Hsf1 (heat shock transcription factor 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Hsf1 (heat shock transcription factor 1) Chinchilla lanigera
Analyze
Symbol: Hsf1
Name: heat shock transcription factor 1
RGD ID: 8816156
Description: ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN cell population proliferation (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to angiotensin (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); Brown-Vialetto-Van Laere syndrome 2 (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: heat shock factor protein 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554542,907,265 - 2,932,351 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554542,907,265 - 2,932,352 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell population proliferation  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to angiotensin  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to copper ion  (ISO)
cellular response to diamide  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to gamma radiation  (ISO)
cellular response to heat  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to L-glutamine  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to nitroglycerin  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to potassium ion  (ISO)
cellular response to radiation  (ISO)
cellular response to sodium arsenite  (ISO)
cellular response to unfolded protein  (ISO)
cellular response to xenobiotic stimulus  (ISO)
defense response  (ISO)
embryonic placenta development  (ISO)
embryonic process involved in female pregnancy  (ISO)
epithelial cell proliferation  (ISO)
female meiotic nuclear division  (ISO)
in utero embryonic development  (ISO)
MAPK cascade  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cellular process  (ISO)
negative regulation of double-strand break repair via nonhomologous end joining  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of inclusion body assembly  (ISO)
negative regulation of protein-containing complex assembly  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
positive regulation of apoptotic DNA fragmentation  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of inclusion body assembly  (ISO)
positive regulation of macrophage differentiation  (ISO)
positive regulation of microtubule binding  (ISO)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of protein modification process  (ISO)
positive regulation of stress granule assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein phosphorylation  (ISO)
protein-containing complex assembly  (ISO)
regulation of cellular response to heat  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to activity  (ISO)
response to amino acid  (ISO)
response to estradiol  (ISO)
response to heat  (ISO)
response to hypobaric hypoxia  (ISO)
response to lipopolysaccharide  (ISO)
response to nutrient  (ISO)
response to peptide  (ISO)
response to psychosocial stress  (ISO)
response to testosterone  (ISO)
spermatogenesis  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Hsf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554542,907,265 - 2,932,351 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554542,907,265 - 2,932,352 (+)NCBIChiLan1.0ChiLan1.0
HSF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388144,291,604 - 144,314,720 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8144,291,591 - 144,314,720 (+)EnsemblGRCh38hg38GRCh38
GRCh378145,515,286 - 145,538,383 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,486,078 - 145,509,193 (+)NCBINCBI36Build 36hg18NCBI36
Build 348145,486,090 - 145,509,187NCBI
Celera8141,707,360 - 141,713,153 (+)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8140,629,839 - 140,652,904 (+)NCBIHuRef
CHM1_18145,553,452 - 145,576,661 (+)NCBICHM1_1
T2T-CHM13v2.08145,460,056 - 145,483,355 (+)NCBIT2T-CHM13v2.0
Hsf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391576,361,562 - 76,385,355 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1576,361,622 - 76,386,113 (+)EnsemblGRCm39 Ensembl
GRCm381576,477,362 - 76,501,155 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1576,477,422 - 76,501,913 (+)EnsemblGRCm38mm10GRCm38
MGSCv371576,307,875 - 76,331,402 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361576,304,700 - 76,328,227 (+)NCBIMGSCv36mm8
Celera1577,977,956 - 78,001,512 (+)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1535.95NCBI
Hsf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87110,076,710 - 110,103,665 (+)NCBIGRCr8
mRatBN7.27108,196,040 - 108,223,011 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7108,196,056 - 108,223,011 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7109,940,443 - 109,967,383 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07112,164,140 - 112,191,080 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07112,122,490 - 112,149,447 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07117,538,523 - 117,565,478 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7117,538,523 - 117,565,478 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07117,526,154 - 117,553,109 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,524,211 - 114,551,166 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17114,580,681 - 114,585,056 (+)NCBI
Celera7104,547,683 - 104,574,508 (+)NCBICelera
Cytogenetic Map7q34NCBI
HSF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27161,778,661 - 161,801,822 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18137,308,606 - 137,331,773 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08141,055,310 - 141,078,360 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18144,062,137 - 144,067,725 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8144,062,137 - 144,067,866 (+)Ensemblpanpan1.1panPan2
HSF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11337,724,741 - 37,745,259 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1337,724,759 - 37,745,252 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1337,688,336 - 37,708,839 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01338,200,982 - 38,221,480 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,200,916 - 38,221,478 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11337,893,218 - 37,913,632 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01338,001,763 - 38,022,270 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01338,478,086 - 38,498,596 (+)NCBIUU_Cfam_GSD_1.0
Hsf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303501,635 - 524,700 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364707,928,095 - 7,933,337 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364707,927,734 - 7,950,805 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4463,393 - 486,473 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14463,531 - 486,483 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24610,323 - 633,482 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18138,503,836 - 138,529,562 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8138,503,831 - 138,529,165 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660391,334,097 - 1,360,855 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473512,537,128 - 12,562,644 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473512,536,818 - 12,562,643 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000014548   ⟹   ENSCLAP00000014390
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554542,907,265 - 2,932,351 (+)Ensembl
RefSeq Acc Id: XM_005395870   ⟹   XP_005395927
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554542,907,265 - 2,932,351 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005395871   ⟹   XP_005395928
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554542,907,265 - 2,932,351 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005395872   ⟹   XP_005395929
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554542,907,265 - 2,932,351 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005395873   ⟹   XP_005395930
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554542,907,265 - 2,932,351 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005395874   ⟹   XP_005395931
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554542,907,265 - 2,932,351 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005395875   ⟹   XP_005395932
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554542,907,503 - 2,932,352 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005395876   ⟹   XP_005395933
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554542,907,265 - 2,932,351 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005395877   ⟹   XP_005395934
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554542,907,265 - 2,932,351 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013520098   ⟹   XP_013375552
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554542,907,265 - 2,932,351 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005395927   ⟸   XM_005395870
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005395928   ⟸   XM_005395871
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005395929   ⟸   XM_005395872
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005395930   ⟸   XM_005395873
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_005395931   ⟸   XM_005395874
- Peptide Label: isoform X6
- UniProtKB: A0A8C2YPT5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005395933   ⟸   XM_005395876
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_005395934   ⟸   XM_005395877
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_005395932   ⟸   XM_005395875
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_013375552   ⟸   XM_013520098
- Peptide Label: isoform X5
- Sequence:
Ensembl Acc Id: ENSCLAP00000014390   ⟸   ENSCLAT00000014548
Protein Domains
HSF-type DNA-binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000009922 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000014548 ENTREZGENE
  ENSCLAT00000014548.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
InterPro HSF_DNA-bd UniProtKB/TrEMBL
  HSF_fam UniProtKB/TrEMBL
  Vert_HSTF_C UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene Hsf1 ENTREZGENE
PANTHER HEAT SHOCK FACTOR PROTEIN 1 UniProtKB/TrEMBL
  PTHR10015 UniProtKB/TrEMBL
Pfam HSF_DNA-bind UniProtKB/TrEMBL
  Vert_HS_TF UniProtKB/TrEMBL
PRINTS HSFDOMAIN UniProtKB/TrEMBL
PROSITE HSF_DOMAIN UniProtKB/TrEMBL
SMART HSF UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
UniProt A0A8C2YPT5 ENTREZGENE, UniProtKB/TrEMBL