PNPLA3 (patatin like phospholipase domain containing 3)

Gene: PNPLA3 (patatin like phospholipase domain containing 3) Sus scrofa

Analyze

Symbol:

PNPLA3

Name:

patatin like phospholipase domain containing 3

RGD ID:

13916548

Description:

ENCODES a protein that exhibits 1-acylglycerol-3-phosphate O-acyltransferase activity (inferred); catalytic activity (inferred); diolein transacylation activity (inferred); INVOLVED IN cellular response to 3,3',5-triiodo-L-thyronine (ortholog); cellular response to insulin stimulus (ortholog); response to dietary excess (ortholog); ASSOCIATED WITH alcoholic liver cirrhosis (ortholog); Alcoholic Liver Diseases (ortholog); coronary artery disease (ortholog); FOUND IN cytoplasm (inferred); lipid droplet (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

adiponutrin; patatin-like phospholipase domain-containing protein 3

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	5,075,622 - 5,092,515 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	5,075,608 - 5,092,599 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcoholic liver cirrhosis (ISO)

Alcoholic Liver Diseases (ISO)

coronary artery disease (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

hypothyroidism (ISO)

intellectual disability (ISO)

liver cirrhosis (ISO)

metabolic dysfunction-associated steatotic liver disease (ISO)

obesity (ISO)

Phelan-McDermid syndrome (ISO)

steatotic liver disease (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to 3,3',5-triiodo-L-thyronine (ISO)

cellular response to insulin stimulus (ISO)

glycerophospholipid metabolic process (IEA)

lipid catabolic process (IEA)

lipid droplet organization (IEA)

lipid homeostasis (IBA,IEA)

lipid metabolic process (IEA)

long-chain fatty acid metabolic process (IEA)

phosphatidic acid biosynthetic process (IEA)

response to dietary excess (ISO)

response to sucrose (ISO)

triglyceride acyl-chain remodeling (IEA)

triglyceride biosynthetic process (IEA)

triglyceride catabolic process (IBA,IEA)

white fat cell differentiation (ISO)

Cellular Component

cytoplasm (IBA,IEA)

lipid droplet (IBA,IEA)

membrane (IBA,IEA)

Molecular Function

1-acylglycerol-3-phosphate O-acyltransferase activity (IEA)

catalytic activity (IEA)

diolein transacylation activity (IEA)

hydrolase activity (IEA)

long-chain fatty acyl-CoA binding (IEA)

lysophosphatidic acid acyltransferase activity (IEA)

lysophosphatidic acid binding (IEA)

mono-olein transacylation activity (IEA)

phospholipase A2 activity (IEA)

triglyceride lipase activity (IBA,IEA)

References

Additional References at PubMed

PMID:14681463	PMID:17145712	PMID:21400235	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PNPLA3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	5,075,622 - 5,092,515 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	5,075,608 - 5,092,599 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

PNPLA3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	43,923,805 - 43,947,582 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	43,923,792 - 43,964,488 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	44,319,685 - 44,343,462 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	42,650,952 - 42,674,781 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	22	28,230,136 - 28,255,047 (+)	NCBI		Celera
Cytogenetic Map	22	q13.31	NCBI
HuRef	22	27,273,880 - 27,298,036 (+)	NCBI		HuRef
CHM1_1	22	44,278,349 - 44,302,177 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	44,406,936 - 44,430,721 (+)	NCBI		T2T-CHM13v2.0

Pnpla3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	84,052,017 - 84,073,720 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	84,052,038 - 84,071,437 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	84,167,776 - 84,189,521 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	84,167,837 - 84,187,236 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	83,998,246 - 84,019,951 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	83,995,603 - 84,017,280 (+)	NCBI		MGSCv36	mm8
Celera	15	86,298,497 - 86,320,441 (+)	NCBI		Celera
Cytogenetic Map	15	E2	NCBI
cM Map	15	39.78	NCBI

Pnpla3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	117,173,485 - 117,194,065 (+)	NCBI		GRCr8
mRatBN7.2	7	115,293,538 - 115,314,077 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	115,293,538 - 115,314,077 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	117,041,315 - 117,061,957 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	119,267,044 - 119,287,685 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	119,236,507 - 119,257,145 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	125,034,760 - 125,056,165 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	125,034,764 - 125,055,976 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	125,023,278 - 125,044,677 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	122,152,092 - 122,171,994 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	111,599,483 - 111,620,054 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

Pnpla3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	28,879,748 - 28,893,938 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	28,879,646 - 28,896,224 (+)	NCBI	ChiLan1.0	ChiLan1.0

PNPLA3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	53,752,467 - 53,780,078 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	56,444,968 - 56,473,064 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	24,812,831 - 24,836,161 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	43,004,329 - 43,027,749 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	43,004,499 - 43,027,003 (+)	Ensembl	panpan1.1		panPan2

PNPLA3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	21,708,439 - 21,722,282 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	21,712,378 - 21,722,135 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	21,647,779 - 21,663,038 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	22,455,884 - 22,471,128 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	22,457,538 - 22,471,215 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	22,175,366 - 22,190,635 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	22,495,689 - 22,510,929 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	22,669,488 - 22,684,748 (-)	NCBI		UU_Cfam_GSD_1.0

Pnpla3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	5,341,850 - 5,360,187 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936718	1,619,948 - 1,638,317 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936718	1,620,034 - 1,638,315 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PNPLA3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	26,435,302 - 26,458,368 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	26,435,599 - 26,462,210 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	98,945,667 - 98,969,751 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in PNPLA3
607 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	nervous system	renal system	reproductive system	respiratory system
High
Medium						2
Low		2		1	2		1
Below cutoff	8	2	3	4	14		1	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001146126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021090847	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK395769	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EF577079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000026951 ⟹ ENSSSCP00000027391

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	5	5,075,622 - 5,092,515 (-)	Ensembl

RefSeq Acc Id:

NM_001146126 ⟹ NP_001139598

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	5	5,075,622 - 5,092,515 (-)	NCBI

Sequence:

show sequence

GGCGGAGCAGCCACGTACTCGGACCTCGGACGCCCCCGCCCCGCCGCGGTTATGTACGACTCCG
AGCGCGGCTGGAGCCTGTCCTTCGTGGGCTGCGGCTTCCTGGGCTTCTACCACGTCGGGGTGAC
CCGCTGCCTGTGCGAGCGCGCCCCGCACCTCATCCGCCACGCGCACAGGTTCTTCGGAACCTCG
GCCGGGGCGCTGCACTGCGCCGTCTTCCTCTCCGGGACCTCGCTGGACCAGACGCTGGAGATGC
TCATGGGCCTTGTCCGCAGTGCCAGGAGCCGGAGCCTCAGCATCCTCCACCCATCCTTCAACCT
GAGCAAGCGCCTCCGAGAAGGTCTGCGCAGAATCCTCCCAGACAACGCCCACCAGCTCCTCTCC
GGCAAACTCTGCATCTCGCTCACCAGAGTGTCCGATGGGAAAAACGTGCTGGTGTCTGACTTTC
GGTCCAAAGAGGAAGTCCTGGACGCCTTGCTGTGCTCCTCCTTCATCCCTCTGGTCAGCGGCTT
CATCTCTCCTTCCTTCAGAGGCGAGCGATATGTGGATGGAGGAGTGAGTGACAATGTGCCTTTC
TTTGATTCCAAAACGACCATCACCGTGTCCCCCTTCTATGGGGAGAATGACATCTGCCCTAAGG
TCAAGTCCACGAACTTTCTTCACGTGGACTTCACCAAGCTCAATCTGCGCCTCTGCTCAGAGAA
CATCTACCTGATAAGCCGGGCACTCTTCCCTCCGGATGTTAAGGTACTTGGAGAGATATGCCTT
CGAGGGTATCTAGATGCCGTCAGGTCCTTGGAAGAGAATGGCATCTGTGACAGGCCCCATCCCG
GCCTGAATGTGTCCTTGGCAGAGTGGGACGTCTTTGAGCCACCCTGGGAGCCCTTGAGCCCGGA
CTCTTCCCCGGGGGTGGCCGCCTGGGAGGCGAGGCCCGAGGGAGACGAGCTGCTGGACCACCTG
CGTCTCAGCATCCTGCCCTGGGACGAGCACATCCGGATCCTGTCGCCCAAGCTCATGCTAGCAC
TGAGGGAAGCAGCTAGAAACCCAGATGGGTACATGAGCAAGATGTGCAACTTCTTACCGATTAA
GGTCGTGTCCTACATGATGCTGCCTTGCACGCTGCCCCTGGAGTCTGCGATTGCTGTGGTCCAG
AGACTGGTGATGTGGCTTCCAGACATGCCTGACGACATCCAGTGGCTGCAGTGGGCCACCTCCC
GGATTTGCTGTCGGGTGATGAGGTGTCTGCTCCCCACATCCAGATCCCAGACAGCAGCAAACGG
CCACCAGCCTCCCCCCACAAACCAGAACACAAGGGGCGCTGCTAGCCTCCCCACTCCTCCTTGG
ACCCGGACGCCCACCCCGTGGACTGGCCAGTAGAGGCCACAGCTGACGTCTGTGATGTCTGGAA
GATGGCCTCGGTGCTGAGTTTATAGCTCACTGAAACCAAAGGCAATCTAGCTGCTTTAGGAAAA
GCCAGGAAGCTACTTTCGGCGTGGGCAGTGGTTCAGAGCTTAAGGAAACCTCACGTGCGGGCGT
GGACGTGAGATGGCTCGGTTGGGAAGTCGTACGGGGAAGACCAGCGTGGAGGGCCCACGGCTGC
CCTCTTGCAGCCCTTCAGCTGCCCAGGGAGGCTCCTAGATTGACTGGAGGAGTTTGGGCGGGAG
GTCTCGTGCAGCGGTGGGGTTGGAGGAAGAGAGAAGCGTGGTCTCTGGTACAGGAAGCGGTCAG
CATGGGGTGAGGGCGGCGAGGGGCGGCCGCTCCCGGCCACCTGGCCCCAGAACAAAGCACTGTC
CCCTCGCTGAGTGGCCTGGCGTCGGGAGGCCATGCCCGCCTGAGGCCCTCGTGGACCCCAACCA
CCCACCTTCATACCCCCGAGCCTGACTCTCAGGACGGATTCCCAGCTGCCTTTTCTGTCAGAAC
CACAGCCTGGTGAACCTCGGCCTAAACGGACACAATTTAACCGGTATTTACAATTTAACCAGCA
CATTCCACTCAGGCAACATCCTACACGCTAGATCTGCGCTCACTCCAAGGAAAGACACGTCGAA
CGGCGGATGGGATCGCATGGGACCTATTTTCTTACGTGTGAAATTATTCTGCCTTCTTCTGAGC
AGCATGTGTTTTATAATTTTAAAAAAAGAAAGAATAACGCTTTTGTCAAAATGGCAAGGCCCCC
CCTCCCACCTGGGCCGGACCCGCGACCCCGTCTATTTACGGCTCGGTTATGCTCTGGAACACGC
CACACGCAGGCGGCACCCGTGTGCGGTCGATCTAATGCCGGGGACCAGTCTGTTTGCTAAACAG
AGAGCAAAACTCGTTGCACAGCATGAGCCTGGTCTCATTAAAAAAAGGTCAAAGAAAAAAAGGA
AGAGCATGTGGGTGGGTGTGTACCTGCAGAACAGACTGGAAGGACGTGTGCCGAAATATTGCCG
GCGCTTCCCGTTTTGCTGTTATCTGAAATTCTATTTTAGATTGAATTTCTATGTATTTCTTTCG
TTGGACGATACTTCATAATAAAAGGTCGTTAAGGTTAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_021090847 ⟹ XP_020946506

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	5	5,075,608 - 5,092,599 (-)	NCBI

Sequence:

show sequence

CCGAGGGGGCCGAGGCCGGCCGGGTGACATCACGCCGGGACCGCCTGGGCCGCGGCGGGGAGGC
AGAGAGGGCTCCTGGGCGCCGGCGGAGCAGCCACGTACTCGGACCTCGGACGCCCCCGCCCCGC
CGCGGTTATGTACGACTCCGAGCGCGGCTGGAGCCTGTCCTTCGTGGGCTGCGGCTTCCTGGGC
TTCTACCACGTCGGGGTGACCCGCTGCCTGTGCGAGCGCGCCCCGCACCTCATCCGCCACGCGC
ACAGGTTCTTCGGAACCTCGGCCGGGGCGCTGCACTGCGCCGTCTTCCTCTCCGGGACCTCGCT
GGACCAGACGCTGGAGATGCTCATGGGCCTTGTCCGCAGTGCCAGGAGCCGGAGCCTCAGCATC
CTCCACCCATCCTTCAACCTGAGCAAGCGCCTCCGAGAAGGTCTGCGCAGAATCCTCCCAGACA
ACGCCCACCAGCTCCTCTCCGGCAAACTCTGCATCTCGCTCACCAGAGTGTCCGATGGGAAAAA
CGTGCTGGTGTCTGACTTTCGGTCCAAAGAGGAAGTCCTGGACGCCTTGCTGTGCTCCTCCTTC
ATCCCTCTGGTCAGCGGCTTCATCCCTCCTTCCTTCAGAGGCGAGCGATATGTGGATGGAGGAG
TGAGTGACAATGTGCCTTTCTTTGATTCCAAAACGACCATCACCGTGTCCCCTTTCTATGGGGA
GAATGACATCTGCCCTAAGGTCAAGTCCACGAACTTTCTTCACGTGGACTTCACCAAGCTCAAT
CTGCGCCTCTGCTCAGAGAACATCTACCTGATAAGCCGGGCACTCTTCCCTCCGGATGTCAAGG
TCCTTGGAGAGATATGCCTTCGAGGATATCTCGATGCCGTCAGGTTCTTGGAAGAGAATGCCTT
TGACCAAAACCGCAGAGAAGGTGTGGCTCACAGGACAGACACGTCTTTATGCAGAAAACGTTTA
CCGTGTATCTCCCAGATGCCAGGCCCTGGGCTCTGTGCTAAGGACAGCGTGGTGGACAGACGGA
TGTGGCCCCCTGTCCTCTGGAGTGTAGTCTTGCGGCAGGCTGGGCACACAGGCATCTGTGACAG
GCCCTATCCCGGCCTGAATGTGTCCTTGGCAGAGTGGGACGTCTTTGAGCCACCCTGGGAGCCC
TTGAGCCCGGACTCTTCCCCGGGGGTGGCCGCCTGGGAGGCGAGGCCCGAGGGAGACGAGCTGC
TGGACCACCTGCGTCTCAGCATCCTGCCCTGGGACGAGCACATCCGGATCCTGTCGCCCAAGCT
CATGCTAGCACTGAGGGAAGCAGCTAGAAACCCGGACGGGTACATAAGCAAGATGTGCAACTTC
TTACCGATTAAGGTCGTGTCCTACATGCTGCTGCCTTGCACGCTGCCCCTGGAGTCTGCGATTG
CTGTGGTCCAGAGACTGGTGATGTGGCTTCCAGACATGCCTGACGACATCCAGTGGCTGCAGTG
GGCCACCTCCCGGATTTGCTGTCGGGTGATGAGGTGTCTGCTCCCCACGTCCAGATCCCAGACA
CCAGCAAATGGCCACCAGCCTCCCCCCACAAACCAGAACACAAGGGGCGCTGCTAGCCTCCCCA
TTCCTCCTTGGACCCGGACGCCCACCCCGTGGACTGGCCAGTAGAGGCCACAGCTGACGTCTGT
GATGTCTGGAAGATGGCCTCGGTGCTGAGTTTATAGCTCGCTGAAACCAAAGGCAATCTAGTTG
CTTTAGGAAAAGCCAGGAAGCTACTTTCAGCGTAGGCAGTGGTTCAGAGCTTAAGGAAACCTCA
CGTGCGGGCGTGGACGTGAGATGGCTCGGTTGGGAAGTCGTACGGGGAAGACCAGCGTGGAGGG
CCCACGGCTGCCCTCTTGCAGCCCTTCAGCTGCCCGGGGAGGCTCCTAGGTTGACTGGAGGAGT
TTGGGCGGGAGGCCTCGTGCTGCGGTGGGGTTGGAGGAAGAGAGAAGCGTGGTCTCTGGTACAG
GAAGCGGTCAGCATGGGGTGAGGGCGGCGAGGGGCGGCCGCTCCCGGCCACCTGGCCCCAGAAC
AAAGCACTGTCCCCTTGCTGAGTGGCCTGGCGTCAGGAGGCCATGCCCGCCTGAGGCCCACGTG
GACCCCAACCACCCACCTTCATACCCCCGAGCCTGACTCTCAGGACGGATTCCCAGCTGCCTTT
TCTGTCAGAACCACAGCCTGGTGAACCTCGGCCTAAACGGACACAATTTAACCGGTATTTACAA
TTTAACCAGCACATTCCACTCAGGCAACATCCTACACGCTAGATCTGCGCTCACTCCAAGGAAA
GACACGTCGAACGGCGGATGGGATCGCATGGGACCTATTTTCTTACGTGTGAAATTATTCCGCC
TTCTTCTGAGCAGCATGTGTTTTATAATTTTAAAAAAAGAAAGAATAACGCTTTTGTCAAAATG
GCAAGGCACCCCCCTCCCACCTGGGCCGGACCCGCGACCCCGTCTATTTACGGCTCGGTTATGC
TCTGGAACACGCCACGCGCAGGCGGCACCCGTGTGCGGTCGATCTAATGCCGGGGACCAGTCTG
TTTGCTAAACAGAGAGCAAAACTCGTTGCACACATGAGCCTGGTCTCTTTAAAAAAAGGTCAAA
GAAAAAAAGGAAGAGCATGTGGGTGGGTGTGTACCTGCAGAACAGACTGGAAGGACGTGTGCCA
AAATATTGCCGGCGCTTCCCGTTTTGCTGTTATCTGAAATTCTATTTTAGATTGAATTTCTATG
TATTTCTTTCGTTGGACGATACTTCATAATAAAAGGTCGTTAAGGTTTTTCCTCACCCCTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001139598	(Get FASTA)	NCBI Sequence Viewer
	XP_020946506	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ABQ52661	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000027391
	ENSSSCP00000027391.2
	ENSSSCP00015025884.1
	ENSSSCP00015025951.1
	ENSSSCP00025020473.1
	ENSSSCP00025020496.1
	ENSSSCP00030022311.1
	ENSSSCP00035011775.1
	ENSSSCP00035011782.1
	ENSSSCP00040033348.1
	ENSSSCP00045008972.1
	ENSSSCP00045009019.1
	ENSSSCP00055043496.1
	ENSSSCP00065036577.1
	ENSSSCP00070048905.1

RefSeq Acc Id:	XP_020946506 ⟸ XM_021090847
- Peptide Label:	isoform X1
- UniProtKB:	A0A8D1S3Y0 (UniProtKB/TrEMBL), I3LTE6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MYDSERGWSLSFVGCGFLGFYHVGVTRCLCERAPHLIRHAHRFFGTSAGALHCAVFLSGTSLDQ TLEMLMGLVRSARSRSLSILHPSFNLSKRLREGLRRILPDNAHQLLSGKLCISLTRVSDGKNVL VSDFRSKEEVLDALLCSSFIPLVSGFIPPSFRGERYVDGGVSDNVPFFDSKTTITVSPFYGEND ICPKVKSTNFLHVDFTKLNLRLCSENIYLISRALFPPDVKVLGEICLRGYLDAVRFLEENAFDQ NRREGVAHRTDTSLCRKRLPCISQMPGPGLCAKDSVVDRRMWPPVLWSVVLRQAGHTGICDRPY PGLNVSLAEWDVFEPPWEPLSPDSSPGVAAWEARPEGDELLDHLRLSILPWDEHIRILSPKLML ALREAARNPDGYISKMCNFLPIKVVSYMLLPCTLPLESAIAVVQRLVMWLPDMPDDIQWLQWAT SRICCRVMRCLLPTSRSQTPANGHQPPPTNQNTRGAASLPIPPWTRTPTPWTGQ hide sequence

RefSeq Acc Id:

NP_001139598 ⟸ NM_001146126

- UniProtKB:

A5JUR7 (UniProtKB/TrEMBL), A0A4X1W362 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MYDSERGWSLSFVGCGFLGFYHVGVTRCLCERAPHLIRHAHRFFGTSAGALHCAVFLSGTSLDQ
TLEMLMGLVRSARSRSLSILHPSFNLSKRLREGLRRILPDNAHQLLSGKLCISLTRVSDGKNVL
VSDFRSKEEVLDALLCSSFIPLVSGFISPSFRGERYVDGGVSDNVPFFDSKTTITVSPFYGEND
ICPKVKSTNFLHVDFTKLNLRLCSENIYLISRALFPPDVKVLGEICLRGYLDAVRSLEENGICD
RPHPGLNVSLAEWDVFEPPWEPLSPDSSPGVAAWEARPEGDELLDHLRLSILPWDEHIRILSPK
LMLALREAARNPDGYMSKMCNFLPIKVVSYMMLPCTLPLESAIAVVQRLVMWLPDMPDDIQWLQ
WATSRICCRVMRCLLPTSRSQTAANGHQPPPTNQNTRGAASLPTPPWTRTPTPWTGQ

hide sequence

RefSeq Acc Id:

ENSSSCP00000027391 ⟸ ENSSSCT00000026951

Protein Domains

PNPLA

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000027266	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00015048268	UniProtKB/TrEMBL
	ENSSSCG00025035017	UniProtKB/TrEMBL
	ENSSSCG00030035516	UniProtKB/TrEMBL
	ENSSSCG00035023110	UniProtKB/TrEMBL
	ENSSSCG00040057156	UniProtKB/TrEMBL
	ENSSSCG00045007767	UniProtKB/TrEMBL
	ENSSSCG00055027566	UniProtKB/TrEMBL
	ENSSSCG00065061266	UniProtKB/TrEMBL
	ENSSSCG00070028666	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000026951	ENTREZGENE
	ENSSSCT00000026951.3	UniProtKB/TrEMBL
	ENSSSCT00015064660.1	UniProtKB/TrEMBL
	ENSSSCT00015064861.1	UniProtKB/TrEMBL
	ENSSSCT00025047762.1	UniProtKB/TrEMBL
	ENSSSCT00025047815.1	UniProtKB/TrEMBL
	ENSSSCT00030049258.1	UniProtKB/TrEMBL
	ENSSSCT00035030260.1	UniProtKB/TrEMBL
	ENSSSCT00035030270.1	UniProtKB/TrEMBL
	ENSSSCT00040077519.1	UniProtKB/TrEMBL
	ENSSSCT00045013016.1	UniProtKB/TrEMBL
	ENSSSCT00045013076.1	UniProtKB/TrEMBL
	ENSSSCT00055054527.1	UniProtKB/TrEMBL
	ENSSSCT00065083929.1	UniProtKB/TrEMBL
	ENSSSCT00070057521.1	UniProtKB/TrEMBL
Gene3D-CATH	Cytosolic phospholipase A2 catalytic domain	UniProtKB/TrEMBL
InterPro	Acyl_Trfase/lysoPLipase	UniProtKB/TrEMBL
	Pat_PNPLA3	UniProtKB/TrEMBL
	PLPL	UniProtKB/TrEMBL
	PNPLA_dom	UniProtKB/TrEMBL
KEGG Report	ssc:100049690	UniProtKB/TrEMBL
NCBI Gene	PNPLA3	ENTREZGENE
PANTHER	1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE PNPLA3	UniProtKB/TrEMBL
	PTHR12406	UniProtKB/TrEMBL
Pfam	Patatin	UniProtKB/TrEMBL
PROSITE	PNPLA	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52151	UniProtKB/TrEMBL
UniProt	A0A4X1W362	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D0NZP0_PIG	UniProtKB/TrEMBL
	A0A8D0NZU2_PIG	UniProtKB/TrEMBL
	A0A8D0RRA8_PIG	UniProtKB/TrEMBL
	A0A8D0Z962_PIG	UniProtKB/TrEMBL
	A0A8D1GTH1_PIG	UniProtKB/TrEMBL
	A0A8D1S3Y0	ENTREZGENE, UniProtKB/TrEMBL
	A5JUR7	ENTREZGENE, UniProtKB/TrEMBL
	I3LTE6	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:103312	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD