RGD Reference Report - Identification of genetic loci involved in diabetes using a rat model of depression. - Rat Genome Database
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Identification of genetic loci involved in diabetes using a rat model of depression.

Authors: Solberg Woods, LC  Ahmadiyeh, N  Baum, A  Shimomura, K  Li, Q  Steiner, DF  Turek, FW  Takahashi, JS  Churchill, GA  Redei, EE 
Citation: Solberg Woods LC, etal., Mamm Genome. 2009 Aug 22.
RGD ID: 2312611
Pubmed: (View Article at PubMed) PMID:19697080
DOI: Full-text: DOI:10.1007/s00335-009-9211-8

While diabetic patients often present with comorbid depression, the underlying mechanisms linking diabetes and depression are unknown. The Wistar Kyoto (WKY) rat is a well-known animal model of depression and stress hyperreactivity. In addition, the WKY rat is glucose intolerant and likely harbors diabetes susceptibility alleles. We conducted a quantitative trait loci (QTL) analysis in the segregating F(2) population of a WKY x Fischer 344 (F344) intercross. We previously published QTL analyses for depressive behavior and hypothalamic-pituitary-adrenal (HPA) activity in this cross. In this study we report results from the QTL analysis for multiple metabolic phenotypes, including fasting glucose, post-restraint stress glucose, postprandial glucose and insulin, and body weight. We identified multiple QTLs for each trait and many of the QTLs overlap with those previously identified using inbred models of type 2 diabetes (T2D). Significant correlations were found between metabolic traits and HPA axis measures, as well as forced swim test behavior. Several metabolic loci overlap with loci previously identified for HPA activity and forced swim behavior in this F(2) intercross, suggesting that the genetic mechanisms underlying these traits may be similar. These results indicate that WKY rats harbor diabetes susceptibility alleles and suggest that this strain may be useful for dissecting the underlying genetic mechanisms linking diabetes, HPA activity, and depression.

Annotation

Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype
Phenotype Values via PhenoMiner

View PhenoMiner data from this reference here 

Objects Annotated

QTLs
Bw85  (Body weight QTL 85)
Bw86  (Body weight QTL 86)
Bw87  (Body weight QTL 87)
Bw88  (Body weight QTL 88)
Bw89  (Body weight QTL 89)
Bw90  (Body weight QTL 90)
Bw91  (Body weight QTL 91)
Bw92  (Body weight QTL 92)
Bw93  (Body weight QTL 93)
Gluco41  (Glucose level QTL 41)
Gluco42  (Glucose level QTL 42)
Gluco43  (Glucose level QTL 43)
Gluco44  (Glucose level QTL 44)
Gluco45  (Glucose level QTL 45)
Gluco46  (Glucose level QTL 46)
Gluco47  (Glucose level QTL 47)
Gluco48  (Glucose level QTL 48)
Gluco49  (Glucose level QTL 49)
Gluco50  (Glucose level QTL 50)
Gluco51  (Glucose level QTL 51)
Gluco52  (Glucose level QTL 52)
Gluco53  (Glucose level QTL 53)
Gluco54  (Glucose level QTL 54)
Gluco55  (Glucose level QTL 55)
Insul12  (Insulin level QTL 12)
Insul13  (Insulin level QTL 13)
Insul14  (Insulin level QTL 14)

Objects referenced in this article
0 Bw115 Body weight QTL 115 All species
0 Bw120 Body weight QTL 120 All species
0 Bw123 Body weight QTL 123 All species
0 Bw15 Body weight QTL 15 All species
0 Bw32 Body weight QTL 32 All species
0 Bw57 Body weight QTL 57 All species
0 Bw67 Body weight QTL 67 All species
0 Bw80 Body weight QTL 80 All species
0 Despr11 Despair related QTL 11 All species
0 Despr5 Despair related QTL 5 All species
0 F344/NHsd F344/NHsd All species
0 Niddm1 Non-insulin dependent diabetes mellitus QTL 1 All species
0 Niddm11 Non-insulin dependent diabetes mellitus QTL 11 All species
0 Niddm19 Non-insulin dependent diabetes mellitus QTL 19 All species
0 Niddm23 Non-insulin dependent diabetes mellitus QTL 23 All species
0 Niddm24 Non-insulin dependent diabetes mellitus QTL 24 All species
0 Niddm25 Non-insulin dependent diabetes mellitus QTL 25 All species
0 Niddm26 Non-insulin dependent diabetes mellitus QTL 26 All species
0 Niddm27 Non-insulin dependent diabetes mellitus QTL 27 All species
0 Niddm30 Non-insulin dependent diabetes mellitus QTL 30 All species
0 Niddm35 Non-insulin dependent diabetes mellitus QTL 35 All species
0 Niddm44 Non-insulin dependent diabetes mellitus QTL 44 All species
0 Niddm45 Non-insulin dependent diabetes mellitus QTL 45 All species
0 Niddm58 Non-insulin dependent diabetes mellitus QTL 58 All species
0 Niddm64 Non-insulin dependent diabetes mellitus QTL 64 All species
0 Niddm65 Non-insulin dependent diabetes mellitus QTL 65 All species
0 Niddm66 Non-insulin dependent diabetes mellitus QTL 66 All species
0 Niddm7 Non-insulin dependent diabetes mellitus QTL 7 All species
0 Sradr5 Stress Responsive Adrenal Weight QTL 5 All species
0 Srcrt2 Stress Responsive Cort QTL 2 All species
0 Srcrtb2 Stress Responsive Cort Basal QTL 2 All species
0 WKY/NHsd null All species

Additional Information