Gene: Dgat1 (diacylglycerol O-acyltransferase 1) Rattus norvegicus
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Symbol: Dgat1
Name: diacylglycerol O-acyltransferase 1
Description: Exhibits diacylglycerol O-acyltransferase activity; diacylglycerol binding activity; and fatty acid binding activity. Involved in several processes, including insulin secretion; positive regulation of hepatic stellate cell activation; and regulation of lipid metabolic process. Localizes to the intracellular membrane-bounded organelle and plasma membrane. Biomarker of chronic kidney disease and nephrotic syndrome. Human ortholog(s) of this gene implicated in cardiomyopathy and congenital diarrhea. Orthologous to human DGAT1 (diacylglycerol O-acyltransferase 1); PARTICIPATES IN retinol metabolic pathway; vitamin A deficiency pathway; glycerolipid metabolic pathway; INTERACTS WITH (R)-mevalonic acid; (RS)-amphetamine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: acyl-CoA retinol O-fatty-acyltransferase; acyl-coenzyme A:diacylglycerol acyltransferase 1; ARAT; Dgat; diacylglycerol acyltransferase; diacylglycerol O-acyltransferase homolog 1; diacylglycerol O-acyltransferase homolog 1 (mouse); diglyceride acyltransferase; retinol O-fatty-acyltransferase
Orthologs:
Homo sapiens (human) : DGAT1 (diacylglycerol O-acyltransferase 1)  HGNC  Alliance
Mus musculus (house mouse) : Dgat1 (diacylglycerol O-acyltransferase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dgat1 (diacylglycerol O-acyltransferase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DGAT1 (diacylglycerol O-acyltransferase 1)
Canis lupus familiaris (dog) : DGAT1 (diacylglycerol O-acyltransferase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dgat1 (diacylglycerol O-acyltransferase 1)
Sus scrofa (pig) : DGAT1 (diacylglycerol O-acyltransferase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07117,566,363 - 117,576,735 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07117,553,994 - 117,564,366 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,552,051 - 114,562,423 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17114,586,280 - 114,596,650 (-)NCBI
Celera7104,575,393 - 104,585,762 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Dgat1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628673
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.