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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619935
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Krt18
Name: keratin 18
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Krt18decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of KRT18 mRNAPMID:33387578
Krt18affects expressionISOKrt18 (Mus musculus)6480464CTDAcetaminophen affects the expression of KRT18 mRNAPMID:17562736
Krt18decreases expressionISOKRT18 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of KRT18 mRNAPMID:21420995
Krt18decreases response to substanceISOKRT18 (Homo sapiens)6480464CTDKRT18 protein results in decreased susceptibility to AcetaminophenPMID:8770877
Krt18increases cleavageISOKrt18 (Mus musculus)6480464CTDAcetaminophen results in increased cleavage of KRT18 proteinPMID:19783637
Krt18increases expressionISOKrt18 (Mus musculus)6480464CTDAcetaminophen results in increased expression of KRT18 proteinPMID:22939915
Krt18multiple interactionsISOKrt18 (Mus musculus)6480464CTDdioscin inhibits the reaction [Acetaminophen results in increased expression of KRT18 protein]PMID:22939915
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