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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309124
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ttll1
Name: TTL family tubulin polyglutamylase complex subunit L1
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ttll1affects expressionISOTtll1 (Mus musculus)6480464CTDRotenone affects the expression of TTLL1 mRNAPMID:21893155
Ttll1increases expressionISOTtll1 (Mus musculus)6480464CTDRotenone results in increased expression of TTLL1 mRNAPMID:32937126
Ttll1multiple interactionsISOTtll1 (Mus musculus)6480464CTDTRP53 affects the reaction [Rotenone affects the expression of TTLL1 mRNA]PMID:21893155
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