Myc (MYC proto-oncogene, bHLH transcription factor) - Rat Genome Database

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Gene: Myc (MYC proto-oncogene, bHLH transcription factor) Rattus norvegicus
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Symbol: Myc
Name: MYC proto-oncogene, bHLH transcription factor
RGD ID: 3130
Description: Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to organonitrogen compound; and positive regulation of ATP metabolic process. Located in cytoplasm and nucleolus. Used to study artery disease (multiple); hepatocellular carcinoma; leiomyoma; osteoporosis; and prostatic hypertrophy. Biomarker of breast cancer; carcinoma (multiple); obesity; polycystic kidney disease; and prolactinoma. Human ortholog(s) of this gene implicated in several diseases, including angiosarcoma; carcinoma (multiple); demyelinating disease; hematologic cancer (multiple); and prostate cancer (multiple). Orthologous to human MYC (MYC proto-oncogene, bHLH transcription factor); PARTICIPATES IN ceramide signaling pathway; interleukin-2 signaling pathway; interleukin-6 signaling pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Avian myelocytomatosis viral (v-myc) oncogene homolog; c-myc; MGC105490; mMyc; myc proto-oncogene protein; myelocytomatosis oncogene; myelocytomatosis viral oncogene homolog; myelocytomatosis viral oncogene homolog (avian); proto-oncogene c-Myc; RNCMYC; transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   W-Tg(MT2A-Myc)1Ys   W-Tg(MT2A-Myc)2Ys  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2793,593,705 - 93,598,633 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl793,593,705 - 93,598,630 (+)Ensembl
Rnor_6.07102,586,313 - 102,591,240 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7102,586,313 - 102,591,240 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07103,157,452 - 103,162,379 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4798,953,142 - 98,958,060 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1798,987,371 - 98,992,287 (+)NCBI
Celera790,263,903 - 90,268,823 (+)NCBICelera
Cytogenetic Map7q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (IDA)
acute kidney failure  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
acute promyelocytic leukemia  (ISO)
adenocarcinoma  (ISO)
Alcoholic Liver Diseases  (ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
breast cancer  (IEP,ISO,ISS)
Breast Neoplasms  (IDA,ISO)
Burkitt lymphoma  (ISO)
carcinoma  (ISO)
Cardiomegaly  (IDA)
Carotid Artery Injuries  (IDA,IEP,IMP)
Chromosome Breakage  (ISO)
chronic lymphocytic leukemia  (ISO)
clear cell renal cell carcinoma  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
Colonic Neoplasms  (IDA,ISO)
Colorectal Neoplasms  (ISO)
coronary restenosis  (IDA)
COVID-19  (ISO)
demyelinating disease  (ISO)
diffuse large B-cell lymphoma  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Ductal Carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
esophageal carcinoma  (ISO)
Esophageal Neoplasms  (IDA)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (IEP,ISO)
fatty liver disease  (ISO)
glioblastoma  (ISO)
Hemorrhagic Shock  (IDA)
hepatitis C  (ISO)
hepatocellular carcinoma  (IDA,IEP,ISO)
hyperparathyroidism  (ISO)
hypertrophic cardiomyopathy  (ISO)
Kidney Reperfusion Injury  (IEP)
Left Ventricular Hypertrophy  (ISO)
leiomyoma  (IDA)
liver cirrhosis  (ISO)
Liver Injury  (IEP)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (IEP)
lung small cell carcinoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
medulloblastoma  (ISO)
Merkel cell carcinoma  (ISO)
myelodysplastic syndrome  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
neuroblastoma  (ISO)
neuroectodermal tumor  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (IEP)
osteoporosis  (IDA)
osteosarcoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISS)
polycystic kidney disease  (IEP,ISO)
polycystic kidney disease 1  (ISO)
primary ovarian insufficiency  (ISO)
prolactinoma  (IEP)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (IDA)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (IDA)
renal cell carcinoma  (IEP,ISO)
renal fibrosis  (ISO)
rhabdoid cancer  (ISO)
skin melanoma  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
thyroid gland cancer  (ISO)
thyroid gland papillary carcinoma  (ISO)
Transplant Rejection  (IMP)
trichorhinophalangeal syndrome type I  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(+)-schisandrin B  (EXP)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-selegiline  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichlorobenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-dichlorobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1D-myo-inositol 1,4,5-trisphosphate  (EXP)
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (ISO)
2-hydroxy-17beta-estradiol  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (EXP)
2-nitrofluorene  (EXP)
2-nitrotoluene  (EXP)
26-hydroxycholesterol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3-aminobenzamide  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
7beta-aminocephalosporanic acid  (ISO)
8-Br-cAMP  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
acetaldehyde  (ISO)
acetohydrazide  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (EXP,ISO)
aconitine  (EXP,ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (EXP,ISO)
adenosine  (ISO)
Aeroplysinin 1  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
AH23848  (ISO)
alachlor  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allethrin  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-naphthoflavone  (EXP)
alpha-pinene  (ISO)
amifostine  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
amsacrine  (ISO)
androstane  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aprepitant  (ISO)
aristolochic acid  (ISO)
arsenic acid  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
Asimicin  (ISO)
aspartame  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
Azaspiracid  (ISO)
bathocuproine disulfonic acid  (ISO)
benazepril  (EXP)
benzamide  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
benzoic acid  (ISO)
benzylpenicillin  (ISO)
berberine  (EXP)
beryllium difluoride  (ISO)
beryllium sulfate  (EXP)
betulin  (ISO)
betulinic acid  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bleomycin A5  (ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
bromochloroacetic acid  (EXP)
bromodichloromethane  (EXP,ISO)
bromoform  (ISO)
bucladesine  (ISO)
budesonide  (ISO)
bufalin  (ISO)
busulfan  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
butyric acid  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (EXP)
calcein am  (ISO)
calcitriol  (ISO)
calcium dichloride  (EXP)
calmidazolium  (ISO)
camptothecin  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbofuran  (EXP,ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carboplatin  (ISO)
carvedilol  (EXP)
catechol  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
chalcone  (ISO)
chelerythrine  (ISO)
CHIR 99021  (ISO)
chlorambucil  (ISO)
Chlorodibromomethane  (ISO)
chloroform  (EXP,ISO)
chlorohydrocarbon  (ISO)
chloropicrin  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
Cinobufagin  (ISO)
cisplatin  (ISO)
clofarabine  (ISO)
clofibrate  (EXP,ISO)
clotrimazole  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
crocin-1  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyanamide  (EXP)
cycloheximide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyproterone acetate  (EXP)
D-glucose  (EXP,ISO)
daidzein  (ISO)
DDE  (ISO)
DDT  (EXP,ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diarylheptanoid  (ISO)
diazinon  (EXP,ISO)
dibenziodolium  (ISO)
dibenzoylmethane  (ISO)
dibromoacetic acid  (ISO)
Dibromoacetonitrile  (EXP)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP,ISO)
dihydroartemisinin  (ISO)
Dimaprit  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP,ISO)
emodin  (EXP)
endosulfan  (ISO)
enzalutamide  (ISO)
epichlorohydrin  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin estolate  (EXP)
estra-1,3,5(10)-triene-3,16beta-diol  (EXP)
estriol  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
everolimus  (ISO)
Evodiamine  (ISO)
fenofibrate  (EXP,ISO)
fenthion  (ISO)
fipronil  (EXP)
fluoranthene  (ISO)
fluoxetine  (ISO)
flusilazole  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
fucoidan  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP,ISO)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gamma-linolenic acid  (ISO)
gamma-tocopherol  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
gemfibrozil  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
Glutethimide  (EXP)
glycerol  (ISO)
glycidol  (EXP)
glycine betaine  (EXP)
glyphosate  (ISO)
guanosine  (ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
harmine  (ISO)
hemin  (ISO)
heparin  (EXP,ISO)
hesperetin  (EXP)
hexachlorophene  (ISO)
hexamethylene diisocyanate  (ISO)
hexanal  (ISO)
Honokiol  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxamic acid  (ISO)
indirubin  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
ionomycin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(III) nitrilotriacetate  (EXP)
isoprenaline  (EXP,ISO)
ketamine  (EXP)
KT 5823  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead nitrate  (ISO)
leflunomide  (ISO)
letrozole  (ISO)
limonene  (EXP,ISO)
linalool  (ISO)
linuron  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP)
lithium chloride  (EXP,ISO)
losartan  (EXP)
lupeol  (ISO)
LY294002  (ISO)
m-xylene  (EXP)
mancozeb  (EXP,ISO)
maneb  (ISO)
masoprocol  (ISO)
Matrine  (ISO)
mebendazole  (ISO)
memantine  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
meso-tetrakis(N-methyl-4-pyridyl)porphine(4+)  (ISO)
mestranol  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
metoprolol  (EXP)
microcystin-LR  (ISO)
mifepristone  (ISO)
mitoxantrone  (ISO)
ML-7  (ISO)
monensin A  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
myricetin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-bis(2-hydroxypropyl)nitrosamine  (EXP)
N,N-dimethylaniline  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nafenopin  (EXP)
naloxone  (EXP)
naphthalene  (ISO)
naphthalenes  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (EXP,ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nifedipine  (ISO)
nitrofurazone  (EXP)
nitroprusside  (ISO)
Nodularin  (ISO)
NS-398  (ISO)
o-anisidine  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oleanolic acid  (EXP,ISO)
oridonin  (ISO)
ortho-Aminoazotoluene  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
oxidopamine  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PD 0325901  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
pevonedistat  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylhydrazine  (ISO)
phenytoin  (ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
phosgene  (ISO)
picene  (ISO)
pinosylvin  (ISO)
piperonyl butoxide  (EXP,ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (EXP)
platycodin D  (ISO)
poly(I:C)  (ISO)
ponatinib  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
promegestone  (ISO)
promethazine  (EXP)
propiconazole  (ISO)
propylparaben  (ISO)
prostaglandin D2  (EXP)
prostaglandin E2  (EXP,ISO)
pterostilbene  (ISO)
puerarin  (ISO)
putrescine  (EXP)
pyrrolidine dithiocarbamate  (ISO)
pyrvinium  (ISO)
quartz  (ISO)
quercetin  (ISO)
quinacrine  (ISO)
quinapril hydrochloride  (EXP)
quinidine  (EXP)
quinolone  (ISO)
quizartinib  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
reserpine  (ISO)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
riboflavin  (ISO)
ritonavir  (ISO)
rotenone  (EXP,ISO)
ruxolitinib  (ISO)
saccharin  (ISO)
Salinomycin  (ISO)
salvianolic acid B  (ISO)
SB 431542  (ISO)
Securinine  (ISO)
selenium atom  (EXP,ISO)
selumetinib  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sirtinol  (EXP)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (EXP)
Soman  (EXP,ISO)
sorafenib  (ISO)
staurosporine  (ISO)
styrene oxide  (ISO)
SU6656  (ISO)
succimer  (ISO)
succinic acid  (ISO)
sulfates  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
sulindac  (EXP,ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
taurocholic acid  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
teniposide  (ISO)
terbufos  (ISO)
terbutylazine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thapsigargin  (ISO)
theaflavin  (ISO)
theophylline  (EXP,ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiophenes  (ISO)
thiram  (ISO)
thymidine  (ISO)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
thymoquinone  (ISO)
tiazofurine  (ISO)
titanium dioxide  (ISO)
tocopherol  (ISO)
toxaphene  (ISO)
trametinib  (ISO)
trans-chalcone  (ISO)
trans-pinosylvin  (ISO)
Tributyltin oxide  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
tubastatin A  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
urethane  (ISO)
uridine  (ISO)
valproic acid  (EXP,ISO)
vemurafenib  (ISO)
vincaleukoblastine  (EXP,ISO)
vincristine  (EXP,ISO)
vinyl carbamate  (ISO)
vorinostat  (EXP,ISO)
WIN 55212-2  (ISO)
WR-1065  (ISO)
xanthohumol  (EXP)
zearalenone  (ISO)
zerumbone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acinar cell proliferation  (ISO)
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
amino acid transport  (IMP)
B cell apoptotic process  (ISO)
branching involved in ureteric bud morphogenesis  (ISO,ISS)
canonical Wnt signaling pathway involved in negative regulation of apoptotic process  (ISO)
canonical Wnt signaling pathway involved in positive regulation of apoptotic process  (ISO)
cell population proliferation  (IMP,ISO)
cellular iron ion homeostasis  (ISO,ISS)
cellular response to angiotensin  (IEP)
cellular response to arsenite(3-)  (IEP)
cellular response to carbohydrate stimulus  (IEP)
cellular response to cycloheximide  (IEP)
cellular response to cytokine stimulus  (IEP)
cellular response to dimethyl sulfoxide  (IEP)
cellular response to DNA damage stimulus  (ISO,ISS)
cellular response to endothelin  (IEP)
cellular response to epidermal growth factor stimulus  (IEP)
cellular response to estrogen stimulus  (IEP)
cellular response to fibroblast growth factor stimulus  (IEP)
cellular response to growth hormone stimulus  (IEP)
cellular response to hydrostatic pressure  (IEP)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (IEP)
cellular response to interferon-alpha  (ISO)
cellular response to interferon-gamma  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to lectin  (IEP)
cellular response to organic cyclic compound  (IEP)
cellular response to phorbol 13-acetate 12-myristate  (IEP)
cellular response to platelet-derived growth factor stimulus  (IEP)
cellular response to prolactin  (IEP)
cellular response to putrescine  (IEP)
cellular response to retinoic acid  (IEP)
cellular response to testosterone stimulus  (IEP)
cellular response to UV  (ISO)
cellular response to xenobiotic stimulus  (IEP,ISO)
chromatin remodeling  (ISO,ISS)
chromosome organization  (ISO,ISS)
detection of mechanical stimulus involved in sensory perception of sound  (ISO)
DNA-templated transcription, initiation  (IDA)
ERK1 and ERK2 cascade  (ISO)
G0 to G1 transition  (IEP)
G1/S transition of mitotic cell cycle  (ISO,ISS)
glucose metabolic process  (IMP)
hypothalamus development  (IEP)
in utero embryonic development  (IEP)
inner mitochondrial membrane organization  (IMP)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
lactic acid secretion  (IMP)
liver regeneration  (IEP)
MAPK cascade  (ISO,ISS)
middle ear morphogenesis  (ISO)
myoblast proliferation  (IEP)
myotube differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell death  (IMP)
negative regulation of cell division  (ISO,ISS)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of gene expression  (IMP)
negative regulation of glucose import  (IMP)
negative regulation of monocyte differentiation  (ISO,ISS)
negative regulation of protein binding  (ISO)
negative regulation of stress-activated MAPK cascade  (ISO)
negative regulation of transcription by RNA polymerase II  (IMP,ISO)
NK T cell proliferation  (ISO)
ovarian follicle development  (IEP)
ovulation  (IEP)
pigmentation  (ISO)
positive regulation of acinar cell proliferation  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of ATP biosynthetic process  (IMP)
positive regulation of B cell apoptotic process  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell cycle  (IMP)
positive regulation of cell population proliferation  (IGI,ISO)
positive regulation of cellular respiration  (IMP)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO,ISS)
positive regulation of DNA binding  (IMP)
positive regulation of DNA biosynthetic process  (ISO,ISS)
positive regulation of DNA methylation  (ISO)
positive regulation of epithelial cell proliferation  (ISO,ISS)
positive regulation of fibroblast proliferation  (IMP,ISO,ISS)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (IMP)
positive regulation of glycolytic process  (IMP)
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO,ISS)
positive regulation of metanephric cap mesenchymal cell proliferation  (ISO,ISS)
positive regulation of miRNA transcription  (ISO)
positive regulation of mitochondrial membrane potential  (IMP)
positive regulation of oxidative phosphorylation  (IMP)
positive regulation of response to DNA damage stimulus  (ISO,ISS)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of telomerase activity  (ISO)
positive regulation of transcription by RNA polymerase II  (IMP,ISO)
positive regulation of transcription initiation from RNA polymerase II promoter  (ISO)
positive regulation of transcription, DNA-templated  (IDA,ISO,ISS)
protein processing  (ISO)
protein-DNA complex disassembly  (ISO)
pyruvate transport  (IMP)
re-entry into mitotic cell cycle  (IMP)
regulation of apoptotic process  (ISO)
regulation of cell cycle process  (ISO)
regulation of gene expression  (ISO)
regulation of mitotic cell cycle  (IMP)
regulation of oxidative phosphorylation  (IMP)
regulation of somatic stem cell population maintenance  (ISO,ISS)
regulation of telomere maintenance  (ISO,ISS)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription, DNA-templated  (IDA,IMP,ISO,TAS)
response to alkaloid  (ISO)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to gamma radiation  (ISO,ISS)
response to human chorionic gonadotropin  (IEP)
response to radiation  (ISO)
response to wounding  (IEP)
response to xenobiotic stimulus  (ISO)
skeletal muscle cell differentiation  (ISO)
skeletal system morphogenesis  (ISO)
transcription by RNA polymerase II  (IDA,ISO)
transcription, DNA-templated  (IDA)
transformation of host cell by virus  (IMP)
Wnt signaling pathway  (ISO)

Cellular Component

References

References - curated
1. Amente S, etal., Oncogene. 2010 Jun 24;29(25):3691-702. doi: 10.1038/onc.2010.120. Epub 2010 Apr 26.
2. Assaf N, etal., Food Chem Toxicol. 2011 Dec;49(12):3055-62. doi: 10.1016/j.fct.2011.09.030. Epub 2011 Oct 1.
3. Bellance N, etal., Biochim Biophys Acta. 2012 Nov;1817(11):2060-71. doi: 10.1016/j.bbabio.2012.07.004. Epub 2012 Jul 25.
4. Bennett MR, etal., Biochem J. 1994 Sep 15;302 ( Pt 3):701-8.
5. Bennett MR, etal., J Clin Invest. 1994 Feb;93(2):820-8.
6. Bhatia K, etal., Nat Genet. 1993 Sep;5(1):56-61.
7. Biro S, etal., Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):654-8.
8. Bjorklund P, etal., J Clin Endocrinol Metab. 2007 Jan;92(1):338-44. Epub 2006 Oct 17.
9. Broaddus WC, etal., Neurosurgery. 1997 Oct;41(4):908-15.
10. Cadieux C, etal., J Biol Chem. 2008 May 16;283(20):13817-24. doi: 10.1074/jbc.M709332200. Epub 2008 Mar 20.
11. Calaf GM and Echiburu-Chau C, Oncol Rep. 2012 Aug;28(2):640-6. doi: 10.3892/or.2012.1817. Epub 2012 May 17.
12. Cardozo AK, etal., J Biol Chem 2001 Dec 28;276(52):48879-86.
13. Casanova EA, etal., PLoS One. 2012;7(10):e47107. doi: 10.1371/journal.pone.0047107. Epub 2012 Oct 15.
14. Chen S, etal., Hypertension. 2006 Feb;47(2):252-8. Epub 2005 Dec 19.
15. Chen SJ, etal., Circulation. 1994 Nov;90(5):2468-73.
16. Clark PE, etal., Am J Pathol. 2011 Dec;179(6):3045-55. doi: 10.1016/j.ajpath.2011.08.006. Epub 2011 Oct 8.
17. Collier JJ, etal., J Biol Chem. 2003 Feb 21;278(8):6588-95. Epub 2002 Dec 11.
18. Corral M, etal., Exp Cell Res. 1988 Jan;174(1):107-15.
19. Cowley BD Jr, etal., Proc Natl Acad Sci U S A. 1987 Dec;84(23):8394-8.
20. Cuny M, etal., Cancer Res. 2000 Feb 15;60(4):1077-83.
21. Dendele B, etal., Toxicol In Vitro. 2012 Feb;26(1):94-101. doi: 10.1016/j.tiv.2011.11.001. Epub 2011 Nov 12.
22. Dong T, etal., Oncol Rep. 2017 Aug;38(2):1287-1294. doi: 10.3892/or.2017.5777. Epub 2017 Jul 3.
23. Ellwood-Yen K, etal., Cancer Cell. 2003 Sep;4(3):223-38.
24. Fabris S, etal., Genes Chromosomes Cancer. 2003 Jul;37(3):261-9.
25. Ferrari D, etal., Cell Mol Life Sci. 2012 Apr;69(7):1193-210. doi: 10.1007/s00018-011-0873-5. Epub 2011 Nov 11.
26. Finot F, etal., Int J Hepatol. 2012;2012:785786. doi: 10.1155/2012/785786. Epub 2012 Oct 16.
27. Frank SR, etal., EMBO Rep 2003 Jun;4(6):575-80.
28. Frau M, etal., Cell Oncol (Dordr). 2012 Jun;35(3):163-73. doi: 10.1007/s13402-011-0067-z. Epub 2012 Mar 21.
29. Fu SL, etal., Biochem Biophys Res Commun. 2005 Dec 16;338(2):830-8. Epub 2005 Oct 21.
30. Furge KA, etal., Cancer Res. 2007 Apr 1;67(7):3171-6.
31. Gadd S, etal., Lab Invest. 2010 May;90(5):724-38. doi: 10.1038/labinvest.2010.66. Epub 2010 Mar 8.
32. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
33. Go H, etal., Mar Biotechnol (NY). 2011 Jun;13(3):433-40. doi: 10.1007/s10126-010-9314-y. Epub 2010 Aug 10.
34. GOA data from the GO Consortium
35. Gomez-Roman N, etal., Nature 2003 Jan 16;421(6920):290-4.
36. Graves JA, etal., PLoS One. 2012;7(5):e37699. doi: 10.1371/journal.pone.0037699. Epub 2012 May 21.
37. Grippo PJ and Sandgren EP, Int J Cancer. 2012 Sep 1;131(5):1243-8. doi: 10.1002/ijc.27322. Epub 2012 Jan 11.
38. Halder SK, etal., Biol Reprod. 2012 Apr 19;86(4):116. Print 2012 Apr.
39. Hao S, etal., Am J Pathol. 2010 Sep;177(3):1164-75. doi: 10.2353/ajpath.2010.091269. Epub 2010 Jul 16.
40. Hayashi K, etal., Nucleic Acids Res 1987 Aug 25;15(16):6419-36.
41. He W, etal., J Am Soc Nephrol. 2009 Apr;20(4):765-76. doi: 10.1681/ASN.2008060566. Epub 2009 Mar 18.
42. He XY, etal., J Cancer Res Clin Oncol. 2010 Jul;136(7):1023-8. doi: 10.1007/s00432-009-0747-5. Epub 2009 Dec 22.
43. Higgs MR, etal., Oncogene. 2013 Sep 26;32(39):4683-93. doi: 10.1038/onc.2012.484. Epub 2012 Oct 29.
44. Hosseini A, etal., J Ocul Pharmacol Ther. 2012 Apr;28(2):194-201. doi: 10.1089/jop.2011.0135. Epub 2011 Dec 7.
45. Iwata T, etal., PLoS One. 2010 Feb 25;5(2):e9427. doi: 10.1371/journal.pone.0009427.
46. Jason Collier J, etal., Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E48-56. Epub 2007 Mar 6.
47. Jian B, etal., Mol Med. 2012 Mar 27;18:209-14. doi: 10.2119/molmed.2011.00365.
48. Jones L, etal., J Exp Med. 2010 Nov 22;207(12):2581-94. doi: 10.1084/jem.20091071. Epub 2010 Nov 8.
49. Jung P, etal., Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15046-51. doi: 10.1073/pnas.0801773105. Epub 2008 Sep 25.
50. Kaneto H, etal., J Biol Chem 2002 Apr 12;277(15):12998-3006.
51. Kerckaert JP, etal., Biochim Biophys Acta 1977 Aug 23;493(2):293-303.
52. Kim SK, etal., PLoS One. 2011;6(10):e26131. doi: 10.1371/journal.pone.0026131. Epub 2011 Oct 10.
53. Klefstrom J, etal., J Biol Chem 2002 Nov 8;277(45):43224-32.
54. Kumar KN, etal., J Agric Food Chem. 2012 Apr 11;60(14):3665-72. doi: 10.1021/jf204128z. Epub 2012 Apr 3.
55. Kurabe N, etal., Oncogene. 2007 Aug 16;26(38):5626-34. Epub 2007 Mar 5.
56. Kusaka M, etal., Transplantation. 2007 Jan 15;83(1):62-70.
57. Langer WJ, etal., Pediatr Nephrol. 2008 Feb;23(2):275-83. Epub 2007 Nov 21.
58. Leibovitch SA, etal., Cancer Res. 1986 Aug;46(8):4097-103.
59. Levendal RA, etal., Phytomedicine. 2012 May 15;19(7):575-82. doi: 10.1016/j.phymed.2012.02.001. Epub 2012 Mar 14.
60. Li B, etal., Biomed Res Int. 2020 Jan 16;2020:2761850. doi: 10.1155/2020/2761850. eCollection 2020.
61. Li L, etal., PLoS One. 2013;8(1):e49915. doi: 10.1371/journal.pone.0049915. Epub 2013 Jan 22.
62. Li P, etal., J Huazhong Univ Sci Technolog Med Sci. 2012 Apr;32(2):181-5. doi: 10.1007/s11596-012-0032-8. Epub 2012 Apr 20.
63. Li XW, etal., Eur J Pharmacol. 2012 Mar 15;679(1-3):117-26. doi: 10.1016/j.ejphar.2012.01.015. Epub 2012 Jan 28.
64. Lim K, etal., J Androl. 1994 Nov-Dec;15(6):543-50.
65. Linden MA, etal., Exp Hematol. 2012 Mar;40(3):216-27. doi: 10.1016/j.exphem.2011.11.006. Epub 2011 Nov 23.
66. Liu L, etal., Am J Physiol Cell Physiol. 2012 Jan 1;302(1):C277-85. doi: 10.1152/ajpcell.00341.2011. Epub 2011 Oct 5.
67. Liu Y, etal., World J Surg Oncol. 2011 Oct 7;9:121. doi: 10.1186/1477-7819-9-121.
68. Liu YT, etal., Am J Pathol. 2007 Dec;171(6):1978-88. Epub 2007 Nov 30.
69. Lv X, etal., J Heart Lung Transplant. 2012 Jun;31(6):655-62. doi: 10.1016/j.healun.2012.03.001. Epub 2012 Apr 13.
70. Malekinejad H, etal., Phytomedicine. 2012 Sep 15;19(12):1077-84. doi: 10.1016/j.phymed.2012.06.011. Epub 2012 Jul 20.
71. MGD data from the GO Consortium
72. Mollaoglu G, etal., Cancer Cell. 2017 Feb 13;31(2):270-285. doi: 10.1016/j.ccell.2016.12.005. Epub 2017 Jan 12.
73. Morimura S, etal., Jpn J Exp Med. 1990 Apr;60(2):51-6.
74. Morrish F, etal., Cell Cycle. 2008 Apr 15;7(8):1054-66. Epub 2008 Feb 8.
75. Morrish F, etal., Genes Dev 2003 Jan 15;17(2):240-55.
76. Murali R, etal., Oncotarget. 2015 Nov 3;6(34):36041-52. doi: 10.18