Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: HSF1 (heat shock transcription factor 1) Homo sapiens
Symbol: HSF1
Name: heat shock transcription factor 1
Description: Exhibits several functions, including DNA binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and Hsp90 protein binding activity. Involved in several processes, including cellular response to diamide; cellular response to metal ion; and regulation of nucleobase-containing compound metabolic process. Localizes to several cellular components, including kinetochore; microtubule cytoskeleton; and nucleus. Implicated in Huntington's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: heat shock factor protein 1; HSF 1; HSTF 1; HSTF1
Mus musculus (house mouse) : Hsf1 (heat shock factor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hsf1 (heat shock transcription factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsf1 (heat shock transcription factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HSF1 (heat shock transcription factor 1)
Canis lupus familiaris (dog) : HSF1 (heat shock transcription factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsf1 (heat shock transcription factor 1)
Sus scrofa (pig) : HSF1 (heat shock transcription factor 1)
Chlorocebus sabaeus (African green monkey) : HSF1 (heat shock transcription factor 1)
Heterocephalus glaber (naked mole-rat) : Hsf1 (heat shock transcription factor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl8144,291,591 - 144,314,720 (+)EnsemblGRCh38hg38GRCh38
GRCh388144,291,603 - 144,314,720 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378145,515,270 - 145,538,385 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,486,078 - 145,509,193 (+)NCBINCBI36hg18NCBI36
Build 348145,486,090 - 145,509,187NCBI
Celera8141,707,360 - 141,713,153 (+)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8140,629,839 - 140,652,904 (+)NCBIHuRef
CHM1_18145,553,452 - 145,576,661 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on HSF1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730995
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.