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Gene: Hsf1 (heat shock transcription factor 1) Rattus norvegicus
Symbol: Hsf1
Name: heat shock transcription factor 1
RGD ID: 620913
Description: Exhibits several functions, including STAT family protein binding activity; promoter-specific chromatin binding activity; and sequence-specific single stranded DNA binding activity. Involved in several processes, including cellular response to lipid; positive regulation of macromolecule metabolic process; and regulation of inclusion body assembly. Localizes to chromatin; cytoplasm; and nucleus. Used to study Parkinson's disease; muscular atrophy; and transient cerebral ischemia. Biomarker of Alzheimer's disease; Parkinson's disease; congestive heart failure; cryptorchidism; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human HSF1 (heat shock transcription factor 1); INTERACTS WITH (+)-schisandrin B; (R)-adrenaline; (Z)-ligustilide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: heat shock factor protein 1
Homo sapiens (human) : HSF1 (heat shock transcription factor 1)  HGNC  Alliance
Mus musculus (house mouse) : Hsf1 (heat shock factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsf1 (heat shock transcription factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HSF1 (heat shock transcription factor 1)
Canis lupus familiaris (dog) : HSF1 (heat shock transcription factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsf1 (heat shock transcription factor 1)
Sus scrofa (pig) : HSF1 (heat shock transcription factor 1)
Chlorocebus sabaeus (African green monkey) : HSF1 (heat shock transcription factor 1)
Heterocephalus glaber (naked mole-rat) : Hsf1 (heat shock transcription factor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.07117,538,523 - 117,565,478 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7117,538,523 - 117,565,478 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07117,526,154 - 117,553,109 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,524,211 - 114,551,166 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17114,580,681 - 114,585,056 (+)NCBI
Celera7104,547,683 - 104,574,508 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Hsf1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620913
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.