RGD Reference Report - Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals. - Rat Genome Database

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Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals.

Authors: Lin, Yu-Cheng  Chang, Pi-Feng  Chang, Mei-Hwei  Ni, Yen-Hsuan 
Citation: Lin YC, etal., Am J Clin Nutr. 2014 Apr;99(4):869-74. doi: 10.3945/ajcn.113.079749. Epub 2014 Jan 29.
RGD ID: 14981593
Pubmed: PMID:24477042   (View Abstract at PubMed)
DOI: DOI:10.3945/ajcn.113.079749   (Journal Full-text)


BACKGROUND: A genome-wide association study identified variants in or near patatin-like phospholipase domain-containing-3 (PNPLA3), neurocan (NCAN), lysophospholipase-like 1 (LYPLAL1), glucokinase regulatory protein (GCKR), and protein phosphatase 1 regulatory subunit 3b (PPP1R3B) that were strongly associated with nonalcoholic fatty liver disease (NAFLD) in adults of European ancestry.
OBJECTIVE: We examined these genetic variants in obese children and tested whether their effects on NAFLD are significant in the Taiwanese Han Chinese population.
DESIGN: We genotyped PNPLA3 rs738409, NCAN rs2228603, LYPLAL1 rs12137855, GCKR rs780094, and PPP1R3B rs4240624 in 797 obese children aged 7-18 y. NAFLD was identified by liver ultrasonography. We analyzed the effect of these genetic variants on NAFLD.
RESULTS: NAFLD was identified in 24% of the recruited obese children. We found significant associations with NAFLD at variants in PNPLA3 and GCKR but not in NCAN, LYPLAL1, and PPP1R3B. Multiple logistic regression analysis showed that, after control for the effects of age- and sex-adjusted body mass index, waist-to-hip ratio, sex, and PNPLA3 rs738409 polymorphism, the variant GCKR rs780094 TT genotype independently increased the OR of NAFLD by 1.997 (95% CI: 1.196, 3.335; P = 0.008) compared with the CC genotype. Subjects with the variant GCKR rs780094 TT genotype had a higher mean serum alanine aminotransferase concentration than did those with the CC genotype (30.8 ± 34.7 compared with 22.2 ± 18.6 IU/L; P = 0.01).
CONCLUSIONS: By studying the genetic variants of obese Taiwanese children, we confirmed that the genetic variants in GCKR rs780094 and PNPLA3 rs738409, but not in NCAN rs2228603, LYPLAL1 rs12137855, and PPP1R3B rs4240624, are associated with an increased risk of NAFLD. GCKR and PNPLA3 variants are the common genetic factors that may confer susceptibility to NAFLD in obese individuals across multiple ethnic groups.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
metabolic dysfunction-associated steatotic liver disease  IAGP 14981593associated with obesity and DNA:SNP: :rs738409 (p.I148M) (human)RGD 
metabolic dysfunction-associated steatotic liver disease  ISOPNPLA3 (Homo sapiens)14981593; 14981593associated with obesity and DNA:SNP: :rs738409 (p.I148M) (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pnpla3  (patatin-like phospholipase domain containing 3)

Genes (Mus musculus)
Pnpla3  (patatin-like phospholipase domain containing 3)

Genes (Homo sapiens)
PNPLA3  (patatin like phospholipase domain containing 3)


Additional Information