(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of HSF1 mRNA] CTD PMID:31150632 (20S)-ginsenoside Rg3 multiple interactions ISO RGD:730995 6480464 ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of HSF1 protein] CTD PMID:26427350 (20S)-ginsenoside Rg3 decreases expression ISO RGD:730995 6480464 ginsenoside Rg3 results in decreased expression of HSF1 protein CTD PMID:26427350 (R)-adrenaline multiple interactions EXP 6480464 Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein] CTD PMID:19135123 (R)-adrenaline affects localization EXP 6480464 Epinephrine affects the localization of HSF1 protein CTD PMID:19135123 (Z)-ligustilide affects localization EXP 6480464 ligustilide affects the localization of HSF1 protein CTD PMID:26212861 1,3,5-trinitro-1,3,5-triazinane increases expression EXP 6480464 cyclonite results in increased expression of HSF1 mRNA CTD PMID:25559034 15-deoxy-Delta(12,14)-prostaglandin J2 multiple interactions ISO RGD:730995 6480464 HSF1 protein inhibits the reaction [15-deoxy-delta(12, 14)-prostaglandin J2 results in increased expression of HMOX1 mRNA] CTD PMID:15618017 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of HSF1 mRNA CTD PMID:16940010 17beta-estradiol increases expression ISO RGD:730996 6480464 Estradiol results in increased expression of HSF1 mRNA CTD PMID:12927369 17beta-estradiol multiple interactions ISO RGD:730996 6480464 fulvestrant inhibits the reaction [Estradiol results in increased expression of HSF1 mRNA] CTD PMID:12927369 2,2',4,4'-Tetrabromodiphenyl ether affects expression ISO RGD:730996 6480464 2 more ... CTD PMID:24680724 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:730996 6480464 Tetrachlorodibenzodioxin affects the expression of HSF1 mRNA CTD PMID:21570461 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:730995 6480464 Tetrachlorodibenzodioxin results in decreased expression of HSF1 mRNA CTD PMID:16039398 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of HSF1 mRNA CTD PMID:21215274 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of HSF1 mRNA CTD PMID:21346803 2-nitrofluorene increases expression EXP 6480464 2-nitrofluorene results in increased expression of HSF1 mRNA CTD PMID:15890375 2-tert-butylhydroquinone increases expression ISO RGD:730995 6480464 2-tert-butylhydroquinone results in increased expression of HSF1 mRNA CTD PMID:30309986 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression EXP 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HSF1 mRNA CTD PMID:15890375 7H-xanthine multiple interactions EXP 6480464 [Xanthine co-treated with XDH protein] affects the localization of HSF1 protein, Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein] CTD PMID:19135123 9H-xanthine multiple interactions EXP 6480464 [Xanthine co-treated with XDH protein] affects the localization of HSF1 protein, Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein] CTD PMID:19135123 acetylsalicylic acid increases activity ISO RGD:730995 6480464 Aspirin results in increased activity of HSF1 protein CTD PMID:10328874 acrylamide increases phosphorylation ISO RGD:730995 6480464 Acrylamide results in increased phosphorylation of HSF1 protein CTD PMID:16129430 actinomycin D multiple interactions ISO RGD:730995 6480464 Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of HSF1 mRNA], Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of HSF1 protein] CTD PMID:30309986 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of HSF1 mRNA CTD PMID:15890375 aflatoxin B1 decreases methylation ISO RGD:730995 6480464 Aflatoxin B1 results in decreased methylation of HSF1 intron CTD PMID:30157460 aflatoxin B1 increases expression ISO RGD:730996 6480464 Aflatoxin B1 results in increased expression of HSF1 mRNA CTD PMID:19770486 all-trans-retinoic acid multiple interactions ISO RGD:730995 6480464 HSF1 protein affects the reaction [Tretinoin inhibits the reaction [sodium arsenite results in increased expression of ATG7 protein]], Tretinoin inhibits the reaction [sodium arsenite results in increased expression of HSF1 protein] CTD PMID:30309986 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of HSF1 mRNA CTD PMID:16483693 amphibole asbestos increases expression ISO RGD:730995 6480464 Asbestos, Amphibole results in increased expression of HSF1 protein CTD PMID:20855422 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:730995 6480464 pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased phosphorylation of HSF1 protein] CTD PMID:15978632 arsenite(3-) multiple interactions EXP 6480464 [arsenite co-treated with Curcumin] results in increased phosphorylation of HSF1 protein CTD PMID:9764755 arsenite(3-) multiple interactions ISO RGD:730996 6480464 HSF1 protein affects the reaction [arsenite results in increased expression of HSPA1B mRNA] more ... CTD PMID:20835880 arsenite(3-) increases expression ISO RGD:730996 6480464 arsenite results in increased expression of HSF1 protein CTD PMID:20835880 arsenite(3-) increases activity ISO RGD:730996 6480464 arsenite results in increased activity of HSF1 protein CTD PMID:20835880 arsenite(3-) affects localization ISO RGD:730996 6480464 arsenite affects the localization of HSF1 protein CTD PMID:20835880 arsenite(3-) increases phosphorylation EXP 6480464 arsenite results in increased phosphorylation of HSF1 protein CTD PMID:9764755 arsenous acid affects response to substance ISO RGD:730995 6480464 HSF1 protein affects the susceptibility to Arsenic Trioxide CTD PMID:20724260 arsenous acid increases phosphorylation ISO RGD:730995 6480464 Arsenic Trioxide results in increased phosphorylation of HSF1 protein CTD PMID:15978632 arsenous acid multiple interactions ISO RGD:730995 6480464 MAP2K4 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of HSF1 protein], pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of HSF1 protein] CTD PMID:15978632 Aurin affects localization ISO RGD:730995 6480464 aurin affects the localization of HSF1 protein CTD PMID:25477506 benzene increases expression ISO RGD:730996 6480464 Benzene results in increased expression of HSF1 mRNA CTD PMID:15050406 benzo[a]pyrene increases expression ISO RGD:730996 6480464 Benzo(a)pyrene results in increased expression of HSF1 mRNA CTD PMID:22228805 benzo[a]pyrene affects methylation ISO RGD:730995 6480464 Benzo(a)pyrene affects the methylation of HSF1 intron CTD PMID:30157460 benzo[a]pyrene affects activity ISO RGD:730995 6480464 Benzo(a)pyrene affects the activity of HSF1 protein CTD PMID:20624995 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of HSF1 protein CTD PMID:21467743 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of HSF1 mRNA CTD PMID:25181051 bisphenol A affects expression ISO RGD:730995 6480464 bisphenol A affects the expression of HSF1 mRNA CTD PMID:30903817 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of HSF1 gene CTD PMID:28505145 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of HSF1 mRNA CTD PMID:30816183 bortezomib increases expression ISO RGD:730995 6480464 Bortezomib results in increased expression of HSF1 mRNA CTD PMID:17895889 bortezomib multiple interactions ISO RGD:730995 6480464 Bortezomib promotes the reaction [HSF1 protein binds to HSPA1A promoter] CTD PMID:23874968 cadmium atom multiple interactions ISO RGD:730996 6480464 HSF1 protein affects the reaction [Cadmium results in increased expression of HSPA1B protein] CTD PMID:16282982 cadmium atom increases activity ISO RGD:730995 6480464 Cadmium results in increased activity of HSF1 protein CTD PMID:16460681 , PMID:17244614 cadmium atom multiple interactions ISO RGD:730995 6480464 Cadmium promotes the reaction [HSF1 protein binds to HMOX1 promoter] more ... CTD PMID:16460681 , PMID:17244614 cadmium atom increases activity ISO RGD:730996 6480464 Cadmium results in increased activity of HSF1 protein CTD PMID:16282982 cadmium dichloride increases phosphorylation ISO RGD:730996 6480464 Cadmium Chloride results in increased phosphorylation of HSF1 protein CTD PMID:18348256 cadmium dichloride decreases expression ISO RGD:730996 6480464 Cadmium Chloride results in decreased expression of HSF1 mRNA CTD PMID:30213552 cadmium dichloride increases phosphorylation EXP 6480464 Cadmium Chloride results in increased phosphorylation of HSF1 protein CTD PMID:9822662 cadmium dichloride multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of HSF1 protein], SB 203580 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of HSF1 protein] CTD PMID:9822662 cadmium dichloride increases expression ISO RGD:730995 6480464 Cadmium Chloride results in increased expression of HSF1 mRNA CTD PMID:12160620 cadmium dichloride decreases phosphorylation ISO RGD:730995 6480464 Cadmium Chloride results in decreased phosphorylation of HSF1 protein CTD PMID:24412756 cadmium dichloride decreases activity ISO RGD:730995 6480464 Cadmium Chloride results in decreased activity of HSF1 protein CTD PMID:10403520 cadmium dichloride decreases expression ISO RGD:730995 6480464 Cadmium Chloride results in decreased expression of HSF1 mRNA CTD PMID:19426795 cadmium dichloride multiple interactions ISO RGD:730995 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased activity of HSF1 protein] more ... CTD PMID:10403520 more ... cadmium dichloride multiple interactions ISO RGD:730996 6480464 [MAP2K4 co-treated with MAP2K7] affects the reaction [Cadmium Chloride results in increased phosphorylation of HSF1 protein] more ... CTD PMID:18348256 , PMID:30213552 cadmium sulfate multiple interactions ISO RGD:730995 6480464 cadmium sulfate promotes the reaction [HSF1 protein binds to HMOX1 promoter] more ... CTD PMID:16460681 , PMID:17244614 cadmium sulfate increases activity ISO RGD:730995 6480464 cadmium sulfate results in increased activity of HSF1 protein CTD PMID:16460681 , PMID:17244614 Calcimycin affects phosphorylation ISO RGD:730995 6480464 Calcimycin affects the phosphorylation of HSF1 protein CTD PMID:8663271 capsaicin increases expression EXP 6480464 Capsaicin results in increased expression of HSF1 mRNA CTD PMID:24746025 carbonyl cyanide p-trifluoromethoxyphenylhydrazone decreases expression ISO RGD:730995 6480464 Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HSF1 mRNA CTD PMID:16039398 celastrol multiple interactions EXP 6480464 tripterine results in increased phosphorylation of and affects the localization of HSF1 protein CTD PMID:25903958 cobalt atom multiple interactions ISO RGD:730996 6480464 [Cobalt co-treated with Organometallic Compounds] results in increased expression of HSF1 mRNA CTD PMID:22147119 cobalt dichloride increases expression ISO RGD:730995 6480464 cobaltous chloride results in increased expression of HSF1 mRNA CTD PMID:19376846 cocaine affects expression EXP 6480464 Cocaine affects the expression of HSF1 mRNA CTD PMID:20187946 curcumin multiple interactions EXP 6480464 [arsenite co-treated with Curcumin] results in increased phosphorylation of HSF1 protein CTD PMID:9764755 curcumin multiple interactions ISO RGD:730995 6480464 Curcumin promotes the reaction [HSF1 protein binds to HSF1 protein] CTD PMID:11322385 cyclosporin A increases expression ISO RGD:730995 6480464 Cyclosporine results in increased expression of HSF1 mRNA CTD PMID:20106945 , PMID:25562108 cylindrospermopsin increases expression ISO RGD:730995 6480464 cylindrospermopsin results in increased expression of HSF1 mRNA CTD PMID:24921660 dexamethasone decreases activity ISO RGD:730996 6480464 Dexamethasone results in decreased activity of HSF1 protein CTD PMID:14673132 dexamethasone multiple interactions ISO RGD:730996 6480464 Mifepristone inhibits the reaction [Dexamethasone results in decreased activity of HSF1 protein] CTD PMID:14673132 diarsenic trioxide affects response to substance ISO RGD:730995 6480464 HSF1 protein affects the susceptibility to Arsenic Trioxide CTD PMID:20724260 diarsenic trioxide multiple interactions ISO RGD:730995 6480464 MAP2K4 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of HSF1 protein], pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of HSF1 protein] CTD PMID:15978632 diarsenic trioxide increases phosphorylation ISO RGD:730995 6480464 Arsenic Trioxide results in increased phosphorylation of HSF1 protein CTD PMID:15978632 dibutyl phthalate decreases expression ISO RGD:730996 6480464 Dibutyl Phthalate results in decreased expression of HSF1 mRNA CTD PMID:17361019 dicrotophos increases expression ISO RGD:730995 6480464 dicrotophos results in increased expression of HSF1 mRNA CTD PMID:28302478 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of HSF1 mRNA CTD PMID:15890375 dioxygen multiple interactions ISO RGD:730995 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA] more ... CTD PMID:11424089 dioxygen increases expression ISO RGD:730995 6480464 Oxygen deficiency results in increased expression of HSF1 mRNA CTD PMID:11424089 disodium selenite increases expression ISO RGD:730995 6480464 Sodium Selenite results in increased expression of HSF1 mRNA CTD PMID:18175754 doxorubicin multiple interactions ISO RGD:730996 6480464 HSF1 protein affects the reaction [Doxorubicin promotes the reaction [TRP53 protein binds to HSPB1 protein modified form]] more ... CTD PMID:20363884 doxorubicin decreases expression ISO RGD:730995 6480464 Doxorubicin results in decreased expression of HSF1 mRNA CTD PMID:29803840 doxorubicin affects response to substance ISO RGD:730996 6480464 HSF1 protein affects the susceptibility to Doxorubicin CTD PMID:20363884 ethanol multiple interactions ISO RGD:730996 6480464 HSF1 protein affects the reaction [Ethanol results in increased expression of HSP90AA1 mRNA] more ... CTD PMID:17189318 ethanol affects response to substance ISO RGD:730996 6480464 HSF1 protein affects the susceptibility to Ethanol CTD PMID:17189318 fenofibrate multiple interactions EXP 6480464 [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of HSF1 mRNA CTD PMID:18253720 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of HSF1 mRNA CTD PMID:18035473 fulvestrant multiple interactions ISO RGD:730996 6480464 fulvestrant inhibits the reaction [Estradiol results in increased expression of HSF1 mRNA] CTD PMID:12927369 geldanamycin multiple interactions ISO RGD:730995 6480464 geldanamycin inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]], geldanamycin results in increased phosphorylation of and results in increased activity of HSF1 protein CTD PMID:10632574 , PMID:25645596 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of HSF1 protein CTD PMID:21081137 gentamycin affects response to substance ISO RGD:730996 6480464 HSF1 protein affects the susceptibility to Gentamicins CTD PMID:18512096 gold atom multiple interactions ISO RGD:730995 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of HSF1 mRNA CTD PMID:28433809 gold(0) multiple interactions ISO RGD:730995 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of HSF1 mRNA CTD PMID:28433809 homocysteic acid decreases expression EXP 6480464 homocysteic acid results in decreased expression of HSF1 protein CTD PMID:24478344 hydrogen chloride affects response to substance ISO RGD:730996 6480464 HSF1 protein affects the susceptibility to Hydrochloric Acid CTD PMID:17189318 hydrogen peroxide multiple interactions EXP 6480464 HSF1 protein inhibits the reaction [Hydrogen Peroxide affects the localization of HMGB1 protein], HSF1 protein inhibits the reaction [Hydrogen Peroxide results in increased expression of and results in increased secretion of HMGB1 protein] CTD PMID:22246807 hydrogen peroxide increases expression ISO RGD:730995 6480464 Hydrogen Peroxide results in increased expression of HSF1 mRNA, Hydrogen Peroxide results in increased expression of HSF1 protein CTD PMID:19401454 , PMID:30309986 ibuprofen increases activity ISO RGD:730995 6480464 Ibuprofen results in increased activity of HSF1 protein CTD PMID:10328874 indometacin increases activity ISO RGD:730996 6480464 Indomethacin results in increased activity of HSF1 protein CTD PMID:14706622 indometacin increases activity ISO RGD:730995 6480464 Indomethacin results in increased activity of HSF1 protein CTD PMID:10701834 , PMID:12065054 lactacystin increases activity ISO RGD:730995 6480464 lactacystin results in increased activity of HSF1 protein CTD PMID:11893605 lead diacetate increases expression ISO RGD:730996 6480464 lead acetate results in increased expression of HSF1 mRNA CTD PMID:21829687 linalool increases expression ISO RGD:730995 6480464 linalool results in increased expression of HSF1 mRNA CTD PMID:19922762 LY294002 multiple interactions ISO RGD:730995 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [squamosamide results in increased expression of HSF1 protein modified form] CTD PMID:11424089 , PMID:21295016 maneb multiple interactions ISO RGD:730996 6480464 [Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA more ... CTD PMID:23963992 melatonin multiple interactions ISO RGD:730996 6480464 Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA] CTD PMID:23963992 mercury atom multiple interactions ISO RGD:730995 6480464 Mercury promotes the reaction [HSF1 protein binds to HMOX1 promoter], Mercury promotes the reaction [HSF1 protein binds to HSPA1A promoter] CTD PMID:17244614 mercury atom increases activity ISO RGD:730995 6480464 Mercury results in increased activity of HSF1 protein CTD PMID:17244614 mercury dichloride multiple interactions ISO RGD:730995 6480464 Mercuric Chloride promotes the reaction [HSF1 protein binds to HMOX1 promoter], Mercuric Chloride promotes the reaction [HSF1 protein binds to HSPA1A promoter] CTD PMID:17244614 mercury dichloride increases activity ISO RGD:730995 6480464 Mercuric Chloride results in increased activity of HSF1 protein CTD PMID:17244614 mercury(0) increases activity ISO RGD:730995 6480464 Mercury results in increased activity of HSF1 protein CTD PMID:17244614 mercury(0) multiple interactions ISO RGD:730995 6480464 Mercury promotes the reaction [HSF1 protein binds to HMOX1 promoter], Mercury promotes the reaction [HSF1 protein binds to HSPA1A promoter] CTD PMID:17244614 methapyrilene increases expression EXP 6480464 Methapyrilene results in increased expression of HSF1 mRNA CTD PMID:15890375 mifepristone multiple interactions ISO RGD:730996 6480464 Mifepristone inhibits the reaction [Dexamethasone results in decreased activity of HSF1 protein] CTD PMID:14673132 N-acetyl-L-cysteine multiple interactions ISO RGD:730995 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased activity of HSF1 protein] more ... CTD PMID:10403520 more ... N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases activity ISO RGD:730995 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of HSF1 protein CTD PMID:11893605 N-ethyl-N-nitrosourea increases mutagenesis ISO RGD:730996 6480464 Ethylnitrosourea results in increased mutagenesis of HSF1 3' UTR CTD PMID:27776689 N-nitrosodiethylamine multiple interactions EXP 6480464 [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of HSF1 mRNA CTD PMID:18253720 N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of HSF1 mRNA CTD PMID:15890375 nickel sulfate increases expression ISO RGD:730995 6480464 nickel sulfate results in increased expression of HSF1 mRNA CTD PMID:18651567 paracetamol increases expression ISO RGD:730995 6480464 Acetaminophen results in increased expression of HSF1 mRNA CTD PMID:22230336 paraquat multiple interactions ISO RGD:730996 6480464 [Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA more ... CTD PMID:23963992 piperonyl butoxide increases expression EXP 6480464 Piperonyl Butoxide results in increased expression of HSF1 mRNA CTD PMID:15890375 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of HSF1 mRNA CTD PMID:15890375 pirinixic acid increases expression ISO RGD:730996 6480464 pirinixic acid results in increased expression of HSF1 mRNA CTD PMID:18445702 pyocyanine increases activity EXP 6480464 Pyocyanine results in increased activity of HSF1 protein CTD PMID:27613716 quercetin increases response to substance ISO RGD:730995 6480464 HSF1 protein results in increased susceptibility to Quercetin CTD PMID:27041924 quercetin multiple interactions ISO RGD:730995 6480464 Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA], Quercetin inhibits the reaction [squamosamide results in increased expression of HSF1 protein modified form] CTD PMID:11424089 , PMID:21295016 quercetin decreases expression ISO RGD:730996 6480464 Quercetin results in decreased expression of HSF1 CTD PMID:16579653 quercetin decreases expression ISO RGD:730995 6480464 Quercetin results in decreased expression of HSF1 protein CTD PMID:27041924 resveratrol multiple interactions ISO RGD:730995 6480464 [resveratrol results in decreased phosphorylation of GSK3B protein] which results in decreased expression of HSF1 mRNA more ... CTD PMID:18429957 more ... rivastigmine increases activity ISO RGD:730995 6480464 Rivastigmine results in increased activity of HSF1 protein CTD PMID:19218096 rotenone increases expression ISO RGD:730995 6480464 Rotenone results in increased expression of HSF1 mRNA CTD PMID:29955902 SB 203580 multiple interactions EXP 6480464 SB 203580 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of HSF1 protein] CTD PMID:9822662 silver atom increases activity ISO RGD:730995 6480464 Silver results in increased activity of HSF1 protein CTD PMID:16460681 , PMID:17244614 silver atom multiple interactions ISO RGD:730995 6480464 Silver promotes the reaction [HSF1 protein binds to HMOX1 promoter] more ... CTD PMID:16460681 , PMID:17244614 silver(0) multiple interactions ISO RGD:730995 6480464 Silver promotes the reaction [HSF1 protein binds to HMOX1 promoter] more ... CTD PMID:16460681 , PMID:17244614 silver(0) increases activity ISO RGD:730995 6480464 Silver results in increased activity of HSF1 protein CTD PMID:16460681 , PMID:17244614 silver(1+) nitrate multiple interactions ISO RGD:730995 6480464 Silver Nitrate promotes the reaction [HSF1 protein binds to HMOX1 promoter] more ... CTD PMID:16460681 , PMID:17244614 silver(1+) nitrate increases activity ISO RGD:730995 6480464 Silver Nitrate results in increased activity of HSF1 protein CTD PMID:16460681 , PMID:17244614 simvastatin affects localization ISO RGD:730995 6480464 Simvastatin affects the localization of HSF1 protein CTD PMID:16375908 sodium arsenite multiple interactions ISO RGD:730995 6480464 Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [NFE2L2 protein binds to HSF1 promoter]] more ... CTD PMID:11322385 more ... sodium arsenite increases expression ISO RGD:730995 6480464 sodium arsenite results in increased expression of HSF1 mRNA, sodium arsenite results in increased expression of HSF1 protein CTD PMID:30309986 sodium arsenite increases activity ISO RGD:730996 6480464 sodium arsenite results in increased activity of HSF1 protein CTD PMID:15327774 , PMID:16447264 sodium arsenite increases expression ISO RGD:730996 6480464 sodium arsenite results in increased expression of HSF1 mRNA CTD PMID:16014739 sodium arsenite decreases phosphorylation ISO RGD:730995 6480464 sodium arsenite results in decreased phosphorylation of HSF1 protein CTD PMID:24412756 sodium arsenite multiple interactions ISO RGD:730996 6480464 HSF1 protein affects the reaction [sodium arsenite results in increased expression of HSPA1A protein] more ... CTD PMID:20566634 Sodium salicylate increases activity ISO RGD:730995 6480464 Sodium Salicylate results in increased activity of HSF1 protein CTD PMID:10328874 solanesol multiple interactions ISO RGD:730995 6480464 2-phenylacetylenesulfonamide inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]] more ... CTD PMID:25645596 solanesol affects localization ISO RGD:730995 6480464 solanesol affects the localization of HSF1 protein CTD PMID:25645596 sulindac increases activity ISO RGD:730995 6480464 Sulindac results in increased activity of HSF1 protein CTD PMID:10328874 sunitinib increases expression ISO RGD:730995 6480464 Sunitinib results in increased expression of HSF1 mRNA CTD PMID:31533062 tanespimycin affects localization ISO RGD:730995 6480464 tanespimycin affects the localization of HSF1 protein CTD PMID:20090934 tanespimycin multiple interactions ISO RGD:730995 6480464 [tanespimycin affects the localization of HSF1 protein] which results in increased expression of HSPA1A protein CTD PMID:20090934 teprenone affects response to substance ISO RGD:730996 6480464 HSF1 protein affects the susceptibility to geranylgeranylacetone CTD PMID:17189318 teprenone increases expression ISO RGD:730996 6480464 geranylgeranylacetone results in increased expression of HSF1 protein CTD PMID:21232033 teprenone multiple interactions ISO RGD:730996 6480464 geranylgeranylacetone promotes the reaction [[HSF1 protein binds to DLG1 promoter] which results in increased expression of DLG1 mRNA] CTD PMID:21232033 tetrachloroethene decreases expression ISO RGD:730996 6480464 Tetrachloroethylene results in decreased expression of HSF1 mRNA CTD PMID:28973375 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of HSF1 mRNA] CTD PMID:31150632 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of HSF1 mRNA CTD PMID:31150632 thalidomide decreases expression ISO RGD:730996 6480464 Thalidomide results in decreased expression of HSF1 mRNA CTD PMID:26006729 , PMID:26217789 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of HSF1 mRNA CTD PMID:23411599 thiopental increases activity ISO RGD:730995 6480464 Thiopental results in increased activity of HSF1 protein CTD PMID:18218830 thiopental increases phosphorylation ISO RGD:730995 6480464 Thiopental results in increased phosphorylation of HSF1 protein CTD PMID:18218830 valproic acid decreases expression ISO RGD:730996 6480464 Valproic Acid results in decreased expression of HSF1 mRNA CTD PMID:21427059 valproic acid increases methylation ISO RGD:730995 6480464 Valproic Acid results in increased methylation of HSF1 gene CTD PMID:29154799 valproic acid affects expression ISO RGD:730996 6480464 Valproic Acid affects the expression of HSF1 mRNA CTD PMID:17292431 wortmannin affects localization ISO RGD:730995 6480464 wortmannin affects the localization of HSF1 protein CTD PMID:20090934 wortmannin multiple interactions ISO RGD:730995 6480464 wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA] CTD PMID:11424089 zinc atom increases activity ISO RGD:730995 6480464 Zinc deficiency results in increased activity of HSF1 protein, Zinc results in increased activity of HSF1 protein CTD PMID:16460681 more ... zinc atom multiple interactions ISO RGD:730995 6480464 Zinc promotes the reaction [HSF1 protein binds to HMOX1 promoter] more ... CTD PMID:16460681 , PMID:17244614 zinc pyrithione increases expression ISO RGD:730995 6480464 pyrithione zinc results in increased expression of HSF1 mRNA CTD PMID:21424779 zinc sulfate multiple interactions ISO RGD:730995 6480464 Zinc Sulfate promotes the reaction [HSF1 protein binds to HMOX1 promoter] more ... CTD PMID:16460681 , PMID:17244614 zinc sulfate increases activity ISO RGD:730995 6480464 Zinc Sulfate results in increased activity of HSF1 protein CTD PMID:16460681 , PMID:17244614 zinc(0) increases activity ISO RGD:730995 6480464 Zinc deficiency results in increased activity of HSF1 protein, Zinc results in increased activity of HSF1 protein CTD PMID:16460681 more ... zinc(0) multiple interactions ISO RGD:730995 6480464 Zinc promotes the reaction [HSF1 protein binds to HMOX1 promoter] more ... CTD PMID:16460681 , PMID:17244614
Biological Process cellular protein-containing complex assembly ISO RGD:730995 1624291 (PMID:11583998) RGD PMID:11583998 cellular response to amino acid stimulus IEP 10402566 homocysteic acid RGD cellular response to amino acid stimulus IDA 10402944 glutamine, ornithine RGD cellular response to angiotensin IDA 10402547 RGD cellular response to cadmium ion ISO RGD:730995 1624291 (PMID:10359787), (PMID:11514557), (PMID:15016915), (PMID:25963659) RGD PMID:10359787 more ... cellular response to copper ion ISO RGD:730995 1624291 (PMID:15016915) RGD PMID:15016915 cellular response to diamide ISO RGD:730995 1624291 (PMID:15016915) RGD PMID:15016915 cellular response to drug IEP 10402816 amlodipine besylate, amlodipine camsylate RGD cellular response to estradiol stimulus IDA 10403030 RGD cellular response to gamma radiation ISO RGD:730995 1624291 (PMID:26359349) RGD PMID:26359349 cellular response to heat ISO RGD:730995 1624291 (PMID:10359787), (PMID:10413683), (PMID:10747973), (PMID:11514557), (PMID:11583998), (PMID:12917326), (PMID:14707147), (PMID:16554823), (PMID:17897941), (PMID:21085490), (PMID:26159920), (PMID:7935471), (PMID:8455624), (PMID:9222587), (PMID:9341107), (PMID:9727490) RGD PMID:10359787 more ... cellular response to heat IMP 10402942 RGD cellular response to hydrogen peroxide IMP 10402789 RGD cellular response to L-glutamine IEP 10450472 ; 10450473 RGD cellular response to lipopolysaccharide IEP 10402943 RGD cellular response to nitroglycerin IEP 10402400 RGD cellular response to organic cyclic compound IDA 10402388 Z-ligustilide RGD cellular response to potassium ion IEP 10402566 RGD cellular response to radiation IDA 10403031 microwave RGD cellular response to sodium arsenite ISO RGD:730995 1624291 (PMID:15016915) RGD PMID:15016915 cellular response to unfolded protein ISO RGD:730995 1624291 (PMID:15016915) RGD PMID:15016915 defense response IDA 625374 RGD embryonic placenta development ISO RGD:730996 1624291 MGI:MGI:2155444 (MGI:MGI:1347429 , PMID:10545106) RGD MGI:MGI:1347429 , PMID:10545106 embryonic process involved in female pregnancy ISO RGD:730996 1624291 MGI:MGI:2155444 (MGI:MGI:1347429 , PMID:10545106) RGD MGI:MGI:1347429 , PMID:10545106 female meiotic nuclear division ISO RGD:730996 1624291 MGI:MGI:2155444 (MGI:MGI:5142351 , PMID:21690297) RGD MGI:MGI:5142351 , PMID:21690297 in utero embryonic development ISO RGD:730996 1624291 MGI:MGI:2155444 (MGI:MGI:1347429 , PMID:10545106) RGD MGI:MGI:1347429 , PMID:10545106 MAPK cascade ISO RGD:730995 1624291 (PMID:12917326) RGD PMID:12917326 mRNA transcription ISO RGD:730995 1624291 (PMID:21597468) RGD PMID:21597468 negative regulation of cardiac muscle cell apoptotic process IMP 10402789 RGD negative regulation of cell population proliferation ISO RGD:730996 1624291 MGI:MGI:1347058 (MGI:MGI:3056833 , PMID:15483628) RGD MGI:MGI:3056833 , PMID:15483628 negative regulation of double-strand break repair via nonhomologous end joining ISO RGD:730995 1624291 (PMID:26359349) RGD PMID:26359349 negative regulation of gene expression IMP 10402547 Igf2r RGD negative regulation of inclusion body assembly IMP 10402367 RGD negative regulation of neuron death IMP 10402566 RGD negative regulation of protein-containing complex assembly ISO RGD:730995 1624291 (PMID:26359349) RGD PMID:26359349 negative regulation of transcription by RNA polymerase II ISO RGD:730995 1624291 (PMID:8926278), (PMID:9341107) RGD PMID:8926278 , PMID:9341107 negative regulation of tumor necrosis factor production ISO RGD:730996 1624291 MGI:MGI:2155444 (MGI:MGI:1347429 , PMID:10545106) RGD MGI:MGI:1347429 , PMID:10545106 positive regulation of apoptotic DNA fragmentation IMP 10403035 RGD positive regulation of cell population proliferation ISO RGD:730995 1624291 (PMID:26754925) RGD PMID:26754925 positive regulation of cold-induced thermogenesis ISS UniProtKB:P38532 11522116 PMID:26344102 YuBioLab positive regulation of cold-induced thermogenesis ISO RGD:730996 1624291 (MGI:MGI:6101145, PMID:26344102) RGD MGI:MGI:6101145 , PMID:26344102 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP 10403035 RGD positive regulation of gene expression IMP 10402553 Dlg4 RGD positive regulation of gene expression ISO RGD:730996 1624291 (MGI:MGI:6378393, PMID:26251235) RGD MGI:MGI:6378393 , PMID:26251235 positive regulation of inclusion body assembly IMP 10402367 RGD positive regulation of microtubule binding IMP 10403032 RGD positive regulation of mitotic cell cycle ISO RGD:730995 1624291 (PMID:18794143) RGD PMID:18794143 positive regulation of mRNA polyadenylation ISO RGD:730995 1624291 (PMID:14707147) RGD PMID:14707147 positive regulation of multicellular organism growth ISO RGD:730996 1624291 MGI:MGI:2155444 (MGI:MGI:1347429 , PMID:10545106) RGD MGI:MGI:1347429 , PMID:10545106 positive regulation of transcription by RNA polymerase II ISO RGD:730995 1624291 (PMID:10561509), (PMID:11514557), (PMID:12917326), (PMID:16278218), (PMID:21085490), (PMID:9341107) RGD PMID:10561509 more ... positive regulation of transcription from RNA polymerase II promoter in response to heat stress ISO RGD:730995 1624291 (PMID:10747973), (PMID:12659875), (PMID:12665592), (PMID:15016915), (PMID:25963659), (PMID:26754925), (PMID:7760831), (PMID:9499401) RGD PMID:10747973 more ... positive regulation of tyrosine phosphorylation of STAT protein IMP 10402789 RGD protein phosphorylation ISO RGD:730996 1624291 (MGI:MGI:3821682, PMID:18755693) RGD MGI:MGI:3821682 , PMID:18755693 regulation of cellular response to heat ISO RGD:730995 1624291 (PMID:11583998) RGD PMID:11583998 regulation of transcription by RNA polymerase II IBA CGD:CAL0000195882 more ... 13792537 PMID:21873635 GO_Central regulation of transcription, DNA-templated TAS 625374 RGD response to activity IEP 10402543 RGD response to amino acid IEP 10402543 L-alanine and L-glutamine RGD response to estradiol IDA 10402365 RGD response to heat ISO RGD:730996 1624291 MGI:MGI:2155444 (MGI:MGI:1347429 , PMID:10545106) RGD MGI:MGI:1347429 , PMID:10545106 response to heat IDA 10402365 RGD response to hypobaric hypoxia IEP 10402551 RGD response to lipopolysaccharide ISO RGD:730996 1624291 MGI:MGI:2155444 (MGI:MGI:1347429 , PMID:10545106) RGD MGI:MGI:1347429 , PMID:10545106 response to nutrient IEP 10402568 RGD response to organic cyclic compound IEP 10402398 celastrol RGD response to organonitrogen compound IEP 10402550 capsaicin RGD response to peptide IEP 10402543 L-alanyl-L-glutamine RGD response to psychosocial stress IEP 10450474 RGD response to testosterone IDA 10402365 RGD spermatogenesis ISO RGD:730996 1624291 MGI:MGI:96239 (MGI:MGI:3029037 , PMID:14994269) RGD MGI:MGI:3029037 , PMID:14994269 Cellular Component centrosome ISO RGD:730995 1624291 (PMID:18794143) RGD PMID:18794143 chaperone complex ISO RGD:730995 1624291 (PMID:8455624) RGD PMID:8455624 cytoplasm IDA 10402371 RGD cytoplasm ISO RGD:730996 1624291 (MGI:MGI:2157574 more ... RGD MGI:MGI:2157574 more ... cytoplasm ISO RGD:730995 1624291 (PMID:10413683), (PMID:10747973), (PMID:12917326), (PMID:21085490), (PMID:26159920), (PMID:8455624) RGD PMID:10413683 more ... cytosol IEA UniProtKB:Q00613 , ensembl:ENSP000004315121600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol ISO RGD:730995 1624291 RGD GO_REF:0000052 euchromatin IDA 10402365 RGD heterochromatin IDA 10402365 RGD kinetochore ISO RGD:730995 1624291 (PMID:18794143) RGD PMID:18794143 mitotic spindle pole ISO RGD:730995 1624291 (PMID:18794143) RGD PMID:18794143 nuclear stress granule ISO RGD:730995 1624291 (PMID:10359787), (PMID:10747973), (PMID:11514557), (PMID:12665592), (PMID:14707147), (PMID:25963659) RGD PMID:10359787 more ... nucleoplasm ISO RGD:730995 1624291 (PMID:10359787) RGD GO_REF:0000052, PMID:10359787 nucleus IDA 10402365 RGD nucleus IBA CGD:CAL0000195882 more ... 13792537 PMID:21873635 GO_Central nucleus ISO RGD:730996 1624291 (MGI:MGI:2157574 more ... RGD MGI:MGI:2157574 more ... nucleus ISO RGD:730995 1624291 (PMID:10413683), (PMID:10747973), (PMID:12665592), (PMID:12917326), (PMID:14707147), (PMID:21085490), (PMID:25963659), (PMID:26159920), (PMID:26359349), (PMID:8455624), (PMID:9341107) RGD PMID:10413683 more ... perinuclear region of cytoplasm ISO RGD:730995 1624291 (PMID:21085490) RGD PMID:21085490 PML body ISO RGD:730995 1624291 (PMID:11514557) RGD PMID:11514557 pronucleus ISO RGD:730996 1624291 (MGI:MGI:3045832, PMID:14766729) RGD MGI:MGI:3045832 , PMID:14766729 protein-containing complex ISO RGD:730996 1624291 PR:Q01853 more ... RGD MGI:MGI:3757892 , PMID:17785525 ribonucleoprotein complex ISO RGD:730995 1624291 (PMID:16554823) RGD PMID:16554823 Molecular Function chromatin binding ISO RGD:730996 1624291 (MGI:MGI:5142351, PMID:21690297) RGD MGI:MGI:5142351 , PMID:21690297 chromatin DNA binding ISO RGD:730995 1624291 (PMID:21085490) RGD PMID:21085490 DNA binding ISO RGD:730996 1624291 (MGI:MGI:2157574, PMID:11032181) RGD MGI:MGI:2157574 , PMID:11032181 DNA binding ISO RGD:730995 1624291 (PMID:10359787), (PMID:10413683), (PMID:10747973), (PMID:11514557), (PMID:11583998), (PMID:12659875), (PMID:12665592), (PMID:12917326), (PMID:16278218), (PMID:16554823), (PMID:26754925), (PMID:7760831), (PMID:7935471), (PMID:8455624), (PMID:9222587), (PMID:9341107), (PMID:9499401), (PMID:9727490) RGD PMID:10359787 more ... DNA-binding transcription factor activity IBA CGD:CAL0000195882 more ... 13792537 PMID:21873635 GO_Central DNA-binding transcription repressor activity, RNA polymerase II-specific ISO RGD:730995 1624291 (PMID:8926278) RGD PMID:8926278 heat shock protein binding IDA 10402754 Hsp90 RGD heat shock protein binding ISO RGD:730995 1624291 (PMID:11583998), (PMID:16278218), (PMID:9727490) RGD PMID:11583998 more ... Hsp90 protein binding ISO RGD:730995 1624291 (PMID:11583998) RGD PMID:11583998 identical protein binding ISO RGD:730995 1624291 UniProtKB:Q00613 (PMID:11583998), (PMID:16554823), (PMID:26727490), (PMID:26754925), (PMID:29997244), (PMID:7935471), (PMID:9222587), (PMID:9727490) RGD PMID:11583998 more ... promoter-specific chromatin binding IDA 10402396 RGD promoter-specific chromatin binding ISO RGD:730995 1624291 (PMID:25963659) RGD PMID:25963659 protein binding ISO RGD:730995 1624291 UniProtKB:O14744 more ... RGD PMID:10747973 more ... protein heterodimerization activity ISO RGD:730995 1624291 (PMID:9222587) RGD PMID:9222587 protein kinase binding ISO RGD:730995 1624291 UniProtKB:P49137 (PMID:16278218) RGD PMID:16278218 protein self-association ISO RGD:730995 1624291 (PMID:7935471) RGD PMID:7935471 RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO RGD:730996 1624291 (MGI:MGI:3814640, PMID:18434628) RGD MGI:MGI:3814640 , PMID:18434628 RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA MGI:MGI:96238 more ... 13792537 PMID:21873635 GO_Central RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO RGD:730995 1624291 (PMID:8926278), (PMID:8972228) RGD PMID:8926278 , PMID:8972228 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding ISO RGD:730995 1624291 (PMID:10561509) RGD PMID:10561509 sequence-specific DNA binding ISO RGD:730996 1624291 (MGI:MGI:3821682, PMID:18755693) RGD MGI:MGI:3821682 , PMID:18755693 sequence-specific DNA binding ISO RGD:730995 1624291 (PMID:25963659) RGD PMID:25963659 sequence-specific double-stranded DNA binding ISO RGD:730995 1624291 (PMID:28473536) RGD PMID:28473536 sequence-specific single stranded DNA binding IDA 10402944 RGD STAT family protein binding IPI RGD:3772 10402789 RGD translation elongation factor binding ISO RGD:730995 1624291 (PMID:16554823) RGD PMID:16554823
Gene-Chemical Interaction Annotations
