Strain Report - Rat Genome Database

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Strain: WKY/NHsd

Symbol: WKY/NHsd
Strain: WKY
Substrain: NHsd
RGD ID: 61105
Citation ID: RRID:RGD_61105
Ontology ID: RS:0000916
Type: inbred
Source: Envigo
Origin: Derived from a nucleus colony obtained from the National Institutes of Health, Bethesda, Maryland. and maintained at Harlan Indianapolis, Indiana U.S.A.
Last Known Status: Unknown

Disease Annotations     Click to see Annotation Detail View


References - curated
# Reference Title Reference Citation
1. Lineage is an epigenetic modifier of QTL influencing behavioral coping with stress. Ahmadiyeh N, etal., Behav Genet 2005 Mar;35(2):189-98.
2. Maternal behavior modulates X-linked inheritance of behavioral coping in the defensive burying test. Ahmadiyeh N, etal., Biol Psychiatry 2004 Jun 1;55(11):1069-74.
3. Test- and behavior-specific genetic factors affect WKY hypoactivity in tests of emotionality. Baum AE, etal., Behav Brain Res. 2006 Feb 17;.
4. Quantitative Trait Loci Associated with Elevated TSH in the Wistar-Kyoto Rat. Baum AE, etal., Endocrinology 2004 Oct 28;.
5. Quantitative trait loci associated with elevated thyroid-stimulating hormone in the Wistar-Kyoto rat. Baum AE, etal., Endocrinology 2005 Feb;146(2):870-8. Epub 2004 Oct 28.
6. The Mcs7 quantitative trait locus is associated with an increased susceptibility to mammary cancer in congenic rats and an allele-specific imbalance. Cotroneo MS, etal., Oncogene. 2006 Aug 17;25(36):5011-7. Epub 2006 Mar 27.
7. Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23
8. Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1. Gu L, etal., J Clin Invest 1996 Feb 1;97(3):777-88
9. Genetic loci controlling breast cancer susceptibility in the Wistar-Kyoto rat. Lan H, etal., Genetics 2001 Jan;157(1):331-9.
10. Context and strain-dependent behavioral response to stress. Nosek K, etal., Behav Brain Funct. 2008 Jun 2;4(1):23.
11. Strains registered by Harlan Laboratories, Inc. Personal communication with Harlan Laboratories
12. RGD Strain RSO annotation pipeline RGD Automated Pipelines
13. The spontaneously hypertensive rat model of ADHD - The importance of selecting the appropriate reference strain. Sagvolden T, etal., Neuropharmacology. 2009 Aug 19.
14. Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk. Samuelson DJ, et al., Proc Natl Acad Sci U S A. 2007 Apr 2; 104(15):6299-304.
15. Sex- and lineage-specific inheritance of depression-like behavior in the rat. Solberg LC, etal., Mamm Genome 2004 Aug;15(8):648-62.
16. Genetic analysis of the stress-responsive adrenocortical axis. Solberg LC, etal., Physiol Genomics. 2006 Nov 27;27(3):362-9. Epub 2006 Aug 8.
17. Fine-mapping a locus for glucose tolerance using heterogeneous stock rats. Solberg Woods L, etal., Physiol Genomics. 2010 Jan 12.
18. Identification of genetic loci involved in diabetes using a rat model of depression. Solberg Woods LC, etal., Mamm Genome. 2009 Aug 22.
19. Fine-mapping diabetes-related traits, including insulin resistance, in heterogeneous stock rats. Solberg Woods LC, etal., Physiol Genomics. 2012 Sep 4.
20. Selectively bred Wistar-Kyoto rats: an animal model of depression and hyper-responsiveness to antidepressants. Will CC, etal., Mol Psychiatry. 2003 Nov;8(11):925-32.


Strain QTL Data
Symbol Name Trait
Anxrr18 Anxiety related response QTL 18 body movement coordination trait   (VT:0005424)    
Anxrr19 Anxiety related response QTL 19 body movement coordination trait   (VT:0005424)    
Anxrr20 Anxiety related response QTL 20 body movement coordination trait   (VT:0005424)    
Bw85 Body weight QTL 85 body mass   (VT:0001259)    
Bw86 Body weight QTL 86 body mass   (VT:0001259)    
Bw87 Body weight QTL 87 body mass   (VT:0001259)    
Bw88 Body weight QTL 88 body mass   (VT:0001259)    
Bw89 Body weight QTL 89 body mass   (VT:0001259)    
Bw90 Body weight QTL 90 body mass   (VT:0001259)    
Bw91 Body weight QTL 91 body mass   (VT:0001259)    
Bw92 Body weight QTL 92 body mass   (VT:0001259)    
Bw93 Body weight QTL 93 body mass   (VT:0001259)    
Despr1 Despair related QTL 1 locomotor behavior trait   (VT:0001392)    
Despr10 Despair related QTL 10 locomotor behavior trait   (VT:0001392)    
Despr11 Despair related QTL 11 locomotor behavior trait   (VT:0001392)    
Despr12 Despair related QTL 12 locomotor behavior trait   (VT:0001392)    
Despr13 Despair related QTL 13 locomotor behavior trait   (VT:0001392)    
Despr14 Despair related QTL 14 locomotor behavior trait   (VT:0001392)    
Despr15 Despair related QTL 15 locomotor behavior trait   (VT:0001392)    
Despr2 Despair related QTL 2 locomotor behavior trait   (VT:0001392)    
Despr3 Despair related QTL3 locomotor behavior trait   (VT:0001392)    
Despr4 Despair related QTL 4 locomotor behavior trait   (VT:0001392)    
Despr5 Despair related QTL 5 locomotor behavior trait   (VT:0001392)    
Despr6 Despair related QTL 6 locomotor behavior trait   (VT:0001392)    
Despr7 Despair related QTL 7 locomotor behavior trait   (VT:0001392)    
Despr8 Despair related QTL 8 locomotor behavior trait   (VT:0001392)    
Despr9 Despair related QTL 9 locomotor behavior trait   (VT:0001392)    
Gluco41 Glucose level QTL 41 blood glucose amount   (VT:0000188)    
Gluco42 Glucose level QTL 42 blood glucose amount   (VT:0000188)    
Gluco43 Glucose level QTL 43 blood glucose amount   (VT:0000188)    
Gluco44 Glucose level QTL 44 blood glucose amount   (VT:0000188)    
Gluco45 Glucose level QTL 45 blood glucose amount   (VT:0000188)    
Gluco46 Glucose level QTL 46 blood glucose amount   (VT:0000188)    
Gluco47 Glucose level QTL 47 blood glucose amount   (VT:0000188)    
Gluco48 Glucose level QTL 48 blood glucose amount   (VT:0000188)    
Gluco49 Glucose level QTL 49 blood glucose amount   (VT:0000188)    
Gluco50 Glucose level QTL 50 blood glucose amount   (VT:0000188)    
Gluco51 Glucose level QTL 51 blood glucose amount   (VT:0000188)    
Gluco52 Glucose level QTL 52 blood glucose amount   (VT:0000188)    
Gluco53 Glucose level QTL 53 blood glucose amount   (VT:0000188)    
Gluco54 Glucose level QTL 54 blood glucose amount   (VT:0000188)    
Gluco55 Glucose level QTL 55 blood glucose amount   (VT:0000188)    
Insul12 Insulin level QTL 12 blood insulin amount   (VT:0001560)    
Insul13 Insulin level QTL 13 blood insulin amount   (VT:0001560)    
Insul14 Insulin level QTL 14 blood insulin amount   (VT:0001560)    
Mcs23 Mammary carcinoma susceptibility QTL 23 mammary gland integrity trait   (VT:0010552)    
Mcs24 Mammary carcinoma susceptibility QTL 24 mammary gland integrity trait   (VT:0010552)    
Mcs5 Mammary carcinoma susceptibility QTL 5 mammary gland integrity trait   (VT:0010552)    
Mcs6 Mammary carcinoma susceptibility QTL 6 mammary gland integrity trait   (VT:0010552)    
Mcs7 Mammary carcinoma susceptibility QTL 7 mammary gland integrity trait   (VT:0010552)    
Mcs8 Mammary carcinoma susceptibility QTL 8 mammary gland integrity trait   (VT:0010552)    
Mcsm1 Mammary carcinoma susceptibility modifier QTL 1 mammary gland integrity trait   (VT:0010552)    
Sradr1 Stress Responsive Adrenal Weight QTL 1 adrenal gland mass   (VT:0010420)    
Sradr2 Stress Responsive Adrenal Weight QTL 2 adrenal gland mass   (VT:0010420)    
Sradr3 Stress Responsive Adrenal Weight QTL 3 adrenal gland mass   (VT:0010420)    
Sradr4 Stress Responsive Adrenal Weight QTL 4 adrenal gland mass   (VT:0010420)    
Sradr5 Stress Responsive Adrenal Weight QTL 5 adrenal gland mass   (VT:0010420)    
Sradr6 Stress Responsive Adrenal Weight QTL 6 adrenal gland mass   (VT:0010420)    
Srcrt1 Stress Responsive Cort QTL1 blood corticosterone amount   (VT:0005345)    
Srcrt2 Stress Responsive Cort QTL 2 blood corticosterone amount   (VT:0005345)    
Srcrt3 Stress Responsive Cort QTL 3 blood corticosterone amount   (VT:0005345)    
Srcrt4 Stress Responsive Cort QTL 4 blood corticosterone amount   (VT:0005345)    
Srcrt5 Stress Responsive Cort QTL 5 blood corticosterone amount   (VT:0005345)    
Srcrtb1 Stress Responsive Cort Basal QTL 1 blood corticosterone amount   (VT:0005345)    
Srcrtb2 Stress Responsive Cort Basal QTL 2 blood corticosterone amount   (VT:0005345)    
Stresp10 Stress response QTL 10 stress-related behavior trait   (VT:0010451)    
Stresp11 Stress response QTL 11 stress-related behavior trait   (VT:0010451)    
Stresp12 Stress response QTL 12 stress-related behavior trait   (VT:0010451)    
Stresp13 Stress response QTL 13 stress-related behavior trait   (VT:0010451)    
Stresp8 Stress response QTL 8 stress-related behavior trait   (VT:0010451)    
Stresp9 Stress response QTL 9 stress-related behavior trait   (VT:0010451)    
Thshl1 Thyroid stimulating hormone level QTL 1 blood thyroid-stimulating hormone amount   (VT:0005119)    
Thshl2 Thyroid stimulating hormone level QTL 2 blood thyroid-stimulating hormone amount   (VT:0005119)    
Damaging Variants
Number of Damaging Variants
WKY/NHsd (ICL) 434
WKY/NHsd (KNAW) 158
WKY/NHsd (RGD) 182

Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-09-25 WKY/NHsd    WKY/NHsd    Name updated 68913 APPROVED
2014-09-25 WKY/NHsd    WKY/NHsd    Name updated 68913 APPROVED