Ttll1 (TTL family tubulin polyglutamylase complex subunit L1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ttll1 (TTL family tubulin polyglutamylase complex subunit L1) Rattus norvegicus
Analyze
Symbol: Ttll1
Name: TTL family tubulin polyglutamylase complex subunit L1
RGD ID: 1309124
Description: Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization and protein polyglutamylation. Predicted to act upstream of or within several processes, including cerebellar Purkinje cell differentiation; mucociliary clearance; and regulation of blastocyst development. Predicted to be located in ciliary basal body. Predicted to be active in cilium. Orthologous to human TTLL1 (TTL family tubulin polyglutamylase complex subunit L1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC362969; PGs3; polyglutamylase complex subunit TTLL1; probable tubulin polyglutamylase TTLL1; tubulin polyglutamylase complex subunit 3; tubulin polyglutamylase TTLL1; tubulin tyrosine ligase like 1; tubulin tyrosine ligase-like 1; tubulin tyrosine ligase-like family, member 1; tubulin--tyrosine ligase-like protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27114,619,509 - 114,648,850 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl7114,619,508 - 114,648,761 (-)Ensembl
Rnor_6.07124,338,396 - 124,367,719 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7124,338,395 - 124,367,630 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07124,327,308 - 124,356,639 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47121,420,125 - 121,441,444 (+)NCBIRGSC3.4rn4RGSC3.4
Celera7110,932,407 - 110,961,694 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:15890843   PMID:17499049   PMID:19182904   PMID:20442420   PMID:20498047   PMID:29440671   PMID:29593216   PMID:30420556  


Genomics

Comparative Map Data
Ttll1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27114,619,509 - 114,648,850 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl7114,619,508 - 114,648,761 (-)Ensembl
Rnor_6.07124,338,396 - 124,367,719 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7124,338,395 - 124,367,630 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07124,327,308 - 124,356,639 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47121,420,125 - 121,441,444 (+)NCBIRGSC3.4rn4RGSC3.4
Celera7110,932,407 - 110,961,694 (-)NCBICelera
Cytogenetic Map7q34NCBI
TTLL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382243,039,516 - 43,089,391 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2243,039,516 - 43,089,419 (-)EnsemblGRCh38hg38GRCh38
GRCh372243,435,522 - 43,485,397 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,765,589 - 41,815,373 (-)NCBINCBI36hg18NCBI36
Build 342241,760,142 - 41,809,927NCBI
Celera2227,346,102 - 27,395,837 (-)NCBI
Cytogenetic Map22q13.2NCBI
HuRef2226,394,153 - 26,443,736 (-)NCBIHuRef
CHM1_12243,395,326 - 43,445,000 (-)NCBICHM1_1
T2T-CHM13v2.02243,520,523 - 43,570,587 (-)NCBI
Ttll1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391583,367,258 - 83,402,675 (-)NCBIGRCm39mm39
GRCm39 Ensembl1583,367,970 - 83,395,094 (-)Ensembl
GRCm381583,483,057 - 83,518,474 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1583,483,769 - 83,510,893 (-)EnsemblGRCm38mm10GRCm38
MGSCv371583,314,199 - 83,341,337 (-)NCBIGRCm37mm9NCBIm37
MGSCv361583,311,538 - 83,338,643 (-)NCBImm8
Celera1585,617,197 - 85,644,203 (-)NCBICelera
Cytogenetic Map15E1NCBI
Ttll1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541328,234,486 - 28,250,688 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541328,234,964 - 28,250,899 (-)NCBIChiLan1.0ChiLan1.0
TTLL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12242,128,224 - 42,174,850 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2242,128,224 - 42,174,850 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02223,924,628 - 23,973,282 (-)NCBIMhudiblu_PPA_v0panPan3
TTLL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11022,456,150 - 22,492,375 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1022,456,146 - 22,488,505 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1022,392,648 - 22,439,139 (+)NCBI
ROS_Cfam_1.01023,200,588 - 23,247,276 (+)NCBI
ROS_Cfam_1.0 Ensembl1023,200,588 - 23,247,305 (+)Ensembl
UMICH_Zoey_3.11022,919,827 - 22,966,313 (+)NCBI
UNSW_CanFamBas_1.01023,239,254 - 23,285,573 (+)NCBI
UU_Cfam_GSD_1.01023,413,992 - 23,460,493 (+)NCBI
Ttll1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049456,091,553 - 6,110,264 (+)NCBI
SpeTri2.0NW_004936718869,901 - 884,708 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTLL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl55,793,780 - 5,827,639 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.155,793,760 - 5,827,622 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.253,216,125 - 3,250,371 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TTLL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11925,576,525 - 25,616,413 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1925,576,379 - 25,616,328 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604599,827,235 - 99,869,254 (+)NCBIVero_WHO_p1.0
Ttll1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247525,883,042 - 5,903,687 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247525,883,039 - 5,901,333 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AV014541  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27114,619,815 - 114,619,909 (+)MAPPERmRatBN7.2
Rnor_6.07124,338,703 - 124,338,796NCBIRnor6.0
Rnor_5.07124,327,615 - 124,327,708UniSTSRnor5.0
Celera7110,932,713 - 110,932,806UniSTS
Cytogenetic Map7q34UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:104
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000055978
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12 2 2 2 73 18 33 1
Low 3 31 55 39 19 39 8 11 1 17 8 10 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001012200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005486678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005486679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC087669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000055978   ⟹   ENSRNOP00000052832
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7114,619,508 - 114,648,761 (-)Ensembl
Rnor_6.0 Ensembl7124,338,395 - 124,367,630 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110361   ⟹   ENSRNOP00000081132
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7114,619,765 - 114,648,751 (-)Ensembl
RefSeq Acc Id: NM_001012200   ⟹   NP_001012200
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27114,619,510 - 114,648,761 (-)NCBI
Rnor_6.07124,338,397 - 124,367,630 (-)NCBI
Rnor_5.07124,327,308 - 124,356,639 (-)NCBI
RGSC_v3.47121,420,125 - 121,441,444 (+)RGD
Celera7110,932,407 - 110,961,694 (-)RGD
Sequence:
RefSeq Acc Id: XM_006242103   ⟹   XP_006242165
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27114,619,509 - 114,648,809 (-)NCBI
Rnor_6.07124,338,396 - 124,367,687 (-)NCBI
Rnor_5.07124,327,308 - 124,356,639 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242104   ⟹   XP_006242166
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27114,619,509 - 114,648,850 (-)NCBI
Rnor_6.07124,338,396 - 124,367,719 (-)NCBI
Rnor_5.07124,327,308 - 124,356,639 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079600   ⟹   XP_038935528
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27114,619,509 - 114,648,812 (-)NCBI
RefSeq Acc Id: XM_039079601   ⟹   XP_038935529
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27114,619,509 - 114,648,850 (-)NCBI
RefSeq Acc Id: XM_039079602   ⟹   XP_038935530
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27114,619,509 - 114,648,814 (-)NCBI
RefSeq Acc Id: XM_039079604   ⟹   XP_038935532
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27114,619,509 - 114,648,814 (-)NCBI
RefSeq Acc Id: XR_005486678
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27114,619,744 - 114,648,810 (-)NCBI
RefSeq Acc Id: XR_005486679
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27114,619,744 - 114,648,813 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001012200   ⟸   NM_001012200
- UniProtKB: Q5PPI9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006242166   ⟸   XM_006242104
- Peptide Label: isoform X2
- UniProtKB: Q5PPI9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006242165   ⟸   XM_006242103
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000052832   ⟸   ENSRNOT00000055978
RefSeq Acc Id: XP_038935529   ⟸   XM_039079601
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038935530   ⟸   XM_039079602
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038935532   ⟸   XM_039079604
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038935528   ⟸   XM_039079600
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000081132   ⟸   ENSRNOT00000110361
Protein Domains
TTL

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5PPI9-F1-model_v2 AlphaFold Q5PPI9 1-423 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695548
Promoter ID:EPDNEW_R6073
Type:initiation region
Name:Ttll1_1
Description:tubulin tyrosine ligase like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07124,367,645 - 124,367,705EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
7 124354541 124354542 A G snv ACI/N (MCW), Buf/N (MCW), F344/NRrrc (MCW), WN/N (MCW), MR/N (MCW), WKY/N (MCW), M520/N (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309124 AgrOrtholog
BioCyc Gene G2FUF-32601 BioCyc
Ensembl Genes ENSRNOG00000010141 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000052832 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000081132 ENTREZGENE
Ensembl Transcript ENSRNOT00000055978 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000110361 ENTREZGENE
IMAGE_CLONE IMAGE:7316813 IMAGE-MGC_LOAD
InterPro TTL/TTLL_fam UniProtKB/Swiss-Prot
  TTLL1 UniProtKB/Swiss-Prot
KEGG Report rno:362969 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105511 IMAGE-MGC_LOAD
NCBI Gene 362969 ENTREZGENE
PANTHER PTHR12241:SF31 UniProtKB/Swiss-Prot
Pfam TTL UniProtKB/Swiss-Prot
PhenoGen Ttll1 PhenoGen
PROSITE TTL UniProtKB/Swiss-Prot
UniProt Q5PPI9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-12-16 Ttll1  TTL family tubulin polyglutamylase complex subunit L1  Ttll1  tubulin tyrosine ligase like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-25 Ttll1  tubulin tyrosine ligase like 1  Ttll1  tubulin tyrosine ligase-like family, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-15 Ttll1  tubulin tyrosine ligase-like family, member 1  Ttll1  tubulin tyrosine ligase-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ttll1  tubulin tyrosine ligase-like 1  Ttll1_predicted  tubulin tyrosine ligase-like 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ttll1_predicted  tubulin tyrosine ligase-like 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED