Dgat1 (diacylglycerol O-acyltransferase 1) - Rat Genome Database

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Gene: Dgat1 (diacylglycerol O-acyltransferase 1) Rattus norvegicus
Analyze
Symbol: Dgat1
Name: diacylglycerol O-acyltransferase 1
RGD ID: 628673
Description: Enables diacylglycerol O-acyltransferase activity; diacylglycerol binding activity; and fatty acid binding activity. Involved in several processes, including insulin secretion; positive regulation of hepatic stellate cell activation; and regulation of lipid metabolic process. Predicted to be located in intracellular membrane-bounded organelle and membrane. Predicted to be active in endoplasmic reticulum membrane. Biomarker of chronic kidney disease and nephrotic syndrome. Human ortholog(s) of this gene implicated in cardiomyopathy and congenital diarrhea 7 with exudative enteropathy. Orthologous to human DGAT1 (diacylglycerol O-acyltransferase 1); PARTICIPATES IN retinol metabolic pathway; vitamin A deficiency pathway; glycerolipid metabolic pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: acyl-CoA retinol O-fatty-acyltransferase; acyl-coenzyme A:diacylglycerol acyltransferase 1; ARAT; Dgat; diacylglycerol acyltransferase; diacylglycerol O-acyltransferase homolog 1; diacylglycerol O-acyltransferase homolog 1 (mouse); diglyceride acyltransferase; retinol O-fatty-acyltransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87110,104,514 - 110,119,091 (-)NCBIGRCr8
mRatBN7.27108,223,860 - 108,235,413 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7108,218,524 - 108,234,299 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7109,968,232 - 109,978,722 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07112,191,929 - 112,202,419 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07112,150,296 - 112,160,779 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07117,566,363 - 117,576,735 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7117,566,368 - 117,576,737 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07117,553,994 - 117,564,366 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,552,051 - 114,562,423 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17114,586,280 - 114,596,650 (-)NCBI
Celera7104,575,393 - 104,585,762 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-camphor  (ISO)
(R)-linalyl acetate  (ISO)
1,8-cineole  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alcohol  (ISO)
all-trans-retinol  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP,ISO)
amlexanox  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
apigenin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atorvastatin calcium  (EXP)
baicalein  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzylpenicillin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
camphor  (ISO)
cannabidiol  (ISO)
carbendazim  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
choline  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clofazimine  (EXP)
clofibrate  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
difenoconazole  (ISO)
dioscin  (EXP,ISO)
doxorubicin  (EXP,ISO)
erythromycin A  (ISO)
ethanol  (EXP,ISO)
farnesol  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fructose  (ISO)
glutathione  (ISO)
glycidyl methacrylate  (ISO)
GW 4064  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lactucin  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
lipopolysaccharide  (ISO)
liraglutide  (ISO)
menadione  (ISO)
methotrexate  (ISO)
mevalonic acid  (EXP)
microcystin-LR  (ISO)
Monobutylphthalate  (ISO)
nefazodone  (EXP)
NMN zwitterion  (ISO)
O-methyleugenol  (ISO)
oleic acid  (ISO)
omeprazole  (EXP)
ozone  (ISO)
palmitoyl-CoA  (ISO)
paracetamol  (EXP,ISO)
penconazole  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
procymidone  (ISO)
sabinene  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
spathulenol  (ISO)
streptozocin  (ISO)
sucrose  (ISO)
sulforaphane  (ISO)
tectoridin  (ISO)
testosterone  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toosendanin  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
Tris(2-ethylhexyl) phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. Cao J, etal., J Biol Chem. 2011 Dec 2;286(48):41838-51. doi: 10.1074/jbc.M111.245456. Epub 2011 Oct 11.
2. Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption. Cheng D, etal., J Biol Chem. 2008 Oct 31;283(44):29802-11. doi: 10.1074/jbc.M800494200. Epub 2008 Sep 3.
3. Role of the DGAT gene C79T single-nucleotide polymorphism in French obese subjects. Coudreau SK, etal., Obes Res. 2003 Oct;11(10):1163-7.
4. Microarray analysis of the infrapatellar fat pad in knee osteoarthritis: relationship with joint inflammation. Gandhi R, etal., J Rheumatol. 2011 Sep;38(9):1966-72. Epub 2011 Jul 15.
5. Alterations in the lipid metabolism of rat aorta: effects of vitamin a deficiency. Gatica LV, etal., J Vasc Res. 2006;43(6):602-10. doi: 10.1159/000096247. Epub 2006 Oct 13.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Measurement of diacylglycerol acyltransferase activity in isolated hepatocytes. Geelen MJ Anal Biochem. 2003 Nov 15;322(2):264-8.
8. A murine model of isolated cardiac steatosis leads to cardiomyopathy. Glenn DJ, etal., Hypertension. 2011 Feb;57(2):216-22. doi: 10.1161/HYPERTENSIONAHA.110.160655. Epub 2011 Jan 10.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Dysregulation of hepatic fatty acid metabolism in chronic kidney disease. Jin K, etal., Nephrol Dial Transplant. 2013 Feb;28(2):313-20. doi: 10.1093/ndt/gfs350. Epub 2012 Oct 8.
11. Increasing triglyceride synthesis inhibits glucose-induced insulin secretion in isolated rat islets of langerhans: a study using adenoviral expression of diacylglycerol acyltransferase. Kelpe CL, etal., Endocrinology 2002 Sep;143(9):3326-32.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Regulation of protein tyrosine phosphatase 4a1, B-cell translocation gene 2, nuclear receptor subfamily 4a1 and diacylglycerol O-acyltransferase 1 by follicle stimulating hormone in the rat ovary. Schmidt J, etal., Reprod Fertil Dev. 2006;18(7):757-65.
20. Diacylglycerol acyltransferase-1 inhibition enhances intestinal fatty acid oxidation and reduces energy intake in rats. Schober G, etal., J Lipid Res. 2013 May;54(5):1369-84. doi: 10.1194/jlr.M035154. Epub 2013 Feb 28.
21. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Smith SJ, etal., Nat Genet 2000 May;25(1):87-90.
22. Up-regulation of hepatic Acyl CoA: Diacylglycerol acyltransferase-1 (DGAT-1) expression in nephrotic syndrome. Vaziri ND, etal., Kidney Int. 2004 Jul;66(1):262-7.
23. Distinct ontogenic patterns of overt and latent DGAT activities of rat liver microsomes. Waterman IJ, etal., J Lipid Res 2002 Sep;43(9):1555-62.
24. Diacylglycerol acyltranferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis. Yamaguchi K, etal., Hepatology. 2008 Feb;47(2):625-35.
25. Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor. Zhao G, etal., J Med Chem. 2008 Feb 14;51(3):380-3. doi: 10.1021/jm7013887. Epub 2008 Jan 10.
Additional References at PubMed
PMID:11481335   PMID:11672446   PMID:12077311   PMID:12477932   PMID:14668353   PMID:15308631   PMID:15576838   PMID:17526931   PMID:18238778   PMID:18252207   PMID:18458083   PMID:19183875  
PMID:21264296   PMID:21317108   PMID:21846726   PMID:27179362   PMID:27249207   PMID:28420705  


Genomics

Comparative Map Data
Dgat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87110,104,514 - 110,119,091 (-)NCBIGRCr8
mRatBN7.27108,223,860 - 108,235,413 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7108,218,524 - 108,234,299 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7109,968,232 - 109,978,722 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07112,191,929 - 112,202,419 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07112,150,296 - 112,160,779 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07117,566,363 - 117,576,735 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7117,566,368 - 117,576,737 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07117,553,994 - 117,564,366 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47114,552,051 - 114,562,423 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17114,586,280 - 114,596,650 (-)NCBI
Celera7104,575,393 - 104,585,762 (-)NCBICelera
Cytogenetic Map7q34NCBI
DGAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388144,314,584 - 144,326,852 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8144,314,584 - 144,326,910 (-)EnsemblGRCh38hg38GRCh38
GRCh378145,538,247 - 145,550,515 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,510,762 - 145,521,375 (-)NCBINCBI36Build 36hg18NCBI36
Build 348145,510,762 - 145,521,350NCBI
Celera8141,713,015 - 141,725,223 (-)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8140,652,765 - 140,665,081 (-)NCBIHuRef
CHM1_18145,576,522 - 145,588,858 (-)NCBICHM1_1
T2T-CHM13v2.08145,483,219 - 145,495,487 (-)NCBIT2T-CHM13v2.0
Dgat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391576,386,215 - 76,396,167 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1576,386,215 - 76,396,153 (-)EnsemblGRCm39 Ensembl
GRCm381576,502,012 - 76,512,021 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1576,502,015 - 76,511,953 (-)EnsemblGRCm38mm10GRCm38
MGSCv371576,332,445 - 76,342,248 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361576,329,270 - 76,339,073 (-)NCBIMGSCv36mm8
Celera1578,002,555 - 78,012,327 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1535.99NCBI
Dgat1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554542,934,152 - 2,944,492 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554542,933,904 - 2,944,675 (-)NCBIChiLan1.0ChiLan1.0
DGAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27161,803,409 - 161,817,182 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18137,333,356 - 137,347,545 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08141,079,948 - 141,090,619 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18144,069,450 - 144,080,155 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8144,064,587 - 144,080,155 (-)Ensemblpanpan1.1panPan2
DGAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11337,745,395 - 37,761,337 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1337,741,706 - 37,756,916 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1337,708,975 - 37,723,874 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01338,221,616 - 38,236,548 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,216,686 - 38,236,374 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11337,913,768 - 37,928,659 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01338,022,406 - 38,037,326 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01338,498,732 - 38,513,659 (-)NCBIUU_Cfam_GSD_1.0
Dgat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303490,312 - 499,990 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364707,916,438 - 7,926,088 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364707,916,438 - 7,926,089 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DGAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4452,662 - 466,684 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14452,890 - 463,665 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24599,685 - 609,272 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DGAT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18138,531,113 - 138,541,721 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8138,531,384 - 138,541,637 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660391,321,925 - 1,332,539 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dgat1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473512,525,284 - 12,535,193 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473512,525,120 - 12,535,436 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dgat1
32 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:61
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000039795
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
AA859529  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27108,224,027 - 108,224,239 (+)MAPPERmRatBN7.2
Rnor_6.07117,566,495 - 117,566,706NCBIRnor6.0
Rnor_5.07117,554,126 - 117,554,337UniSTSRnor5.0
RGSC_v3.47114,552,183 - 114,552,394UniSTSRGSC3.4
Celera7104,575,525 - 104,575,736UniSTS
RH 3.4 Map7790.6UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010053050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB062759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB062760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB062761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB062762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB062763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC139605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF296131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ345014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000039795   ⟹   ENSRNOP00000035110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7108,223,891 - 108,234,257 (-)Ensembl
Rnor_6.0 Ensembl7117,566,368 - 117,576,737 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094708   ⟹   ENSRNOP00000085353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7108,218,524 - 108,234,285 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095211   ⟹   ENSRNOP00000088171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7108,223,892 - 108,234,299 (-)Ensembl
RefSeq Acc Id: NM_053437   ⟹   NP_445889
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87110,104,514 - 110,115,016 (-)NCBI
mRatBN7.27108,223,860 - 108,234,362 (-)NCBI
Rnor_6.07117,566,363 - 117,576,735 (-)NCBI
Rnor_5.07117,553,994 - 117,564,366 (-)NCBI
RGSC_v3.47114,552,051 - 114,562,423 (-)RGD
Celera7104,575,393 - 104,585,762 (-)RGD
Sequence:
RefSeq Acc Id: XM_063264335   ⟹   XP_063120405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87110,104,545 - 110,119,054 (-)NCBI
RefSeq Acc Id: XM_063264336   ⟹   XP_063120406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87110,104,545 - 110,119,039 (-)NCBI
RefSeq Acc Id: XM_063264337   ⟹   XP_063120407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87110,104,545 - 110,119,018 (-)NCBI
RefSeq Acc Id: XM_063264338   ⟹   XP_063120408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87110,105,167 - 110,119,091 (-)NCBI
RefSeq Acc Id: XM_063264339   ⟹   XP_063120409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87110,104,545 - 110,114,699 (-)NCBI
RefSeq Acc Id: XR_010053050
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87110,105,021 - 110,119,091 (-)NCBI
RefSeq Acc Id: NP_445889   ⟸   NM_053437
- UniProtKB: Q9ERM3 (UniProtKB/Swiss-Prot),   Q8BHI5 (UniProtKB/TrEMBL),   A6HSA3 (UniProtKB/TrEMBL),   Q793I4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035110   ⟸   ENSRNOT00000039795
Ensembl Acc Id: ENSRNOP00000088171   ⟸   ENSRNOT00000095211
Ensembl Acc Id: ENSRNOP00000085353   ⟸   ENSRNOT00000094708
RefSeq Acc Id: XP_063120405   ⟸   XM_063264335
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063120406   ⟸   XM_063264336
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063120407   ⟸   XM_063264337
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063120409   ⟸   XM_063264339
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063120408   ⟸   XM_063264338
- Peptide Label: isoform X4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ERM3-F1-model_v2 AlphaFold Q9ERM3 1-498 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695427
Promoter ID:EPDNEW_R5949
Type:initiation region
Name:Dgat1_1
Description:diacylglycerol O-acyltransferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07117,576,759 - 117,576,819EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628673 AgrOrtholog
BioCyc Gene G2FUF-32925 BioCyc
BioCyc Pathway TRIGLSYN-PWY [diacylglycerol and triacylglycerol biosynthesis] BioCyc
BioCyc Pathway Image TRIGLSYN-PWY BioCyc
Ensembl Genes ENSRNOG00000028711 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039795.4 UniProtKB/TrEMBL
  ENSRNOT00000094708.1 UniProtKB/TrEMBL
  ENSRNOT00000095211.1 UniProtKB/TrEMBL
InterPro Diacylglycerol_acylTrfase1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MBOAT_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oat_ACAT_DAG_ARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84497 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 84497 ENTREZGENE
PANTHER DIACYLGLYCEROL O-ACYLTRANSFERASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10408 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MBOAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dgat1 PhenoGen
PIRSF Oat_ACAT_DAG_ARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oat_dag UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028711 RatGTEx
UniProt A0A8I6AI97_RAT UniProtKB/TrEMBL
  A0A8I6GCT2_RAT UniProtKB/TrEMBL
  A6HSA3 ENTREZGENE
  DGAT1_RAT UniProtKB/Swiss-Prot
  F7FKA4_RAT UniProtKB/TrEMBL
  Q793I4 ENTREZGENE, UniProtKB/TrEMBL
  Q8BHI5 ENTREZGENE, UniProtKB/TrEMBL
  Q9ERM3 ENTREZGENE
UniProt Secondary A6HSA3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Dgat1  diacylglycerol O-acyltransferase 1  Dgat1  diacylglycerol O-acyltransferase homolog 1 (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Dgat1  diacylglycerol O-acyltransferase homolog 1 (mouse)  Dgat1  diacylglycerol O-acyltransferase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Dgat1  diacylglycerol O-acyltransferase 1      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Dgat1  diacylglycerol O-acyltransferase 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to microsomes 628375
gene_expression expressed in isolated islets and insulin-secreting cells 628375
gene_function catalyzes the last and only committed step of triglyceride synthesis 628375
gene_mutations_overexpression overexpression in islets with elevated glucose levels for 72 h markedly reduces insulin secretion in response to glucose, but responds normally to the nonglucose secretagogues glyburide and potassium chloride 628375
gene_process overexpression in islets causes a significant increase in the incorporation of palmitate into triglyceride without any detectable change in the rate of oxidation of either palmitate or glucose 628375