Acvr1b (activin A receptor type 1B) - Rat Genome Database

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Gene: Acvr1b (activin A receptor type 1B) Rattus norvegicus
Analyze
Symbol: Acvr1b
Name: activin A receptor type 1B
RGD ID: 735207
Description: Predicted to enable several functions, including ATP binding activity; I-SMAD binding activity; and activin binding activity. Predicted to contribute to activin receptor activity and growth factor binding activity. Involved in several processes, including activin receptor signaling pathway; cardiac fibroblast cell development; and positive regulation of biosynthetic process. Predicted to be located in cell surface and cytosol. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; lung small cell carcinoma; malignant mesothelioma; pancreatic cancer; and stomach cancer. Orthologous to human ACVR1B (activin A receptor type 1B); PARTICIPATES IN activin signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: activin A receptor, type 1B; activin A receptor, type IB; activin receptor type IB; activin receptor type-1B; activin receptor-like kinase 4; ACTR-IB; ALK-4; Serine/threonine-protein kinase receptor R2; Serine/threonine-protein kinase receptor R2 precursor; Skr2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,164,987 - 134,208,389 (+)NCBIGRCr8
mRatBN7.27132,286,266 - 132,329,679 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,286,275 - 132,329,673 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,087,851 - 134,129,328 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,317,365 - 136,358,842 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,228,155 - 136,269,290 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,817,174 - 142,858,365 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,817,157 - 142,860,572 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,617,642 - 140,659,246 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,910,157 - 139,958,740 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,015,437 - 140,035,177 (+)NCBI
Celera7128,775,059 - 128,793,132 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
activin receptor complex  (IBA,IEA,ISO)
cell surface  (IEA,ISO)
cytosol  (IEA,ISO)
plasma membrane  (IBA,ISO)
receptor complex  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Activin B can signal through both ALK4 and ALK7 in gonadotrope cells. Bernard DJ, etal., Reprod Biol Endocrinol. 2006 Oct 13;4:52.
2. The transforming growth factor-beta superfamily of receptors. de Caestecker M Cytokine Growth Factor Rev. 2004 Feb;15(1):1-11.
3. Expression and localization of activin receptors, Smads, and beta glycan to the postnatal rat ovary. Drummond AE, etal., Endocrinology. 2002 Apr;143(4):1423-33.
4. Ovarian follicle populations of the rat express TGF-beta signalling pathways. Drummond AE, etal., Mol Cell Endocrinol. 2003 Apr 28;202(1-2):53-7.
5. Expression of myostatin, myostatin receptors and follistatin in diabetic rats submitted to exercise. Dutra DB, etal., Clin Exp Pharmacol Physiol. 2012 May;39(5):417-22. doi: 10.1111/j.1440-1681.2012.05690.x.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Activin A stimulates the proliferation and differentiation of cardiac fibroblasts via the ERK1/2 and p38-MAPK pathways. Hu J, etal., Eur J Pharmacol. 2016 Oct 15;789:319-327. doi: 10.1016/j.ejphar.2016.07.053. Epub 2016 Jul 29.
9. Genetic Mutation Analysis in Small Cell Lung Cancer by a Novel NGS-Based Targeted Resequencing Gene Panel and Relation with Clinical Features. Jin W, etal., Biomed Res Int. 2021 Apr 5;2021:3609028. doi: 10.1155/2021/3609028. eCollection 2021.
10. Concomitant over-expression of activin/inhibin beta subunits and their receptors in human pancreatic cancer. Kleeff J, etal., Int J Cancer. 1998 Sep 11;77(6):860-8.
11. CFIm25-regulated lncRNA acv3UTR promotes gastric tumorigenesis via miR-590-5p/YAP1 axis. Liu K, etal., Oncogene. 2020 Apr;39(15):3075-3088. doi: 10.1038/s41388-020-1213-8. Epub 2020 Feb 17.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Distinct localization of two serine-threonine kinase receptors for activin and TGF-beta in the rat brain and down-regulation of type I activin receptor during peripheral nerve regeneration. Morita N, etal., Brain Res Mol Brain Res. 1996 Dec;42(2):263-71. doi: 10.1016/s0169-328x(96)00136-2.
14. Differential regulation of the sphere formation and maintenance of cancer-initiating cells of malignant mesothelioma via CD44 and ALK4 signaling pathways. Ohno Y, etal., Oncogene. 2018 Dec;37(49):6357-6367. doi: 10.1038/s41388-018-0405-y. Epub 2018 Jul 30.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Expression of serine/threonine kinase receptors including the bone morphogenetic factor type II receptor in the developing and adult rat brain. Soderstrom S, etal., Cell Tissue Res. 1996 Nov;286(2):269-79.
20. Variants in inflammation genes are implicated in risk of lung cancer in never smokers exposed to second-hand smoke. Spitz MR, etal., Cancer Discov. 2011 Oct;1(5):420-9. doi: 10.1158/2159-8290.CD-11-0080. Epub 2011 Aug 25.
21. ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma. Su GH, etal., Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3254-7.
22. Molecular characterization of a type I serine-threonine kinase receptor for TGF-beta and activin in the rat pituitary tumor cell line GH3. Takumi T, etal., Exp Cell Res 1995 Jan;216(1):208-14.
23. Activin signal transduction in the fetal rat adrenal gland and in human H295R cells. Wang EY, etal., J Endocrinol 2003 Jul;178(1):137-48.
24. Elevated levels of activin A in heart failure: potential role in myocardial remodeling. Yndestad A, etal., Circulation. 2004 Mar 23;109(11):1379-85. Epub 2004 Mar 1.
Additional References at PubMed
PMID:7577669   PMID:7890768   PMID:8395914   PMID:8622651   PMID:9032295   PMID:9512518   PMID:9884026   PMID:9892009   PMID:11117535   PMID:11389842   PMID:12065756   PMID:12665502  
PMID:14517293   PMID:15485907   PMID:16115198   PMID:16127153   PMID:16564040   PMID:16720724   PMID:17936261   PMID:18039968   PMID:19953087   PMID:21356369   PMID:23152446   PMID:23376485  


Genomics

Comparative Map Data
Acvr1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,164,987 - 134,208,389 (+)NCBIGRCr8
mRatBN7.27132,286,266 - 132,329,679 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,286,275 - 132,329,673 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,087,851 - 134,129,328 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,317,365 - 136,358,842 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,228,155 - 136,269,290 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,817,174 - 142,858,365 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,817,157 - 142,860,572 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,617,642 - 140,659,246 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,910,157 - 139,958,740 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,015,437 - 140,035,177 (+)NCBI
Celera7128,775,059 - 128,793,132 (+)NCBICelera
Cytogenetic Map7q36NCBI
ACVR1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381251,951,699 - 51,997,078 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1251,951,699 - 51,997,078 (+)EnsemblGRCh38hg38GRCh38
GRCh371252,345,483 - 52,390,862 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,631,753 - 50,677,127 (+)NCBINCBI36Build 36hg18NCBI36
Build 341250,631,752 - 50,667,398NCBI
Celera1251,147,747 - 51,193,153 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1249,378,333 - 49,424,012 (+)NCBIHuRef
CHM1_11252,311,750 - 52,357,160 (+)NCBICHM1_1
T2T-CHM13v2.01251,915,269 - 51,960,644 (+)NCBIT2T-CHM13v2.0
Acvr1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,071,953 - 101,111,565 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,071,948 - 101,111,565 (+)EnsemblGRCm39 Ensembl
GRCm3815101,174,072 - 101,213,684 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,174,067 - 101,213,684 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715101,004,556 - 101,043,032 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,002,159 - 101,040,635 (+)NCBIMGSCv36mm8
Celera15103,342,168 - 103,360,926 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.48NCBI
Acvr1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555472,323,771 - 2,367,263 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555472,311,573 - 2,366,106 (+)NCBIChiLan1.0ChiLan1.0
ACVR1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21042,198,106 - 42,243,827 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11242,194,869 - 42,240,573 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01236,765,655 - 36,811,355 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11237,541,867 - 37,563,487 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1237,541,867 - 37,566,660 (-)Ensemblpanpan1.1panPan2
ACVR1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,009,710 - 3,029,726 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,994,857 - 3,042,396 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2743,211,235 - 43,247,173 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0273,006,162 - 3,042,091 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,006,172 - 3,042,070 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,022,821 - 3,058,700 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0273,009,289 - 3,045,207 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,609,429 - 43,645,365 (+)NCBIUU_Cfam_GSD_1.0
Acvr1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,715,220 - 63,757,148 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365129,407,581 - 9,449,632 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365129,407,578 - 9,449,611 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACVR1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl517,314,276 - 17,350,722 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1517,314,322 - 17,350,726 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2517,901,783 - 17,938,189 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACVR1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,120,765 - 48,166,520 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1148,145,003 - 48,166,813 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037197,923,884 - 197,969,817 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acvr1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624816331,695 - 374,193 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624816331,695 - 374,187 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acvr1b
254 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:218
Count of miRNA genes:146
Interacting mature miRNAs:176
Transcripts:ENSRNOT00000009345
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
RH142902  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21207,183,794 - 207,183,909 (+)MAPPERmRatBN7.2
Rnor_6.01226,588,339 - 226,588,453NCBIRnor6.0
Rnor_5.01233,534,594 - 233,534,708UniSTSRnor5.0
RGSC_v3.47139,916,134 - 139,916,248UniSTSRGSC3.4
RGSC_v3.41213,024,806 - 213,024,920UniSTSRGSC3.4
Celera1204,677,251 - 204,677,365UniSTS
RH 3.4 Map11510.2UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map7q35UniSTS
RH139325  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21207,183,793 - 207,183,924 (+)MAPPERmRatBN7.2
Rnor_6.01226,588,338 - 226,588,468NCBIRnor6.0
Rnor_5.01233,534,593 - 233,534,723UniSTSRnor5.0
RGSC_v3.47139,916,133 - 139,916,263UniSTSRGSC3.4
RGSC_v3.41213,024,805 - 213,024,935UniSTSRGSC3.4
Celera1204,677,250 - 204,677,380UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map7q35UniSTS
Acvr1b  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27132,326,830 - 132,327,558 (+)MAPPERmRatBN7.2
Rnor_6.07142,857,717 - 142,858,444NCBIRnor6.0
Rnor_5.07140,658,598 - 140,659,325UniSTSRnor5.0
RGSC_v3.47139,958,092 - 139,958,819UniSTSRGSC3.4
Celera7128,792,484 - 128,793,211UniSTS
Cytogenetic Map7q35UniSTS
UniSTS:496629  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27132,308,328 - 132,309,180 (+)MAPPERmRatBN7.2
Rnor_6.07142,839,216 - 142,840,067NCBIRnor6.0
Rnor_5.07140,639,845 - 140,640,696UniSTSRnor5.0
RGSC_v3.47139,939,138 - 139,939,989UniSTSRGSC3.4
Celera7128,775,195 - 128,776,046UniSTS
Cytogenetic Map7q35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 21 78 30 18 6 18 21 248 109 124 49
Low 63 197 129 63 129 24 24 21 24
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000009345   ⟹   ENSRNOP00000009345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,286,275 - 132,329,673 (+)Ensembl
Rnor_6.0 Ensembl7142,817,157 - 142,860,572 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095680   ⟹   ENSRNOP00000094222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,307,363 - 132,329,673 (+)Ensembl
RefSeq Acc Id: NM_199230   ⟹   NP_954700
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,165,001 - 134,206,192 (+)NCBI
mRatBN7.27132,286,285 - 132,327,479 (+)NCBI
Rnor_6.07142,817,174 - 142,858,365 (+)NCBI
Rnor_5.07140,617,642 - 140,659,246 (+)NCBI
RGSC_v3.47139,910,157 - 139,958,740 (+)RGD
Celera7128,775,059 - 128,793,132 (+)RGD
Sequence:
RefSeq Acc Id: XM_006242315   ⟹   XP_006242377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,183,803 - 134,208,389 (+)NCBI
mRatBN7.27132,305,095 - 132,329,679 (+)NCBI
Rnor_6.07142,837,459 - 142,858,231 (+)NCBI
Rnor_5.07140,617,642 - 140,659,246 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078578   ⟹   XP_038934506
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,183,803 - 134,208,389 (+)NCBI
mRatBN7.27132,305,095 - 132,329,679 (+)NCBI
RefSeq Acc Id: XM_039078579   ⟹   XP_038934507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,164,987 - 134,208,389 (+)NCBI
mRatBN7.27132,286,266 - 132,329,679 (+)NCBI
RefSeq Acc Id: NP_954700   ⟸   NM_199230
- Peptide Label: precursor
- UniProtKB: P80202 (UniProtKB/Swiss-Prot),   A0A8I6AKG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242377   ⟸   XM_006242315
- Peptide Label: isoform X1
- UniProtKB: A6KCN3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009345   ⟸   ENSRNOT00000009345
RefSeq Acc Id: XP_038934507   ⟸   XM_039078579
- Peptide Label: isoform X1
- UniProtKB: A6KCN3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934506   ⟸   XM_039078578
- Peptide Label: isoform X1
- UniProtKB: A6KCN3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094222   ⟸   ENSRNOT00000095680
Protein Domains
GS   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P80202-F1-model_v2 AlphaFold P80202 1-505 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695665
Promoter ID:EPDNEW_R6189
Type:initiation region
Name:Acvr1b_1
Description:activin A receptor type 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07142,817,164 - 142,817,224EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735207 AgrOrtholog
BioCyc Gene G2FUF-31997 BioCyc
Ensembl Genes ENSRNOG00000006934 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055026359 UniProtKB/Swiss-Prot
  ENSRNOG00060015573 UniProtKB/Swiss-Prot
  ENSRNOG00065023030 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009345.8 UniProtKB/Swiss-Prot
  ENSRNOT00000095680.1 UniProtKB/TrEMBL
  ENSRNOT00055045464 UniProtKB/Swiss-Prot
  ENSRNOT00060026649 UniProtKB/Swiss-Prot
  ENSRNOT00065039368 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.60.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Activin_recp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Snake_toxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFB_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29381 UniProtKB/Swiss-Prot
NCBI Gene 29381 ENTREZGENE
PANTHER ACTIVIN RECEPTOR TYPE-1B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23255 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Activin_recp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_beta_GS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acvr1b PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS51256 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006934 RatGTEx
  ENSRNOG00055026359 RatGTEx
  ENSRNOG00060015573 RatGTEx
  ENSRNOG00065023030 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00467 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57302 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AKG7 ENTREZGENE, UniProtKB/TrEMBL
  A6KCN3 ENTREZGENE, UniProtKB/TrEMBL
  ACV1B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Acvr1b  activin A receptor type 1B  Acvr1b  activin A receptor, type IB  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Acvr1b  activin A receptor, type IB  Acvr1b  activin A receptor, type 1B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Acvr1b  activin A receptor, type 1B      Symbol and Name status set to approved 1299863 APPROVED