Krt18 (keratin 18) - Rat Genome Database

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Gene: Krt18 (keratin 18) Rattus norvegicus
Analyze
Symbol: Krt18
Name: keratin 18
RGD ID: 619935
Description: Predicted to enable scaffold protein binding activity. Involved in several processes, including cholangiocyte apoptotic process; hepatocyte differentiation; and response to fructose. Located in external side of plasma membrane; extracellular space; and keratin filament. Part of protein-containing complex. Biomarker of metabolic dysfunction-associated steatohepatitis and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in liver cirrhosis and metabolic dysfunction-associated steatohepatitis. Orthologous to human KRT18 (keratin 18); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CK-18; cytokeratin-18; K18; keratin 18, type I; keratin complex 1, acidic, gene 18; keratin, type I cytoskeletal 18; keratin-18; Krt1-18; MGC109143
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,036,168 - 135,039,844 (+)NCBIGRCr8
mRatBN7.27133,157,486 - 133,161,162 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,157,475 - 133,161,166 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,918,930 - 134,922,650 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,148,293 - 137,152,013 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,127,118 - 137,130,838 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,629,455 - 143,633,131 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,629,455 - 143,633,131 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,425,684 - 141,429,360 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1279,988,565 - 79,989,008 (+)NCBI
Celera7129,594,039 - 129,597,715 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3'-diindolylmethane  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
ABT-737  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
azoxystrobin  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-carotene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bufalin  (ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroform  (EXP)
chromium trinitrate  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cumene  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
DDE  (ISO)
DDT  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
diethylstilbestrol  (ISO)
diiodine  (EXP)
dimercaprol  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP,ISO)
dioscin  (EXP,ISO)
dioxygen  (ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
estramustine  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (ISO)
finasteride  (EXP)
fipronil  (EXP)
flavone  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glutathione  (EXP)
glycidol  (EXP)
glyphosate  (EXP)
griseofulvin  (ISO)
heparin  (ISO)
hydrazine  (EXP)
indometacin  (ISO)
irinotecan  (ISO)
iron(III) nitrilotriacetate  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
mercury dibromide  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methylarsonic acid  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nevirapine  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
Nutlin-3  (ISO)
nystatin  (ISO)
obeticholic acid  (ISO)
octreotide  (ISO)
oxybenzone  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorobutyric acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
procymidone  (EXP)
progesterone  (ISO)
pyrimidifen  (ISO)
pyrogallol  (ISO)
quartz  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sodium perchlorate  (EXP)
SU6656  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thapsigargin  (EXP)
thioacetamide  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimethylarsine oxide  (EXP)
triphenyl phosphate  (ISO)
trovafloxacin  (EXP)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vinorelbine  (ISO)
vorinostat  (ISO)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Evaluation of the diagnostic value of serum and tissue apoptotic cytokeratin-18 in patients with chronic hepatitis C. Abdel Haleem H, etal., Arab J Gastroenterol. 2013 Jun;14(2):68-72. doi: 10.1016/j.ajg.2013.03.004. Epub 2013 Apr 28.
2. Recovery of the Cholangiocytes After Ischemia and Reperfusion Injury: Ultra-Structural, Hystological and Molecular Assessment in Rats. Aloia TPA, etal., J Clin Exp Hepatol. 2018 Dec;8(4):380-389. doi: 10.1016/j.jceh.2018.01.003. Epub 2018 Feb 11.
3. Relationship between liver injury and serum cytokeratin 18 levels in asymptomatic hepatitis B virus carriers and in patients with chronic hepatitis B infection. Balkan A, etal., Arab J Gastroenterol. 2017 Jun;18(2):98-103. doi: 10.1016/j.ajg.2017.05.008. Epub 2017 Jun 1.
4. Keratin 18-deficiency results in steatohepatitis and liver tumors in old mice: A model of steatohepatitis-associated liver carcinogenesis. Bettermann K, etal., Oncotarget. 2016 Nov 8;7(45):73309-73322. doi: 10.18632/oncotarget.12325.
5. Association Between Serum CK-18 Levels and the Degree of Liver Damage in Fructose-Induced Metabolic Syndrome. Bratoeva K, etal., Metab Syndr Relat Disord. 2018 Sep;16(7):350-357. doi: 10.1089/met.2017.0162. Epub 2018 Jul 10.
6. In vitro and in vivo study of the application of volvox spheres to co-culture vehicles in liver tissue engineering. Chang SH, etal., Acta Biomater. 2017 Nov;63:261-273. doi: 10.1016/j.actbio.2017.09.028. Epub 2017 Sep 21.
7. Elevated serum cytokeratin-18 concentration in patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease. Chang YH, etal., Ann Clin Biochem. 2019 Jan;56(1):141-147. doi: 10.1177/0004563218796259. Epub 2018 Aug 27.
8. Serum cytokeratin-18 and its relation to liver fibrosis and steatosis diagnosed by FibroScan and controlled attenuation parameter in nonalcoholic fatty liver disease and hepatitis C virus patients. Darweesh SK, etal., Eur J Gastroenterol Hepatol. 2019 May;31(5):633-641. doi: 10.1097/MEG.0000000000001385.
9. Hepatic stellate cells modulate the differentiation of bone marrow mesenchymal stem cells into hepatocyte-like cells. Deng X, etal., J Cell Physiol. 2008 Oct;217(1):138-44. doi: 10.1002/jcp.21481.
10. Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients. Diab DL, etal., Clin Gastroenterol Hepatol. 2008 Nov;6(11):1249-54. doi: 10.1016/j.cgh.2008.07.016. Epub 2008 Jul 26.
11. Apoptotic and anti-apoptotic seromarkers for assessment of disease severity of non-alcoholic steatohepatitis. El Bassat H, etal., Arab J Gastroenterol. 2014 Mar;15(1):6-11. doi: 10.1016/j.ajg.2014.01.009. Epub 2014 Feb 7.
12. Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study. Feldstein AE, etal., Hepatology. 2009 Oct;50(4):1072-8. doi: 10.1002/hep.23050.
13. Switch in the expression of the K19/K18 keratin genes as a very early evidence of testicular differentiation in the rat. Fridmacher V, etal., Mech Dev 1995 Aug;52(2-3):199-207.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Arsenite induced oxidative damage in mouse liver is associated with increased cytokeratin 18 expression. Gonsebatt ME, etal., Arch Toxicol. 2007 Sep;81(9):619-26. doi: 10.1007/s00204-007-0192-7. Epub 2007 Mar 6.
17. Caspase-cleaved cytokeratin 18 and 20 S proteasome in liver degeneration. Hetz H, etal., J Clin Lab Anal. 2007;21(5):277-81. doi: 10.1002/jcla.20180.
18. Elevated serum CK18 levels in chronic hepatitis C patients are associated with advanced fibrosis but not steatosis. Jazwinski AB, etal., J Viral Hepat. 2012 Apr;19(4):278-82. doi: 10.1111/j.1365-2893.2011.01546.x. Epub 2011 Nov 24.
19. [Subcellular proteome analysis of immune or alcohol induced rat liver fibrosis]. Jia XF, etal., Zhonghua Gan Zang Bing Za Zhi. 2010 Nov;18(11):826-30. doi: 10.3760/cma.j.issn.1007-3418.2010.11.009.
20. Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis. Joka D, etal., Hepatology. 2012 Feb;55(2):455-64. doi: 10.1002/hep.24734. Epub 2011 Nov 29.
21. Mutation of human keratin 18 in association with cryptogenic cirrhosis. Ku NO, etal., J Clin Invest. 1997 Jan 1;99(1):19-23.
22. Cell death markers in patients with cirrhosis and acute decompensation. Macdonald S, etal., Hepatology. 2018 Mar;67(3):989-1002. doi: 10.1002/hep.29581. Epub 2018 Jan 24.
23. Identification of cytokeratin 18 as a biomarker of mouse and human hepatosplenic schistosomiasis. Manivannan B, etal., Infect Immun. 2011 May;79(5):2051-8. doi: 10.1128/IAI.01214-10. Epub 2011 Feb 28.
24. Individuals with Primary Sclerosing Cholangitis Have Elevated Levels of Biomarkers for Apoptosis but Not Necrosis. Masuoka HC, etal., Dig Dis Sci. 2015 Dec;60(12):3642-6. doi: 10.1007/s10620-015-3805-7. Epub 2015 Jul 21.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Comprehensive gene review and curation RGD comprehensive gene curation
31. Serum cell death biomarkers for prediction of liver fibrosis and poor prognosis in primary biliary cirrhosis. Sekiguchi T, etal., PLoS One. 2015 Jun 25;10(6):e0131658. doi: 10.1371/journal.pone.0131658. eCollection 2015.
32. Keratin 18 phosphorylation as a progression marker of chronic hepatitis B. Shi Y, etal., Virol J. 2010 Mar 24;7:70. doi: 10.1186/1743-422X-7-70.
33. Differentiation and migration of bone marrow mesenchymal stem cells transplanted through the spleen in rats with portal hypertension. Sun S, etal., PLoS One. 2013 Dec 10;8(12):e83523. doi: 10.1371/journal.pone.0083523. eCollection 2013.
34. Mutation of caspase-digestion sites in keratin 18 interferes with filament reorganization, and predisposes to hepatocyte necrosis and loss of membrane integrity. Weerasinghe SV, etal., J Cell Sci. 2014 Apr 1;127(Pt 7):1464-75. doi: 10.1242/jcs.138479. Epub 2014 Jan 24.
35. Cytokeratin 18 is expressed on the hepatocyte plasma membrane surface and interacts with thrombin-antithrombin complexes. Wells MJ, etal., J Biol Chem. 1997 Nov 7;272(45):28574-81. doi: 10.1074/jbc.272.45.28574.
36. Serum CK 18-M30 reflect liver pathological severity during NAFLD progression in a rat model. Xue L, etal., Pathol Res Pract. 2018 Nov;214(11):1778-1786. doi: 10.1016/j.prp.2018.08.016. Epub 2018 Aug 20.
37. Elevated apoptosis-associated cytokeratin 18 fragments (CK18Asp386) in serum of patients with chronic liver diseases indicate hepatic and biliary inflammation. Yagmur E, etal., Clin Biochem. 2007 Jun;40(9-10):651-5. doi: 10.1016/j.clinbiochem.2006.12.010. Epub 2007 Jan 17.
38. Phosphorylation of keratin intermediate filaments by protein kinase C, by calmodulin-dependent protein kinase and by cAMP-dependent protein kinase. Yano T, etal., Eur J Biochem. 1991 Apr 23;197(2):281-90.
39. High-fat-cholesterol diet mainly induced necrosis in fibrotic steatohepatitis rat by suppressing caspase activity. Yetti H, etal., Life Sci. 2013 Nov 4;93(18-19):673-80. doi: 10.1016/j.lfs.2013.09.013. Epub 2013 Sep 23.
40. Elevated serum levels of caspase-cleaved cytokeratin 18 (CK18-Asp396) in patients with nonalcoholic steatohepatitis and chronic hepatitis C. Yilmaz Y, etal., Med Sci Monit. 2009 Apr;15(4):CR189-93.
Additional References at PubMed
PMID:10747083   PMID:10852826   PMID:11684708   PMID:12477932   PMID:15489334   PMID:15529338   PMID:16128803   PMID:16424149   PMID:16641100   PMID:18000879   PMID:19199708   PMID:19407366  
PMID:19409407   PMID:20346438   PMID:21930775   PMID:22658674   PMID:22685604   PMID:23284756   PMID:24625528   PMID:25468996   PMID:36395917  


Genomics

Comparative Map Data
Krt18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,036,168 - 135,039,844 (+)NCBIGRCr8
mRatBN7.27133,157,486 - 133,161,162 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,157,475 - 133,161,166 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,918,930 - 134,922,650 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,148,293 - 137,152,013 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,127,118 - 137,130,838 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,629,455 - 143,633,131 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,629,455 - 143,633,131 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,425,684 - 141,429,360 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1279,988,565 - 79,989,008 (+)NCBI
Celera7129,594,039 - 129,597,715 (+)NCBICelera
Cytogenetic Map7q36NCBI
KRT18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,948,855 - 52,952,906 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,948,871 - 52,952,906 (+)EnsemblGRCh38hg38GRCh38
GRCh371253,342,639 - 53,346,690 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,628,922 - 51,632,952 (+)NCBINCBI36Build 36hg18NCBI36
Build 341251,628,921 - 51,632,951NCBI
Celera1252,989,626 - 52,993,657 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,386,471 - 50,390,501 (+)NCBIHuRef
CHM1_11253,309,411 - 53,313,442 (+)NCBICHM1_1
T2T-CHM13v2.01252,913,414 - 52,917,465 (+)NCBIT2T-CHM13v2.0
Krt18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,936,651 - 101,940,461 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,936,615 - 101,940,462 (+)EnsemblGRCm39 Ensembl
GRCm3815102,028,216 - 102,032,026 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,028,180 - 102,032,027 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715101,858,647 - 101,862,457 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,856,259 - 101,860,055 (+)NCBIMGSCv36mm8
Celera15104,183,109 - 104,186,912 (+)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1557.22NCBI
Krt18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458226,805 - 232,728 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955458227,017 - 230,752 (+)NCBIChiLan1.0ChiLan1.0
KRT18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21041,240,278 - 41,244,325 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11241,237,041 - 41,241,089 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01235,807,660 - 35,811,691 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11236,587,149 - 36,591,196 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,587,149 - 36,591,196 (-)Ensemblpanpan1.1panPan2
KRT18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,189,269 - 2,193,368 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,189,269 - 2,193,368 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2744,058,883 - 44,062,982 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,190,002 - 2,194,108 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,189,986 - 2,194,112 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1272,207,095 - 2,210,994 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,193,381 - 2,197,266 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,457,950 - 44,461,835 (+)NCBIUU_Cfam_GSD_1.0
Krt18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,870,183 - 62,874,137 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651210,290,690 - 10,294,651 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651210,290,706 - 10,294,647 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRT18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,217,691 - 18,221,429 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,217,686 - 18,221,432 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,726,205 - 18,729,755 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KRT18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,073,733 - 49,081,706 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037196,990,833 - 196,994,833 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Krt18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249041,011,755 - 1,015,416 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249041,011,675 - 1,015,319 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Krt18
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:43
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000073951
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
RH131703  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0825,170,981 - 25,171,164NCBIRnor5.0
Rnor_5.02100,546,425 - 100,546,621NCBIRnor5.0
RGSC_v3.4823,625,335 - 23,625,517UniSTSRGSC3.4
RGSC_v3.4280,044,296 - 80,044,491UniSTSRGSC3.4
Celera824,075,285 - 24,075,467UniSTS
Celera274,545,867 - 74,546,062UniSTS
RH 3.4 Map71065.8UniSTS
Cytogenetic Map7q36UniSTS
AA891608  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,160,631 - 133,161,119 (+)MAPPERmRatBN7.2
Rnor_6.07143,632,601 - 143,633,088NCBIRnor6.0
Rnor_5.07141,428,830 - 141,429,317UniSTSRnor5.0
Celera7129,597,185 - 129,597,672UniSTS
RH 3.4 Map2401.5UniSTS
Cytogenetic Map7q36UniSTS
Krt18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2278,910,620 - 78,911,453 (+)MAPPERmRatBN7.2
mRatBN7.2278,910,690 - 78,911,453 (+)MAPPERmRatBN7.2
Rnor_6.0280,878,793 - 80,879,555NCBIRnor6.0
Rnor_6.0280,878,570 - 80,879,555NCBIRnor6.0
Rnor_5.02100,545,637 - 100,546,399UniSTSRnor5.0
Rnor_5.02100,545,414 - 100,546,399UniSTSRnor5.0
RGSC_v3.4280,043,507 - 80,044,269UniSTSRGSC3.4
Celera274,545,078 - 74,545,840UniSTS
Cytogenetic Map7q36UniSTS
Krt18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2278,911,416 - 78,911,583 (+)MAPPERmRatBN7.2
mRatBN7.2822,497,552 - 22,497,716 (+)MAPPERmRatBN7.2
Rnor_6.0280,879,519 - 80,879,685NCBIRnor6.0
Rnor_6.0825,137,020 - 25,137,183NCBIRnor6.0
Rnor_5.0825,170,922 - 25,171,085UniSTSRnor5.0
Rnor_5.02100,546,363 - 100,546,529UniSTSRnor5.0
RGSC_v3.4823,625,275 - 23,625,438UniSTSRGSC3.4
RGSC_v3.4280,044,233 - 80,044,399UniSTSRGSC3.4
Celera824,075,225 - 24,075,388UniSTS
Celera274,545,804 - 74,545,970UniSTS
Cytogenetic Map7q36UniSTS
Cytogenetic Map8q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 9 49 113 91 90 59 25 59 6 215 94 93 45 59 31

Sequence


Ensembl Acc Id: ENSRNOT00000073951   ⟹   ENSRNOP00000067234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7133,157,475 - 133,161,166 (+)Ensembl
Rnor_6.0 Ensembl7143,629,455 - 143,633,131 (+)Ensembl
RefSeq Acc Id: NM_053976   ⟹   NP_446428
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,036,168 - 135,039,844 (+)NCBI
mRatBN7.27133,157,486 - 133,161,162 (+)NCBI
Rnor_6.07143,629,455 - 143,633,131 (+)NCBI
Rnor_5.07141,425,684 - 141,429,360 (+)NCBI
Celera7129,594,039 - 129,597,715 (+)RGD
Sequence:
RefSeq Acc Id: NP_446428   ⟸   NM_053976
- UniProtKB: Q63278 (UniProtKB/Swiss-Prot),   Q5BJY9 (UniProtKB/Swiss-Prot),   A0A8I6A244 (UniProtKB/TrEMBL),   A6KCS5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067234   ⟸   ENSRNOT00000073951
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BJY9-F1-model_v2 AlphaFold Q5BJY9 1-423 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695686
Promoter ID:EPDNEW_R6211
Type:multiple initiation site
Name:Krt18_1
Description:keratin 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,629,441 - 143,629,501EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619935 AgrOrtholog
BioCyc Gene G2FUF-31953 BioCyc
Ensembl Genes ENSRNOG00000047393 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000069468 UniProtKB/TrEMBL
  ENSRNOG00055026600 UniProtKB/Swiss-Prot
  ENSRNOG00060014085 UniProtKB/Swiss-Prot
  ENSRNOG00065020251 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073951.3 UniProtKB/Swiss-Prot
  ENSRNOT00000100179.1 UniProtKB/TrEMBL
  ENSRNOT00055045933 UniProtKB/Swiss-Prot
  ENSRNOT00060024125 UniProtKB/Swiss-Prot
  ENSRNOT00065034194 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single helix bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7383311 IMAGE-MGC_LOAD
InterPro IF_conserved UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_rod_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Keratin_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:294853 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:109143 IMAGE-MGC_LOAD
NCBI Gene Krt18 ENTREZGENE
PANTHER INTERMEDIATE FILAMENT UniProtKB/TrEMBL
  KERATIN, TYPE I CYTOSKELETAL 18 UniProtKB/TrEMBL
  PTHR23239 UniProtKB/Swiss-Prot
  PTHR23239:SF349 UniProtKB/Swiss-Prot
Pfam Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Krt18 PhenoGen
PRINTS TYPE1KERATIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_ROD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047393 RatGTEx
  ENSRNOG00000069468 RatGTEx
  ENSRNOG00055026600 RatGTEx
  ENSRNOG00060014085 RatGTEx
  ENSRNOG00065020251 RatGTEx
SMART Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A244 ENTREZGENE, UniProtKB/TrEMBL
  A6KCS5 ENTREZGENE, UniProtKB/TrEMBL
  K1C18_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63278 ENTREZGENE
UniProt Secondary Q63278 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Krt18  keratin 18  Krt18  keratin 18, type I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-28 Krt18  keratin 18, type I  Krt18  keratin 18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Krt18  keratin 18  Krt1-18  keratin complex 1, acidic, gene 18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Krt1-18  keratin complex 1, acidic, gene 18      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Krt1-18  keratin complex 1, acidic, gene 18      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed at the onset of testicular differentiation and in male gonads 633091
gene_expression exclusively expressed in fetal Sertoli cells from 14.5 days of gestation 633091
gene_regulation expression regulated at the transcriptional level 633091