Function

  
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Original Reference(s)
Arid2RatDNA binding enablesISORGD:13223831624291 PMID:15640446RGDPMID:15640446
Arid2RatDNA binding enablesIEAUniProtKB:Q68CP9|ensembl:ENSP000003350441600115GO_REF:0000107EnsemblGO_REF:0000107
Arid2RatDNA binding enablesIBAPANTHER:PTN008586427|SGD:S0000045961600115GO_REF:0000033GO_CentralGO_REF:0000033
Arid2RatDNA binding enablesIEAInterPro:IPR001606|InterPro:IPR003150|InterPro:IPR0364311600115GO_REF:0000002InterProGO_REF:0000002
Arid2Ratprotein binding enablesISORGD:13223831624291UniProtKB:P51532|UniProtKB:Q12824|UniProtKB:Q86U86|UniProtKB:Q969G3 PMID:15985610, PMID:22140357, PMID:24981860, PMID:30108113, PMID:31759698, PMID:33961781, PMID:34591612, PMID:35271311RGDPMID:15985610|PMID:22140357|PMID:24981860|PMID:30108113|PMID:31759698|PMID:33961781|PMID:34591612|PMID:35271311

RGD Manual Annotations


  
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Original Reference(s)
Arid2RatSWI/SNF family mediated chromatin remodeling pathway  ISORGD:13214378694154 RGD 
Arid2RatSWI/SNF family mediated chromatin remodeling pathway  ISORGD:13223839495920 RGD 

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Reference Title
Reference Citation
1. Exome sequencing identifies ARID2 as a novel tumor suppressor in early-onset sporadic rectal cancer. Bala P, etal., Oncogene. 2021 Jan;40(4):863-874. doi: 10.1038/s41388-020-01537-z. Epub 2020 Dec 1.
2. Chromatin remodeling gene ARID2 targets cyclin D1 and cyclin E1 to suppress hepatoma cell progression. Duan Y, etal., Oncotarget. 2016 Jul 19;7(29):45863-45875. doi: 10.18632/oncotarget.10244.
3. HBx protein-mediated ATOH1 downregulation suppresses ARID2 expression and promotes hepatocellular carcinoma. Gao Q, etal., Cancer Sci. 2017 Jul;108(7):1328-1337. doi: 10.1111/cas.13277. Epub 2017 Jun 14.
4. ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Hargreaves DC and Crabtree GR, Cell Res. 2011 Mar;21(3):396-420. doi: 10.1038/cr.2011.32. Epub 2011 Mar 1.
5. Chromatin remodeling factor ARID2 suppresses hepatocellular carcinoma metastasis via DNMT1-Snail axis. Jiang H, etal., Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4770-4780. doi: 10.1073/pnas.1914937117. Epub 2020 Feb 18.
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. The spectrum of SWI/SNF mutations, ubiquitous in human cancers. Shain AH and Pollack JR, PLoS One. 2013;8(1):e55119. doi: 10.1371/journal.pone.0055119. Epub 2013 Jan 23.
11. MiR-155-5p promotes oral cancer progression by targeting chromatin remodeling gene ARID2. Wu M, etal., Biomed Pharmacother. 2020 Feb;122:109696. doi: 10.1016/j.biopha.2019.109696. Epub 2019 Dec 30.
12. AT-rich interactive domain 2, p110α, p53, and β-catenin protein expression in hepatocellular carcinoma and clinicopathologic implications. You J, etal., Hum Pathol. 2015 Apr;46(4):583-92. doi: 10.1016/j.humpath.2015.01.001. Epub 2015 Jan 14.
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PMID:8895581   PMID:21873635   PMID:24335282   PMID:25299188   PMID:26169693   PMID:28381560  



Arid2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87129,326,371 - 129,443,813 (+)NCBIGRCr8
mRatBN7.27127,447,192 - 127,565,987 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7127,447,278 - 127,563,512 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.07137,680,564 - 137,798,329 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7137,680,530 - 137,795,655 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07137,312,585 - 137,430,353 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47134,959,992 - 135,077,477 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17135,036,399 - 135,153,718 (+)NCBI
Celera7123,951,414 - 124,071,020 (+)NCBICelera
Cytogenetic Map7q35NCBI
ARID2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381245,729,706 - 45,908,037 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1245,729,706 - 45,908,040 (+)EnsemblGRCh38hg38GRCh38
GRCh371246,123,489 - 46,301,820 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361244,409,887 - 44,588,086 (+)NCBINCBI36Build 36hg18NCBI36
Celera1244,920,557 - 45,099,159 (+)NCBICelera
Cytogenetic Map12q12NCBI
HuRef1243,152,842 - 43,332,608 (+)NCBIHuRef
CHM1_11246,088,579 - 46,266,707 (+)NCBICHM1_1
T2T-CHM13v2.01245,688,334 - 45,867,621 (+)NCBIT2T-CHM13v2.0
Arid2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391596,185,403 - 96,303,344 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1596,185,399 - 96,302,873 (+)EnsemblGRCm39 Ensembl
GRCm381596,287,522 - 96,405,463 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1596,287,518 - 96,404,992 (+)EnsemblGRCm38mm10GRCm38
MGSCv371596,117,953 - 96,235,894 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361596,197,538 - 96,230,331 (+)NCBIMGSCv36mm8
Celera1598,438,688 - 98,556,626 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1552.37NCBI
Arid2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555004,998,555 - 5,175,776 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555004,998,555 - 5,177,180 (+)NCBIChiLan1.0ChiLan1.0
ARID2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21048,261,225 - 48,443,133 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11248,257,983 - 48,439,555 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01242,823,236 - 43,004,465 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11243,692,717 - 43,871,652 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1243,692,914 - 43,871,564 (-)Ensemblpanpan1.1panPan2
ARID2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1278,411,092 - 8,579,735 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl278,412,377 - 8,579,882 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2737,733,310 - 37,902,134 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0278,605,853 - 8,775,028 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl278,605,848 - 8,775,217 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1278,413,511 - 8,582,264 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0278,452,603 - 8,621,753 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02737,971,938 - 38,141,085 (+)NCBIUU_Cfam_GSD_1.0
Arid2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494568,966,896 - 69,144,185 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365124,020,966 - 4,196,459 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365124,020,303 - 4,199,390 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARID2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl576,636,967 - 76,797,043 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1576,637,385 - 76,800,155 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2579,655,352 - 79,725,991 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARID2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11141,933,650 - 42,117,495 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1142,028,083 - 42,118,892 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037204,323,064 - 204,512,703 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arid2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248166,332,612 - 6,521,535 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248166,329,888 - 6,521,535 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Arid2
551 total Variants


Assembly: Rnor_5.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
7 137394806 137394807 C T snv ZFDM (KyushuU) View more Information

Predicted Target Of
Summary Value
Count of predictions:222
Count of miRNA genes:160
Interacting mature miRNAs:175
Transcripts:ENSRNOT00000006970, ENSRNOT00000072800
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 21 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat

1 to 10 of 21 rows
D7Got154  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27127,455,195 - 127,455,343 (+)MAPPERmRatBN7.2
Rnor_6.07137,687,927 - 137,688,074NCBIRnor6.0
Rnor_5.07137,319,951 - 137,320,098UniSTSRnor5.0
RGSC_v3.47134,969,369 - 134,969,516RGDRGSC3.4
RGSC_v3.47134,969,369 - 134,969,516UniSTSRGSC3.4
RGSC_v3.17135,045,806 - 135,045,953RGD
Celera7123,961,191 - 123,961,343UniSTS
RH 3.4 Map71092.0RGD
RH 3.4 Map71092.0UniSTS
RH 2.0 Map7773.9RGD
Cytogenetic Map7q35UniSTS
RH143678  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27127,445,042 - 127,445,162 (+)MAPPERmRatBN7.2
Rnor_6.07137,678,394 - 137,678,513NCBIRnor6.0
Rnor_5.07137,310,390 - 137,310,509UniSTSRnor5.0
RGSC_v3.47134,959,850 - 134,959,969UniSTSRGSC3.4
Celera7123,951,272 - 123,951,391UniSTS
RH 3.4 Map71098.9UniSTS
Cytogenetic Map7q35UniSTS
BF398770  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27127,460,365 - 127,460,572 (+)MAPPERmRatBN7.2
Rnor_6.07137,693,095 - 137,693,301NCBIRnor6.0
Rnor_5.07137,325,119 - 137,325,325UniSTSRnor5.0
RGSC_v3.47134,974,537 - 134,974,743UniSTSRGSC3.4
Celera7123,966,364 - 123,966,570UniSTS
RH 3.4 Map2180.4UniSTS
Cytogenetic Map7q35UniSTS
ARID2_3730  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27127,563,909 - 127,564,650 (+)MAPPERmRatBN7.2
Rnor_6.07137,796,251 - 137,796,991NCBIRnor6.0
Rnor_5.07137,428,275 - 137,429,015UniSTSRnor5.0
RGSC_v3.47135,078,075 - 135,078,815UniSTSRGSC3.4
Celera7124,068,942 - 124,069,682UniSTS
Cytogenetic Map7q35UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000006970   ⟹   ENSRNOP00000006970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7127,447,278 - 127,563,512 (+)Ensembl
Rnor_6.0 Ensembl7137,680,530 - 137,795,655 (+)Ensembl
RefSeq Acc Id: XM_063264356   ⟹   XP_063120426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87129,343,693 - 129,443,813 (+)NCBI
RefSeq Acc Id: XM_345867   ⟹   XP_345868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87129,326,371 - 129,443,813 (+)NCBI
mRatBN7.27127,447,192 - 127,565,987 (+)NCBI
Rnor_6.07137,680,564 - 137,798,329 (+)NCBI
Rnor_5.07137,312,585 - 137,430,353 (+)NCBI
RGSC_v3.47134,959,992 - 135,077,477 (+)RGD
Sequence:
Protein RefSeqs NP_001419436 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120426 (Get FASTA)   NCBI Sequence Viewer  
  XP_345868 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006970
  ENSRNOP00000006970.6
  ENSRNOP00000112346
RefSeq Acc Id: XP_345868   ⟸   XM_345867
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000006970   ⟸   ENSRNOT00000006970
RefSeq Acc Id: XP_063120426   ⟸   XM_063264356
- Peptide Label: isoform X2
- UniProtKB: A6KC19 (UniProtKB/TrEMBL)
ARID   RFX-type winged-helix

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJU0-F1-model_v2 AlphaFold D3ZJU0 1-1826 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695617
Promoter ID:EPDNEW_R6132
Type:initiation region
Name:Arid2_1
Description:AT-rich interaction domain 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07137,680,606 - 137,680,666EPDNEW


1 to 33 of 33 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-32260 BioCyc
Ensembl Genes ENSRNOG00000004831 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006970 ENTREZGENE
  ENSRNOT00000006970.9 UniProtKB/TrEMBL
  ENSRNOT00000139404 ENTREZGENE
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.10.150.60 UniProtKB/TrEMBL
InterPro ARID/BRIGHT_DNA-bd UniProtKB/TrEMBL
  ARID_dom_sf UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Chromatin_Remodeling_Comp UniProtKB/TrEMBL
  DNA-bd_RFX UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
KEGG Report rno:366980 UniProtKB/TrEMBL
NCBI Gene 366980 ENTREZGENE
PANTHER AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
  AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
Pfam ARID UniProtKB/TrEMBL
  RFX_DNA_binding UniProtKB/TrEMBL
PhenoGen Arid2 PhenoGen
PROSITE ARID UniProtKB/TrEMBL
  RFX_DBD UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004831 RatGTEx
SMART ARID UniProtKB/TrEMBL
  BRIGHT UniProtKB/TrEMBL
Superfamily-SCOP ARID UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
  SSF48371 UniProtKB/TrEMBL
UniProt A6KC19 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJU0 ENTREZGENE, UniProtKB/TrEMBL
1 to 33 of 33 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Arid2  AT-rich interaction domain 2  Arid2  AT rich interactive domain 2 (Arid-rfx like)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Arid2  AT rich interactive domain 2 (Arid-rfx like)   Arid2_predicted  AT rich interactive domain 2 (Arid-rfx like) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Arid2_predicted  AT rich interactive domain 2 (Arid-rfx like) (predicted)      Symbol and Name status set to approved 70820 APPROVED