Gene: Pnpla3 (patatin-like phospholipase domain containing 3) Rattus norvegicus
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Symbol: Pnpla3
Name: patatin-like phospholipase domain containing 3
Description: ENCODES a protein that exhibits 1-acylglycerol-3-phosphate O-acyltransferase activity (ortholog); diolein transacylation activity (ortholog); long-chain fatty acyl-CoA binding (ortholog); INVOLVED IN glycerophospholipid metabolic process (ortholog); lipid droplet organization (ortholog); long-chain fatty acid metabolic process (ortholog); ASSOCIATED WITH alcoholic liver cirrhosis (ortholog); Alcoholic Liver Diseases (ortholog); fatty liver disease (ortholog); FOUND IN lipid droplet (ortholog); membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A
AGR Description: Predicted to have anion binding activity, hydrolase activity, acting on ester bonds, and transferase activity, transferring acyl groups other than amino-acyl groups; predicted to be involved in several processes, including glycerolipid metabolic process, lipid droplet organization, and lipid homeostasis; predicted to localize to the cytoplasm, lipid droplet, and membrane; orthologous to human PNPLA3 (patatin like phospholipase domain containing 3).
Merged Description: Predicted to have anion binding activity, hydrolase activity, acting on ester bonds, and transferase activity, transferring acyl groups other than amino-acyl groups; predicted to be involved in several processes, including glycerolipid metabolic process, lipid droplet organization, and lipid homeostasis; predicted to localize to the cytoplasm, lipid droplet, and membrane; orthologous to human PNPLA3 (patatin like phospholipase domain containing 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: adiponutrin; Adpn; LOC362972; patatin-like phospholipase domain-containing protein 3; similar to adiponutrin
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07125,034,760 - 125,056,165 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07125,023,278 - 125,044,677 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47122,152,092 - 122,171,994 (+)NCBIRGSC3.4rn4RGSC3.4
Celera7111,599,483 - 111,620,054 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Pnpla3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1595843
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.