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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620913
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsf1
Name: heat shock transcription factor 1
Acc ID: CHEBI:31649
Term: teprenone
Definition: A terpene ketone in which a (9E,13E)-geranylgernayl group is bonded to one of the alpha-methyls of acetone (it is a mixture of 5E- and 5Z-geoisomers in a 3:2 ratio).
Chemical ID: MESH:C031049
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsf1affects response to substanceISOHsf1 (Mus musculus)6480464CTDHSF1 protein affects the susceptibility to geranylgeranylacetonePMID:17189318
Hsf1increases expressionISOHsf1 (Mus musculus)6480464CTDgeranylgeranylacetone results in increased expression of HSF1 proteinPMID:21232033
Hsf1multiple interactionsISOHsf1 (Mus musculus)6480464CTDgeranylgeranylacetone promotes the reaction [[HSF1 protein binds to DLG1 promoter] which results in increased expression of DLG1 mRNA]PMID:21232033
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