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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620913
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsf1
Name: heat shock transcription factor 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsf1increases expressionISOHsf1 (Mus musculus)6480464CTDEstradiol results in increased expression of HSF1 mRNAPMID:12927369
Hsf1increases phosphorylationISOHSF1 (Homo sapiens)6480464CTDEstradiol results in increased phosphorylation of HSF1 proteinPMID:31614463
Hsf1multiple interactionsISOHSF1 (Homo sapiens)6480464CTDafimoxifene inhibits the reaction [Estradiol results in increased phosphorylation of HSF1 protein]; ESR1 protein affects the reaction [Estradiol results in increased phosphorylation of HSF1 protein]; Fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of HSF1 protein]; U 0126 inhibits the reaction [Estradiol results in increased phosphorylation of HSF1 protein]PMID:31614463
Hsf1multiple interactionsISOHsf1 (Mus musculus)6480464CTDfulvestrant inhibits the reaction [Estradiol results in increased expression of HSF1 mRNA]PMID:12927369
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