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Gene: TTLL1 (tubulin tyrosine ligase like 1) Homo sapiens
Symbol: TTLL1
Name: tubulin tyrosine ligase like 1
Description: Predicted to have tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in several processes, including immune response in nasopharyngeal-associated lymphoid tissue; mucociliary clearance; and protein polyglutamylation. Predicted to localize to cilium; INTERACTS WITH (-)-epigallocatechin 3-gallate; bisphenol A; cisplatin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C22orf7; catalytic subunit of neural tubulin polyglutamylase; HS323M22B; PGs3; probable tubulin polyglutamylase TTLL1; tubulin polyglutamylase complex subunit 3; tubulin tyrosine ligase-like family member 1; tubulin tyrosine ligase-like family, member 1; tubulin--tyrosine ligase-like protein 1; tubulin-tyrosine ligase
Mus musculus (house mouse) : Ttll1 (tubulin tyrosine ligase-like 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ttll1 (tubulin tyrosine ligase like 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ttll1 (tubulin tyrosine ligase like 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TTLL1 (tubulin tyrosine ligase like 1)
Canis lupus familiaris (dog) : TTLL1 (tubulin tyrosine ligase like 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ttll1 (tubulin tyrosine ligase like 1)
Sus scrofa (pig) : TTLL1 (tubulin tyrosine ligase like 1)
Chlorocebus sabaeus (African green monkey) : TTLL1 (tubulin tyrosine ligase like 1)
Heterocephalus glaber (naked mole-rat) : Ttll1 (tubulin tyrosine ligase like 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2243,039,516 - 43,089,419 (-)EnsemblGRCh38hg38GRCh38
GRCh382243,039,516 - 43,089,428 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372243,435,522 - 43,485,434 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,765,589 - 41,815,373 (-)NCBINCBI36hg18NCBI36
Build 342241,760,142 - 41,809,927NCBI
Celera2227,346,102 - 27,395,837 (-)NCBI
Cytogenetic Map22q13.2NCBI
HuRef2226,394,153 - 26,443,736 (-)NCBIHuRef
CHM1_12243,395,326 - 43,445,000 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TTLL1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319289
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.