Enpp2 (ectonucleotide pyrophosphatase/phosphodiesterase 2) - Rat Genome Database

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Gene: Enpp2 (ectonucleotide pyrophosphatase/phosphodiesterase 2) Rattus norvegicus
Analyze
Symbol: Enpp2
Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
RGD ID: 69298
Description: Enables lysophospholipase activity; metal ion binding activity; and phosphoric diester hydrolase activity. Involved in several processes, including cellular response to estradiol stimulus; estrous cycle; and regulation of cell-substrate adhesion. Located in extracellular space. Orthologous to human ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2); PARTICIPATES IN ether lipid metabolic pathway; ether lipid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1-octadec-9-enoylglycero-3-phosphate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: autotaxin; E-NPP 2; ectonucleotide pyrophosphatase/phosphodiesterase family member 2; extracellular lysophospholipase D; lysoPLD; MGC93258; phosphodiesterase I/nucleotide pyrophosphatase 2 (autotaxin)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2786,202,345 - 86,325,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl786,202,350 - 86,324,827 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx788,094,023 - 88,174,188 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0790,295,230 - 90,375,410 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0790,100,706 - 90,180,878 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0794,479,931 - 94,563,086 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl794,480,396 - 94,563,001 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0795,120,407 - 95,202,176 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4791,295,824 - 91,377,850 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1791,330,053 - 91,412,080 (-)NCBI
Celera783,005,494 - 83,085,339 (-)NCBICelera
Cytogenetic Map7q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2,3-Trichloropropane  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3'-O-(4-Benzoyl)benzoyl ATP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (ISO)
AACOCF3  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP)
alpha-naphthoflavone  (ISO)
amitrole  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
benzyl acetate  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
capsaicin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorendic acid  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
Cinnamyl anthranilate  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
cumene  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dizocilpine maleate  (ISO)
dorsomorphin  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (ISO)
flurbiprofen  (ISO)
flusilazole  (EXP)
formaldehyde  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
glafenine  (EXP)
GW 4064  (ISO)
indometacin  (ISO)
ketamine  (EXP)
lead diacetate  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
lysophosphatidylcholine  (ISO)
medroxyprogesterone acetate  (ISO)
mercaptopurine  (EXP)
methapyrilene  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
Monobutylphthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
o-anisidine  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
Phenelzine  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
protein kinase inhibitor  (ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (EXP)
riddelliine  (EXP)
roxarsone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
toluene 2,6-diisocyanate  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
xestospongin C  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of lysophosphatidic acid, autotaxin and acylglycerol kinase as biomarkers in diabetic retinopathy. Abu El-Asrar AM, etal., Acta Diabetol. 2013 Jun;50(3):363-71. doi: 10.1007/s00592-012-0422-1. Epub 2012 Aug 4.
2. Expression and regulation of Enpp2 in rat uterus during the estrous cycle. Ahn HJ, etal., J Vet Sci. 2011 Dec;12(4):379-85.
3. Serum lysophosphatidic acid is produced through diverse phospholipase pathways. Aoki J, etal., J Biol Chem. 2002 Dec 13;277(50):48737-44. doi: 10.1074/jbc.M206812200. Epub 2002 Sep 26.
4. P2Y12 receptor expression is a critical determinant of functional responsiveness to ATX's MORFO domain. Dennis J, etal., Purinergic Signal. 2012 Jun;8(2):181-90. doi: 10.1007/s11302-011-9283-2. Epub 2011 Dec 4.
5. Effect of histidine on autotaxin activity in experimentally induced liver fibrosis. El-Batch M, etal., J Biochem Mol Toxicol. 2011 May-Jun;25(3):143-50. doi: 10.1002/jbt.20370. Epub 2010 Oct 18.
6. Phosphodiesterase-Ialpha/autotaxin: a counteradhesive protein expressed by oligodendrocytes during onset of myelination. Fox MA, etal., Mol Cell Neurosci 2003 Jul;23(3):507-19.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation. Gierse J, etal., J Pharmacol Exp Ther. 2010 Jul;334(1):310-7. doi: 10.1124/jpet.110.165845. Epub 2010 Apr 14.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Structural basis of substrate discrimination and integrin binding by autotaxin. Hausmann J, etal., Nat Struct Mol Biol. 2011 Feb;18(2):198-204. doi: 10.1038/nsmb.1980. Epub 2011 Jan 16.
11. An essential oligomannosidic glycan chain in the catalytic domain of autotaxin, a secreted lysophospholipase-D. Jansen S, etal., J Biol Chem. 2007 Apr 13;282(15):11084-91. Epub 2007 Feb 16.
12. Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D. Jansen S, etal., J Cell Sci. 2005 Jul 15;118(Pt 14):3081-9. Epub 2005 Jun 28.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Molecular cloning, expression, and localization of a brain-specific phosphodiesterase I/nucleotide pyrophosphatase (PD-I alpha) from rat brain. Narita M, etal., J Biol Chem 1994 Nov 11;269(45):28235-42.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. A novel highly potent autotaxin/ENPP2 inhibitor produces prolonged decreases in plasma lysophosphatidic acid formation in vivo and regulates urethral tension. Saga H, etal., PLoS One. 2014 Apr 18;9(4):e93230. doi: 10.1371/journal.pone.0093230. eCollection 2014.
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. Identification of Igf2, Igfbp2 and Enpp2 as estrogen-responsive genes in rat hippocampus. Takeo C, etal., Endocr J. 2009 Mar;56(1):113-20. Epub 2008 Oct 22.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. The potential protective role of lysophospholipid mediators in nephrotoxicity induced by chronically exposed cadmium. Tsutsumi T, etal., Food Chem Toxicol. 2014 Mar;65:52-62. doi: 10.1016/j.fct.2013.12.019. Epub 2013 Dec 20.
23. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. Umezu-Goto M, etal., J Cell Biol 2002 Jul 22;158(2):227-33.
24. Serum metabolomics analysis reveals impaired lipid metabolism in rats after oral exposure to benzo(a)pyrene. Wang X, etal., Mol Biosyst. 2014 Dec 10.
25. Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity. Watanabe N, etal., Life Sci. 2007 Sep 1;81(12):1009-15. Epub 2007 Aug 19.
Additional References at PubMed
PMID:1733949   PMID:12633853   PMID:14500380   PMID:15280042   PMID:15489334   PMID:16436050   PMID:16837466   PMID:17071136   PMID:17192809   PMID:18054784   PMID:18164210   PMID:18565716  
PMID:19329427   PMID:20823544   PMID:20823545   PMID:21240269   PMID:21393252   PMID:22952646   PMID:25596343   PMID:26027517   PMID:26269646   PMID:26371182   PMID:26861177   PMID:27075612  
PMID:28539367   PMID:29551679   PMID:35917632  


Genomics

Comparative Map Data
Enpp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2786,202,345 - 86,325,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl786,202,350 - 86,324,827 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx788,094,023 - 88,174,188 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0790,295,230 - 90,375,410 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0790,100,706 - 90,180,878 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0794,479,931 - 94,563,086 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl794,480,396 - 94,563,001 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0795,120,407 - 95,202,176 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4791,295,824 - 91,377,850 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1791,330,053 - 91,412,080 (-)NCBI
Celera783,005,494 - 83,085,339 (-)NCBICelera
Cytogenetic Map7q32NCBI
ENPP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388119,557,086 - 119,673,390 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8119,557,086 - 119,673,453 (-)EnsemblGRCh38hg38GRCh38
GRCh378120,569,326 - 120,685,630 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368120,638,500 - 120,720,287 (-)NCBINCBI36Build 36hg18NCBI36
Build 348120,638,506 - 120,720,251NCBI
Celera8116,758,340 - 116,840,155 (-)NCBICelera
Cytogenetic Map8q24.12NCBI
HuRef8115,890,120 - 115,971,909 (-)NCBIHuRef
CHM1_18120,609,842 - 120,691,629 (-)NCBICHM1_1
T2T-CHM13v2.08120,685,947 - 120,802,252 (-)NCBIT2T-CHM13v2.0
Enpp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391554,702,297 - 54,816,284 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1554,702,297 - 54,816,288 (-)EnsemblGRCm39 Ensembl
GRCm381554,838,901 - 54,952,789 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1554,838,901 - 54,952,892 (-)EnsemblGRCm38mm10GRCm38
MGSCv371554,670,453 - 54,751,701 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361554,668,984 - 54,750,085 (-)NCBIMGSCv36mm8
Celera1556,378,103 - 56,459,629 (-)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1521.6NCBI
Enpp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541725,308,361 - 25,384,443 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541725,308,424 - 25,384,307 (-)NCBIChiLan1.0ChiLan1.0
ENPP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan18112,495,861 - 112,612,481 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08116,248,587 - 116,364,966 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18118,998,530 - 119,114,271 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8118,998,530 - 119,114,273 (-)Ensemblpanpan1.1panPan2
ENPP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11318,586,886 - 18,697,339 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1318,587,129 - 18,697,324 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1318,592,370 - 18,703,990 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01318,914,487 - 19,026,345 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1318,914,493 - 19,026,330 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11318,641,970 - 18,753,536 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01318,740,906 - 18,852,507 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01318,972,068 - 19,083,534 (-)NCBIUU_Cfam_GSD_1.0
Enpp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530319,568,579 - 19,673,659 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647026,994,215 - 27,100,999 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647026,994,549 - 27,099,758 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENPP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl419,319,810 - 19,433,488 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1419,319,815 - 19,433,492 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2420,337,269 - 20,453,087 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ENPP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18114,113,780 - 114,232,656 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8114,113,778 - 114,195,956 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603926,053,797 - 26,176,243 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Enpp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476317,677,722 - 17,765,292 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476317,677,825 - 17,775,284 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Enpp2
548 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:342
Count of miRNA genes:180
Interacting mature miRNAs:205
Transcripts:ENSRNOT00000005561, ENSRNOT00000051139
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
724537Niddm52Non-insulin dependent diabetes mellitus QTL 520.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)78022129993595843Rat
1641908Teswt1Testicular weight QTL 13.28testis mass (VT:1000644)both testes wet weight (CMO:0000175)78022129994811326Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat

Markers in Region
RH133318  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2786,202,557 - 86,202,745 (+)MAPPERmRatBN7.2
Rnor_6.0794,480,139 - 94,480,326NCBIRnor6.0
Rnor_5.0795,120,615 - 95,120,802UniSTSRnor5.0
RGSC_v3.4791,296,032 - 91,296,219UniSTSRGSC3.4
Celera783,005,702 - 83,005,889UniSTS
RH 3.4 Map7589.7UniSTS
Cytogenetic Map7q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 4 45 29 19 29 4 6 68 30 36 11 4
Low 1 35 12 12 12 4 5 6 5 5 4
Below cutoff 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_057104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC081747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D28560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ131564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000005561   ⟹   ENSRNOP00000005561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl786,202,350 - 86,324,827 (-)Ensembl
Rnor_6.0 Ensembl794,480,396 - 94,563,001 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000051139   ⟹   ENSRNOP00000047118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl786,202,350 - 86,282,474 (-)Ensembl
Rnor_6.0 Ensembl794,480,396 - 94,563,001 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101657   ⟹   ENSRNOP00000076476
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl786,202,350 - 86,282,474 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118544   ⟹   ENSRNOP00000090400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl786,202,350 - 86,282,474 (-)Ensembl
RefSeq Acc Id: NM_057104   ⟹   NP_476445
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2786,202,350 - 86,282,474 (-)NCBI
Rnor_6.0794,479,931 - 94,563,086 (-)NCBI
Rnor_5.0795,120,407 - 95,202,176 (-)NCBI
RGSC_v3.4791,295,824 - 91,377,850 (-)RGD
Celera783,005,494 - 83,085,339 (-)RGD
Sequence:
RefSeq Acc Id: XM_039079972   ⟹   XP_038935900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2786,202,345 - 86,325,048 (-)NCBI
RefSeq Acc Id: XM_039079973   ⟹   XP_038935901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2786,202,345 - 86,325,050 (-)NCBI
RefSeq Acc Id: XM_039079974   ⟹   XP_038935902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2786,202,345 - 86,325,041 (-)NCBI
RefSeq Acc Id: XM_039079975   ⟹   XP_038935903
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2786,202,345 - 86,325,043 (-)NCBI
RefSeq Acc Id: XM_039079976   ⟹   XP_038935904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2786,202,345 - 86,325,031 (-)NCBI
RefSeq Acc Id: XM_039079977   ⟹   XP_038935905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2786,202,345 - 86,324,874 (-)NCBI
RefSeq Acc Id: XM_039079978   ⟹   XP_038935906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2786,202,345 - 86,325,031 (-)NCBI
RefSeq Acc Id: XM_039079979   ⟹   XP_038935907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2786,202,345 - 86,282,571 (-)NCBI
RefSeq Acc Id: XM_039079980   ⟹   XP_038935908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2786,202,345 - 86,282,571 (-)NCBI
RefSeq Acc Id: XM_039079981   ⟹   XP_038935909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2786,202,345 - 86,282,569 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_476445   ⟸   NM_057104
- UniProtKB: Q64610 (UniProtKB/Swiss-Prot),   A6HRG3 (UniProtKB/TrEMBL),   D3ZES5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000047118   ⟸   ENSRNOT00000051139
RefSeq Acc Id: ENSRNOP00000005561   ⟸   ENSRNOT00000005561
RefSeq Acc Id: XP_038935901   ⟸   XM_039079973
- Peptide Label: isoform X2
- UniProtKB: D3ZES5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935900   ⟸   XM_039079972
- Peptide Label: isoform X1
- UniProtKB: D3ZES5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935903   ⟸   XM_039079975
- Peptide Label: isoform X4
- UniProtKB: D3ZES5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935902   ⟸   XM_039079974
- Peptide Label: isoform X3
- UniProtKB: D3ZES5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935906   ⟸   XM_039079978
- Peptide Label: isoform X7
- UniProtKB: A6HRG2 (UniProtKB/TrEMBL),   D3ZES5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935904   ⟸   XM_039079976
- Peptide Label: isoform X5
- UniProtKB: D3ZES5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935905   ⟸   XM_039079977
- Peptide Label: isoform X6
- UniProtKB: D3ZES5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935908   ⟸   XM_039079980
- Peptide Label: isoform X9
- UniProtKB: D3ZES5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935907   ⟸   XM_039079979
- Peptide Label: isoform X8
- UniProtKB: A0A8I6ADH1 (UniProtKB/TrEMBL),   D3ZES5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935909   ⟸   XM_039079981
- Peptide Label: isoform X10
- UniProtKB: Q64610 (UniProtKB/Swiss-Prot),   Q66HQ0 (UniProtKB/Swiss-Prot),   A6HRG5 (UniProtKB/TrEMBL),   D3ZES5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000090400   ⟸   ENSRNOT00000118544
RefSeq Acc Id: ENSRNOP00000076476   ⟸   ENSRNOT00000101657
Protein Domains
SMB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64610-F1-model_v2 AlphaFold Q64610 1-887 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69298 AgrOrtholog
BioCyc Gene G2FUF-33387 BioCyc
Ensembl Genes ENSRNOG00000004089 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000005561 ENTREZGENE
  ENSRNOP00000005561.7 UniProtKB/TrEMBL
  ENSRNOP00000047118.5 UniProtKB/TrEMBL
  ENSRNOP00000076476 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000090400 ENTREZGENE
  ENSRNOP00000090400.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005561 ENTREZGENE
  ENSRNOT00000005561.7 UniProtKB/TrEMBL
  ENSRNOT00000051139.6 UniProtKB/TrEMBL
  ENSRNOT00000101657 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000118544 ENTREZGENE
  ENSRNOT00000118544.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.570.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.720.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.410.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7115236 IMAGE-MGC_LOAD
InterPro Alkaline_phosphatase_core_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA/RNA_non-sp_Endonuclease UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA/RNA_non-sp_Endonuclease_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Extracellular_endonuc_su_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His-Me_finger_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phosphodiest/P_Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatomedin_B-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatomedin_B_chordata UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatomedin_B_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84050 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93258 IMAGE-MGC_LOAD
NCBI Gene 84050 ENTREZGENE
PANTHER ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10151:SF21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Endonuclease_NS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phosphodiest UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatomedin_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Enpp2 PhenoGen
PRINTS SOMATOMEDINB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SMB_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Endonuclease_NS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00201 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53649 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54060 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90188 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC219209
UniProt A0A8I6ADH1 ENTREZGENE, UniProtKB/TrEMBL
  A6HRG2 ENTREZGENE, UniProtKB/TrEMBL
  A6HRG3 ENTREZGENE, UniProtKB/TrEMBL
  A6HRG5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZES5 ENTREZGENE, UniProtKB/TrEMBL
  ENPP2_RAT UniProtKB/Swiss-Prot
  F1LSF4_RAT UniProtKB/TrEMBL
  Q64610 ENTREZGENE
  Q66HQ0 ENTREZGENE
UniProt Secondary Q66HQ0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Enpp2  ectonucleotide pyrophosphatase/phosphodiesterase 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference