RGD Reference Report - Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle. - Rat Genome Database

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Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle.

Authors: Macpherson, PC  Wang, X  Goldman, D 
Citation: Macpherson PC, etal., J Cell Biochem. 2011 Aug;112(8):2149-59. doi: 10.1002/jcb.23136.
RGD ID: 8553783
Pubmed: PMID:21465538   (View Abstract at PubMed)
PMCID: PMC3135771   (View Article at PubMed Central)
DOI: DOI:10.1002/jcb.23136   (Journal Full-text)

Muscle inactivity due to injury or disease results in muscle atrophy. The molecular mechanisms contributing to muscle atrophy are poorly understood. However, it is clear that expression of atrophy-related genes, like Atrogin-1 and MuRF-1, are intimately tied to loss of muscle mass. When these atrophy-related genes are knocked out, inactive muscles retain mass. Muscle denervation stimulates muscle atrophy and Myogenin (Myog) is a muscle-specific transcription factor that is highly induced following muscle denervation. To investigate if Myog contributes to muscle atrophy, we have taken advantage of conditional Myog null mice. We show that in the denervated soleus muscle Myog expression contributes to reduced muscle force, mass, and cross-sectional area. We found that Myog mediates these effects, at least in part, by regulating expression of the Atrogin-1 and MuRF-1 genes. Indeed Myog over-expression in innervated muscle stimulates Atrogin-1 gene expression and Myog over-expression stimulates Atrogin-1 promoter activity. Thus, Myog and the signaling cascades regulating its induction following muscle denervation may represent novel targets for therapies aimed at reducing denervation-induced muscle atrophy.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to electrical stimulus involved in regulation of muscle adaptation involved_inIDA 8553783; 8553783; 8553783PMID:21465538UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Fbxo32  (F-box protein 32)
Myog  (myogenin)
Trim63  (tripartite motif containing 63)


Additional Information