Pnpla3 (patatin-like phospholipase domain containing 3) - Rat Genome Database

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Gene: Pnpla3 (patatin-like phospholipase domain containing 3) Rattus norvegicus
Analyze
Symbol: Pnpla3
Name: patatin-like phospholipase domain containing 3
RGD ID: 1595843
Description: Predicted to enable acylglycerol O-acyltransferase activity; anion binding activity; and lipase activity. Involved in several processes, including cellular response to 3,3',5-triiodo-L-thyronine; cellular response to insulin stimulus; and white fat cell differentiation. Predicted to be active in cytoplasm; lipid droplet; and membrane. Biomarker of hypothyroidism and obesity. Human ortholog(s) of this gene implicated in coronary artery disease; liver disease (multiple); and type 2 diabetes mellitus. Orthologous to human PNPLA3 (patatin like phospholipase domain containing 3); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3; adiponutrin; Adpn; LOC362972; patatin-like phospholipase domain-containing protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87117,173,485 - 117,194,065 (+)NCBIGRCr8
mRatBN7.27115,293,538 - 115,314,077 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7115,293,538 - 115,314,077 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7117,041,315 - 117,061,957 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07119,267,044 - 119,287,685 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07119,236,507 - 119,257,145 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07125,034,760 - 125,056,165 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7125,034,764 - 125,055,976 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07125,023,278 - 125,044,677 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47122,152,092 - 122,171,994 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7111,599,483 - 111,620,054 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
CL316243  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
entinostat  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
fructose  (ISO)
furan  (ISO)
genistein  (ISO)
glucose  (ISO)
GW 4064  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isosilybin  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
metformin  (EXP)
methotrexate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
morphine  (ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
oleic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
quercetin  (ISO)
rotenone  (EXP)
rutin  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
lipid droplet  (IBA,IEA,ISO)
membrane  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Adiponutrin, a transmembrane protein corresponding to a novel dietary- and obesity-linked mRNA specifically expressed in the adipose lineage. Baulande S, etal., J Biol Chem. 2001 Sep 7;276(36):33336-44. doi: 10.1074/jbc.M105193200. Epub 2001 Jun 28.
2. The impact of PNPLA3 (rs738409 C>G) polymorphisms on liver histology and long-term clinical outcome in chronic hepatitis B patients. Brouwer WP, etal., Liver Int. 2015 Feb;35(2):438-47. doi: 10.1111/liv.12695. Epub 2014 Oct 24.
3. Tri-iodothyronine upregulates adiponutrin mRNA expression in rat and human adipocytes. Calvo RM and Obregon MJ, Mol Cell Endocrinol. 2009 Nov 13;311(1-2):39-46. doi: 10.1016/j.mce.2009.07.006. Epub 2009 Jul 18.
4. Genetic analysis of nonalcoholic fatty liver disease within a Caribbean-Hispanic population. Edelman D, etal., Mol Genet Genomic Med. 2015 Aug 11;3(6):558-69. doi: 10.1002/mgg3.168. eCollection 2015 Nov.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Genetic variants in the PNPLA3 gene are associated with nonalcoholic steatohepatitis. Islek EE, etal., Genet Test Mol Biomarkers. 2014 Jul;18(7):489-96. doi: 10.1089/gtmb.2014.0019. Epub 2014 May 15.
7. PNPLA3 rs738409 polymorphism is associated with liver fibrosis progression in patients with chronic hepatitis C: A repeated measures study. Jiménez-Sousa MÁ, etal., J Clin Virol. 2018 Jun;103:71-74. doi: 10.1016/j.jcv.2018.04.008. Epub 2018 Apr 12.
8. Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals. Lin YC, etal., Am J Clin Nutr. 2014 Apr;99(4):869-74. doi: 10.3945/ajcn.113.079749. Epub 2014 Jan 29.
9. PNPLA3 gene polymorphism in Brazilian patients with type 2 diabetes: A prognostic marker beyond liver disease? Machado CM, etal., Nutr Metab Cardiovasc Dis. 2019 Sep;29(9):965-971. doi: 10.1016/j.numecd.2019.06.002. Epub 2019 Jun 14.
10. Adiponutrin mRNA expression in white adipose tissue is rapidly induced by meal-feeding a high-sucrose diet. Polson DA and Thompson MP, Biochem Biophys Res Commun. 2003 Feb 7;301(2):261-6. doi: 10.1016/s0006-291x(02)03027-9.
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Hepatic steatosis in Wilson disease--Role of copper and PNPLA3 mutations. Stattermayer AF, etal., J Hepatol. 2015 Jul;63(1):156-63. doi: 10.1016/j.jhep.2015.01.034. Epub 2015 Feb 9.
14. I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease. Valenti L, etal., Hepatology. 2010 Oct;52(4):1274-80. doi: 10.1002/hep.23823.
15. Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C. Valenti L, etal., Hepatology. 2011 Mar;53(3):791-9. doi: 10.1002/hep.24123. Epub 2011 Feb 11.
16. Patatin-like phospholipase domain-containing 3 I148M affects liver steatosis in patients with chronic hepatitis B. Viganò M, etal., Hepatology. 2013 Oct;58(4):1245-52. doi: 10.1002/hep.26445. Epub 2013 Aug 6.
Additional References at PubMed
PMID:12477932   PMID:15364929   PMID:17372308   PMID:20034933   PMID:21914237   PMID:22560221   PMID:23398201   PMID:24511104   PMID:28433418   PMID:35908495  


Genomics

Comparative Map Data
Pnpla3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87117,173,485 - 117,194,065 (+)NCBIGRCr8
mRatBN7.27115,293,538 - 115,314,077 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7115,293,538 - 115,314,077 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7117,041,315 - 117,061,957 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07119,267,044 - 119,287,685 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07119,236,507 - 119,257,145 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07125,034,760 - 125,056,165 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7125,034,764 - 125,055,976 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07125,023,278 - 125,044,677 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47122,152,092 - 122,171,994 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7111,599,483 - 111,620,054 (+)NCBICelera
Cytogenetic Map7q34NCBI
PNPLA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382243,923,805 - 43,947,582 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2243,923,792 - 43,964,488 (+)EnsemblGRCh38hg38GRCh38
GRCh372244,319,685 - 44,343,462 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362242,650,952 - 42,674,781 (+)NCBINCBI36Build 36hg18NCBI36
Celera2228,230,136 - 28,255,047 (+)NCBICelera
Cytogenetic Map22q13.31NCBI
HuRef2227,273,880 - 27,298,036 (+)NCBIHuRef
CHM1_12244,278,349 - 44,302,177 (+)NCBICHM1_1
T2T-CHM13v2.02244,406,936 - 44,430,721 (+)NCBIT2T-CHM13v2.0
Pnpla3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391584,052,017 - 84,073,720 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1584,052,038 - 84,071,437 (+)EnsemblGRCm39 Ensembl
GRCm381584,167,776 - 84,189,521 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1584,167,837 - 84,187,236 (+)EnsemblGRCm38mm10GRCm38
MGSCv371583,998,246 - 84,019,951 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361583,995,603 - 84,017,280 (+)NCBIMGSCv36mm8
Celera1586,298,497 - 86,320,441 (+)NCBICelera
Cytogenetic Map15E2NCBI
cM Map1539.78NCBI
Pnpla3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541328,879,748 - 28,893,938 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541328,879,646 - 28,896,224 (+)NCBIChiLan1.0ChiLan1.0
PNPLA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22353,752,467 - 53,780,078 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12256,444,968 - 56,473,064 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02224,812,831 - 24,836,161 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12243,004,329 - 43,027,749 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2243,004,499 - 43,027,003 (+)Ensemblpanpan1.1panPan2
PNPLA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11021,708,439 - 21,722,282 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1021,712,378 - 21,722,135 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1021,647,779 - 21,663,038 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01022,455,884 - 22,471,128 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1022,457,538 - 22,471,215 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11022,175,366 - 22,190,635 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01022,495,689 - 22,510,929 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01022,669,488 - 22,684,748 (-)NCBIUU_Cfam_GSD_1.0
Pnpla3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049455,341,850 - 5,360,187 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367181,619,948 - 1,638,317 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367181,620,034 - 1,638,315 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNPLA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl55,075,622 - 5,092,515 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.155,075,608 - 5,092,599 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PNPLA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11926,435,302 - 26,458,368 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1926,435,599 - 26,462,210 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604598,945,667 - 98,969,751 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Pnpla3
142 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:388
Count of miRNA genes:227
Interacting mature miRNAs:270
Transcripts:ENSRNOT00000015767
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
BI277600  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27115,296,694 - 115,296,861 (+)MAPPERmRatBN7.2
Rnor_6.07125,037,972 - 125,038,138NCBIRnor6.0
Rnor_5.07125,026,484 - 125,026,650UniSTSRnor5.0
RGSC_v3.47122,155,256 - 122,155,422UniSTSRGSC3.4
Celera7111,602,640 - 111,602,806UniSTS
RH 3.4 Map7906.9UniSTS
Cytogenetic Map7q34UniSTS
BE097963  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87117,176,960 - 117,177,109 (+)Marker Load Pipeline
mRatBN7.27115,296,970 - 115,297,119 (+)MAPPERmRatBN7.2
Rnor_6.07125,038,248 - 125,038,396NCBIRnor6.0
Rnor_5.07125,026,760 - 125,026,908UniSTSRnor5.0
RGSC_v3.47122,155,532 - 122,155,680UniSTSRGSC3.4
Celera7111,602,916 - 111,603,064UniSTS
RH 3.4 Map7908.6UniSTS
Cytogenetic Map7q34UniSTS
RH141751  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27115,312,901 - 115,313,103 (+)MAPPERmRatBN7.2
Rnor_6.07125,054,396 - 125,054,597NCBIRnor6.0
Rnor_5.07125,042,908 - 125,043,109UniSTSRnor5.0
RGSC_v3.47122,172,254 - 122,172,455UniSTSRGSC3.4
Celera7111,618,878 - 111,619,079UniSTS
RH 3.4 Map7912.1UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000015767   ⟹   ENSRNOP00000015767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7115,293,538 - 115,314,077 (+)Ensembl
Rnor_6.0 Ensembl7125,034,764 - 125,055,976 (+)Ensembl
RefSeq Acc Id: NM_001282324   ⟹   NP_001269253
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87117,173,528 - 117,194,065 (+)NCBI
mRatBN7.27115,293,538 - 115,314,077 (+)NCBI
Rnor_6.07125,034,815 - 125,055,571 (+)NCBI
Rnor_5.07125,023,278 - 125,044,677 (+)NCBI
Celera7111,599,483 - 111,620,054 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063263942   ⟹   XP_063120012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87117,173,485 - 117,184,179 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001269253 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120012 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM15608 (Get FASTA)   NCBI Sequence Viewer  
  EDM15609 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015767
  ENSRNOP00000015767.5
RefSeq Acc Id: NP_001269253   ⟸   NM_001282324
- UniProtKB: D3Z9J9 (UniProtKB/TrEMBL),   A6HTB3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015767   ⟸   ENSRNOT00000015767
RefSeq Acc Id: XP_063120012   ⟸   XM_063263942
- Peptide Label: isoform X1
Protein Domains
PNPLA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z9J9-F1-model_v2 AlphaFold D3Z9J9 1-425 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695554
Promoter ID:EPDNEW_R6079
Type:single initiation site
Name:Pnpla3_1
Description:patatin-like phospholipase domain containing 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07125,034,803 - 125,034,863EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595843 AgrOrtholog
BioCyc Gene G2FUF-32582 BioCyc
Ensembl Genes ENSRNOG00000022268 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015767 ENTREZGENE
  ENSRNOT00000015767.8 UniProtKB/TrEMBL
Gene3D-CATH Cytosolic phospholipase A2 catalytic domain UniProtKB/TrEMBL
InterPro Acyl_Trfase/lysoPlipase UniProtKB/TrEMBL
  Patatin UniProtKB/TrEMBL
  PLPL UniProtKB/TrEMBL
KEGG Report rno:362972 UniProtKB/TrEMBL
NCBI Gene 362972 ENTREZGENE
PANTHER 1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE PNPLA3 UniProtKB/TrEMBL
  PTHR12406 UniProtKB/TrEMBL
Pfam Patatin UniProtKB/TrEMBL
PhenoGen Pnpla3 PhenoGen
PROSITE PNPLA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022268 RatGTEx
Superfamily-SCOP Acyl_Trfase/lysoPlipase UniProtKB/TrEMBL
UniProt A6HTB3 ENTREZGENE, UniProtKB/TrEMBL
  D3Z9J9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Pnpla3  patatin-like phospholipase domain containing 3  LOC362972  similar to adiponutrin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC362972  similar to adiponutrin      Symbol and Name status set to provisional 70820 PROVISIONAL