KRT18 (keratin 18) - Rat Genome Database
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Gene: KRT18 (keratin 18) Homo sapiens
Analyze
Symbol: KRT18
Name: keratin 18
RGD ID: 735767
HGNC Page HGNC
Description: Exhibits scaffold protein binding activity. Involved in Golgi to plasma membrane CFTR protein transport; intermediate filament cytoskeleton organization; and negative regulation of apoptotic process. Localizes to centriolar satellite; cytosol; and keratin filament. Implicated in liver cirrhosis. Biomarker of liver disease (multiple); non-alcoholic fatty liver disease (multiple); and primary sclerosing cholangitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cell proliferation-inducing gene 46 protein; cell proliferation-inducing protein 46; CK-18; CYK18; cytokeratin 18; cytokeratin-18; K18; keratin 18, type I; keratin, type I cytoskeletal 18; keratin-18
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: KRT18P1   KRT18P10   KRT18P11   KRT18P12   KRT18P13   KRT18P14   KRT18P15   KRT18P16   KRT18P17   KRT18P18   KRT18P19   KRT18P2   KRT18P20   KRT18P21   KRT18P22   KRT18P23   KRT18P24   KRT18P25   KRT18P26   KRT18P27   KRT18P28   KRT18P29   KRT18P3   KRT18P30   KRT18P31   KRT18P32   KRT18P33   KRT18P34   KRT18P35   KRT18P36   KRT18P37   KRT18P38   KRT18P39   KRT18P4   KRT18P40   KRT18P41   KRT18P42   KRT18P43   KRT18P44   KRT18P45   KRT18P46   KRT18P47   KRT18P48   KRT18P49   KRT18P5   KRT18P50   KRT18P51   KRT18P52   KRT18P53   KRT18P54   KRT18P55   KRT18P56   KRT18P57   KRT18P58   KRT18P59   KRT18P6   KRT18P60   KRT18P61   KRT18P62   KRT18P63   KRT18P64   KRT18P65   KRT18P66   KRT18P67   KRT18P68   KRT18P7   KRT18P8   KRT18P9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1252,948,871 - 52,952,906 (+)EnsemblGRCh38hg38GRCh38
GRCh381252,948,855 - 52,952,906 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371253,342,639 - 53,346,690 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,628,922 - 51,632,952 (+)NCBINCBI36hg18NCBI36
Build 341251,628,921 - 51,632,951NCBI
Celera1252,989,626 - 52,993,657 (+)NCBI
Cytogenetic Map12q13.13NCBI
HuRef1250,386,471 - 50,390,501 (+)NCBIHuRef
CHM1_11253,309,411 - 53,313,442 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(S)-colchicine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
9-cis-retinoic acid  (EXP)
acetamide  (ISO)
acrolein  (EXP)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-4-oxoretinol  (EXP)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
alpha-pinene  (EXP)
ammonium chloride  (ISO)
arachidonic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
belinostat  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-carotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bufalin  (EXP)
buspirone  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
caffeine  (EXP)
calcitriol  (EXP)
carbon nanotube  (EXP,ISO)
chloroform  (ISO)
chromium trinitrate  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (EXP)
crocidolite asbestos  (ISO)
cumene  (ISO)
cylindrospermopsin  (EXP)
DDE  (EXP)
DDT  (EXP)
Deguelin  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diethylstilbestrol  (ISO)
diiodine  (ISO)
dimercaprol  (ISO)
dimethylarsinic acid  (ISO)
dioscin  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
elemental selenium  (EXP)
entinostat  (EXP)
erythromycin estolate  (ISO)
estramustine  (EXP)
ethanol  (EXP,ISO)
fenofibrate  (ISO)
finasteride  (ISO)
fipronil  (ISO)
flavone  (EXP)
flutamide  (ISO)
folic acid  (ISO)
fructose  (ISO)
fulvestrant  (EXP)
fumonisin B1  (ISO)
furan  (ISO)
genistein  (EXP,ISO)
glafenine  (ISO)
glutathione  (ISO)
glycidol  (ISO)
griseofulvin  (EXP,ISO)
heparin  (EXP)
hydrazine  (ISO)
indometacin  (EXP)
irinotecan  (EXP)
iron(III) nitrilotriacetate  (EXP)
isoprenaline  (ISO)
levofloxacin  (ISO)
lovastatin  (ISO)
mercury dibromide  (EXP)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP)
microcystin-LR  (EXP,ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
nefazodone  (ISO)
nevirapine  (EXP)
nickel atom  (EXP)
nystatin  (ISO)
octreotide  (EXP)
oxybenzone  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (EXP)
paclitaxel  (EXP)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
procymidone  (ISO)
progesterone  (EXP,ISO)
pyrogallol  (ISO)
quartz  (EXP)
quercetin  (EXP)
rac-lactic acid  (EXP)
SB 203580  (EXP)
SB 431542  (EXP,ISO)
selenium atom  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (ISO)
sodium perchlorate  (ISO)
SU6656  (EXP)
sunitinib  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
triadimefon  (EXP)
trichostatin A  (EXP)
trimethylarsine oxide  (ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (ISO)
vinorelbine  (EXP)
vorinostat  (EXP)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Abdel Haleem H, etal., Arab J Gastroenterol. 2013 Jun;14(2):68-72. doi: 10.1016/j.ajg.2013.03.004. Epub 2013 Apr 28.
2. Balkan A, etal., Arab J Gastroenterol. 2017 Jun;18(2):98-103. doi: 10.1016/j.ajg.2017.05.008. Epub 2017 Jun 1.
3. Bettermann K, etal., Oncotarget. 2016 Nov 8;7(45):73309-73322. doi: 10.18632/oncotarget.12325.
4. Bratoeva K, etal., Metab Syndr Relat Disord. 2018 Sep;16(7):350-357. doi: 10.1089/met.2017.0162. Epub 2018 Jul 10.
5. Chang YH, etal., Ann Clin Biochem. 2019 Jan;56(1):141-147. doi: 10.1177/0004563218796259. Epub 2018 Aug 27.
6. Darweesh SK, etal., Eur J Gastroenterol Hepatol. 2019 May;31(5):633-641. doi: 10.1097/MEG.0000000000001385.
7. Diab DL, etal., Clin Gastroenterol Hepatol. 2008 Nov;6(11):1249-54. doi: 10.1016/j.cgh.2008.07.016. Epub 2008 Jul 26.
8. El Bassat H, etal., Arab J Gastroenterol. 2014 Mar;15(1):6-11. doi: 10.1016/j.ajg.2014.01.009. Epub 2014 Feb 7.
9. Feldstein AE, etal., Hepatology. 2009 Oct;50(4):1072-8. doi: 10.1002/hep.23050.
10. GOA_HUMAN data from the GO Consortium
11. Gonsebatt ME, etal., Arch Toxicol. 2007 Sep;81(9):619-26. doi: 10.1007/s00204-007-0192-7. Epub 2007 Mar 6.
12. Hetz H, etal., J Clin Lab Anal. 2007;21(5):277-81. doi: 10.1002/jcla.20180.
13. Jazwinski AB, etal., J Viral Hepat. 2012 Apr;19(4):278-82. doi: 10.1111/j.1365-2893.2011.01546.x. Epub 2011 Nov 24.
14. Jia XF, etal., Zhonghua Gan Zang Bing Za Zhi. 2010 Nov;18(11):826-30. doi: 10.3760/cma.j.issn.1007-3418.2010.11.009.
15. Joka D, etal., Hepatology. 2012 Feb;55(2):455-64. doi: 10.1002/hep.24734. Epub 2011 Nov 29.
16. Ku NO, etal., J Clin Invest. 1997 Jan 1;99(1):19-23.
17. Macdonald S, etal., Hepatology. 2018 Mar;67(3):989-1002. doi: 10.1002/hep.29581. Epub 2018 Jan 24.
18. Manivannan B, etal., Infect Immun. 2011 May;79(5):2051-8. doi: 10.1128/IAI.01214-10. Epub 2011 Feb 28.
19. Masuoka HC, etal., Dig Dis Sci. 2015 Dec;60(12):3642-6. doi: 10.1007/s10620-015-3805-7. Epub 2015 Jul 21.
20. OMIM Disease Annotation Pipeline
21. Pipeline to import KEGG annotations from KEGG into RGD
22. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. RGD automated import pipeline for gene-chemical interactions
24. RGD automated import pipeline for human HPO-to-gene-to-disease annotations
25. Sekiguchi T, etal., PLoS One. 2015 Jun 25;10(6):e0131658. doi: 10.1371/journal.pone.0131658. eCollection 2015.
26. Shi Y, etal., Virol J. 2010 Mar 24;7:70. doi: 10.1186/1743-422X-7-70.
27. Weerasinghe SV, etal., J Cell Sci. 2014 Apr 1;127(Pt 7):1464-75. doi: 10.1242/jcs.138479. Epub 2014 Jan 24.
28. Xue L, etal., Pathol Res Pract. 2018 Nov;214(11):1778-1786. doi: 10.1016/j.prp.2018.08.016. Epub 2018 Aug 20.
29. Yagmur E, etal., Clin Biochem. 2007 Jun;40(9-10):651-5. doi: 10.1016/j.clinbiochem.2006.12.010. Epub 2007 Jan 17.
30. Yetti H, etal., Life Sci. 2013 Nov 4;93(18-19):673-80. doi: 10.1016/j.lfs.2013.09.013. Epub 2013 Sep 23.
31. Yilmaz Y, etal., Med Sci Monit. 2009 Apr;15(4):CR189-93.
Additional References at PubMed
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PMID:7529764   PMID:7536183   PMID:7538124   PMID:7541767   PMID:8125298   PMID:8522590   PMID:9150948   PMID:9298992   PMID:9353322   PMID:9367879   PMID:9409741   PMID:9524113  
PMID:9560222   PMID:9630597   PMID:9786957   PMID:10022517   PMID:10444072   PMID:10625605   PMID:10747083   PMID:10809736   PMID:10852826   PMID:10891503   PMID:10954706   PMID:11162351  
PMID:11278913   PMID:11356849   PMID:11581269   PMID:11684708   PMID:11788583   PMID:11917136   PMID:11923318   PMID:11955647   PMID:12191991   PMID:12235123   PMID:12388748   PMID:12429849  
PMID:12473120   PMID:12477932   PMID:12577067   PMID:12707304   PMID:12717381   PMID:12724528   PMID:14556659   PMID:14648556   PMID:14710194   PMID:14744259   PMID:14756564   PMID:14968112  
PMID:15102669   PMID:15194421   PMID:15231747   PMID:15314064   PMID:15316390   PMID:15339273   PMID:15368451   PMID:15489334   PMID:15493875   PMID:15529338   PMID:15671067   PMID:15731013  
PMID:15731014   PMID:15822942   PMID:15831101   PMID:15838910   PMID:15846844   PMID:15952740   PMID:15987600   PMID:16046547   PMID:16143128   PMID:16189514   PMID:16212417   PMID:16367866  
PMID:16424149   PMID:16831889   PMID:16836912   PMID:16892178   PMID:17034788   PMID:17353931   PMID:17542994   PMID:17545523   PMID:17617404   PMID:17891046   PMID:17954264   PMID:18000879  
PMID:18029348   PMID:18038249   PMID:18349119   PMID:18432282   PMID:18460214   PMID:18577580   PMID:18705345   PMID:18712172   PMID:18941637   PMID:19032382   PMID:19087356   PMID:19199708  
PMID:19246484   PMID:19249390   PMID:19282868   PMID:19302716   PMID:19357195   PMID:19378390   PMID:19407366   PMID:19419951   PMID:19447876   PMID:19529960   PMID:19549727   PMID:19575986  
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PMID:20309963   PMID:20346438   PMID:20348541   PMID:20362077   PMID:20372788   PMID:20374042   PMID:20398190   PMID:20538000   PMID:20618440   PMID:20634891   PMID:20659422   PMID:20729549  
PMID:20936779   PMID:21119362   PMID:21145805   PMID:21195700   PMID:21420381   PMID:21460362   PMID:21548936   PMID:21565611   PMID:21654808   PMID:21682752   PMID:21705376   PMID:21877197  
PMID:21988832   PMID:22119785   PMID:22191568   PMID:22304920   PMID:22412904   PMID:22623428   PMID:22658674   PMID:22677743   PMID:22699783   PMID:22853896   PMID:22863883   PMID:22890829  
PMID:22939629   PMID:22967118   PMID:23045527   PMID:23112296   PMID:23154549   PMID:23164509   PMID:23326448   PMID:23327593   PMID:23341946   PMID:23398456   PMID:23438482   PMID:23449973  
PMID:23536001   PMID:23752877   PMID:23767766   PMID:23784459   PMID:23792028   PMID:23801282   PMID:23812330   PMID:23864450   PMID:23945185   PMID:23979707   PMID:23981197   PMID:23990477  
PMID:24067262   PMID:24157880   PMID:24237940   PMID:24324749   PMID:24457600   PMID:24605039   PMID:24622872   PMID:24660549   PMID:24667697   PMID:24711643   PMID:24857367   PMID:24898082  
PMID:24915158   PMID:24930437   PMID:24990820   PMID:25028131   PMID:25277244   PMID:25290885   PMID:25326440   PMID:25416956   PMID:25468996   PMID:25579144   PMID:25677198   PMID:25822281  
PMID:25846732   PMID:25910212   PMID:25963833   PMID:25973684   PMID:25982273   PMID:26138305   PMID:26209609   PMID:26280121   PMID:26286715   PMID:26320552   PMID:26416346   PMID:26436355  
PMID:26462837   PMID:26496610   PMID:26527279   PMID:26618866   PMID:26643866   PMID:26671131   PMID:26728375   PMID:26769854   PMID:26823019   PMID:26831064   PMID:26835904   PMID:26841866  
PMID:26871637   PMID:26892177   PMID:26910849   PMID:26911253   PMID:27059955   PMID:27060708   PMID:27151703   PMID:27248496   PMID:27304995   PMID:27468866   PMID:27479531   PMID:27545878  
PMID:27578003   PMID:27601168   PMID:27684187   PMID:27706656   PMID:27734227   PMID:27740519   PMID:27780869   PMID:27880917   PMID:27893299   PMID:28326329   PMID:28378594   PMID:28468590  
PMID:28472039   PMID:28475172   PMID:28514295   PMID:28515276   PMID:28606991   PMID:28647696   PMID:28652657   PMID:28698650   PMID:28770701   PMID:28977666   PMID:29040984   PMID:29167192  
PMID:29180619   PMID:29401296   PMID:29437899   PMID:29467282   PMID:29507755   PMID:29573748   PMID:29651326   PMID:29802200   PMID:29845934   PMID:29859926   PMID:29863745   PMID:29884220  
PMID:29911972   PMID:29925934   PMID:29950693   PMID:30021884   PMID:30179852   PMID:30344098   PMID:30451962   PMID:30459231   PMID:30528602   PMID:30559450   PMID:30804502   PMID:30809309  
PMID:30833792   PMID:30896886   PMID:31002407   PMID:31073040   PMID:31115582   PMID:31120986   PMID:31177093   PMID:31180492   PMID:31199680   PMID:31239290   PMID:31343991   PMID:31345960  
PMID:31515488   PMID:32078038   PMID:32296183   PMID:32306001   PMID:32337295   PMID:32457219   PMID:32780723   PMID:32814053   PMID:32915852   PMID:32971115   PMID:33027920  


Genomics

Comparative Map Data
KRT18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1252,948,871 - 52,952,906 (+)EnsemblGRCh38hg38GRCh38
GRCh381252,948,855 - 52,952,906 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371253,342,639 - 53,346,690 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,628,922 - 51,632,952 (+)NCBINCBI36hg18NCBI36
Build 341251,628,921 - 51,632,951NCBI
Celera1252,989,626 - 52,993,657 (+)NCBI
Cytogenetic Map12q13.13NCBI
HuRef1250,386,471 - 50,390,501 (+)NCBIHuRef
CHM1_11253,309,411 - 53,313,442 (+)NCBICHM1_1
Krt18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,936,651 - 101,940,461 (+)NCBIGRCm39mm39
GRCm39 Ensembl15101,936,615 - 101,940,462 (+)Ensembl
GRCm3815102,028,216 - 102,032,026 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,028,180 - 102,032,027 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715101,858,647 - 101,862,457 (+)NCBIGRCm37mm9NCBIm37
MGSCv3615101,856,259 - 101,860,055 (+)NCBImm8
Celera15104,183,109 - 104,186,912 (+)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1557.22NCBI
Krt18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27133,157,486 - 133,161,162 (+)NCBI
Rnor_6.0 Ensembl7143,629,455 - 143,633,131 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07143,629,455 - 143,633,131 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07141,425,684 - 141,429,360 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1279,988,565 - 79,989,008 (+)NCBI
Celera7129,594,039 - 129,597,715 (+)NCBICelera
Cytogenetic Map7q36NCBI
Krt18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458226,805 - 232,728 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955458227,017 - 230,752 (+)NCBIChiLan1.0ChiLan1.0
KRT18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11236,587,149 - 36,591,196 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,587,149 - 36,591,196 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01235,807,660 - 35,811,691 (-)NCBIMhudiblu_PPA_v0panPan3
KRT18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl272,189,269 - 2,193,368 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1272,189,269 - 2,193,368 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Krt18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493651210,290,706 - 10,294,647 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRT18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,217,691 - 18,222,833 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,217,686 - 18,221,432 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,726,205 - 18,729,755 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KRT18
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,073,733 - 49,081,706 (+)NCBI
Krt18
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249041,011,675 - 1,015,319 (+)NCBI

Position Markers
D12S764  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371253,346,341 - 53,346,753UniSTSGRCh37
Build 361251,632,608 - 51,633,020RGDNCBI36
Celera1252,993,313 - 52,993,725RGD
Cytogenetic Map12q13UniSTS
HuRef1250,390,157 - 50,390,569UniSTS
RH71455  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371253,346,567 - 53,346,732UniSTSGRCh37
Build 361251,632,834 - 51,632,999RGDNCBI36
Celera1252,993,539 - 52,993,704RGD
Cytogenetic Map12q13UniSTS
HuRef1250,390,383 - 50,390,548UniSTS
GeneMap99-GB4 RH Map12227.66UniSTS
NCBI RH Map12439.9UniSTS
SHGC-11808  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12q13UniSTS
PMC17321P1  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12q13UniSTS
G66074  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map12q13UniSTS
G66248  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12q13UniSTS
STS-N95819  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12q13UniSTS
GeneMap99-GB4 RH Map1145.61UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR122hsa-miR-122-5pMirtarbaseexternal_infoProteomicsFunctional MTI (Weak)17612493

Predicted Target Of
Summary Value
Count of predictions:1615
Count of miRNA genes:720
Interacting mature miRNAs:829
Transcripts:ENST00000388835, ENST00000388837, ENST00000546656, ENST00000548015, ENST00000548496, ENST00000549078, ENST00000550600
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 134 48 29 1 33 3 4 15 21 127 116 11 2
Medium 1514 1348 1634 592 498 430 2296 581 901 391 1079 1476 171 859 1188 2
Low 787 1542 39 3 1084 2 1931 1470 2071 6 245 14 334 1477 1 2
Below cutoff 3 97 4 298 126 132 720 1 6 6 3 1 123

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_008351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NG_008402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_199187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC107016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY762101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC072017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG753529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD106591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC921479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HD063881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L32537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X12876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X12881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X12883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000388835   ⟹   ENSP00000373487
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1252,949,118 - 52,952,906 (+)Ensembl
RefSeq Acc Id: ENST00000388837   ⟹   ENSP00000373489
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1252,948,871 - 52,952,900 (+)Ensembl
RefSeq Acc Id: ENST00000546656
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1252,951,496 - 52,952,278 (+)Ensembl
RefSeq Acc Id: ENST00000548015
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1252,949,805 - 52,951,645 (+)Ensembl
RefSeq Acc Id: ENST00000548496
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1252,951,742 - 52,952,815 (+)Ensembl
RefSeq Acc Id: ENST00000549078
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1252,949,127 - 52,952,872 (+)Ensembl
RefSeq Acc Id: ENST00000550600   ⟹   ENSP00000447278
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1252,948,886 - 52,952,812 (+)Ensembl
RefSeq Acc Id: NM_000224   ⟹   NP_000215
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381252,949,118 - 52,952,906 (+)NCBI
GRCh371253,342,655 - 53,346,690 (+)NCBI
Build 361251,629,110 - 51,632,952 (+)NCBI Archive
HuRef1250,386,471 - 50,390,501 (+)ENTREZGENE
CHM1_11253,309,599 - 53,313,442 (+)NCBI
Sequence:
RefSeq Acc Id: NM_199187   ⟹   NP_954657
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381252,948,855 - 52,952,906 (+)NCBI
GRCh371253,342,655 - 53,346,690 (+)NCBI
Build 361251,628,922 - 51,632,952 (+)NCBI Archive
HuRef1250,386,471 - 50,390,501 (+)ENTREZGENE
CHM1_11253,309,411 - 53,313,442 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_954657   ⟸   NM_199187
- UniProtKB: P05783 (UniProtKB/Swiss-Prot),   A0A024RAY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_000215   ⟸   NM_000224
- UniProtKB: P05783 (UniProtKB/Swiss-Prot),   A0A024RAY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000373489   ⟸   ENST00000388837
RefSeq Acc Id: ENSP00000373487   ⟸   ENST00000388835
RefSeq Acc Id: ENSP00000447278   ⟸   ENST00000550600
Protein Domains
IF rod

Promoters
RGD ID:6790178
Promoter ID:HG_KWN:15720
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562
Transcripts:NM_000224,   NM_199187,   UC001SBF.1,   UC009ZMN.1,   UC009ZMO.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361251,628,181 - 51,629,282 (+)MPROMDB
RGD ID:6852154
Promoter ID:EP73883
Type:multiple initiation site
Name:HS_KRT18
Description:Keratin 18.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361251,629,167 - 51,629,227EPD
RGD ID:7224051
Promoter ID:EPDNEW_H17771
Type:initiation region
Name:KRT18_2
Description:keratin 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17772  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381252,948,867 - 52,948,927EPDNEW
RGD ID:7224053
Promoter ID:EPDNEW_H17772
Type:initiation region
Name:KRT18_1
Description:keratin 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17771  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381252,949,121 - 52,949,181EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000224.3(KRT18):c.383A>T (p.His128Leu) single nucleotide variant Cirrhosis, cryptogenic [RCV000015686]|Cirrhosis, noncryptogenic, susceptibility to [RCV000015687]|not provided [RCV000056435] Chr12:52949556 [GRCh38]
Chr12:53343340 [GRCh37]
Chr12:12q13.13
pathogenic|risk factor|not provided
NM_000224.3(KRT18):c.1230C>G (p.Thr410=) single nucleotide variant Hepatitis c virus, susceptibility to [RCV000049576] Chr12:52952779 [GRCh38]
Chr12:53346563 [GRCh37]
Chr12:12q13.13
not provided
NM_000224.3(KRT18):c.282C>T (p.Tyr94=) single nucleotide variant Hepatitis c virus, susceptibility to [RCV000049577] Chr12:52949455 [GRCh38]
Chr12:53343239 [GRCh37]
Chr12:12q13.13
not provided
NM_000224.3(KRT18):c.134G>C (p.Arg45Pro) single nucleotide variant Hepatitis c virus, susceptibility to [RCV000049578] Chr12:52949307 [GRCh38]
Chr12:53343091 [GRCh37]
Chr12:12q13.13
not provided
NM_000224.2(KRT18):c.1236G>T (p.Arg412=) single nucleotide variant Malignant melanoma [RCV000070058] Chr12:52952785 [GRCh38]
Chr12:53346569 [GRCh37]
Chr12:51632836 [NCBI36]
Chr12:12q13.13
not provided
NM_000224.3(KRT18):c.-15C>T single nucleotide variant not provided [RCV000056430] Chr12:52949159 [GRCh38]
Chr12:53342943 [GRCh37]
Chr12:12q13.13
not provided
NM_000224.3(KRT18):c.1018G>A (p.Gly340Arg) single nucleotide variant not provided [RCV000056431] Chr12:52952188 [GRCh38]
Chr12:53345972 [GRCh37]
Chr12:12q13.13
not provided
NM_000224.3(KRT18):c.1232G>A (p.Arg411His) single nucleotide variant not provided [RCV000056432] Chr12:52952781 [GRCh38]
Chr12:53346565 [GRCh37]
Chr12:12q13.13
not provided
NM_000224.3(KRT18):c.193_216del (p.Thr65_Ala72del) deletion not provided [RCV000056433] Chr12:52949366..52949389 [GRCh38]
Chr12:53343150..53343173 [GRCh37]
Chr12:12q13.13
not provided
NM_000224.3(KRT18):c.307A>G (p.Thr103Ala) single nucleotide variant not provided [RCV000056434] Chr12:52949480 [GRCh38]
Chr12:53343264 [GRCh37]
Chr12:12q13.13
not provided
NM_000224.3(KRT18):c.418-4C>G single nucleotide variant not provided [RCV000056436] Chr12:52950324 [GRCh38]
Chr12:53344108 [GRCh37]
Chr12:12q13.13
not provided
NM_000224.3(KRT18):c.448A>G (p.Ile150Val) single nucleotide variant not provided [RCV000056437] Chr12:52950358 [GRCh38]
Chr12:53344142 [GRCh37]
Chr12:12q13.13
not provided
NM_000224.3(KRT18):c.500+38G>A single nucleotide variant not provided [RCV000056438] Chr12:52950448 [GRCh38]
Chr12:53344232 [GRCh37]
Chr12:12q13.13
not provided
NM_000224.3(KRT18):c.689G>C (p.Ser230Thr) single nucleotide variant not provided [RCV000056439] Chr12:52951512 [GRCh38]
Chr12:53345296 [GRCh37]
Chr12:12q13.13
likely benign|not provided
NM_000224.3(KRT18):c.782G>A (p.Arg261Gln) single nucleotide variant not provided [RCV000056440] Chr12:52951605 [GRCh38]
Chr12:53345389 [GRCh37]
Chr12:12q13.13
not provided
NM_000224.3(KRT18):c.827A>G (p.Glu276Gly) single nucleotide variant not provided [RCV000056441] Chr12:52951735 [GRCh38]
Chr12:53345519 [GRCh37]
Chr12:12q13.13
not provided
NM_000224.3(KRT18):c.854A>G (p.Gln285Arg) single nucleotide variant not provided [RCV000056442] Chr12:52951762 [GRCh38]
Chr12:53345546 [GRCh37]
Chr12:12q13.13
not provided
NM_000224.3(KRT18):c.884C>T (p.Thr295Met) single nucleotide variant not provided [RCV000056443] Chr12:52951792 [GRCh38]
Chr12:53345576 [GRCh37]
Chr12:12q13.13
not provided
NM_000224.3(KRT18):c.890C>T (p.Thr297Ile) single nucleotide variant not provided [RCV000056444] Chr12:52951798 [GRCh38]
Chr12:53345582 [GRCh37]
Chr12:12q13.13
not provided
NM_000224.3(KRT18):c.993C>T (p.Tyr331=) single nucleotide variant not provided [RCV000056445] Chr12:52952163 [GRCh38]
Chr12:53345947 [GRCh37]
Chr12:12q13.13
not provided
NM_000224.2(KRT18):c.489C>T (p.Asp163=) single nucleotide variant Malignant melanoma [RCV000062539] Chr12:52950399 [GRCh38]
Chr12:53344183 [GRCh37]
Chr12:51630450 [NCBI36]
Chr12:12q13.13
not provided
GRCh38/hg38 12q13.13(chr12:52851850-53558824)x3 copy number gain See cases [RCV000138030] Chr12:52851850..53558824 [GRCh38]
Chr12:53245634..53952608 [GRCh37]
Chr12:51531901..52238875 [NCBI36]
Chr12:12q13.13
likely pathogenic
GRCh38/hg38 12q13.13(chr12:52748391-52950618)x3 copy number gain See cases [RCV000138642] Chr12:52748391..52950618 [GRCh38]
Chr12:53142175..53344402 [GRCh37]
Chr12:51428442..51630669 [NCBI36]
Chr12:12q13.13
likely benign
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12q13.12-13.13(chr12:50122359-53248460)x1 copy number loss See cases [RCV000142033] Chr12:50122359..53248460 [GRCh38]
Chr12:50516142..53642244 [GRCh37]
Chr12:48802409..51928511 [NCBI36]
Chr12:12q13.12-13.13
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
NC_000012.11:g.26370251_54361538inv inversion not specified [RCV000714265] Chr12:26370251..54361538 [GRCh37]
Chr12:12p12.1-q13.13
uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
NM_000224.3(KRT18):c.822+5G>A single nucleotide variant not provided [RCV000900641] Chr12:52951650 [GRCh38]
Chr12:53345434 [GRCh37]
Chr12:12q13.13
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6430 AgrOrtholog
COSMIC KRT18 COSMIC
Ensembl Genes ENSG00000111057 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000373487 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000373489 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000447278 UniProtKB/TrEMBL
Ensembl Transcript ENST00000388835 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000388837 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000550600 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.1160 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000111057 GTEx
HGNC ID HGNC:6430 ENTREZGENE
Human Proteome Map KRT18 Human Proteome Map
InterPro IF_conserved UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_rod_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_rod_dom_coil1B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Keratin-18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Keratin_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3875 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 3875 ENTREZGENE
OMIM 148070 OMIM
  215600 OMIM
PANTHER PTHR23239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23239:SF349 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30217 PharmGKB
PRINTS TYPE1KERATIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_ROD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024RAY2 ENTREZGENE, UniProtKB/TrEMBL
  F8VZY9_HUMAN UniProtKB/TrEMBL
  I6L965_HUMAN UniProtKB/TrEMBL
  K1C18_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q53G38 UniProtKB/Swiss-Prot
  Q5U0N8 UniProtKB/Swiss-Prot
  Q9BW26 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-14 KRT18  keratin 18    keratin 18, type I  Symbol and/or name change 5135510 APPROVED
2015-01-27 KRT18  keratin 18, type I    keratin 18  Symbol and/or name change 5135510 APPROVED
2011-08-16 KRT18  keratin 18  KRT18  keratin 18  Symbol and/or name change 5135510 APPROVED