(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of HSF1 mRNA] CTD PMID:31150632 (20S)-ginsenoside Rg3 multiple interactions ISO RGD:730995 6480464 ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in increased expression of HSF1 protein] CTD PMID:26427350 (20S)-ginsenoside Rg3 decreases expression ISO RGD:730995 6480464 ginsenoside Rg3 results in decreased expression of HSF1 protein CTD PMID:26427350 (R)-adrenaline multiple interactions EXP 6480464 Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein] CTD PMID:19135123 (R)-adrenaline affects localization EXP 6480464 Epinephrine affects the localization of HSF1 protein CTD PMID:19135123 (R,S)-Scoulerine increases activity ISO RGD:730995 6480464 discretamine results in increased activity of HSF1 protein CTD PMID:34170685 (Z)-ligustilide affects localization EXP 6480464 ligustilide affects the localization of HSF1 protein CTD PMID:26212861 1,3,5-trinitro-1,3,5-triazinane increases expression EXP 6480464 cyclonite results in increased expression of HSF1 mRNA CTD PMID:25559034 1-naphthyl isothiocyanate increases activity ISO RGD:730995 6480464 1-Naphthylisothiocyanate results in increased activity of HSF1 protein CTD PMID:34170685 15-deoxy-Delta(12,14)-prostaglandin J2 multiple interactions ISO RGD:730995 6480464 HSF1 protein inhibits the reaction [15-deoxy-delta(12, 14)-prostaglandin J2 results in increased expression of HMOX1 mRNA] CTD PMID:15618017 15-deoxy-Delta(12,14)-prostaglandin J2 increases activity ISO RGD:730995 6480464 15-deoxy-delta(12, 14)-prostaglandin J2 results in increased activity of HSF1 protein CTD PMID:34170685 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of HSF1 mRNA CTD PMID:16940010 17beta-estradiol increases expression ISO RGD:730996 6480464 Estradiol results in increased expression of HSF1 mRNA CTD PMID:12927369 17beta-estradiol multiple interactions ISO RGD:730996 6480464 fulvestrant inhibits the reaction [Estradiol results in increased expression of HSF1 mRNA] CTD PMID:12927369 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one decreases activity ISO RGD:730995 6480464 Metribolone results in decreased activity of HSF1 protein CTD PMID:34170685 2,2',4,4'-Tetrabromodiphenyl ether affects expression ISO RGD:730996 6480464 2 more ... CTD PMID:24680724 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:730996 6480464 Tetrachlorodibenzodioxin affects the expression of HSF1 mRNA CTD PMID:21570461 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases activity ISO RGD:730995 6480464 Tetrachlorodibenzodioxin results in decreased activity of HSF1 protein CTD PMID:34170685 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:730995 6480464 Tetrachlorodibenzodioxin results in decreased expression of HSF1 mRNA CTD PMID:16039398 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of HSF1 mRNA CTD PMID:21215274 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of HSF1 mRNA CTD PMID:21346803 2-nitrofluorene increases expression EXP 6480464 2-nitrofluorene results in increased expression of HSF1 mRNA CTD PMID:15890375 2-tert-butylhydroquinone increases expression ISO RGD:730995 6480464 2-tert-butylhydroquinone results in increased expression of HSF1 mRNA CTD PMID:30309986 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression EXP 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of HSF1 mRNA CTD PMID:15890375 4-hydroxyphenyl retinamide increases activity ISO RGD:730995 6480464 Fenretinide results in increased activity of HSF1 protein CTD PMID:34170685 5-azacytidine decreases activity ISO RGD:730995 6480464 Azacitidine results in decreased activity of HSF1 protein CTD PMID:34170685 6-propyl-2-thiouracil increases activity ISO RGD:730995 6480464 Propylthiouracil results in increased activity of HSF1 protein CTD PMID:34170685 7H-xanthine multiple interactions EXP 6480464 [Xanthine co-treated with XDH protein] affects the localization of HSF1 protein, Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein] CTD PMID:19135123 9H-xanthine multiple interactions EXP 6480464 [Xanthine co-treated with XDH protein] affects the localization of HSF1 protein, Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein] CTD PMID:19135123 acetate ester decreases activity ISO RGD:730995 6480464 Acetates results in decreased activity of HSF1 protein CTD PMID:34170685 acetylsalicylic acid increases activity ISO RGD:730995 6480464 Aspirin results in increased activity of HSF1 protein CTD PMID:10328874 acrolein multiple interactions ISO RGD:730995 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of HSF1 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of HSF1 mRNA CTD PMID:32699268 acrolein increases activity ISO RGD:730995 6480464 Acrolein results in increased activity of HSF1 protein CTD PMID:34170685 acrylamide increases phosphorylation ISO RGD:730995 6480464 Acrylamide results in increased phosphorylation of HSF1 protein CTD PMID:16129430 actinomycin D multiple interactions ISO RGD:730995 6480464 Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of HSF1 mRNA], Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of HSF1 protein] CTD PMID:30309986 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of HSF1 mRNA CTD PMID:15890375 aflatoxin B1 decreases methylation ISO RGD:730995 6480464 Aflatoxin B1 results in decreased methylation of HSF1 intron CTD PMID:30157460 aflatoxin B1 increases expression ISO RGD:730996 6480464 Aflatoxin B1 results in increased expression of HSF1 mRNA CTD PMID:19770486 albendazole increases activity ISO RGD:730995 6480464 Albendazole results in increased activity of HSF1 protein CTD PMID:34170685 aldehydo-D-glucose decreases activity ISO RGD:730995 6480464 Glucose results in decreased activity of HSF1 protein CTD PMID:34170685 all-trans-retinoic acid multiple interactions ISO RGD:730995 6480464 HSF1 protein affects the reaction [Tretinoin inhibits the reaction [sodium arsenite results in increased expression of ATG7 protein]], Tretinoin inhibits the reaction [sodium arsenite results in increased expression of HSF1 protein] CTD PMID:30309986 allyl alcohol increases activity ISO RGD:730995 6480464 allyl alcohol results in increased activity of HSF1 protein CTD PMID:34170685 alpha-D-galactose increases activity ISO RGD:730995 6480464 Galactose results in increased activity of HSF1 protein CTD PMID:34170685 alpha-pinene multiple interactions ISO RGD:730995 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of HSF1 mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of HSF1 mRNA CTD PMID:32699268 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of HSF1 mRNA CTD PMID:16483693 amphibole asbestos increases expression ISO RGD:730995 6480464 Asbestos, Amphibole results in increased expression of HSF1 protein CTD PMID:20855422 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:730995 6480464 pyrazolanthrone inhibits the reaction [arsenic trioxide results in increased phosphorylation of HSF1 protein] CTD PMID:15978632 apratoxin A increases activity ISO RGD:730995 6480464 apratoxin A results in increased activity of HSF1 protein CTD PMID:34170685 arsenite(3-) multiple interactions EXP 6480464 [arsenite co-treated with Curcumin] results in increased phosphorylation of HSF1 protein CTD PMID:9764755 arsenite(3-) multiple interactions ISO RGD:730996 6480464 HSF1 protein affects the reaction [arsenite results in increased expression of HSPA1B mRNA] more ... CTD PMID:20835880 arsenite(3-) increases expression ISO RGD:730996 6480464 arsenite results in increased expression of HSF1 protein CTD PMID:20835880 arsenite(3-) increases activity ISO RGD:730996 6480464 arsenite results in increased activity of HSF1 protein CTD PMID:20835880 arsenite(3-) affects localization ISO RGD:730996 6480464 arsenite affects the localization of HSF1 protein CTD PMID:20835880 arsenite(3-) increases phosphorylation EXP 6480464 arsenite results in increased phosphorylation of HSF1 protein CTD PMID:9764755 arsenous acid affects response to substance ISO RGD:730995 6480464 HSF1 protein affects the susceptibility to Arsenic Trioxide CTD PMID:20724260 arsenous acid increases activity ISO RGD:730995 6480464 Arsenic Trioxide results in increased activity of HSF1 protein CTD PMID:34170685 arsenous acid increases phosphorylation ISO RGD:730995 6480464 Arsenic Trioxide results in increased phosphorylation of HSF1 protein CTD PMID:15978632 arsenous acid multiple interactions ISO RGD:730995 6480464 MAP2K4 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of HSF1 protein], pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of HSF1 protein] CTD PMID:15978632 Aurin affects localization ISO RGD:730995 6480464 aurin affects the localization of HSF1 protein CTD PMID:25477506 azathioprine increases activity ISO RGD:730995 6480464 Azathioprine results in increased activity of HSF1 protein CTD PMID:34170685 Bardoxolone methyl increases activity ISO RGD:730995 6480464 bardoxolone methyl results in increased activity of HSF1 protein CTD PMID:34170685 benzene increases expression ISO RGD:730996 6480464 Benzene results in increased expression of HSF1 mRNA CTD PMID:15050406 benzo[a]pyrene increases expression ISO RGD:730996 6480464 Benzo(a)pyrene results in increased expression of HSF1 mRNA CTD PMID:22228805 benzo[a]pyrene increases activity ISO RGD:730995 6480464 Benzo(a)pyrene results in increased activity of HSF1 protein CTD PMID:34170685 benzo[a]pyrene affects methylation ISO RGD:730995 6480464 Benzo(a)pyrene affects the methylation of HSF1 intron CTD PMID:30157460 benzo[a]pyrene affects activity ISO RGD:730995 6480464 Benzo(a)pyrene affects the activity of HSF1 protein CTD PMID:20624995 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of HSF1 protein CTD PMID:21467743 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of HSF1 mRNA CTD PMID:25181051 bisphenol A affects expression ISO RGD:730995 6480464 bisphenol A affects the expression of HSF1 mRNA CTD PMID:30903817 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of HSF1 gene CTD PMID:28505145 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of HSF1 mRNA CTD PMID:30816183 bortezomib increases expression ISO RGD:730995 6480464 Bortezomib results in increased expression of HSF1 mRNA CTD PMID:17895889 bortezomib increases activity ISO RGD:730995 6480464 Bortezomib results in increased activity of HSF1 protein CTD PMID:31540997 bortezomib multiple interactions ISO RGD:730995 6480464 Bortezomib promotes the reaction [HSF1 protein binds to HSPA1A promoter] CTD PMID:23874968 C.I. Natural Red 20 increases activity ISO RGD:730995 6480464 shikonin results in increased activity of HSF1 protein CTD PMID:34170685 cadmium atom multiple interactions ISO RGD:730996 6480464 HSF1 protein affects the reaction [Cadmium results in increased expression of HSPA1B protein] CTD PMID:16282982 cadmium atom increases activity ISO RGD:730995 6480464 Cadmium results in increased activity of HSF1 protein CTD PMID:16460681 , PMID:17244614 cadmium atom multiple interactions ISO RGD:730995 6480464 Cadmium promotes the reaction [HSF1 protein binds to HMOX1 promoter] more ... CTD PMID:16460681 , PMID:17244614 cadmium atom increases activity ISO RGD:730996 6480464 Cadmium results in increased activity of HSF1 protein CTD PMID:16282982 cadmium dichloride increases phosphorylation ISO RGD:730996 6480464 Cadmium Chloride results in increased phosphorylation of HSF1 protein CTD PMID:18348256 cadmium dichloride decreases expression ISO RGD:730996 6480464 Cadmium Chloride results in decreased expression of HSF1 mRNA CTD PMID:30213552 cadmium dichloride increases phosphorylation EXP 6480464 Cadmium Chloride results in increased phosphorylation of HSF1 protein CTD PMID:9822662 cadmium dichloride multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of HSF1 protein], SB 203580 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of HSF1 protein] CTD PMID:9822662 cadmium dichloride increases expression ISO RGD:730995 6480464 Cadmium Chloride results in increased expression of HSF1 mRNA CTD PMID:12160620 cadmium dichloride decreases phosphorylation ISO RGD:730995 6480464 Cadmium Chloride results in decreased phosphorylation of HSF1 protein CTD PMID:24412756 cadmium dichloride decreases activity ISO RGD:730995 6480464 Cadmium Chloride results in decreased activity of HSF1 protein CTD PMID:10403520 cadmium dichloride decreases expression ISO RGD:730995 6480464 Cadmium Chloride results in decreased expression of HSF1 mRNA CTD PMID:19426795 cadmium dichloride multiple interactions ISO RGD:730995 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased activity of HSF1 protein] more ... CTD PMID:10403520 more ... cadmium dichloride multiple interactions ISO RGD:730996 6480464 [MAP2K4 co-treated with MAP2K7] affects the reaction [Cadmium Chloride results in increased phosphorylation of HSF1 protein] more ... CTD PMID:18348256 , PMID:30213552 cadmium sulfate multiple interactions ISO RGD:730995 6480464 cadmium sulfate promotes the reaction [HSF1 protein binds to HMOX1 promoter] more ... CTD PMID:16460681 , PMID:17244614 cadmium sulfate increases activity ISO RGD:730995 6480464 cadmium sulfate results in increased activity of HSF1 protein CTD PMID:16460681 , PMID:17244614 Calcimycin affects phosphorylation ISO RGD:730995 6480464 Calcimycin affects the phosphorylation of HSF1 protein CTD PMID:8663271 capsaicin increases expression EXP 6480464 Capsaicin results in increased expression of HSF1 mRNA CTD PMID:24746025 carbamazepine increases activity ISO RGD:730995 6480464 Carbamazepine results in increased activity of HSF1 protein CTD PMID:34170685 carbonyl cyanide p-trifluoromethoxyphenylhydrazone decreases expression ISO RGD:730995 6480464 Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of HSF1 mRNA CTD PMID:16039398 ceftazidime pentahydrate decreases activity ISO RGD:730995 6480464 Ceftazidime results in decreased activity of HSF1 protein CTD PMID:34170685 celastrol multiple interactions EXP 6480464 celastrol results in increased phosphorylation of and affects the localization of HSF1 protein CTD PMID:25903958 celastrol increases activity ISO RGD:730995 6480464 celastrol results in increased activity of HSF1 protein CTD PMID:34170685 chelidonine increases activity ISO RGD:730995 6480464 chelidonine results in increased activity of HSF1 protein CTD PMID:34170685 chlorphenamine decreases activity ISO RGD:730995 6480464 Chlorpheniramine results in decreased activity of HSF1 protein CTD PMID:34170685 cisplatin increases activity ISO RGD:730995 6480464 Cisplatin results in increased activity of HSF1 protein CTD PMID:34170685 clotrimazole increases activity ISO RGD:730995 6480464 Clotrimazole results in increased activity of HSF1 protein CTD PMID:34170685 cobalt atom multiple interactions ISO RGD:730996 6480464 [Cobalt co-treated with Organometallic Compounds] results in increased expression of HSF1 mRNA CTD PMID:22147119 cobalt dichloride increases expression ISO RGD:730995 6480464 cobaltous chloride results in increased expression of HSF1 mRNA CTD PMID:19376846 cocaine affects expression EXP 6480464 Cocaine affects the expression of HSF1 mRNA CTD PMID:20187946 curcumin multiple interactions EXP 6480464 [arsenite co-treated with Curcumin] results in increased phosphorylation of HSF1 protein CTD PMID:9764755 curcumin multiple interactions ISO RGD:730995 6480464 Curcumin promotes the reaction [HSF1 protein binds to HSF1 protein] CTD PMID:11322385 cycloheximide decreases activity ISO RGD:730995 6480464 Cycloheximide results in decreased activity of HSF1 protein CTD PMID:34170685 cyclosporin A increases expression ISO RGD:730995 6480464 Cyclosporine results in increased expression of HSF1 mRNA CTD PMID:20106945 , PMID:25562108 cylindrospermopsin increases expression ISO RGD:730995 6480464 cylindrospermopsin results in increased expression of HSF1 mRNA CTD PMID:24921660 cyproheptadine increases activity ISO RGD:730995 6480464 Cyproheptadine results in increased activity of HSF1 protein CTD PMID:34170685 D-glucose decreases activity ISO RGD:730995 6480464 Glucose results in decreased activity of HSF1 protein CTD PMID:34170685 dactolisib decreases activity ISO RGD:730995 6480464 dactolisib results in decreased activity of HSF1 protein CTD PMID:34170685 dexamethasone decreases activity ISO RGD:730996 6480464 Dexamethasone results in decreased activity of HSF1 protein CTD PMID:14673132 dexamethasone increases activity ISO RGD:730995 6480464 Dexamethasone results in increased activity of HSF1 protein CTD PMID:34170685 dexamethasone multiple interactions ISO RGD:730996 6480464 Mifepristone inhibits the reaction [Dexamethasone results in decreased activity of HSF1 protein] CTD PMID:14673132 diarsenic trioxide affects response to substance ISO RGD:730995 6480464 HSF1 protein affects the susceptibility to Arsenic Trioxide CTD PMID:20724260 diarsenic trioxide increases activity ISO RGD:730995 6480464 Arsenic Trioxide results in increased activity of HSF1 protein CTD PMID:34170685 diarsenic trioxide multiple interactions ISO RGD:730995 6480464 MAP2K4 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of HSF1 protein], pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of HSF1 protein] CTD PMID:15978632 diarsenic trioxide increases phosphorylation ISO RGD:730995 6480464 Arsenic Trioxide results in increased phosphorylation of HSF1 protein CTD PMID:15978632 diazinon increases activity ISO RGD:730995 6480464 Diazinon results in increased activity of HSF1 protein CTD PMID:34170685 dibutyl phthalate decreases expression ISO RGD:730996 6480464 Dibutyl Phthalate results in decreased expression of HSF1 mRNA CTD PMID:17361019 diclofenac increases activity ISO RGD:730995 6480464 Diclofenac results in increased activity of HSF1 protein CTD PMID:34170685 dicrotophos increases expression ISO RGD:730995 6480464 dicrotophos results in increased expression of HSF1 mRNA CTD PMID:28302478 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of HSF1 mRNA CTD PMID:15890375 diethylstilbestrol increases activity ISO RGD:730995 6480464 Diethylstilbestrol results in increased activity of HSF1 protein CTD PMID:34170685 diltiazem decreases activity ISO RGD:730995 6480464 Diltiazem results in decreased activity of HSF1 protein CTD PMID:34170685 dioxygen multiple interactions ISO RGD:730995 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA] more ... CTD PMID:11424089 dioxygen increases expression ISO RGD:730995 6480464 Oxygen deficiency results in increased expression of HSF1 mRNA CTD PMID:11424089 disodium selenite increases expression ISO RGD:730995 6480464 Sodium Selenite results in increased expression of HSF1 mRNA CTD PMID:18175754 doxorubicin multiple interactions ISO RGD:730996 6480464 HSF1 protein affects the reaction [Doxorubicin promotes the reaction [TRP53 protein binds to HSPB1 protein modified form]] more ... CTD PMID:20363884 doxorubicin decreases expression ISO RGD:730995 6480464 Doxorubicin results in decreased expression of HSF1 mRNA CTD PMID:29803840 doxorubicin affects response to substance ISO RGD:730996 6480464 HSF1 protein affects the susceptibility to Doxorubicin CTD PMID:20363884 ebselen increases activity ISO RGD:730995 6480464 ebselen results in increased activity of HSF1 protein CTD PMID:34170685 elesclomol increases activity ISO RGD:730995 6480464 elesclomol results in increased activity of HSF1 protein CTD PMID:34170685 epoxomicin increases activity ISO RGD:730995 6480464 epoxomicin results in increased activity of HSF1 protein CTD PMID:34170685 etacrynic acid increases activity ISO RGD:730995 6480464 Ethacrynic Acid results in increased activity of HSF1 protein CTD PMID:34170685 ethanol multiple interactions ISO RGD:730996 6480464 HSF1 protein affects the reaction [Ethanol results in increased expression of HSP90AA1 mRNA] more ... CTD PMID:17189318 ethanol affects response to substance ISO RGD:730996 6480464 HSF1 protein affects the susceptibility to Ethanol CTD PMID:17189318 ethyl methanesulfonate increases activity ISO RGD:730995 6480464 Ethyl Methanesulfonate results in increased activity of HSF1 protein CTD PMID:34170685 fenbendazole increases activity ISO RGD:730995 6480464 Fenbendazole results in increased activity of HSF1 protein CTD PMID:34170685 fenofibrate multiple interactions EXP 6480464 [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of HSF1 mRNA CTD PMID:18253720 fipronil decreases expression EXP 6480464 fipronil results in decreased expression of HSF1 mRNA CTD PMID:34044035 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of HSF1 mRNA CTD PMID:18035473 formaldehyde increases activity ISO RGD:730995 6480464 Formaldehyde results in increased activity of HSF1 protein CTD PMID:34170685 fotemustine increases activity ISO RGD:730995 6480464 fotemustine results in increased activity of HSF1 protein CTD PMID:34170685 fulvestrant multiple interactions ISO RGD:730996 6480464 fulvestrant inhibits the reaction [Estradiol results in increased expression of HSF1 mRNA] CTD PMID:12927369 furosemide increases activity ISO RGD:730995 6480464 Furosemide results in increased activity of HSF1 protein CTD PMID:34170685 galactose increases activity ISO RGD:730995 6480464 Galactose results in increased activity of HSF1 protein CTD PMID:34170685 geldanamycin multiple interactions ISO RGD:730995 6480464 geldanamycin inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]], geldanamycin results in increased phosphorylation of and results in increased activity of HSF1 protein CTD PMID:10632574 , PMID:25645596 geneticin increases activity ISO RGD:730995 6480464 antibiotic G 418 results in increased activity of HSF1 protein CTD PMID:34170685 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of HSF1 protein CTD PMID:21081137 gentamycin affects response to substance ISO RGD:730996 6480464 HSF1 protein affects the susceptibility to Gentamicins CTD PMID:18512096 glucose decreases activity ISO RGD:730995 6480464 Glucose results in decreased activity of HSF1 protein CTD PMID:34170685 gold atom multiple interactions ISO RGD:730995 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of HSF1 mRNA CTD PMID:28433809 gold(0) multiple interactions ISO RGD:730995 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of HSF1 mRNA CTD PMID:28433809 hemin increases activity ISO RGD:730995 6480464 Hemin results in increased activity of HSF1 protein CTD PMID:34170685 homocysteic acid decreases expression EXP 6480464 homocysteic acid results in decreased expression of HSF1 protein CTD PMID:24478344 hydrogen chloride affects response to substance ISO RGD:730996 6480464 HSF1 protein affects the susceptibility to Hydrochloric Acid CTD PMID:17189318 hydrogen peroxide multiple interactions EXP 6480464 HSF1 protein inhibits the reaction [Hydrogen Peroxide affects the localization of HMGB1 protein], HSF1 protein inhibits the reaction [Hydrogen Peroxide results in increased expression of and results in increased secretion of HMGB1 protein] CTD PMID:22246807 hydrogen peroxide increases activity ISO RGD:730995 6480464 Hydrogen Peroxide results in increased activity of HSF1 protein CTD PMID:34170685 hydrogen peroxide increases expression ISO RGD:730995 6480464 Hydrogen Peroxide results in increased expression of HSF1 mRNA, Hydrogen Peroxide results in increased expression of HSF1 protein CTD PMID:19401454 , PMID:30309986 ibuprofen increases activity ISO RGD:730995 6480464 Ibuprofen results in increased activity of HSF1 protein CTD PMID:10328874 imipramine decreases activity ISO RGD:730995 6480464 Imipramine results in decreased activity of HSF1 protein CTD PMID:34170685 indole-3-methanol increases activity ISO RGD:730995 6480464 indole-3-carbinol results in increased activity of HSF1 protein CTD PMID:34170685 indometacin increases activity ISO RGD:730996 6480464 Indomethacin results in increased activity of HSF1 protein CTD PMID:14706622 indometacin increases activity ISO RGD:730995 6480464 Indomethacin results in increased activity of HSF1 protein CTD PMID:10701834 , PMID:12065054 L-serine increases activity ISO RGD:730995 6480464 Serine results in increased activity of HSF1 protein CTD PMID:34170685 lactacystin increases activity ISO RGD:730995 6480464 lactacystin results in increased activity of HSF1 protein CTD PMID:11893605 lead diacetate increases expression ISO RGD:730996 6480464 lead acetate results in increased expression of HSF1 mRNA CTD PMID:21829687 linalool increases expression ISO RGD:730995 6480464 linalool results in increased expression of HSF1 mRNA CTD PMID:19922762 LY294002 multiple interactions ISO RGD:730995 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [squamosamide results in increased expression of HSF1 protein modified form] CTD PMID:11424089 , PMID:21295016 maneb multiple interactions ISO RGD:730996 6480464 [Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA more ... CTD PMID:23963992 melatonin multiple interactions ISO RGD:730996 6480464 Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA] CTD PMID:23963992 menadione increases activity ISO RGD:730995 6480464 Vitamin K 3 results in increased activity of HSF1 protein CTD PMID:34170685 mercury atom multiple interactions ISO RGD:730995 6480464 Mercury promotes the reaction [HSF1 protein binds to HMOX1 promoter], Mercury promotes the reaction [HSF1 protein binds to HSPA1A promoter] CTD PMID:17244614 mercury atom increases activity ISO RGD:730995 6480464 Mercury results in increased activity of HSF1 protein CTD PMID:17244614 mercury dichloride multiple interactions ISO RGD:730995 6480464 Mercuric Chloride promotes the reaction [HSF1 protein binds to HMOX1 promoter], Mercuric Chloride promotes the reaction [HSF1 protein binds to HSPA1A promoter] CTD PMID:17244614 mercury dichloride increases activity ISO RGD:730995 6480464 Mercuric Chloride results in increased activity of HSF1 protein CTD PMID:17244614 mercury(0) increases activity ISO RGD:730995 6480464 Mercury results in increased activity of HSF1 protein CTD PMID:17244614 mercury(0) multiple interactions ISO RGD:730995 6480464 Mercury promotes the reaction [HSF1 protein binds to HMOX1 promoter], Mercury promotes the reaction [HSF1 protein binds to HSPA1A promoter] CTD PMID:17244614 mesalamine decreases activity ISO RGD:730995 6480464 Mesalamine results in decreased activity of HSF1 protein CTD PMID:34170685 methapyrilene increases expression EXP 6480464 Methapyrilene results in increased expression of HSF1 mRNA CTD PMID:15890375 methyl methanesulfonate increases activity ISO RGD:730995 6480464 Methyl Methanesulfonate results in increased activity of HSF1 protein CTD PMID:34170685 mifepristone multiple interactions ISO RGD:730996 6480464 Mifepristone inhibits the reaction [Dexamethasone results in decreased activity of HSF1 protein] CTD PMID:14673132 mometasone furoate increases activity ISO RGD:730995 6480464 Mometasone Furoate results in increased activity of HSF1 protein CTD PMID:34170685 monohexyl phthalate increases activity ISO RGD:730995 6480464 mono-n-hexyl phthalate results in increased activity of HSF1 protein CTD PMID:34170685 N-acetyl-L-cysteine multiple interactions ISO RGD:730995 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased activity of HSF1 protein] more ... CTD PMID:10403520 more ... N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases activity ISO RGD:730995 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of HSF1 protein CTD PMID:11893605 N-ethyl-N-nitrosourea increases mutagenesis ISO RGD:730996 6480464 Ethylnitrosourea results in increased mutagenesis of HSF1 3' UTR CTD PMID:27776689 N-nitrosodiethylamine multiple interactions EXP 6480464 [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of HSF1 mRNA CTD PMID:18253720 N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of HSF1 mRNA CTD PMID:15890375 nickel sulfate increases expression ISO RGD:730995 6480464 nickel sulfate results in increased expression of HSF1 mRNA CTD PMID:18651567 nifedipine increases activity ISO RGD:730995 6480464 Nifedipine results in increased activity of HSF1 protein CTD PMID:34170685 nimesulide increases activity ISO RGD:730995 6480464 nimesulide results in increased activity of HSF1 protein CTD PMID:34170685 nitrofurantoin increases activity ISO RGD:730995 6480464 Nitrofurantoin results in increased activity of HSF1 protein CTD PMID:34170685 oxaprozin increases activity ISO RGD:730995 6480464 Oxaprozin results in increased activity of HSF1 protein CTD PMID:34170685 oxyphenbutazone increases activity ISO RGD:730995 6480464 Oxyphenbutazone results in increased activity of HSF1 protein CTD PMID:34170685 ozone multiple interactions ISO RGD:730995 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of HSF1 mRNA more ... CTD PMID:32699268 papaverine increases activity ISO RGD:730995 6480464 Papaverine results in increased activity of HSF1 protein CTD PMID:34170685 paracetamol increases expression ISO RGD:730995 6480464 Acetaminophen results in increased expression of HSF1 mRNA CTD PMID:22230336 paraquat multiple interactions ISO RGD:730996 6480464 [Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA more ... CTD PMID:23963992 , PMID:31216030 paraquat increases expression ISO RGD:730996 6480464 Paraquat results in increased expression of HSF1 mRNA CTD PMID:31216030 parthenolide increases activity ISO RGD:730995 6480464 parthenolide results in increased activity of HSF1 protein CTD PMID:34170685 PD 0325901 decreases activity ISO RGD:730995 6480464 mirdametinib results in decreased activity of HSF1 protein CTD PMID:34170685 pevonedistat increases activity ISO RGD:730995 6480464 pevonedistat results in increased activity of HSF1 protein CTD PMID:34170685 Phenoxybenzamine increases activity ISO RGD:730995 6480464 Phenoxybenzamine results in increased activity of HSF1 protein CTD PMID:34170685 phenprocoumon decreases activity ISO RGD:730995 6480464 Phenprocoumon results in decreased activity of HSF1 protein CTD PMID:34170685 phosphocholine increases activity ISO RGD:730995 6480464 Phosphorylcholine results in increased activity of HSF1 protein CTD PMID:34170685 phosphorylcholine chloride increases activity ISO RGD:730995 6480464 Phosphorylcholine results in increased activity of HSF1 protein CTD PMID:34170685 piperidones increases activity ISO RGD:730995 6480464 Piperidones results in increased activity of HSF1 protein CTD PMID:34170685 piperonyl butoxide increases expression EXP 6480464 Piperonyl Butoxide results in increased expression of HSF1 mRNA CTD PMID:15890375 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of HSF1 mRNA CTD PMID:15890375 pirinixic acid increases expression ISO RGD:730996 6480464 pirinixic acid results in increased expression of HSF1 mRNA CTD PMID:18445702 PLX-4720 decreases activity ISO RGD:730995 6480464 PLX 4720 results in decreased activity of HSF1 protein CTD PMID:34170685 promegestone increases activity ISO RGD:730995 6480464 Promegestone results in increased activity of HSF1 protein CTD PMID:34170685 promethazine decreases activity ISO RGD:730995 6480464 Promethazine results in decreased activity of HSF1 protein CTD PMID:34170685 pyocyanine increases activity EXP 6480464 Pyocyanine results in increased activity of HSF1 protein CTD PMID:27613716 pyridine increases activity ISO RGD:730995 6480464 pyridine results in increased activity of HSF1 protein CTD PMID:34170685 quercetin increases response to substance ISO RGD:730995 6480464 HSF1 protein results in increased susceptibility to Quercetin CTD PMID:27041924 quercetin multiple interactions ISO RGD:730995 6480464 Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA], Quercetin inhibits the reaction [squamosamide results in increased expression of HSF1 protein modified form] CTD PMID:11424089 , PMID:21295016 quercetin decreases expression ISO RGD:730996 6480464 Quercetin results in decreased expression of HSF1 CTD PMID:16579653 quercetin decreases expression ISO RGD:730995 6480464 Quercetin results in decreased expression of HSF1 protein CTD PMID:27041924 resveratrol multiple interactions ISO RGD:730995 6480464 [resveratrol results in decreased phosphorylation of GSK3B protein] which results in decreased expression of HSF1 mRNA more ... CTD PMID:18429957 more ... resveratrol increases activity ISO RGD:730995 6480464 Resveratrol results in increased activity of HSF1 protein CTD PMID:34170685 rivastigmine increases activity ISO RGD:730995 6480464 Rivastigmine results in increased activity of HSF1 protein CTD PMID:19218096 rotenone increases expression ISO RGD:730995 6480464 Rotenone results in increased expression of HSF1 mRNA CTD PMID:29955902 SB 203580 multiple interactions EXP 6480464 SB 203580 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of HSF1 protein] CTD PMID:9822662 Securinine increases activity ISO RGD:730995 6480464 securinine results in increased activity of HSF1 protein CTD PMID:34170685 senecionine increases activity ISO RGD:730995 6480464 senecionine results in increased activity of HSF1 protein CTD PMID:34170685 Shikonin increases activity ISO RGD:730995 6480464 shikonin results in increased activity of HSF1 protein CTD PMID:34170685 silver atom increases activity ISO RGD:730995 6480464 Silver results in increased activity of HSF1 protein CTD PMID:16460681 , PMID:17244614 silver atom multiple interactions ISO RGD:730995 6480464 Silver promotes the reaction [HSF1 protein binds to HMOX1 promoter] more ... CTD PMID:16460681 , PMID:17244614 silver(0) multiple interactions ISO RGD:730995 6480464 Silver promotes the reaction [HSF1 protein binds to HMOX1 promoter] more ... CTD PMID:16460681 , PMID:17244614 silver(0) increases activity ISO RGD:730995 6480464 Silver results in increased activity of HSF1 protein CTD PMID:16460681 , PMID:17244614 silver(1+) nitrate multiple interactions ISO RGD:730995 6480464 Silver Nitrate promotes the reaction [HSF1 protein binds to HMOX1 promoter] more ... CTD PMID:16460681 , PMID:17244614 silver(1+) nitrate increases activity ISO RGD:730995 6480464 Silver Nitrate results in increased activity of HSF1 protein CTD PMID:16460681 more ... simvastatin affects localization ISO RGD:730995 6480464 Simvastatin affects the localization of HSF1 protein CTD PMID:16375908 sirolimus increases activity ISO RGD:730995 6480464 Sirolimus results in increased activity of HSF1 protein CTD PMID:34170685 sodium arsenite multiple interactions ISO RGD:730995 6480464 Acetylcysteine inhibits the reaction [sodium arsenite promotes the reaction [NFE2L2 protein binds to HSF1 promoter]] more ... CTD PMID:11322385 more ... sodium arsenite increases activity ISO RGD:730995 6480464 sodium arsenite results in increased activity of HSF1 protein CTD PMID:34170685 sodium arsenite increases expression ISO RGD:730995 6480464 sodium arsenite results in increased expression of HSF1 mRNA, sodium arsenite results in increased expression of HSF1 protein CTD PMID:30309986 sodium arsenite increases activity ISO RGD:730996 6480464 sodium arsenite results in increased activity of HSF1 protein CTD PMID:15327774 , PMID:16447264 sodium arsenite increases expression ISO RGD:730996 6480464 sodium arsenite results in increased expression of HSF1 mRNA CTD PMID:16014739 sodium arsenite decreases phosphorylation ISO RGD:730995 6480464 sodium arsenite results in decreased phosphorylation of HSF1 protein CTD PMID:24412756 sodium arsenite multiple interactions ISO RGD:730996 6480464 HSF1 protein affects the reaction [sodium arsenite results in increased expression of HSPA1A protein] more ... CTD PMID:20566634 Sodium salicylate increases activity ISO RGD:730995 6480464 Sodium Salicylate results in increased activity of HSF1 protein CTD PMID:10328874 solanesol multiple interactions ISO RGD:730995 6480464 2-phenylacetylenesulfonamide inhibits the reaction [solanesol promotes the reaction [HSF1 protein binds to STUB1 protein]] more ... CTD PMID:25645596 solanesol affects localization ISO RGD:730995 6480464 solanesol affects the localization of HSF1 protein CTD PMID:25645596 sphingosine 1-phosphate increases activity ISO RGD:730995 6480464 sphingosine 1-phosphate results in increased activity of HSF1 protein CTD PMID:34170685 sulforaphane increases activity ISO RGD:730995 6480464 sulforaphane results in increased activity of HSF1 protein CTD PMID:34170685 sulindac increases activity ISO RGD:730995 6480464 Sulindac results in increased activity of HSF1 protein CTD PMID:10328874 sunitinib increases expression ISO RGD:730995 6480464 Sunitinib results in increased expression of HSF1 mRNA CTD PMID:31533062 tanespimycin affects localization ISO RGD:730995 6480464 tanespimycin affects the localization of HSF1 protein CTD PMID:20090934 tanespimycin increases activity ISO RGD:730995 6480464 tanespimycin results in increased activity of HSF1 protein CTD PMID:34170685 tanespimycin multiple interactions ISO RGD:730995 6480464 [tanespimycin affects the localization of HSF1 protein] which results in increased expression of HSPA1A protein CTD PMID:20090934 teprenone affects response to substance ISO RGD:730996 6480464 HSF1 protein affects the susceptibility to geranylgeranylacetone CTD PMID:17189318 teprenone increases expression ISO RGD:730996 6480464 geranylgeranylacetone results in increased expression of HSF1 protein CTD PMID:21232033 teprenone multiple interactions ISO RGD:730996 6480464 geranylgeranylacetone promotes the reaction [[HSF1 protein binds to DLG1 promoter] which results in increased expression of DLG1 mRNA] CTD PMID:21232033 teriflunomide increases activity ISO RGD:730995 6480464 teriflunomide results in increased activity of HSF1 protein CTD PMID:34170685 tetrachloroethene decreases expression ISO RGD:730996 6480464 Tetrachloroethylene results in decreased expression of HSF1 mRNA CTD PMID:28973375 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of HSF1 mRNA] CTD PMID:31150632 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of HSF1 mRNA CTD PMID:31150632 thalidomide decreases expression ISO RGD:730996 6480464 Thalidomide results in decreased expression of HSF1 mRNA CTD PMID:26006729 , PMID:26217789 thiazoles increases activity ISO RGD:730995 6480464 Thiazoles results in increased activity of HSF1 protein CTD PMID:34170685 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of HSF1 mRNA CTD PMID:23411599 thiopental increases activity ISO RGD:730995 6480464 Thiopental results in increased activity of HSF1 protein CTD PMID:18218830 thiopental increases phosphorylation ISO RGD:730995 6480464 Thiopental results in increased phosphorylation of HSF1 protein CTD PMID:18218830 trichostatin A decreases activity ISO RGD:730995 6480464 trichostatin A results in decreased activity of HSF1 protein CTD PMID:34170685 valproic acid decreases expression ISO RGD:730996 6480464 Valproic Acid results in decreased expression of HSF1 mRNA CTD PMID:21427059 valproic acid increases methylation ISO RGD:730995 6480464 Valproic Acid results in increased methylation of HSF1 gene CTD PMID:29154799 valproic acid affects expression ISO RGD:730996 6480464 Valproic Acid affects the expression of HSF1 mRNA CTD PMID:17292431 withaferin A increases activity ISO RGD:730995 6480464 withaferin A results in increased activity of HSF1 protein CTD PMID:34170685 wortmannin affects localization ISO RGD:730995 6480464 wortmannin affects the localization of HSF1 protein CTD PMID:20090934 wortmannin multiple interactions ISO RGD:730995 6480464 wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA] CTD PMID:11424089 zinc atom increases activity ISO RGD:730995 6480464 Zinc deficiency results in increased activity of HSF1 protein, Zinc results in increased activity of HSF1 protein CTD PMID:16460681 more ... zinc atom multiple interactions ISO RGD:730995 6480464 Zinc promotes the reaction [HSF1 protein binds to HMOX1 promoter] more ... CTD PMID:16460681 , PMID:17244614 zinc oxide increases activity ISO RGD:730995 6480464 Zinc Oxide results in increased activity of HSF1 protein CTD PMID:34170685 zinc pyrithione increases expression ISO RGD:730995 6480464 pyrithione zinc results in increased expression of HSF1 mRNA CTD PMID:21424779 zinc sulfate multiple interactions ISO RGD:730995 6480464 Zinc Sulfate promotes the reaction [HSF1 protein binds to HMOX1 promoter] more ... CTD PMID:16460681 , PMID:17244614 zinc sulfate increases activity ISO RGD:730995 6480464 Zinc Sulfate results in increased activity of HSF1 protein CTD PMID:16460681 , PMID:17244614 zinc(0) increases activity ISO RGD:730995 6480464 Zinc deficiency results in increased activity of HSF1 protein, Zinc results in increased activity of HSF1 protein CTD PMID:16460681 more ... zinc(0) multiple interactions ISO RGD:730995 6480464 Zinc promotes the reaction [HSF1 protein binds to HMOX1 promoter] more ... CTD PMID:16460681 , PMID:17244614
