Pnpla3 (patatin-like phospholipase domain containing 3)

Gene: Pnpla3 (patatin-like phospholipase domain containing 3) Rattus norvegicus

Analyze

Symbol:

Pnpla3

Name:

patatin-like phospholipase domain containing 3

RGD ID:

1595843

Description:

Predicted to enable acylglycerol O-acyltransferase activity; anion binding activity; and lipase activity. Involved in cellular response to organonitrogen compound; response to sucrose; and white fat cell differentiation. Predicted to be active in cytoplasm; lipid droplet; and membrane. Biomarker of hypothyroidism and obesity. Human ortholog(s) of this gene implicated in coronary artery disease; liver disease (multiple); and type 2 diabetes mellitus. Orthologous to human PNPLA3 (patatin like phospholipase domain containing 3); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

1-acylglycerol-3-phosphate O-acyltransferase PNPLA3; adiponutrin; Adpn; LOC362972; patatin-like phospholipase domain-containing protein 3

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	117,173,485 - 117,194,065 (+)	NCBI		GRCr8
mRatBN7.2	7	115,293,538 - 115,314,077 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	115,293,538 - 115,314,077 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	117,041,315 - 117,061,957 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	119,267,044 - 119,287,685 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	119,236,507 - 119,257,145 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	125,034,760 - 125,056,165 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	125,034,764 - 125,055,976 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	125,023,278 - 125,044,677 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	122,152,092 - 122,171,994 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	111,599,483 - 111,620,054 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcoholic liver cirrhosis (ISO)

Alcoholic Liver Diseases (ISO)

coronary artery disease (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

hypothyroidism (IEP)

intellectual disability (ISO)

liver cirrhosis (ISO)

metabolic dysfunction-associated steatotic liver disease (ISO,ISS)

obesity (IEP)

Phelan-McDermid syndrome (ISO)

steatotic liver disease (ISO)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-D (ISO)

2-palmitoylglycerol (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromobenzene (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

choline (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

D-glucose (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

dicrotophos (ISO)

dimethylarsinic acid (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

enilconazole (ISO)

entinostat (ISO)

fluoxetine (ISO)

folic acid (ISO)

fructose (ISO)

furan (ISO)

genistein (ISO)

glucose (ISO)

GW 4064 (ISO)

hexadecanoic acid (ISO)

hydrogen peroxide (ISO)

indometacin (ISO)

isosilybin (ISO)

isotretinoin (ISO)

L-methionine (ISO)

metformin (EXP)

methotrexate (ISO)

methylarsonic acid (ISO)

methylmercury chloride (ISO)

monosodium L-glutamate (ISO)

morphine (ISO)

N-acetyl-L-cysteine (EXP)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

N-nitrosodiethylamine (ISO)

nickel atom (ISO)

O-methyleugenol (ISO)

oleic acid (ISO)

paracetamol (EXP,ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenformin (EXP)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propanal (ISO)

quercetin (ISO)

rotenone (EXP)

rutin (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sunitinib (ISO)

tamoxifen (ISO)

tetrachloromethane (EXP)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP,ISO)

trichostatin A (ISO)

Triptolide (ISO)

troglitazone (ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to 3,3',5-triiodo-L-thyronine (IEP)

cellular response to insulin stimulus (IEP)

glycerophospholipid metabolic process (ISO)

lipid droplet organization (ISO)

lipid homeostasis (IBA)

long-chain fatty acid metabolic process (ISO)

phosphatidic acid biosynthetic process (ISO)

response to dietary excess (ISO)

response to sucrose (IEP)

triglyceride acyl-chain remodeling (ISO)

triglyceride biosynthetic process (ISO)

triglyceride catabolic process (IBA,ISO)

white fat cell differentiation (IEP)

Cellular Component

cytoplasm (IBA)

lipid droplet (IBA,ISO)

membrane (IBA,ISO)

Molecular Function

1-acylglycerol-3-phosphate O-acyltransferase activity (ISO)

diolein transacylation activity (ISO)

long-chain fatty acyl-CoA binding (ISO)

lysophosphatidic acid acyltransferase activity (ISO)

lysophosphatidic acid binding (ISO)

mono-olein transacylation activity (ISO)

phospholipase A2 activity (ISO)

triglyceride lipase activity (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Adiponutrin, a transmembrane protein corresponding to a novel dietary- and obesity-linked mRNA specifically expressed in the adipose lineage.	Baulande S, etal., J Biol Chem. 2001 Sep 7;276(36):33336-44. doi: 10.1074/jbc.M105193200. Epub 2001 Jun 28.
2.	The impact of PNPLA3 (rs738409 C>G) polymorphisms on liver histology and long-term clinical outcome in chronic hepatitis B patients.	Brouwer WP, etal., Liver Int. 2015 Feb;35(2):438-47. doi: 10.1111/liv.12695. Epub 2014 Oct 24.
3.	Tri-iodothyronine upregulates adiponutrin mRNA expression in rat and human adipocytes.	Calvo RM and Obregon MJ, Mol Cell Endocrinol. 2009 Nov 13;311(1-2):39-46. doi: 10.1016/j.mce.2009.07.006. Epub 2009 Jul 18.
4.	Genetic analysis of nonalcoholic fatty liver disease within a Caribbean-Hispanic population.	Edelman D, etal., Mol Genet Genomic Med. 2015 Aug 11;3(6):558-69. doi: 10.1002/mgg3.168. eCollection 2015 Nov.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Genetic variants in the PNPLA3 gene are associated with nonalcoholic steatohepatitis.	Islek EE, etal., Genet Test Mol Biomarkers. 2014 Jul;18(7):489-96. doi: 10.1089/gtmb.2014.0019. Epub 2014 May 15.
7.	PNPLA3 rs738409 polymorphism is associated with liver fibrosis progression in patients with chronic hepatitis C: A repeated measures study.	Jiménez-Sousa MÁ, etal., J Clin Virol. 2018 Jun;103:71-74. doi: 10.1016/j.jcv.2018.04.008. Epub 2018 Apr 12.
8.	Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals.	Lin YC, etal., Am J Clin Nutr. 2014 Apr;99(4):869-74. doi: 10.3945/ajcn.113.079749. Epub 2014 Jan 29.
9.	PNPLA3 gene polymorphism in Brazilian patients with type 2 diabetes: A prognostic marker beyond liver disease?	Machado CM, etal., Nutr Metab Cardiovasc Dis. 2019 Sep;29(9):965-971. doi: 10.1016/j.numecd.2019.06.002. Epub 2019 Jun 14.
10.	Adiponutrin mRNA expression in white adipose tissue is rapidly induced by meal-feeding a high-sucrose diet.	Polson DA and Thompson MP, Biochem Biophys Res Commun. 2003 Feb 7;301(2):261-6. doi: 10.1016/s0006-291x(02)03027-9.
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Comprehensive gene review and curation	RGD comprehensive gene curation
13.	Hepatic steatosis in Wilson disease--Role of copper and PNPLA3 mutations.	Stattermayer AF, etal., J Hepatol. 2015 Jul;63(1):156-63. doi: 10.1016/j.jhep.2015.01.034. Epub 2015 Feb 9.
14.	I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease.	Valenti L, etal., Hepatology. 2010 Oct;52(4):1274-80. doi: 10.1002/hep.23823.
15.	Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C.	Valenti L, etal., Hepatology. 2011 Mar;53(3):791-9. doi: 10.1002/hep.24123. Epub 2011 Feb 11.
16.	Patatin-like phospholipase domain-containing 3 I148M affects liver steatosis in patients with chronic hepatitis B.	Viganò M, etal., Hepatology. 2013 Oct;58(4):1245-52. doi: 10.1002/hep.26445. Epub 2013 Aug 6.

Additional References at PubMed

PMID:12477932	PMID:15364929	PMID:17372308	PMID:20034933	PMID:21914237	PMID:22560221	PMID:23398201	PMID:24511104	PMID:28433418	PMID:35908495

Genomics

Comparative Map Data

Pnpla3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	117,173,485 - 117,194,065 (+)	NCBI		GRCr8
mRatBN7.2	7	115,293,538 - 115,314,077 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	115,293,538 - 115,314,077 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	117,041,315 - 117,061,957 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	119,267,044 - 119,287,685 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	119,236,507 - 119,257,145 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	125,034,760 - 125,056,165 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	125,034,764 - 125,055,976 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	125,023,278 - 125,044,677 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	122,152,092 - 122,171,994 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	111,599,483 - 111,620,054 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

PNPLA3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	43,923,805 - 43,947,582 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	43,923,792 - 43,964,488 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	44,319,685 - 44,343,462 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	42,650,952 - 42,674,781 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	22	28,230,136 - 28,255,047 (+)	NCBI		Celera
Cytogenetic Map	22	q13.31	NCBI
HuRef	22	27,273,880 - 27,298,036 (+)	NCBI		HuRef
CHM1_1	22	44,278,349 - 44,302,177 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	44,406,936 - 44,430,721 (+)	NCBI		T2T-CHM13v2.0

Pnpla3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	84,052,017 - 84,073,720 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	84,052,038 - 84,071,437 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	84,167,776 - 84,189,521 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	84,167,837 - 84,187,236 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	83,998,246 - 84,019,951 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	83,995,603 - 84,017,280 (+)	NCBI		MGSCv36	mm8
Celera	15	86,298,497 - 86,320,441 (+)	NCBI		Celera
Cytogenetic Map	15	E2	NCBI
cM Map	15	39.78	NCBI

Pnpla3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	28,879,748 - 28,893,938 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	28,879,646 - 28,896,224 (+)	NCBI	ChiLan1.0	ChiLan1.0

PNPLA3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	53,752,467 - 53,780,078 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	56,444,968 - 56,473,064 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	24,812,831 - 24,836,161 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	43,004,329 - 43,027,749 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	43,004,499 - 43,027,003 (+)	Ensembl	panpan1.1		panPan2

PNPLA3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	21,708,439 - 21,722,282 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	21,712,378 - 21,722,135 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	21,647,779 - 21,663,038 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	22,455,884 - 22,471,128 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	22,457,538 - 22,471,215 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	22,175,366 - 22,190,635 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	22,495,689 - 22,510,929 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	22,669,488 - 22,684,748 (-)	NCBI		UU_Cfam_GSD_1.0

Pnpla3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	5,341,850 - 5,360,187 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936718	1,619,948 - 1,638,317 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936718	1,620,034 - 1,638,315 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PNPLA3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	5,075,622 - 5,092,515 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	5,075,608 - 5,092,599 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

PNPLA3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	26,435,302 - 26,458,368 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	26,435,599 - 26,462,210 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	98,945,667 - 98,969,751 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Pnpla3
142 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	388
Count of miRNA genes:	227
Interacting mature miRNAs:	270
Transcripts:	ENSRNOT00000015767
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	69736226	117455174	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	73829340	130221005	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	80221299	124373579	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	80221299	125221299	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	81737938	126737938	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	83153392	128153392	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
71114	Niddm14	Non-insulin dependent diabetes mellitus QTL 14	4.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	84257275	129257275	Rat
2298475	Eau6	Experimental allergic uveoretinitis QTL 6		0.0029	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	7	84257275	129257275	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	86983365	131983365	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	91412594	129807172	Rat
2313102	Bmd79	Bone mineral density QTL 79	2.3	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	7	94811085	116738842	Rat
1357336	Gluco6	Glucose level QTL 6	3.4		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	7	94811326	116294265	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	102297359	133492884	Rat
70159	Bp61	Blood pressure QTL 61		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	103146217	116738842	Rat
731174	Uae23	Urinary albumin excretion QTL 23	2.4	0.0042	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	7	104603555	135012528	Rat
2306821	Bp335	Blood pressure QTL 335		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	106571501	135012528	Rat
631663	Bw6	Body weight QTL 6	3.4		body mass (VT:0001259)	body weight (CMO:0000012)	7	111075573	134976056	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	111182207	135012528	Rat
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	112308254	133492884	Rat
1357339	Stl14	Serum triglyceride level QTL 14	3.45	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	112729683	133492707	Rat

Markers in Region

BI277600

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	115,296,694 - 115,296,861 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	125,037,972 - 125,038,138	NCBI	Rnor6.0
Rnor_5.0	7	125,026,484 - 125,026,650	UniSTS	Rnor5.0
RGSC_v3.4	7	122,155,256 - 122,155,422	UniSTS	RGSC3.4
Celera	7	111,602,640 - 111,602,806	UniSTS
RH 3.4 Map	7	906.9	UniSTS
Cytogenetic Map	7	q34	UniSTS

BE097963

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	115,296,970 - 115,297,119 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	125,038,248 - 125,038,396	NCBI	Rnor6.0
Rnor_5.0	7	125,026,760 - 125,026,908	UniSTS	Rnor5.0
RGSC_v3.4	7	122,155,532 - 122,155,680	UniSTS	RGSC3.4
Celera	7	111,602,916 - 111,603,064	UniSTS
RH 3.4 Map	7	908.6	UniSTS
Cytogenetic Map	7	q34	UniSTS

RH141751

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	115,312,901 - 115,313,103 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	125,054,396 - 125,054,597	NCBI	Rnor6.0
Rnor_5.0	7	125,042,908 - 125,043,109	UniSTS	Rnor5.0
RGSC_v3.4	7	122,172,254 - 122,172,455	UniSTS	RGSC3.4
Celera	7	111,618,878 - 111,619,079	UniSTS
RH 3.4 Map	7	912.1	UniSTS
Cytogenetic Map	7	q34	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		2	20	12	3	12			20	17	3	3
Low	3	39	37	29	16	29	8	11	54	18	35	8	8
Below cutoff		2									3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001282324	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594995	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263942	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC161881	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM042237	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM043479	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000015767 ⟹ ENSRNOP00000015767

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	115,293,538 - 115,314,077 (+)	Ensembl
Rnor_6.0 Ensembl	7	125,034,764 - 125,055,976 (+)	Ensembl

RefSeq Acc Id:

NM_001282324 ⟹ NP_001269253

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	117,173,528 - 117,194,065 (+)	NCBI
mRatBN7.2	7	115,293,538 - 115,314,077 (+)	NCBI
Rnor_6.0	7	125,034,815 - 125,055,571 (+)	NCBI
Rnor_5.0	7	125,023,278 - 125,044,677 (+)	NCBI
Celera	7	111,599,483 - 111,620,054 (+)	NCBI

Sequence:

show sequence

CCCGGAGCAGAATTGAGCTGCATCGCCTTCCGGAGCCTCCAGCGCCATGTACGACCCAGAGCGC
CGCTGGAGCCTGTCGTTCGCAGGCTGCGGCTTCCTAGGCTTCTACCACATCGGGGCTACGCTAT
GTCTGAGCGAGCGCGCTCCGCACATCCTCCGCGAAGCGCGCACTTTCTTCGGCTGCTCGGCCGG
TGCACTGCACGCGGTCACCTTCGTGTGCAGTCTCCCTCTCGATCACATCATGGAGATCCTCATG
GACCTCGTGCGGAAAGCCAGGAGCCGCAACATCGGCACCCTCCACCCGTTCTTCAACATTAACA
AGTGCGTCAGAGACGGCCTTCAGGAGACCCTCCCAGACAACGTCCACCAGATCATTTCTGGCAA
GGTTTACATCTCACTCACCAGAGTGTCCGATGGGGAGAACGTGCTGGTGTCTGAGTTCCATTCC
AAAGACGAAGTGGTGGATGCCCTGGTGTGCTCCTGCTTCATTCCTCTCTTCTCTGGCCTAATCC
CTCCTTCCTTCCGAGGTGAGCGGTACGTGGATGGAGGAGTGAGTGACAACGTCCCTGTGCTGGA
CGCCAAAACCACCATCACGGTGTCCCCTTTCTATGGTGAGCATGACATCTGTCCCAAAGTGAAG
TCCACCAACTTCCTCCAGGTGAATATCACCAACCTCAGTCTTCGTCTCTGCACTGGGAACCTTC
ATCTTCTGACCAGAGCACTCTTCCCATCTGATGTGAAGGTGATGGGAGAGCTGTGCTTTCAAGG
GTACCTGGACGCCTTCCGGTTCCTGGAAGAGAACGGCATCTGTAATGGGCCACAGCGCAGCCTG
AGTCTGTCCTTGGAGAAGGAAATGGCGCCAGAAACCATGATACCCTGCTTGGAAAATGGCCACC
TTGTAGCAGGGAACAAGGTGCCAGTAAGCTGTGTATGCCTTACAGCTGTGCCGTCGGATGAGAG
CATCTGGGAGATGCTGTCCCCCAAGCTCAGCACAGCTCTGACTGAAGCGATTAAAGACAGGGGG
GGCTACCTGAACAAAGTCTGCAACCTCCTGCCCATTAGGATCCTGTCCTACATCTTGCTGCCCT
GCACTCTGCCCGTGGAGTCGGCCATCGCTGCAGTCCACAGGCTGGTGATGTGGCTCCCTGATAT
CCATGAAGATATCCAGTGGCTACAGTGGGCAACATCCCAGGTGTGTGCCCGAATGACCATGTGC
CTGCTCCCCTCTACCAGATCCAGAGCATCCAAGGATAACCATCAAACACTCAAGCATGGATATC
ACCCATCTCTCCACAAACCCCAAGGCAGCTCTGCCGGTTTGTAAATTGCTGGTCTCCGTGCTTC
CGATGAACTTGGGCATTCTCCCTGTGGATGGTTCCAGGAGAGGCCATAGCTGAAGGCACTCTGC
CTTCCACCCCAAGTCCAGTTTGACCTTTATCTAGAGCAACAGTGTCTAGATGATAGGTGGGTGG
GGGGTGCTGTCTCTCTGTTTCCCTCTGGGAAGGGTTCTGTTAACTTTTGGAGGCAGCTAGGAAA
TTTCTCTCCAGGAGCTGAGCCTGTGCAGCTGCCCCCTTGGTGCTGTGTGGTAACCTCATTGCCT
GTGACCCTAGGATCATAGGATCTGGGCTAAATAGGTAGTTCATAGAAACCAAAGACAATAATTT
GGTGTTTAGAAAACTACTTTTGGTCTGGGTGAAGTCTGGTGCTTGAGAGTTAGTGCAGAGAGAA
CGGTCAAACCGTCTCTCAGCCTGTGGATCTATGGGGATTCCAAGGGCTTCAGTGTTTGGAAACG
GCAATCCAAACGGGCAATCTTGTGCAATCTTGGAAGGAGAACTGTTCAGGAAGTGTGATGGGAT
GAGCTGTGGCTGTCTCTGAAAAGGGCCTACCATATAACTTATTACTTTCAAGGATACCTTTGGC
TCTTACTAAAATAGTTTATAAAGCATTTTATAGAAACACACCAGGGAATGCGTGGTGAACTACA
TGTATGATCAGTGAACTGTGACTAGAATTAACCTTAAAATCTCTTGTATGTGGGGCCAGAGCAA
CACAGGTGGGAAACGCAGCGGACCTCTGCCTCCTCGGCCTCAACATGAACTTGGCTTGCTTTCT
CCACCGTCTCCAAATCTTTGTATAGTCATCGACCATTACCACCTCTCCTTTCCCATCTACTACA
GCAGCCTTAATGGGGATAAGTACCCCCTTTTCTCAGGTGTCCGAATAAGCTGTGGGTGTGGCCT
GTGTTTCCTGTAATTCTGAGGTTAGATTGGAACATAAGCAAGCAGACAAACAAGCAGACAAACA
AACAAGGTTCTACTCATATTCCTAAGCAGTGACAGTGAAGGCATGTGTCTCCCATGCCTGAGTC
TCCTAGGGTCCTAGTGAGCTCTGGGTTCATGCAAGCACTTCCGGAGGAATTGCACCCTCCATGG
AACACATAATCTCCACTGGGTTGATCCTGATTGGATAAGAAAGGATCTCGGGGAGAGAATGTGG
TTCCAGAGGCAAAGTGTCTAGGCTACACAGAAAAGGTAAGACTGTCCCCAAGGGAAGAAAACAA
ACTGGGAGCTGGGGTCCAGCTCAATTGTTAAGAGTGCTTCTCTAGTATGCGTGAAGCCCAGAGT
CCAATCTCAGTACCAGATACACGGTACAGGCAGTGACATATGCCTGTAATCCCAACCCTCAAGC
AGTAGAGGCAAGAGGATCAGAAGTTCATGGTCATCCTTGACTACTTATACTTAGGGAGTTGGAG
GTCAGCC

hide sequence

RefSeq Acc Id:

XM_063263942 ⟹ XP_063120012

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	117,173,485 - 117,184,179 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001269253	(Get FASTA)	NCBI Sequence Viewer
	XP_063120012	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM15608	(Get FASTA)	NCBI Sequence Viewer
	EDM15609	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000015767
	ENSRNOP00000015767.5

RefSeq Acc Id:

NP_001269253 ⟸ NM_001282324

- UniProtKB:

D3Z9J9 (UniProtKB/TrEMBL), A6HTB3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MYDPERRWSLSFAGCGFLGFYHIGATLCLSERAPHILREARTFFGCSAGALHAVTFVCSLPLDH
IMEILMDLVRKARSRNIGTLHPFFNINKCVRDGLQETLPDNVHQIISGKVYISLTRVSDGENVL
VSEFHSKDEVVDALVCSCFIPLFSGLIPPSFRGERYVDGGVSDNVPVLDAKTTITVSPFYGEHD
ICPKVKSTNFLQVNITNLSLRLCTGNLHLLTRALFPSDVKVMGELCFQGYLDAFRFLEENGICN
GPQRSLSLSLEKEMAPETMIPCLENGHLVAGNKVPVSCVCLTAVPSDESIWEMLSPKLSTALTE
AIKDRGGYLNKVCNLLPIRILSYILLPCTLPVESAIAAVHRLVMWLPDIHEDIQWLQWATSQVC
ARMTMCLLPSTRSRASKDNHQTLKHGYHPSLHKPQGSSAGL

hide sequence

RefSeq Acc Id:

ENSRNOP00000015767 ⟸ ENSRNOT00000015767

RefSeq Acc Id:	XP_063120012 ⟸ XM_063263942
- Peptide Label:	isoform X1

Protein Domains

PNPLA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3Z9J9-F1-model_v2	AlphaFold	D3Z9J9	1-425	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695554

Promoter ID:

EPDNEW_R6079

Type:

single initiation site

Name:

Pnpla3_1

Description:

patatin-like phospholipase domain containing 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	125,034,803 - 125,034,863	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1595843	AgrOrtholog
BioCyc Gene	G2FUF-32582	BioCyc
Ensembl Genes	ENSRNOG00000022268	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000015767	ENTREZGENE
	ENSRNOT00000015767.8	UniProtKB/TrEMBL
Gene3D-CATH	Cytosolic phospholipase A2 catalytic domain	UniProtKB/TrEMBL
InterPro	Acyl_Trfase/lysoPlipase	UniProtKB/TrEMBL
	Patatin	UniProtKB/TrEMBL
	PLPL	UniProtKB/TrEMBL
KEGG Report	rno:362972	UniProtKB/TrEMBL
NCBI Gene	362972	ENTREZGENE
PANTHER	1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE PNPLA3	UniProtKB/TrEMBL
	PTHR12406	UniProtKB/TrEMBL
Pfam	Patatin	UniProtKB/TrEMBL
PhenoGen	Pnpla3	PhenoGen
PROSITE	PNPLA	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000022268	RatGTEx
Superfamily-SCOP	Acyl_Trfase/lysoPlipase	UniProtKB/TrEMBL
UniProt	A6HTB3	ENTREZGENE, UniProtKB/TrEMBL
	D3Z9J9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-05	Pnpla3	patatin-like phospholipase domain containing 3	LOC362972	similar to adiponutrin	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC362972	similar to adiponutrin			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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