Bw115 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Bw115 (Body weight QTL 115) Rattus norvegicus

Symbol: Bw115
Name: Body weight QTL 115
RGD ID: 71112
Previously known as: Dmo1; Diabetes Mellitus OLETF QTL 1; Non-insulin dependent diabetes mellitus QTL 13; Niddm13
Trait: body mass   (VT:0001259)    
Measurement Type: body weight   (CMO:0000012)    
LOD Score: 6.0
P Value: 1.0E-4
Variance: Not Available
Inheritance Type: additive
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21259,647,732 - 260,522,016RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01281,795,624 - 282,763,074RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01262,617,374 - 289,137,107RGDRnor5.0
RGSC_v3.41240,980,321 - 267,110,921RGDRGSC3.4
RGSC_v3.11241,163,920 - 267,322,011RGD
Cross Type: F2
Strains Crossed: BN OLETF 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement
body weight  (IDA)

Experimental Condition

Measurement Method

Vertebrate Trait
body mass  (IDA)

Rat Strain
BN  (IEA)
OLETF  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Genetic dissection of "OLETF", a rat model for non-insulin-dependent diabetes mellitus. Kanemoto N, etal., Mamm Genome 1998 Jun;9(6):419-25
2. Pnlip encoding pancreatic lipase is possible candidate for obesity QTL in the OLETF rat. Muramatsu Y, etal., Biochem Biophys Res Commun 2005 Jun 17;331(4):1270-6.
3. Identification of genetic loci involved in diabetes using a rat model of depression. Solberg Woods LC, etal., Mamm Genome. 2009 Aug 22.
4. Genetic dissection of "OLETF," a rat model for non-insulin-dependent diabetes mellitus: quantitative trait locus analysis of (OLETF x BN) x OLETF. Watanabe TK, etal., Genomics 1999 Jun 15;58(3):233-9.
5. Quantitative trait loci for lipid metabolism in the study of OLETF x (OLETF x Fischer 344) backcross rats. Yamasaki Y, etal., Clin Exp Pharmacol Physiol 2000 Nov;27(11):881-6.
Related QTLs

Related QTL Description Reference
Bw54 maps to same region RGD:1358859
Scl67 interacts with RGD:619669
Stl31 maps to same region RGD:619669
Bw116 maps to same region RGD:619678
Bw85 maps to same region RGD:2312611


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1308127Cacul1CDK2-associated, cullin domain 11259666335259726249Rat
2323620Snu13-ps5small nuclear ribonucleoprotein 13, pseudogene 51259716056259716928Rat
11433684LOC108349715uncharacterized LOC1083497151259740912259748207Rat
1308194Nanos1nanos C2HC-type zinc finger 11259897663259901561Rat
1307269Eif3aeukaryotic translation initiation factor 3, subunit A1259902767259932976Rat
41358313LOC120093054small nucleolar RNA SNORA191259917206259917337Rat
1308326Dennd10DENN domain containing 101259950955259974459Rat
1306088Sfxn4sideroflexin 41259976480259998778Rat
620040Prdx3peroxiredoxin 31260001642260014064Rat
61985Grk5G protein-coupled receptor kinase 51260028269260223699Rat
41231749LOC120100371small nucleolar RNA SNORA441260136759260136887Rat
7570552Zfp950zinc finger protein 9501260248231260265211Rat
41267676Rnu6-28RNA, U6 small nuclear 281260249584260249690Rat
1563099Gcshl1glycine cleavage system protein H like11260311346260312097Rat
1565045Ces2icarboxylesterase 2I1260321595260329110Rat
1564578Ces2c-ps1carboxylesterase 2C, pseudogene 11260343090260350642Rat
621510Ces2ccarboxylesterase 2C1260391190260398757Rat
41324348Ces2e-ps1carboxylesterase 2E, pseudogene 11260422075260434417Rat
6503025Ybx1-ps4Y box binding protein 1, pseudogene 41260442452260455955Rat
7528461Zfp933l1zinc finger protein 9331260293716260306040Rat
40972971Ybx1-ps16Y box binding protein 1, pseudogene 161260452111260455956Rat
41244292Ybx1-ps14Y box binding protein 1, pseudogene 141260471423260475268Rat
41299975Ybx1-ps17Y box binding protein 1, pseudogene 171260490737260494592Rat
7652013Ybx1-ps12Y box binding protein 1, pseudogene 121260481081260494581Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
36358D1Mit351231260274101260274224Ratregion
35457D1Rat901481259647732259647894Ratregion
42550D1Rat4592081260122597260122809Ratregion
40904D19Rat862131260432881260433115Ratregion
67792D1Uwm102081259900306259900476Ratregion
5038896RH1273951891260001900260002089Ratregion
5026236RH1314372041259976525259976729Ratregion
5033397RH1386861361259974256259974392Ratregion
5031103BE1096821961259973238259973434Ratregion
5052361X846511991259908603259908802Ratregion
5057802BE1015771661259812363259812529Ratregion
5040768RH1284721951259668623259668818Ratregion
5045826RH1314012151260397898260398537Ratregion
5039404RH1276861851260225636260225821Ratregion
5042750RH1296241911260222013260222204Ratregion
5042750RH1296241911260222013260222204Ratregion
5074350RH1379661661259902256259902427Ratregion
5075834RH1388241311259969638259970922Ratregion
5076418RH1391641261260219003260219129Ratregion
5080002RH1413262191259903029259903248Ratregion
5079294RH1408982061259666491259666697Ratregion
5061788AW5335051501260305027260305177Ratregion
5068638AU0470242211260122572260122795Ratregion
5065974BE1163681531259665465259665618Ratregion
5503316UniSTS:2379881321259903266259903398Ratregion
5504895ha310315911259714867259716458Ratregion
5505895UniSTS:4960091031260212603260212706Ratregion
Position Markers

Flank 1: (D1Rat90)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21259,647,732 - 259,647,894 (+)MAPPER
Rnor_6.01281,795,624 - 281,795,785NCBI
Rnor_5.01289,137,107 - 289,137,268UniSTS
RGSC_v3.41267,110,926 - 267,111,087UniSTS
RGSC_v3.41267,110,921 - 267,111,153RGD
RGSC_v3.11267,322,011 - 267,322,172RGD
Celera1255,291,309 - 255,291,470UniSTS
RH 3.4 Map11708.8RGD
RH 3.4 Map11708.8UniSTS
RH 2.0 Map11313.1999RGD
SHRSP x BN Map1148.15RGD
Peak: (D1Mit8)
Rat AssemblyChrPosition (strand)Source
RGSC_v3.41257,363,489 - 257,363,728UniSTS
RGSC_v3.41257,363,488 - 257,363,728RGD
RGSC_v3.11257,629,405 - 257,629,644RGD
Celera1246,339,308 - 246,339,561UniSTS
RH 3.4 Map11655.8RGD
RH 2.0 Map11274.7999RGD
FHH x ACI Map1131.4099RGD
Cytogenetic Map1 RGD
Flank 2: (D1Mit7)
Rat AssemblyChrPosition (strand)Source
Rnor_5.01262,617,194 - 262,617,374NCBI
RGSC_v3.41240,980,142 - 240,980,321RGD
RGSC_v3.11241,163,531 - 241,163,920RGD
Cytogenetic Map1 RGD


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
71112Bw115Body weight QTL 11560.0001body mass (VT:0001259)body weight (CMO:0000012)1259647732260522016Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
737975Bw122Body weight QTL 1229.110.005body mass (VT:0001259)body weight (CMO:0000012)1258843780260122809Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat


Additional Information

Database Acc Id Source(s)
NCBI Gene Niddm13


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-21 Bw115  Body weight QTL 115  Niddm13  Non-insulin dependent diabetes mellitus QTL 13  Symbol updated 68687 APPROVED
2013-03-21 Bw115  Body weight QTL 115  Niddm13  Non-insulin dependent diabetes mellitus QTL 13  Name updated 68913 APPROVED
2005-04-04 Niddm13  Non-insulin dependent diabetes mellitus QTL 13  Dmo1  Diabetes Mellitus OLETF QTL 1  Data merged 737654 APPROVED

RGD Curation Notes
Note Type Note Reference
qtl_cross_type intercross  
qtl_disease affects lipid homeostasis, obesity control and glucose homeostasis 61072
qtl_general regulates the weight of adipose tissue, no effect on glucose level 619678
qtl_general also verifed by the congenic strain BN.OLETF-(D1Rat169-D1Rat90)/Got 619678