Tns2 (tensin 2) - Rat Genome Database
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Gene: Tns2 (tensin 2) Rattus norvegicus
Analyze
Symbol: Tns2
Name: tensin 2
RGD ID: 1310917
Description: Predicted to have identical protein binding activity; kinase binding activity; and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including negative regulation of insulin receptor signaling pathway; peptidyl-tyrosine dephosphorylation; and response to muscle activity. Predicted to localize to focal adhesion. Orthologous to human TNS2 (tensin 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC315326; Tenc1; tensin like C1 domain containing phosphatase; tensin like C1 domain containing phosphatase (tensin 2); tensin-2; tensin-like C1 domain-containing phosphatase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07143,702,623 - 143,720,995 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,707,237 - 143,720,595 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,502,878 - 141,517,546 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,842,199 - 140,857,001 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17140,917,125 - 140,933,434 (+)NCBI
Celera7129,664,892 - 129,683,186 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10823724   PMID:16951145   PMID:21423176   PMID:22019427   PMID:23401856  


Genomics

Comparative Map Data
Tns2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07143,702,623 - 143,720,995 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,707,237 - 143,720,595 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,502,878 - 141,517,546 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,842,199 - 140,857,001 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17140,917,125 - 140,933,434 (+)NCBI
Celera7129,664,892 - 129,683,186 (+)NCBICelera
Cytogenetic Map7q36NCBI
TNS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1253,046,969 - 53,064,372 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1253,046,969 - 53,064,379 (+)EnsemblGRCh38hg38GRCh38
GRCh381253,046,980 - 53,064,379 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371253,440,810 - 53,458,163 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,727,077 - 51,744,430 (+)NCBINCBI36hg18NCBI36
Celera1253,088,528 - 53,106,057 (+)NCBI
Cytogenetic Map12q13.13NCBI
HuRef1250,483,949 - 50,501,247 (+)NCBIHuRef
CHM1_11253,407,410 - 53,424,570 (+)NCBICHM1_1
Tns2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915102,006,910 - 102,024,836 (+)NCBIGRCm39mm39
GRCm3815102,098,475 - 102,116,401 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,100,413 - 102,116,401 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715101,933,419 - 101,946,832 (+)NCBIGRCm37mm9NCBIm37
MGSCv3615101,930,264 - 101,944,433 (+)NCBImm8
Celera15104,258,906 - 104,272,318 (+)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1557.29NCBI
Tns2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458333,985 - 346,927 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955458333,104 - 347,399 (+)NCBIChiLan1.0ChiLan1.0
TNS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11236,473,106 - 36,488,469 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,473,106 - 36,488,471 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01235,692,148 - 35,712,685 (-)NCBIMhudiblu_PPA_v0panPan3
TNS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl272,096,616 - 2,113,619 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1272,096,287 - 2,112,626 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tns2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493651210,376,442 - 10,390,421 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,299,916 - 18,320,784 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,305,488 - 18,320,784 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,901,927 - 18,908,694 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNS2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1149,169,060 - 49,182,611 (+)Ensembl
ChlSab1.11149,163,217 - 49,183,110 (+)NCBI
Tns2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249041,110,149 - 1,128,848 (+)NCBI

Position Markers
D7Rat101  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07143,711,663 - 143,711,799NCBIRnor6.0
Rnor_5.07141,508,246 - 141,508,382UniSTSRnor5.0
RGSC_v3.47140,846,742 - 140,846,878UniSTSRGSC3.4
RGSC_v3.47140,846,401 - 140,846,882RGDRGSC3.4
RGSC_v3.17140,923,179 - 140,923,315RGD
Celera7129,673,895 - 129,674,031UniSTS
Cytogenetic Map7q36UniSTS
RH 3.4 Map71064.8RGD
RH 3.4 Map71064.8UniSTS
RH 2.0 Map7793.9RGD
SHRSP x BN Map788.4599RGD
AA818518  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07143,720,667 - 143,720,812NCBIRnor6.0
Rnor_5.07141,517,218 - 141,517,363UniSTSRnor5.0
RGSC_v3.47140,856,674 - 140,856,819UniSTSRGSC3.4
Celera7129,682,858 - 129,683,003UniSTS
Cytogenetic Map7q36UniSTS
RH 3.4 Map71065.8UniSTS
AA893657  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07143,720,551 - 143,720,691NCBIRnor6.0
Rnor_5.07141,517,102 - 141,517,242UniSTSRnor5.0
RGSC_v3.47140,856,558 - 140,856,698UniSTSRGSC3.4
Celera7129,682,742 - 129,682,882UniSTS
Cytogenetic Map7q36UniSTS
RH 3.4 Map6516.3UniSTS
RH135385  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07143,707,740 - 143,707,932NCBIRnor6.0
Rnor_5.07141,504,323 - 141,504,515UniSTSRnor5.0
RGSC_v3.47140,842,819 - 140,843,011UniSTSRGSC3.4
Celera7129,669,972 - 129,670,164UniSTS
Cytogenetic Map7q36UniSTS
RH 3.4 Map71064.0UniSTS
MARC_7649-7650:996688053:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0672,933,904 - 72,934,134NCBIRnor6.0
Rnor_6.07143,717,527 - 143,718,257NCBIRnor6.0
Rnor_5.07141,514,111 - 141,514,841UniSTSRnor5.0
Rnor_5.0682,494,665 - 82,494,895UniSTSRnor5.0
RGSC_v3.47140,852,606 - 140,853,336UniSTSRGSC3.4
RGSC_v3.4672,305,758 - 72,305,988UniSTSRGSC3.4
Celera7129,679,761 - 129,680,491UniSTS
Celera668,476,527 - 68,476,757UniSTS
Cytogenetic Map7q36UniSTS
Cytogenetic Map6q23UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)771448715145729302Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7111519266143965591Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7121986439143965591Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7120746024145692398Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7129412003145729302Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7115922628145729302Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7114825174145729302Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)7106564316145729302Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7122421276143965415Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7121654760145729302Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)751251919145729302Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7100028953145729302Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)7100192194145192194Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)791832949145158140Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)791832949145158140Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:142
Count of miRNA genes:67
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000014310, ENSRNOT00000074212
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 30 20 13 20 1 4 42 35 36 11 1
Low 27 21 6 21 7 7 32 5 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001108114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008776609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008776611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008776612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008776613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAHX01052775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01052776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC110347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF419140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000074212   ⟹   ENSRNOP00000064911
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7143,707,237 - 143,720,595 (+)Ensembl
RefSeq Acc Id: XM_008765865   ⟹   XP_008764087
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,704,814 - 143,720,995 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008765867   ⟹   XP_008764089
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,704,804 - 143,720,995 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008765868   ⟹   XP_008764090
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,704,804 - 143,720,995 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008765869   ⟹   XP_008764091
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,704,691 - 143,720,995 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008776609   ⟹   XP_008774831
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera7129,667,048 - 129,683,186 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008776611   ⟹   XP_008774833
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera7129,667,039 - 129,683,186 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008776612   ⟹   XP_008774834
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera7129,667,039 - 129,683,186 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008776613   ⟹   XP_008774835
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera7129,666,926 - 129,683,186 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595336   ⟹   XP_017450825
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,702,623 - 143,720,995 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595337   ⟹   XP_017450826
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,712,475 - 143,720,995 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595338   ⟹   XP_017450827
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,712,426 - 143,720,995 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017603520   ⟹   XP_017459009
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera7129,664,892 - 129,683,186 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017603521   ⟹   XP_017459010
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera7129,674,707 - 129,683,186 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017603522   ⟹   XP_017459011
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera7129,674,658 - 129,683,186 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_008774835   ⟸   XM_008776613
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008774831   ⟸   XM_008776609
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008774833   ⟸   XM_008776611
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008774834   ⟸   XM_008776612
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008764091   ⟸   XM_008765869
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008764087   ⟸   XM_008765865
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008764089   ⟸   XM_008765867
- Peptide Label: isoform X2
- UniProtKB: M0R671 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764090   ⟸   XM_008765868
- Peptide Label: isoform X2
- UniProtKB: M0R671 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017459009   ⟸   XM_017603520
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017459011   ⟸   XM_017603522
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017459010   ⟸   XM_017603521
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017450825   ⟸   XM_017595336
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017450827   ⟸   XM_017595338
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017450826   ⟸   XM_017595337
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000064911   ⟸   ENSRNOT00000074212
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310917 AgrOrtholog
Ensembl Genes ENSRNOG00000010588 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000064911 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074212 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro PH_like_dom UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  Prot_Kinase_C-like_PE/DAG-bd UniProtKB/TrEMBL
  PTB UniProtKB/TrEMBL
  PTyr_interaction_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  Tensin_like_SH2 UniProtKB/TrEMBL
  Tensin_lipid_phosphatase_dom UniProtKB/TrEMBL
  Tensin_phosphatase_C2-dom UniProtKB/TrEMBL
  Tensin_PTB UniProtKB/TrEMBL
NCBI Gene 315326 ENTREZGENE
Pfam PTB UniProtKB/TrEMBL
  PTEN_C2 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PhenoGen Tns2 PhenoGen
PROSITE C2_TENSIN UniProtKB/TrEMBL
  PPASE_TENSIN UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART PTB UniProtKB/TrEMBL
  PTEN_C2 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt M0R671 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-01-26 Tns2  tensin 2  Tenc1  tensin like C1 domain containing phosphatase (tensin 2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Tenc1  tensin like C1 domain containing phosphatase (tensin 2)  Tenc1  tensin like C1 domain containing phosphatase   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tenc1  tensin like C1 domain containing phosphatase   Tenc1_predicted  tensin like C1 domain containing phosphatase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tenc1_predicted  tensin like C1 domain containing phosphatase (predicted)      Symbol and Name status set to approved 70820 APPROVED