KRT18 (keratin 18) - Rat Genome Database

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Gene: KRT18 (keratin 18) Canis lupus familiaris
Analyze
Symbol: KRT18
Name: keratin 18
RGD ID: 12358542
Description: ENCODES a protein that exhibits scaffold protein binding (ortholog); INVOLVED IN cholangiocyte apoptotic process (ortholog); extrinsic apoptotic signaling pathway (ortholog); Golgi to plasma membrane CFTR protein transport (ortholog); ASSOCIATED WITH Acute Liver Failure (ortholog); Breast Neoplasms (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cell periphery (ortholog); centriolar satellite (ortholog); cytoplasm (ortholog); INTERACTS WITH clofibrate
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CK18; cytokeratin 18; keratin, type I cytoskeletal 18
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,189,269 - 2,193,368 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,189,269 - 2,193,368 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2744,058,883 - 44,062,982 (+)NCBI
ROS_Cfam_1.0272,190,002 - 2,194,108 (-)NCBI
ROS_Cfam_1.0 Ensembl272,189,986 - 2,194,112 (-)Ensembl
UMICH_Zoey_3.1272,207,095 - 2,210,994 (-)NCBI
UNSW_CanFamBas_1.0272,193,381 - 2,197,266 (-)NCBI
UU_Cfam_GSD_1.02744,457,950 - 44,461,835 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
clofibrate  (EXP)

References
Additional References at PubMed
PMID:18196537   PMID:18213634  


Genomics

Comparative Map Data
KRT18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,189,269 - 2,193,368 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,189,269 - 2,193,368 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2744,058,883 - 44,062,982 (+)NCBI
ROS_Cfam_1.0272,190,002 - 2,194,108 (-)NCBI
ROS_Cfam_1.0 Ensembl272,189,986 - 2,194,112 (-)Ensembl
UMICH_Zoey_3.1272,207,095 - 2,210,994 (-)NCBI
UNSW_CanFamBas_1.0272,193,381 - 2,197,266 (-)NCBI
UU_Cfam_GSD_1.02744,457,950 - 44,461,835 (+)NCBI
KRT18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,948,855 - 52,952,906 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1252,948,871 - 52,952,906 (+)EnsemblGRCh38hg38GRCh38
GRCh371253,342,639 - 53,346,690 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,628,922 - 51,632,952 (+)NCBINCBI36hg18NCBI36
Build 341251,628,921 - 51,632,951NCBI
Celera1252,989,626 - 52,993,657 (+)NCBI
Cytogenetic Map12q13.13NCBI
HuRef1250,386,471 - 50,390,501 (+)NCBIHuRef
CHM1_11253,309,411 - 53,313,442 (+)NCBICHM1_1
T2T-CHM13v2.01252,913,414 - 52,917,465 (+)NCBI
Krt18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,936,651 - 101,940,461 (+)NCBIGRCm39mm39
GRCm39 Ensembl15101,936,615 - 101,940,462 (+)Ensembl
GRCm3815102,028,216 - 102,032,026 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,028,180 - 102,032,027 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715101,858,647 - 101,862,457 (+)NCBIGRCm37mm9NCBIm37
MGSCv3615101,856,259 - 101,860,055 (+)NCBImm8
Celera15104,183,109 - 104,186,912 (+)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1557.22NCBI
Krt18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27133,157,486 - 133,161,162 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl7133,157,475 - 133,161,166 (+)Ensembl
Rnor_6.07143,629,455 - 143,633,131 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,629,455 - 143,633,131 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,425,684 - 141,429,360 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1279,988,565 - 79,989,008 (+)NCBI
Celera7129,594,039 - 129,597,715 (+)NCBICelera
Cytogenetic Map7q36NCBI
Krt18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458226,805 - 232,728 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955458227,017 - 230,752 (+)NCBIChiLan1.0ChiLan1.0
KRT18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11236,587,149 - 36,591,196 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,587,149 - 36,591,196 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01235,807,660 - 35,811,691 (-)NCBIMhudiblu_PPA_v0panPan3
Krt18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,870,183 - 62,874,137 (-)NCBI
SpeTri2.0NW_00493651210,290,706 - 10,294,647 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRT18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,217,691 - 18,221,429 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,217,686 - 18,221,432 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,726,205 - 18,729,755 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KRT18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,073,733 - 49,081,706 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037196,990,833 - 196,994,833 (-)NCBIVero_WHO_p1.0
Krt18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249041,011,755 - 1,015,416 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046249041,011,675 - 1,015,319 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 1
Medium 4 17 6 5 6 6 6 10 6
Low 4 1 1 1
Below cutoff 1 4 2 5 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000011515   ⟹   ENSCAFP00000010672
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl272,189,269 - 2,193,368 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845041762   ⟹   ENSCAFP00845032755
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl272,189,986 - 2,194,112 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845041807   ⟹   ENSCAFP00845032792
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl272,190,002 - 2,194,112 (-)Ensembl
RefSeq Acc Id: NM_001346040   ⟹   NP_001332969
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1272,189,269 - 2,193,368 (-)NCBI
Dog10K_Boxer_Tasha2744,058,883 - 44,062,982 (+)NCBI
ROS_Cfam_1.0272,190,002 - 2,194,108 (-)NCBI
UMICH_Zoey_3.1272,207,095 - 2,210,994 (-)NCBI
UNSW_CanFamBas_1.0272,193,381 - 2,197,266 (-)NCBI
UU_Cfam_GSD_1.02744,457,950 - 44,461,835 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001332969 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001332969   ⟸   NM_001346040
- Sequence:
RefSeq Acc Id: ENSCAFP00000010672   ⟸   ENSCAFT00000011515
RefSeq Acc Id: ENSCAFP00845032755   ⟸   ENSCAFT00845041762
RefSeq Acc Id: ENSCAFP00845032792   ⟸   ENSCAFT00845041807
Protein Domains
IF rod


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007154 Ensembl
  ENSCAFG00030025674 UniProtKB/TrEMBL
  ENSCAFG00845023645 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030041447.1 UniProtKB/TrEMBL
  ENSCAFP00845032755.1 UniProtKB/TrEMBL
  ENSCAFP00845032792 ENTREZGENE
  ENSCAFP00845032792.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030047403.1 UniProtKB/TrEMBL
  ENSCAFT00845041762.1 UniProtKB/TrEMBL
  ENSCAFT00845041807 ENTREZGENE
  ENSCAFT00845041807.1 UniProtKB/TrEMBL
InterPro IF_conserved UniProtKB/TrEMBL
  IF_rod_dom UniProtKB/TrEMBL
  Keratin-18 UniProtKB/TrEMBL
  Keratin_I UniProtKB/TrEMBL
NCBI Gene KRT18 ENTREZGENE
PANTHER PTHR23239 UniProtKB/TrEMBL
  PTHR23239:SF349 UniProtKB/TrEMBL
Pfam Filament UniProtKB/TrEMBL
PRINTS TYPE1KERATIN UniProtKB/TrEMBL
PROSITE IF_ROD_1 UniProtKB/TrEMBL
  IF_ROD_2 UniProtKB/TrEMBL
SMART Filament UniProtKB/TrEMBL
UniProt A0A8C0PK81_CANLF UniProtKB/TrEMBL
  A0A8I3PJ84_CANLF UniProtKB/TrEMBL
  A0A8I3PJS6_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:106506 ENTREZGENE