Message Center
{{ messageCount }} Messages
Watched Genes
{{$index + 1}}. {{ watchedObject.symbol }} (RGD ID:{{watchedObject.rgdId}})
Watched Ontology Terms
{{$index + 1}}. {{ watchedTerm.term }} ({{watchedTerm.accId}})
{{gene.symbol}}: {{ gene.description }}
Save what matters to you
{{ loginError }}
Sign in with your RGD account
Gene: Gfus (GDP-L-fucose synthase) Rattus norvegicus
Analyze
Symbol:
Gfus
Name:
GDP-L-fucose synthase
RGD ID:
1307028
Description:
Predicted to have GDP-L-fucose synthase activity; GDP-mannose 3,5-epimerase activity; and identical protein binding activity. Predicted to be involved in several processes, including T cell mediated cytotoxicity; nucleotide-sugar metabolic process; and positive regulation of endothelial cell-matrix adhesion via fibronectin. Orthologous to human GFUS (GDP-L-fucose synthase); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; INTERACTS WITH acetamide; bisphenol A; Brodifacoum.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase; LOC300036; tissue specific transplantation antigen P35B; Tsta3
RGD Orthologs
Alliance Genes
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
GFUS (GDP-L-fucose synthase)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther, Treefam
Mus musculus (house mouse):
Gfus (GDP-L-fucose synthase)
HGNC
Treefam, EggNOG, NCBI, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Gfus (GDP-L-fucose synthase)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
GFUS (GDP-L-fucose synthase)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
GFUS (GDP-L-fucose synthase)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Gfus (GDP-L-fucose synthase)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
GFUS (GDP-L-fucose synthase)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
GFUS (GDP-L-fucose synthase)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Gfus (GDP-L-fucose synthase)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
GFUS (GDP-L-fucose synthase)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Mus musculus (house mouse):
Gfus (GDP-L-fucose synthase)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
tsta3l2 (tissue specific transplantation antigen P35B, like 2)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
zgc:100864
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
tsta3 (tissue specific transplantation antigen P35B)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Caenorhabditis elegans (roundworm):
ger-1
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Drosophila melanogaster (fruit fly):
Gmer
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl mRatBN7.2 7 107,612,087 - 107,617,005 (-) NCBI Rnor_6.0 Ensembl 7 116,958,392 - 116,963,295 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_6.0 7 116,958,427 - 116,963,281 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 7 116,851,230 - 116,856,084 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 7 113,929,477 - 113,934,330 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 7 113,963,706 - 113,967,872 (-) NCBI Celera 7 103,969,092 - 103,973,946 (-) NCBI Celera Cytogenetic Map 7 q34 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
1,2-dimethylhydrazine multiple interactions ISO RGD:1315980 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of GFUS mRNA CTD PMID:22206623 14-Deoxy-11,12-didehydroandrographolide decreases expression ISO RGD:1315979 6480464 14-deoxy-11, 12-didehydroandrographolide results in decreased expression of GFUS mRNA CTD PMID:22101062 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1315980 6480464 Tetrachlorodibenzodioxin affects the expression of GFUS mRNA CTD PMID:21570461 3,3',4,4'-tetrachlorobiphenyl multiple interactions ISO RGD:1315980 6480464 3 more ... CTD PMID:19467301 acetamide decreases expression EXP 6480464 acetamide results in decreased expression of GFUS mRNA CTD PMID:31881176 acrolein multiple interactions ISO RGD:1315979 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of GFUS mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of GFUS mRNA CTD PMID:32699268 alpha-pinene multiple interactions ISO RGD:1315979 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of GFUS mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of GFUS mRNA CTD PMID:32699268 Aroclor 1254 increases expression ISO RGD:1315980 6480464 Chlorodiphenyl 54% Chlorine results in increased expression of GFUS mRNA CTD PMID:23650126 arsenous acid multiple interactions ISO RGD:1315979 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to GFUS protein] CTD PMID:26598702 atrazine decreases expression ISO RGD:1315979 6480464 Atrazine results in decreased expression of GFUS mRNA CTD PMID:22378314 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of GFUS mRNA CTD PMID:25181051 Brodifacoum increases expression EXP 6480464 bromfenacoum results in increased expression of GFUS protein CTD PMID:28903499 cadmium dichloride increases expression ISO RGD:1315979 6480464 Cadmium Chloride results in increased expression of GFUS protein CTD PMID:24527689 carbon nanotube increases expression ISO RGD:1315980 6480464 Nanotubes more ... CTD PMID:25554681 choline multiple interactions ISO RGD:1315980 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GFUS gene CTD PMID:20938992 cobalt dichloride decreases expression ISO RGD:1315979 6480464 cobaltous chloride results in decreased expression of GFUS mRNA CTD PMID:19320972 , PMID:19376846 cyclosporin A decreases methylation ISO RGD:1315979 6480464 Cyclosporine results in decreased methylation of GFUS promoter CTD PMID:27989131 dextran sulfate multiple interactions ISO RGD:1315980 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of GFUS mRNA CTD PMID:29950665 diarsenic trioxide multiple interactions ISO RGD:1315979 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to GFUS protein] CTD PMID:26598702 diazinon increases methylation ISO RGD:1315979 6480464 Diazinon results in increased methylation of GFUS gene CTD PMID:22964155 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of GFUS mRNA CTD PMID:21266533 dorsomorphin multiple interactions ISO RGD:1315979 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of GFUS mRNA CTD PMID:27188386 doxorubicin decreases expression ISO RGD:1315979 6480464 Doxorubicin results in decreased expression of GFUS mRNA CTD PMID:29803840 elemental selenium increases expression ISO RGD:1315979 6480464 Selenium results in increased expression of GFUS mRNA CTD PMID:19244175 ethyl methanesulfonate decreases expression ISO RGD:1315979 6480464 Ethyl Methanesulfonate results in decreased expression of GFUS mRNA CTD PMID:23649840 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of GFUS mRNA CTD PMID:24793618 folic acid multiple interactions ISO RGD:1315980 6480464 [1 more ... CTD PMID:20938992 , PMID:22206623 L-methionine multiple interactions ISO RGD:1315980 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of GFUS gene CTD PMID:20938992 NADP zwitterion multiple interactions ISO RGD:1315979 6480464 NADP binds to and results in increased activity of GFUS protein CTD PMID:25526675 NADP(+) multiple interactions ISO RGD:1315979 6480464 NADP binds to and results in increased activity of GFUS protein CTD PMID:25526675 nickel atom increases expression ISO RGD:1315979 6480464 Nickel results in increased expression of GFUS mRNA CTD PMID:25583101 nickel sulfate increases expression ISO RGD:1315979 6480464 nickel sulfate results in increased expression of GFUS mRNA CTD PMID:18651567 ozone multiple interactions ISO RGD:1315979 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of GFUS mRNA more ... CTD PMID:32699268 paracetamol affects expression ISO RGD:1315980 6480464 Acetaminophen affects the expression of GFUS mRNA CTD PMID:17562736 paracetamol affects response to substance ISO RGD:1315979 6480464 GFUS gene polymorphism affects the susceptibility to Acetaminophen CTD PMID:26104854 potassium chromate decreases expression ISO RGD:1315979 6480464 potassium chromateVI results in decreased expression of GFUS mRNA CTD PMID:22714537 SB 431542 multiple interactions ISO RGD:1315979 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of GFUS mRNA CTD PMID:27188386 selenium atom increases expression ISO RGD:1315979 6480464 Selenium results in increased expression of GFUS mRNA CTD PMID:19244175 sodium arsenite decreases expression ISO RGD:1315979 6480464 sodium arsenite results in decreased expression of GFUS mRNA CTD PMID:25879800 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of GFUS protein CTD PMID:29459688 titanium dioxide multiple interactions ISO RGD:1315980 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of GFUS mRNA CTD PMID:29950665 valproic acid increases methylation ISO RGD:1315979 6480464 Valproic Acid results in increased methylation of GFUS gene CTD PMID:29154799 valproic acid multiple interactions ISO RGD:1315979 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of GFUS mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:1315979 6480464 Valproic Acid results in increased expression of GFUS mRNA CTD PMID:23179753 , PMID:26272509 valproic acid affects expression ISO RGD:1315979 6480464 Valproic Acid affects the expression of GFUS mRNA CTD PMID:25979313 valproic acid decreases expression ISO RGD:1315979 6480464 Valproic Acid results in decreased expression of GFUS mRNA CTD PMID:29154799 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of GFUS mRNA CTD PMID:23034163 vitamin E increases expression ISO RGD:1315979 6480464 Vitamin E results in increased expression of GFUS mRNA CTD PMID:19244175
Molecular Function
GDP-L-fucose synthase activity ISO RGD:1315979 1624291 PMID:8910301 , PMID:9525924 RGD PMID:8910301 , PMID:9525924 GDP-L-fucose synthase activity enables ISO RGD:1315979 1624291 PMID:8910301 , PMID:9525924 RGD PMID:8910301 , PMID:9525924 GDP-L-fucose synthase activity enables IBA FB:FBgn0267823 more ... 13792537 PMID:21873635 GO_Central GDP-L-fucose synthase activity IBA FB:FBgn0267823 more ... 13792537 PMID:21873635 GO_Central GDP-mannose 3,5-epimerase activity ISO RGD:1315979 1624291 PMID:8910301 RGD PMID:8910301 GDP-mannose 3,5-epimerase activity enables ISO RGD:1315979 1624291 PMID:8910301 RGD PMID:8910301 identical protein binding ISO RGD:1315979 1624291 UniProtKB:Q13630 more ... RGD PMID:23774504 , PMID:32296183 identical protein binding enables ISO RGD:1315979 1624291 UniProtKB:Q13630 more ... RGD PMID:23774504 , PMID:32296183 protein binding ISO RGD:1315979 1624291 UniProtKB:Q5SYC1 , PMID:32296183 RGD PMID:32296183 protein binding enables ISO RGD:1315979 1624291 UniProtKB:Q5SYC1 , PMID:32296183 RGD PMID:32296183
Imported Annotations - SMPDB
Imported Annotations - KEGG (archival)
References
Additional References at PubMed
Genomics
QTLs in Region (Rnor_6.0)
634336 Anxrr17 Anxiety related response QTL 17 3.66 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) 7 2920071 124838025 Rat 61357 Bp38 Blood pressure QTL 38 1.6 0.052 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 7 48118835 128611831 Rat 631504 Cm27 Cardiac mass QTL 27 3.45 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) 7 50704769 128085642 Rat 1358361 Sradr5 Stress Responsive Adrenal Weight QTL 5 5.55 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) 7 51251919 118477612 Rat 1300179 Kidm5 Kidney mass QTL 5 3.51 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) 7 51251919 145729302 Rat 2316947 Rf58 Renal function QTL 58 7.8 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) 7 55072862 123602998 Rat 2316952 Pur22 Proteinuria QTL 22 5.2 urine protein amount (VT:0005160) urine protein level (CMO:0000591) 7 55072862 123602998 Rat 2316955 Stl24 Serum triglyceride level QTL 24 7.1 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) 7 55072862 123602998 Rat 70173 Niddm19 Non-insulin dependent diabetes mellitus QTL 19 4.33 0.00005 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 7 71448715 145729302 Rat 631540 Bw9 Body weight QTL 9 4.5 body mass (VT:0001259) body weight (CMO:0000012) 7 77428105 127748511 Rat 1357338 Stl17 Serum triglyceride level QTL 17 3.23 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) 7 77428234 122421148 Rat 634331 Pia17 Pristane induced arthritis QTL 17 4.7 joint integrity trait (VT:0010548) arthritic paw count (CMO:0001460) 7 81645773 140745067 Rat 7411607 Foco15 Food consumption QTL 15 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 7 85595369 130595369 Rat 7411654 Foco25 Food consumption QTL 25 9.3 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 7 85595369 130595369 Rat 631529 Tls2 T-lymphoma susceptibility QTL 2 0 0.001 thymus integrity trait (VT:0010555) percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911) 7 88365265 119318087 Rat 1331746 Kidm9 Kidney mass QTL 9 3.934 kidney mass (VT:0002707) right kidney wet weight (CMO:0000082) 7 88365265 121986709 Rat 1331768 Kidm10 Kidney mass QTL 10 4.62096 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) 7 88365265 133365265 Rat 1331728 Bp214 Blood pressure QTL 214 2.825 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 7 88365265 134673427 Rat 2317052 Aia17 Adjuvant induced arthritis QTL 17 2.13 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) 7 91018361 136018361 Rat 1358914 Bp266 Blood pressure QTL 266 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 7 91832949 145158140 Rat 1358891 Bp265 Blood pressure QTL 265 2.21 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 7 91832949 145158140 Rat 71114 Niddm14 Non-insulin dependent diabetes mellitus QTL 14 4.5 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 7 93726906 138726906 Rat 2298475 Eau6 Experimental allergic uveoretinitis QTL 6 0.0029 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) 7 93726906 138726906 Rat 1558655 Swd4 Spike wave discharge measurement QTL 4 3.68 0.0002 brain electrophysiology trait (VT:0010557) brain spike-and-wave discharge severity grade (CMO:0001988) 7 96630946 141630946 Rat 2299163 Iddm34 Insulin dependent diabetes mellitus QTL 34 2.71 blood glucose amount (VT:0000188) age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140) 7 100028953 145729302 Rat 631687 Hcas1 Hepatocarcinoma susceptibility QTL 1 3.9 0.001 liver integrity trait (VT:0010547) liver tumorous lesion volume to total liver volume ratio (CMO:0001082) 7 100160423 140335001 Rat 1549899 Stresp8 Stress response QTL 8 4.37 0.0008 stress-related behavior trait (VT:0010451) defensive burying duration (CMO:0001961) 7 100192194 145192194 Rat 2313102 Bmd79 Bone mineral density QTL 79 2.3 0.0001 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) 7 103815550 126525386 Rat 1357336 Gluco6 Glucose level QTL 6 3.4 blood glucose amount (VT:0000188) serum glucose level (CMO:0000543) 7 103867802 126080176 Rat 731176 Glom5 Glomerulus QTL 5 2.5 0.0035 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002) 7 106564316 145729302 Rat 1331731 Bp216 Blood pressure QTL 216 2.851 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 7 111519266 143965591 Rat 70159 Bp61 Blood pressure QTL 61 0.0001 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 7 112429186 126525386 Rat 731174 Uae23 Urinary albumin excretion QTL 23 2.4 0.0042 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 7 114825174 145729302 Rat 2306821 Bp335 Blood pressure QTL 335 0.001 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 7 115922628 145729302 Rat