Fbxo32 (F-box protein 32) - Rat Genome Database

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Gene: Fbxo32 (F-box protein 32) Rattus norvegicus
Analyze
Symbol: Fbxo32
Name: F-box protein 32
RGD ID: 620373
Description: Predicted to enable ubiquitin-protein transferase activity. Involved in muscle atrophy; positive regulation of cardiac muscle cell apoptotic process; and regulation of muscle adaptation. Predicted to be located in Z disc; cytosol; and nucleoplasm. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Used to study muscular atrophy. Orthologous to human FBXO32 (F-box protein 32); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: atrogin-1; Atrogin1; atrophy gene 1; F-box only protein 32; MAFbx; muscle atrophy F-box protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8791,620,925 - 91,654,491 (-)NCBIGRCr8
mRatBN7.2789,731,428 - 89,764,997 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl789,730,232 - 89,765,436 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx791,607,526 - 91,640,897 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0793,808,794 - 93,842,166 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0793,639,384 - 93,672,680 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0798,065,664 - 98,098,071 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl798,063,735 - 98,098,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0798,669,144 - 98,701,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4794,909,568 - 94,942,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1794,943,797 - 94,976,674 (-)NCBI
Celera786,503,248 - 86,536,357 (-)NCBICelera
Cytogenetic Map7q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fbxo32Ratmuscular atrophy  IDA 633893 RGD 
Fbxo32Ratprimary pulmonary hypertension  ISORGD:734419329812002mRNA:increased expression:vastus lateralisRGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fbxo32Rattrichorhinophalangeal syndrome type I  ISORGD:7344198554872ClinVar Annotator: match by term: Trichorhinophalangeal dysplasia type IClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fbxo32Ratatrial fibrillation  ISORGD:73441911554173CTD Direct Evidence: marker/mechanismCTDPMID:29892015|PMID:30061737
Fbxo32Ratmuscular atrophy  ISORGD:73441911554173CTD Direct Evidence: marker/mechanismCTDPMID:21139329

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fbxo32Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of FBXO32 mRNA]CTDPMID:31150632
Fbxo32Rat(S)-(-)-perillyl alcohol increases expressionISORGD:7375526480464perillyl alcohol results in increased expression of FBXO32 mRNA; perillyl alcohol results in increased expression more ...CTDPMID:19406843
Fbxo32Rat1,2-dichloroethane decreases expressionISORGD:7375526480464ethylene dichloride results in decreased expression of FBXO32 mRNACTDPMID:28960355
Fbxo32Rat1,2-dimethylhydrazine decreases expressionISORGD:73755264804641,2-Dimethylhydrazine results in decreased expression of FBXO32 mRNACTDPMID:22206623
Fbxo32Rat17beta-estradiol increases expressionISORGD:7344196480464Estradiol results in increased expression of FBXO32 mRNACTDPMID:16474171
Fbxo32Rat17beta-estradiol decreases expressionISORGD:7344196480464Estradiol results in decreased expression of FBXO32 mRNACTDPMID:24758408|PMID:31614463
Fbxo32Rat17beta-estradiol multiple interactionsISORGD:7344196480464[Progesterone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with Estradiol] results in increased expression of more ...CTDPMID:23275455|PMID:24758408
Fbxo32Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:7344196480464Tetrachlorodibenzodioxin results in decreased expression of FBXO32 mRNACTDPMID:20106945
Fbxo32Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of FBXO32 mRNACTDPMID:33387578|PMID:34747641
Fbxo32Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:7344196480464Tetrachlorodibenzodioxin results in increased expression of FBXO32 mRNACTDPMID:30096437
Fbxo32Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:7375526480464Tetrachlorodibenzodioxin affects the expression of FBXO32 mRNACTDPMID:21570461
Fbxo32Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:7375526480464Tetrachlorodibenzodioxin results in increased expression of FBXO32 mRNACTDPMID:19933214
Fbxo32Rat2-butoxyethanol decreases expressionISORGD:7375526480464n-butoxyethanol results in decreased expression of FBXO32 mRNACTDPMID:19812364
Fbxo32Rat2-hydroxypropanoic acid decreases expressionISORGD:7344196480464Lactic Acid results in decreased expression of FBXO32 mRNACTDPMID:30851411
Fbxo32Rat2-trans,6-trans,10-trans-geranylgeranyl diphosphate multiple interactionsISORGD:7375526480464geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]; geranylgeranyl pyrophosphate more ...CTDPMID:19406843
Fbxo32Rat3,3',4,4',5-pentachlorobiphenyl decreases expressionEXP 64804643,4,5,3',4'-pentachlorobiphenyl results in decreased expression of FBXO32 mRNACTDPMID:23196670
Fbxo32Rat3,3',5,5'-tetrabromobisphenol A decreases expressionISORGD:7375526480464tetrabromobisphenol A results in decreased expression of FBXO32 mRNACTDPMID:25172293
Fbxo32Rat3,4-methylenedioxymethamphetamine increases expressionISORGD:7375526480464N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of FBXO32 mRNACTDPMID:20188158
Fbxo32Rat3-chloropropane-1,2-diol increases expressionEXP 6480464alpha-Chlorohydrin results in increased expression of FBXO32 mRNACTDPMID:28522335
Fbxo32Rat3-hydroxyisovaleric acid increases expressionEXP 6480464beta-hydroxyisovaleric acid results in increased expression of FBXO32 mRNACTDPMID:24124592

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Biological Process
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fbxo32Ratcellular response to dexamethasone stimulus acts_upstream_of_or_withinISORGD:7375521624291 PMID:23752591RGDPMID:23752591
Fbxo32Ratmuscle atrophy  IDA 633893 RGD 
Fbxo32Ratnegative regulation of cardiac muscle hypertrophy involved_inIMP 11079185PMID:24117217BHF-UCL 
Fbxo32Ratpositive regulation of cardiac muscle cell apoptotic process involved_inIGIUniProtKB:O8849811079185PMID:24117217BHF-UCL 
Fbxo32Ratpositive regulation of cardiac muscle cell apoptotic process involved_inIGIUniProtKB:G3V6Z411079185PMID:24117217BHF-UCL 
Fbxo32Ratprotein ubiquitination involved_inISORGD:7344191624291 PMID:26753747RGDPMID:26753747
Fbxo32Ratprotein ubiquitination involved_inIBAMGI:1914072|PANTHER:PTN002295006|UniProtKB:Q969P51600115GO_REF:0000033GO_CentralGO_REF:0000033
Fbxo32Ratprotein ubiquitination involved_inISSUniProtKB:Q969P51600115GO_REF:0000024UniProtGO_REF:0000024
Fbxo32Ratprotein ubiquitination involved_inIEAUniPathway:UPA001431600115GO_REF:0000041UniProtGO_REF:0000041
Fbxo32Ratresponse to denervation involved in regulation of muscle adaptation involved_inISSUniProtKB:Q9CPU71600115GO_REF:0000024UniProtGO_REF:0000024
Fbxo32Ratresponse to denervation involved in regulation of muscle adaptation involved_inISORGD:7375521624291 PMID:21465538RGDPMID:21465538
Fbxo32Ratresponse to electrical stimulus involved in regulation of muscle adaptation involved_inIDA 8553783PMID:21465538UniProt 
Fbxo32Ratubiquitin-dependent protein catabolic process  TAS 728366 RGD 
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Cellular Component
1 to 15 of 15 rows

  
Object Symbol
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Evidence
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Reference
Notes
Source
Original Reference(s)
Fbxo32Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Fbxo32Ratcytoplasm is_active_inIBAMGI:1914981|PANTHER:PTN002295006|UniProtKB:Q969P5|ZFIN:ZDB-GENE-040426-10401600115GO_REF:0000033GO_CentralGO_REF:0000033
Fbxo32Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Fbxo32Ratcytoplasm located_inISORGD:7344191624291 PMID:26768247RGDPMID:26768247
Fbxo32Ratcytoplasm located_inISSUniProtKB:Q969P51600115GO_REF:0000024UniProtGO_REF:0000024
Fbxo32Ratcytosol located_inISORGD:734419|UniProtKB:Q969P5-1|UniProtKB:Q969P5-21624291 RGDGO_REF:0000052
Fbxo32Ratnucleoplasm located_inISORGD:734419|UniProtKB:Q969P5-1|UniProtKB:Q969P5-21624291 RGDGO_REF:0000052
Fbxo32Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Fbxo32Ratnucleus located_inISORGD:7375521624291 PMID:21611832RGDPMID:21611832
Fbxo32Ratnucleus is_active_inIBAMGI:1914072|MGI:1914981|PANTHER:PTN002295006|UniProtKB:Q8TCJ0|UniProtKB:Q969P51600115GO_REF:0000033GO_CentralGO_REF:0000033
Fbxo32Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Fbxo32RatSCF ubiquitin ligase complex part_ofISORGD:7344191624291 PMID:26753747RGDPMID:26753747
Fbxo32RatSCF ubiquitin ligase complex part_ofIBAMGI:1914072|PANTHER:PTN002295006|UniProtKB:Q969P51600115GO_REF:0000033GO_CentralGO_REF:0000033
Fbxo32Ratubiquitin ligase complex part_ofNAS 11079185PMID:24117217BHF-UCL 
Fbxo32RatZ disc located_inISORGD:7375521624291 PMID:19850579RGDPMID:19850579
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Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fbxo32Ratprotein binding enablesISORGD:7344191624291UniProtKB:O00303 PMID:18354498RGDPMID:18354498
Fbxo32Ratprotein binding enablesISORGD:7375521624291UniProtKB:Q14896 PMID:19850579RGDPMID:19850579
Fbxo32Ratubiquitin-protein transferase activity  TAS 728366 RGD 


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Reference Title
Reference Citation
1. Skeletal muscle dysfunction in idiopathic pulmonary arterial hypertension. Batt J, etal., Am J Respir Cell Mol Biol. 2014 Jan;50(1):74-86. doi: 10.1165/rcmb.2012-0506OC.
2. Identification of ubiquitin ligases required for skeletal muscle atrophy. Bodine SC, etal., Science 2001 Nov 23;294(5547):1704-8.
3. Induction of MafBx and Murf ubiquitin ligase mRNAs in rat skeletal muscle after LPS injection. Dehoux MJ, etal., FEBS Lett 2003 Jun 5;544(1-3):214-7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle. Macpherson PC, etal., J Cell Biochem. 2011 Aug;112(8):2149-59. doi: 10.1002/jcb.23136.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. The miR-19a/b family positively regulates cardiomyocyte hypertrophy by targeting atrogin-1 and MuRF-1. Song DW, etal., Biochem J. 2014 Jan 1;457(1):151-62. doi: 10.1042/BJ20130833.
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PMID:15284206   PMID:15726428   PMID:16714087   PMID:16949134   PMID:17034040   PMID:17622304   PMID:17721978   PMID:17916612   PMID:18644837   PMID:19028597   PMID:19211729   PMID:19728616  
PMID:19777444   PMID:19803207   PMID:19850579   PMID:20191313   PMID:20349269   PMID:20371624   PMID:20519361   PMID:20555375   PMID:21611832   PMID:21617130   PMID:21691063   PMID:22146233  
PMID:22328594   PMID:22702057   PMID:22854904   PMID:23084640   PMID:23335977   PMID:23388481   PMID:23526547   PMID:23752591   PMID:23866982   PMID:24084216   PMID:25300705   PMID:26483344  
PMID:26691660   PMID:26753747   PMID:26768247   PMID:27521792   PMID:27841025   PMID:28000044   PMID:28246104   PMID:30312703   PMID:31311969   PMID:32646070  



Fbxo32
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8791,620,925 - 91,654,491 (-)NCBIGRCr8
mRatBN7.2789,731,428 - 89,764,997 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl789,730,232 - 89,765,436 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx791,607,526 - 91,640,897 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0793,808,794 - 93,842,166 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0793,639,384 - 93,672,680 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0798,065,664 - 98,098,071 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl798,063,735 - 98,098,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0798,669,144 - 98,701,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4794,909,568 - 94,942,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1794,943,797 - 94,976,674 (-)NCBI
Celera786,503,248 - 86,536,357 (-)NCBICelera
Cytogenetic Map7q33NCBI
FBXO32
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388123,497,889 - 123,541,206 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8123,497,889 - 123,541,206 (-)EnsemblGRCh38hg38GRCh38
GRCh378124,510,129 - 124,553,446 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368124,584,539 - 124,622,627 (-)NCBINCBI36Build 36hg18NCBI36
Build 348124,584,539 - 124,613,564NCBI
Celera8120,703,016 - 120,741,104 (-)NCBICelera
Cytogenetic Map8q24.13NCBI
HuRef8119,835,717 - 119,879,094 (-)NCBIHuRef
CHM1_18124,550,510 - 124,593,876 (-)NCBICHM1_1
T2T-CHM13v2.08124,628,980 - 124,672,309 (-)NCBIT2T-CHM13v2.0
Fbxo32
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391558,039,275 - 58,078,288 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1558,039,275 - 58,078,328 (-)EnsemblGRCm39 Ensembl
GRCm381558,175,879 - 58,214,892 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1558,175,879 - 58,214,932 (-)EnsemblGRCm38mm10GRCm38
MGSCv371558,011,634 - 58,046,433 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361558,010,162 - 58,044,957 (-)NCBIMGSCv36mm8
Celera1559,700,046 - 59,734,826 (-)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1524.43NCBI
Fbxo32
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555402,309,315 - 2,340,956 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555402,309,315 - 2,334,735 (-)NCBIChiLan1.0ChiLan1.0
FBXO32
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27140,929,665 - 140,973,569 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18116,440,872 - 116,484,172 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08120,192,822 - 120,236,116 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18122,948,853 - 122,992,157 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8122,954,343 - 122,992,157 (-)Ensemblpanpan1.1panPan2
FBXO32
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11321,804,442 - 21,838,157 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1321,809,292 - 21,838,169 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1321,770,175 - 21,803,891 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01322,146,431 - 22,178,526 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1322,148,672 - 22,178,548 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11321,873,240 - 21,906,944 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01321,975,418 - 22,009,111 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01322,218,984 - 22,252,700 (-)NCBIUU_Cfam_GSD_1.0
Fbxo32
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530316,460,677 - 16,496,758 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647023,886,970 - 23,918,258 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647023,886,836 - 23,919,063 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXO32
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl415,895,689 - 15,930,931 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1415,895,875 - 15,925,929 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2416,639,187 - 16,669,235 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FBXO32
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18118,071,856 - 118,115,761 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603922,118,961 - 22,162,524 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxo32
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473531,475,041 - 31,509,245 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473531,475,008 - 31,511,837 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Fbxo32
162 total Variants

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:65
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000010361
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat

1 to 10 of 43 rows
D7Uwm16  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2789,740,273 - 89,740,457 (+)MAPPERmRatBN7.2
Rnor_6.0798,074,313 - 98,074,496NCBIRnor6.0
Rnor_5.0798,677,793 - 98,677,976UniSTSRnor5.0
RGSC_v3.4794,918,218 - 94,918,401UniSTSRGSC3.4
RGSC_v3.4794,918,217 - 94,918,401RGDRGSC3.4
RGSC_v3.1794,952,447 - 94,952,631RGD
Celera786,511,895 - 86,512,068UniSTS
Cytogenetic Map7q33UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000010361   ⟹   ENSRNOP00000010361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl789,730,232 - 89,765,436 (-)Ensembl
Rnor_6.0 Ensembl798,063,735 - 98,098,268 (-)Ensembl
RefSeq Acc Id: NM_133521   ⟹   NP_598205
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8791,620,925 - 91,654,491 (-)NCBI
mRatBN7.2789,731,428 - 89,764,997 (-)NCBI
Rnor_6.0798,065,664 - 98,098,071 (-)NCBI
Rnor_5.0798,669,144 - 98,701,551 (-)NCBI
RGSC_v3.4794,909,568 - 94,942,444 (-)RGD
Celera786,503,248 - 86,536,357 (-)RGD
Sequence:
Protein RefSeqs NP_598205 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL16406 (Get FASTA)   NCBI Sequence Viewer  
  EDM16222 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000104530
GenBank Protein Q91Z62 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_598205   ⟸   NM_133521
- UniProtKB: Q91Z62 (UniProtKB/Swiss-Prot),   G3V6Z4 (UniProtKB/TrEMBL),   A6HRK0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010361   ⟸   ENSRNOT00000010361
F-box

Name Modeler Protein Id AA Range Protein Structure
AF-Q91Z62-F1-model_v2 AlphaFold Q91Z62 1-350 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695348
Promoter ID:EPDNEW_R5872
Type:multiple initiation site
Name:Fbxo32_1
Description:F-box protein 32
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0798,098,307 - 98,098,367EPDNEW


1 to 17 of 17 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-33323 BioCyc
Ensembl Genes ENSRNOG00000006738 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000130982 ENTREZGENE
Gene3D-CATH 1.20.1280.50 UniProtKB/Swiss-Prot
InterPro F-box-like_dom_sf UniProtKB/Swiss-Prot
  FBX25/32 UniProtKB/Swiss-Prot
KEGG Report rno:171043 UniProtKB/Swiss-Prot
NCBI Gene 171043 ENTREZGENE
PANTHER F-BOX ONLY PROTEIN 32 UniProtKB/Swiss-Prot
  PTHR13123 UniProtKB/Swiss-Prot
PhenoGen Fbxo32 PhenoGen
RatGTEx ENSRNOG00000006738 RatGTEx
Superfamily-SCOP SSF81383 UniProtKB/Swiss-Prot
UniProt A6HRK0 ENTREZGENE, UniProtKB/TrEMBL
  FBX32_RAT UniProtKB/Swiss-Prot
  G3V6Z4 ENTREZGENE, UniProtKB/TrEMBL
  Q91Z62 ENTREZGENE
1 to 17 of 17 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Fbxo32  F-box protein 32  Fbxo32  F-box only protein 32  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Fbxo32  F-box only protein 32    f-box only protein 32  Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Fbxo32  f-box only protein 32      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_disease displays increased mRNA expression in denervation, immobilization, and hindlimb suspension models of muscle atrophy 633893