Pnpla3 (patatin-like phospholipase domain containing 3) - Rat Genome Database

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Gene: Pnpla3 (patatin-like phospholipase domain containing 3) Mus musculus
Analyze
Symbol: Pnpla3
Name: patatin-like phospholipase domain containing 3
RGD ID: 1314261
MGI Page MGI
Description: Enables several functions, including 1-acylglycerol-3-phosphate O-acyltransferase activity; long-chain fatty acyl-CoA binding activity; and lysophosphatidic acid binding activity. Involved in glycerolipid metabolic process; long-chain fatty acid metabolic process; and response to dietary excess. Located in lipid droplet and membrane. Is expressed in left lung; olfactory epithelium; and right lung. Used to study non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in coronary artery disease; fatty liver disease (multiple); liver disease (multiple); and type 2 diabetes mellitus. Orthologous to human PNPLA3 (patatin like phospholipase domain containing 3); INTERACTS WITH 1,2-dichloroethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1-acylglycerol-3-phosphate O-acyltransferase Pnpla3; A; acylglycerol O-acyltransferase; acylglycerol transacylase; adiponutrin; Adpn; calcium-independent phospholipase A2-epsilon; iPLA2-epsilon; lysophosphatidic acid acyltransferase; patatin-like phospholipase domain-containing protein 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391584,051,977 - 84,073,722 (+)NCBIGRCm39mm39
GRCm39 Ensembl1584,052,038 - 84,071,437 (+)Ensembl
GRCm381584,167,776 - 84,189,521 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1584,167,837 - 84,187,236 (+)EnsemblGRCm38mm10GRCm38
MGSCv371583,998,246 - 84,019,951 (+)NCBIGRCm37mm9NCBIm37
MGSCv361583,995,603 - 84,017,280 (+)NCBImm8
Celera1586,298,497 - 86,320,441 (+)NCBICelera
Cytogenetic Map15E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
choline  (EXP)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
enilconazole  (ISO)
entinostat  (ISO)
folic acid  (EXP)
furan  (EXP)
genistein  (EXP)
GW 4064  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
L-methionine  (EXP)
metformin  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (EXP)
morphine  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
O-methyleugenol  (ISO)
oleic acid  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
quercetin  (EXP,ISO)
rotenone  (ISO)
rutin  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
tetrachloromethane  (ISO)
thimerosal  (ISO)
titanium dioxide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (EXP)
troglitazone  (EXP)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16380488  
PMID:18799693   PMID:20015565   PMID:20648554   PMID:21068004   PMID:21145868   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22560221   PMID:23023705   PMID:24114809   PMID:24917523  
PMID:27180240   PMID:28433418   PMID:28520213   PMID:29555681   PMID:30272815   PMID:30447270   PMID:30772256   PMID:31019090   PMID:33672787  


Genomics

Comparative Map Data
Pnpla3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391584,051,977 - 84,073,722 (+)NCBIGRCm39mm39
GRCm39 Ensembl1584,052,038 - 84,071,437 (+)Ensembl
GRCm381584,167,776 - 84,189,521 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1584,167,837 - 84,187,236 (+)EnsemblGRCm38mm10GRCm38
MGSCv371583,998,246 - 84,019,951 (+)NCBIGRCm37mm9NCBIm37
MGSCv361583,995,603 - 84,017,280 (+)NCBImm8
Celera1586,298,497 - 86,320,441 (+)NCBICelera
Cytogenetic Map15E2NCBI
PNPLA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2243,923,792 - 43,964,488 (+)EnsemblGRCh38hg38GRCh38
GRCh382243,923,805 - 43,947,582 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372244,319,685 - 44,343,462 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362242,650,952 - 42,674,781 (+)NCBINCBI36hg18NCBI36
Celera2228,230,136 - 28,255,047 (+)NCBI
Cytogenetic Map22q13.31NCBI
HuRef2227,273,880 - 27,298,036 (+)NCBIHuRef
CHM1_12244,278,349 - 44,302,177 (+)NCBICHM1_1
Pnpla3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27115,293,538 - 115,314,077 (+)NCBI
Rnor_6.0 Ensembl7125,034,764 - 125,055,976 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07125,034,760 - 125,056,165 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07125,023,278 - 125,044,677 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47122,152,092 - 122,171,994 (+)NCBIRGSC3.4rn4RGSC3.4
Celera7111,599,483 - 111,620,054 (+)NCBICelera
Cytogenetic Map7q34NCBI
Pnpla3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541328,879,748 - 28,893,938 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541328,879,646 - 28,896,224 (+)NCBIChiLan1.0ChiLan1.0
PNPLA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12243,004,329 - 43,027,749 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2243,004,499 - 43,027,003 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02224,812,831 - 24,836,161 (+)NCBIMhudiblu_PPA_v0panPan3
PNPLA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11021,708,439 - 21,722,282 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1021,712,378 - 21,722,135 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1021,647,779 - 21,663,038 (-)NCBI
ROS_Cfam_1.01022,455,884 - 22,471,128 (-)NCBI
UMICH_Zoey_3.11022,175,366 - 22,190,635 (-)NCBI
UNSW_CanFamBas_1.01022,495,689 - 22,510,929 (-)NCBI
UU_Cfam_GSD_1.01022,669,488 - 22,684,748 (-)NCBI
Pnpla3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049455,341,850 - 5,360,187 (-)NCBI
SpeTri2.0NW_0049367181,620,034 - 1,638,315 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNPLA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl55,075,622 - 5,092,515 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.155,075,608 - 5,092,599 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PNPLA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11926,435,302 - 26,458,368 (+)NCBI
ChlSab1.1 Ensembl1926,435,599 - 26,462,210 (+)Ensembl
Vero_WHO_p1.0NW_02366604598,945,667 - 98,969,751 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15610000086800000Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156100000100900000Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15690000084700000Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402117102988123Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800000102100000Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578270103517472Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800000086800000Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154230000095600000Mouse
1300644Fob3_mF-line obesity QTL 3 (mouse)11.3Not determined154414443889377036Mouse
26884397Humsd5_mhumerus midshaft diameter 5, 10 week (mouse)154850000098500000Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548500000101800000Mouse
4142198Hbtq_mhabituation QTL (mouse)Not determined155128885985288984Mouse
10045637Heal27_mwound healing/regeneration 29 (mouse)Not determined155154651285546662Mouse
10412067Pain2_mpain 2 (mouse)Not determined155177349085773777Mouse
1302080Szs13_mseizure susceptibility 13 (mouse)Not determined155181398385822600Mouse
1301708Cocrb14_mcocaine related behavior 14 (mouse)Not determined155193466685934802Mouse
38501067Tip3_mtuberculosis immunophenotype 3, IFN-g level (mouse)155370000089700000Mouse
13504731Cath5_mcarotid atherosclerosis 5 (mouse)155491728088917280Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556323312103517472Mouse
27095936Ulnl4_mulna length 4, 5 week (mouse)155690000087800000Mouse
1300800Ses3_msalmonella enteritidis susceptibility 3 (mouse)Not determined155724515691245304Mouse
1357407Pfat4_mpredicted fat percentage 4 (mouse)8.6Body fat amountpredicted fat percentage155724515691245304Mouse
12880420V25Dq8_mvitamin D inactive form serum level QTL 8 (mouse)156170000095700000Mouse
1301601Faq9_mfluctuating asymmetry QTL 9 (mouse)Not determined156327970297279794Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564434485103517472Mouse
4141135Cia35_mcollagen induced arthritis 35 (mouse)Not determined156492762598927745Mouse
1301119Drb7_mdopamine receptor binding 7 (mouse)Not determined156545237799456827Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156564117599641298Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567386497101386646Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570461452104043685Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570465070104043685Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570465070104043685Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572498466104043685Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573545941104043685Mouse
1301472Pain1_mpain 1 (mouse)Not determined157544899790928982Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577629711104043685Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78716903102993272Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578716903102993272Mouse
14928306Manh79_mmandible shape 79 (mouse)1578949676104043685Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1579000000104043685Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579265530104043685Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined80011059104043685Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580415753104043685Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580987052104043685Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580987052104043685Mouse
4141511Gdcr1_mglycerolphosphate dehydrogenase regulator 1 (mouse)Not determined82717593104043685Mouse
11532732Pitm5_mprion incubation time 5 (mouse)158307986087170187Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1114
Count of miRNA genes:599
Interacting mature miRNAs:719
Transcripts:ENSMUST00000045289
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000045289   ⟹   ENSMUSP00000043826
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1584,167,837 - 84,186,206 (+)Ensembl
RefSeq Acc Id: ENSMUST00000230926
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1584,186,014 - 84,187,236 (+)Ensembl
RefSeq Acc Id: NM_054088   ⟹   NP_473429
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391584,052,017 - 84,073,722 (+)NCBI
GRCm381584,167,816 - 84,189,521 (+)NCBI
MGSCv371583,998,246 - 84,019,951 (+)RGD
Celera1586,298,497 - 86,320,441 (+)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006520345   ⟹   XP_006520408
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391584,051,977 - 84,073,714 (+)NCBI
GRCm381584,167,776 - 84,189,513 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006520346   ⟹   XP_006520409
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391584,051,977 - 84,073,714 (+)NCBI
GRCm381584,167,776 - 84,189,519 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036159091   ⟹   XP_036014984
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391584,051,986 - 84,073,714 (+)NCBI
RefSeq Acc Id: XR_001781492
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391584,051,987 - 84,073,609 (+)NCBI
GRCm381584,167,786 - 84,189,512 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003951345
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391584,051,980 - 84,073,609 (+)NCBI
GRCm381584,167,779 - 84,189,512 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_473429   ⟸   NM_054088
- UniProtKB: Q91WW7 (UniProtKB/Swiss-Prot),   E9QNZ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006520408   ⟸   XM_006520345
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006520409   ⟸   XM_006520346
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSMUSP00000043826   ⟸   ENSMUST00000045289
RefSeq Acc Id: XP_036014984   ⟸   XM_036159091
- Peptide Label: isoform X2
Protein Domains
PNPLA

Promoters
RGD ID:6826351
Promoter ID:MM_KWN:19278
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung
Transcripts:NM_054088
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361583,998,026 - 83,998,526 (+)MPROMDB
RGD ID:8684596
Promoter ID:EPDNEW_M20329
Type:initiation region
Name:Pnpla3_1
Description:Mus musculus patatin-like phospholipase domain containing 3 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381584,167,816 - 84,167,876EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2151796 AgrOrtholog
Ensembl Genes ENSMUSG00000041653 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000043826 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000045289 ENTREZGENE, UniProtKB/TrEMBL
InterPro Acyl_Trfase/lysoPLipase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pat_PNPLA3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLPL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PNPLA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:116939 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2151796 ENTREZGENE
NCBI Gene 116939 ENTREZGENE
PANTHER PTHR12406 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Patatin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pnpla3 PhenoGen
PROSITE PNPLA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52151 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9QNZ9 ENTREZGENE, UniProtKB/TrEMBL
  PLPL3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE