Ndufb11b (NADH:ubiquinone oxidoreductase subunit B11B) - Rat Genome Database

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Gene: Ndufb11b (NADH:ubiquinone oxidoreductase subunit B11B) Rattus norvegicus
Analyze
Symbol: Ndufb11b
Name: NADH:ubiquinone oxidoreductase subunit B11B
RGD ID: 1306782
Description: Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 3 and nuclear type mitochondrial complex I deficiency 30. Orthologous to human NDUFB11 (NADH:ubiquinone oxidoreductase subunit B11); INTERACTS WITH cadmium dichloride; Cuprizon; all-trans-retinoic acid (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC300091; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial-like; RGD1306782; similar to RIKEN cDNA 1700029P11
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87115,384,968 - 115,386,486 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7115,381,671 - 115,386,868 (+)EnsemblGRCr8
mRatBN7.27113,505,048 - 113,506,359 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,505,053 - 113,506,360 (+)EnsemblmRatBN7.2
Rnor_6.07123,221,878 - 123,223,195 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7123,222,161 - 123,222,610 (+)Ensemblrn6Rnor6.0
Rnor_5.07123,206,636 - 123,207,885 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47120,364,057 - 120,364,512 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7109,820,839 - 109,822,156 (+)NCBICelera
RGSC_v3.17120,398,286 - 120,398,742 (+)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Ndufb11b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87115,384,968 - 115,386,486 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7115,381,671 - 115,386,868 (+)EnsemblGRCr8
mRatBN7.27113,505,048 - 113,506,359 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,505,053 - 113,506,360 (+)EnsemblmRatBN7.2
Rnor_6.07123,221,878 - 123,223,195 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7123,222,161 - 123,222,610 (+)Ensemblrn6Rnor6.0
Rnor_5.07123,206,636 - 123,207,885 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47120,364,057 - 120,364,512 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7109,820,839 - 109,822,156 (+)NCBICelera
RGSC_v3.17120,398,286 - 120,398,742 (+)NCBI
Cytogenetic Map7q34NCBI
Ndufb11b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391581,864,741 - 81,865,764 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1581,864,741 - 81,865,764 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381581,980,540 - 81,981,563 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1581,980,540 - 81,981,563 (+)Ensemblmm10GRCm38
MGSCv371581,810,975 - 81,811,993 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361581,807,800 - 81,808,818 (+)NCBIMGSCv36mm8
Celera1584,102,838 - 84,103,226 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.32NCBI

Variants

.
Variants in Ndufb11b
8 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:79
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000007357
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
AU028719  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27113,503,234 - 113,503,473 (+)MAPPERmRatBN7.2
Rnor_6.07123,220,073 - 123,220,309NCBIRnor6.0
Rnor_5.07123,205,430 - 123,205,666UniSTSRnor5.0
Rnor_5.07123,189,317 - 123,189,553UniSTSRnor5.0
RGSC_v3.47120,361,969 - 120,362,205UniSTSRGSC3.4
Celera7109,819,034 - 109,819,270UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 9 64 143 72 71 40 69 40 6 297 163 9 123 75 87 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000007357   ⟹   ENSRNOP00000007357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7115,385,447 - 115,386,331 (+)Ensembl
mRatBN7.2 Ensembl7113,505,053 - 113,506,360 (+)Ensembl
Rnor_6.0 Ensembl7123,222,161 - 123,222,610 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000153507   ⟹   ENSRNOP00000100505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7115,384,791 - 115,386,868 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000153576   ⟹   ENSRNOP00000098712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7115,381,671 - 115,386,331 (+)Ensembl
RefSeq Acc Id: XM_006242135   ⟹   XP_006242197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87115,384,968 - 115,386,486 (+)NCBI
mRatBN7.27113,505,048 - 113,506,359 (+)NCBI
Rnor_6.07123,221,878 - 123,223,195 (+)NCBI
Rnor_5.07123,206,636 - 123,207,885 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_006242197 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007357
  ENSRNOP00000007357.5
  ENSRNOP00000098712.1
  ENSRNOP00000100505.1
RefSeq Acc Id: XP_006242197   ⟸   XM_006242135
- UniProtKB: D4AAT2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007357   ⟸   ENSRNOT00000007357
Ensembl Acc Id: ENSRNOP00000100505   ⟸   ENSRNOT00000153507
Ensembl Acc Id: ENSRNOP00000098712   ⟸   ENSRNOT00000153576

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AAT2-F1-model_v2 AlphaFold D4AAT2 1-150 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695528
Promoter ID:EPDNEW_R6047
Type:single initiation site
Name:RGD1306782_1
Description:similar to RIKEN cDNA 1700029P11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07123,222,145 - 123,222,205EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306782 AgrOrtholog
BioCyc Gene G2FUF-32652 BioCyc
Ensembl Genes ENSRNOG00000005572 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007357 ENTREZGENE
  ENSRNOT00000007357.6 UniProtKB/TrEMBL
  ENSRNOT00000153507.1 UniProtKB/TrEMBL
  ENSRNOT00000153576.1 UniProtKB/TrEMBL
InterPro NADH_UbQ_OxRdtase_ESSS_su UniProtKB/TrEMBL
KEGG Report rno:300091 UniProtKB/TrEMBL
NCBI Gene 300091 ENTREZGENE
PANTHER COMPLEX I-ESSS UniProtKB/TrEMBL
  PTHR13327 UniProtKB/TrEMBL
Pfam ESSS UniProtKB/TrEMBL
PhenoGen Ndufb11b PhenoGen
RatGTEx ENSRNOG00000005572 RatGTEx
UniProt D4AAT2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-01-10 Ndufb11b  NADH:ubiquinone oxidoreductase subunit B11B  RGD1306782  similar to RIKEN cDNA 1700029P11  Name and Symbol changed 629549 APPROVED
2008-04-30 RGD1306782  similar to RIKEN cDNA 1700029P11   RGD1306782_predicted  similar to RIKEN cDNA 1700029P11 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1306782_predicted  similar to RIKEN cDNA 1700029P11 (predicted)  LOC300091_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC300091_predicted  similar to RIKEN cDNA 1700029P11 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL