RGD Reference Report - PNPLA3 rs738409 polymorphism is associated with liver fibrosis progression in patients with chronic hepatitis C: A repeated measures study. - Rat Genome Database

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PNPLA3 rs738409 polymorphism is associated with liver fibrosis progression in patients with chronic hepatitis C: A repeated measures study.

Authors: Jiménez-Sousa, María Ángeles  Gómez-Moreno, Ana Zaida  Pineda-Tenor, Daniel  Sánchez-Ruano, Juan José  Fernández-Rodríguez, Amanda  Artaza-Varasa, Tomas  Gómez-Sanz, Alicia  Martín-Vicente, María  Vázquez-Morón, Sonia  Resino, Salvador 
Citation: Jiménez-Sousa MÁ, etal., J Clin Virol. 2018 Jun;103:71-74. doi: 10.1016/j.jcv.2018.04.008. Epub 2018 Apr 12.
RGD ID: 14981591
Pubmed: PMID:29674183   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jcv.2018.04.008   (Journal Full-text)


BACKGROUND: Host genetic background has been associated with liver fibrosis progression.
OBJECTIVE: To analyze the association between the patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 polymorphism and liver fibrosis progression in hepatitis C virus (HCV)-infected patients.
STUDY DESIGN: In this retrospective cohort study, 187 patients with chronic HCV infection were included, who had at least two liver stiffness measurements (LSM) by transient elastography during the follow-up. Results were expressed in kilopascals (kPa). The analysis of genetic association was carried out according to additive model by using Generalized Linear Models.
RESULTS: No patients had advanced fibrosis/cirrhosis at baseline. During a median follow-up time of 47.9 months, 15 patients developed advanced fibrosis and 17 cirrhosis. In multivariate analysis adjusted by the main clinical and epidemiological covariates, the rs738409 G allele was related to higher increase of LSM values during the follow-up (adjusted arithmetic mean ratio (aAMR) = 1.16 (95%CI = 1.04; 1.29); p = .006) and higher odds of having progression to advanced fibrosis [aOR = 2.03 (95%CI = 1.01; 4.06); p = .045], and progression to cirrhosis [aOR = 3.03 (95%CI = 1.26; 7.30); p = .014].
CONCLUSIONS: PNPLA3 rs738409 polymorphism appears to be related to the increased progression of liver fibrosis in HCV infected patients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
liver cirrhosis disease_progressionIAGP 14981591associated with Hepatitis C more ...RGD 
liver cirrhosis disease_progressionISOPNPLA3 (Homo sapiens)14981591; 14981591associated with Hepatitis C more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pnpla3  (patatin-like phospholipase domain containing 3)

Genes (Mus musculus)
Pnpla3  (patatin-like phospholipase domain containing 3)

Genes (Homo sapiens)
PNPLA3  (patatin like phospholipase domain containing 3)


Additional Information