RGD Reference Report - Identification of genetic loci involved in diabetes using a rat model of depression. - Rat Genome Database

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Identification of genetic loci involved in diabetes using a rat model of depression.

Authors: Solberg Woods, LC  Ahmadiyeh, N  Baum, A  Shimomura, K  Li, Q  Steiner, DF  Turek, FW  Takahashi, JS  Churchill, GA  Redei, EE 
Citation: Solberg Woods LC, etal., Mamm Genome. 2009 Aug 22.
RGD ID: 2312611
Pubmed: PMID:19697080   (View Abstract at PubMed)
PMCID: PMC2775460   (View Article at PubMed Central)
DOI: DOI:10.1007/s00335-009-9211-8   (Journal Full-text)

While diabetic patients often present with comorbid depression, the underlying mechanisms linking diabetes and depression are unknown. The Wistar Kyoto (WKY) rat is a well-known animal model of depression and stress hyperreactivity. In addition, the WKY rat is glucose intolerant and likely harbors diabetes susceptibility alleles. We conducted a quantitative trait loci (QTL) analysis in the segregating F(2) population of a WKY x Fischer 344 (F344) intercross. We previously published QTL analyses for depressive behavior and hypothalamic-pituitary-adrenal (HPA) activity in this cross. In this study we report results from the QTL analysis for multiple metabolic phenotypes, including fasting glucose, post-restraint stress glucose, postprandial glucose and insulin, and body weight. We identified multiple QTLs for each trait and many of the QTLs overlap with those previously identified using inbred models of type 2 diabetes (T2D). Significant correlations were found between metabolic traits and HPA axis measures, as well as forced swim test behavior. Several metabolic loci overlap with loci previously identified for HPA activity and forced swim behavior in this F(2) intercross, suggesting that the genetic mechanisms underlying these traits may be similar. These results indicate that WKY rats harbor diabetes susceptibility alleles and suggest that this strain may be useful for dissecting the underlying genetic mechanisms linking diabetes, HPA activity, and depression.



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Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Gluco41Ratdecreased circulating glucose level  IDA  RGD 
Gluco44Ratdecreased circulating glucose level  IDA  RGD 
Gluco46Ratdecreased circulating glucose level  IDA  RGD 
Gluco52Ratdecreased circulating glucose level  IDA  RGD 
Bw85Ratincreased body weight  IDA  RGD 
Bw86Ratincreased body weight  IDA  RGD 
Bw87Ratincreased body weight  IDA  RGD 
Bw88Ratincreased body weight  IDA  RGD 
Bw89Ratincreased body weight  IDA  RGD 
Bw90Ratincreased body weight  IDA  RGD 
Bw91Ratincreased body weight  IDA  RGD 
Bw92Ratincreased body weight  IDA  RGD 
Bw93Ratincreased body weight  IDA  RGD 
Gluco42Ratincreased circulating glucose level  IDA  RGD 
Gluco43Ratincreased circulating glucose level  IDA  RGD 
Gluco45Ratincreased circulating glucose level  IDA  RGD 
Gluco47Ratincreased circulating glucose level  IDA  RGD 
Gluco48Ratincreased circulating glucose level  IDA  RGD 
Gluco49Ratincreased circulating glucose level  IDA  RGD 
Gluco50Ratincreased circulating glucose level  IDA  RGD 
Gluco51Ratincreased circulating glucose level  IDA  RGD 
Gluco53Ratincreased circulating glucose level  IDA  RGD 
Gluco54Ratincreased circulating glucose level  IDA  RGD 
Gluco55Ratincreased circulating glucose level  IDA  RGD 
Insul12Ratincreased circulating insulin level  IDA  RGD 
Insul13Ratincreased circulating insulin level  IDA  RGD 
Insul14Ratincreased circulating insulin level  IDA  RGD 

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Select a value below to view phenotype data for a specific strain, measurment, or condition.

Objects Annotated

QTLs
Bw85  (Body weight QTL 85)
Bw86  (Body weight QTL 86)
Bw87  (Body weight QTL 87)
Bw88  (Body weight QTL 88)
Bw89  (Body weight QTL 89)
Bw90  (Body weight QTL 90)
Bw91  (Body weight QTL 91)
Bw92  (Body weight QTL 92)
Bw93  (Body weight QTL 93)
Gluco41  (Glucose level QTL 41)
Gluco42  (Glucose level QTL 42)
Gluco43  (Glucose level QTL 43)
Gluco44  (Glucose level QTL 44)
Gluco45  (Glucose level QTL 45)
Gluco46  (Glucose level QTL 46)
Gluco47  (Glucose level QTL 47)
Gluco48  (Glucose level QTL 48)
Gluco49  (Glucose level QTL 49)
Gluco50  (Glucose level QTL 50)
Gluco51  (Glucose level QTL 51)
Gluco52  (Glucose level QTL 52)
Gluco53  (Glucose level QTL 53)
Gluco54  (Glucose level QTL 54)
Gluco55  (Glucose level QTL 55)
Insul12  (Insulin level QTL 12)
Insul13  (Insulin level QTL 13)
Insul14  (Insulin level QTL 14)

Strains
F344/NHsd  (F344/NHsd)
WKY/NHsd  (NA)

Objects referenced in this article
QTL Bw115 Body weight QTL 115 Rattus norvegicus
QTL Bw120 Body weight QTL 120 Rattus norvegicus
QTL Bw123 Body weight QTL 123 Rattus norvegicus
QTL Bw15 Body weight QTL 15 Rattus norvegicus
QTL Bw32 Body weight QTL 32 Rattus norvegicus
QTL Bw57 Body weight QTL 57 Rattus norvegicus
QTL Bw67 Body weight QTL 67 Rattus norvegicus
QTL Bw80 Body weight QTL 80 Rattus norvegicus
QTL Despr11 Despair related QTL 11 Rattus norvegicus
QTL Despr5 Despair related QTL 5 Rattus norvegicus
QTL Niddm1 Non-insulin dependent diabetes mellitus QTL 1 Rattus norvegicus
QTL Niddm11 Non-insulin dependent diabetes mellitus QTL 11 Rattus norvegicus
QTL Niddm19 Non-insulin dependent diabetes mellitus QTL 19 Rattus norvegicus
QTL Niddm23 Non-insulin dependent diabetes mellitus QTL 23 Rattus norvegicus
QTL Niddm24 Non-insulin dependent diabetes mellitus QTL 24 Rattus norvegicus
QTL Niddm25 Non-insulin dependent diabetes mellitus QTL 25 Rattus norvegicus
QTL Niddm26 Non-insulin dependent diabetes mellitus QTL 26 Rattus norvegicus
QTL Niddm27 Non-insulin dependent diabetes mellitus QTL 27 Rattus norvegicus
QTL Niddm30 Non-insulin dependent diabetes mellitus QTL 30 Rattus norvegicus
QTL Niddm35 Non-insulin dependent diabetes mellitus QTL 35 Rattus norvegicus
QTL Niddm44 Non-insulin dependent diabetes mellitus QTL 44 Rattus norvegicus
QTL Niddm45 Non-insulin dependent diabetes mellitus QTL 45 Rattus norvegicus
QTL Niddm58 Non-insulin dependent diabetes mellitus QTL 58 Rattus norvegicus
QTL Niddm64 Non-insulin dependent diabetes mellitus QTL 64 Rattus norvegicus
QTL Niddm65 Non-insulin dependent diabetes mellitus QTL 65 Rattus norvegicus
QTL Niddm66 Non-insulin dependent diabetes mellitus QTL 66 Rattus norvegicus
QTL Niddm7 Non-insulin dependent diabetes mellitus QTL 7 Rattus norvegicus
QTL Sradr5 Stress Responsive Adrenal Weight QTL 5 Rattus norvegicus
QTL Srcrt2 Stress Responsive Cort QTL 2 Rattus norvegicus
QTL Srcrtb2 Stress Responsive Cort Basal QTL 2 Rattus norvegicus

Additional Information