STARD5 (StAR related lipid transfer domain containing 5)

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Gene: STARD5 (StAR related lipid transfer domain containing 5) Homo sapiens

Analyze

Symbol:

STARD5

Name:

StAR related lipid transfer domain containing 5

RGD ID:

1317618

HGNC Page

HGNC

Description:

Exhibits cholesterol binding activity and cholesterol transfer activity. Involved in cholesterol import. Predicted to localize to cytosol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

MGC10327; StAR-related lipid transfer (START) domain containing 5; StAR-related lipid transfer domain containing 5; stAR-related lipid transfer protein 5; START domain containing 5; START domain-containing protein 5

RGD Orthologs

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	15	81,309,053 - 81,324,183 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	15	81,309,053 - 81,324,141 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	15	81,601,394 - 81,616,482 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	15	81,605,007 - 81,616,524 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	79,392,062 - 79,403,579 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	15	79,392,062 - 79,403,579	NCBI
Celera	15	58,542,985 - 58,554,503 (-)	NCBI
Cytogenetic Map	15	q25.1	NCBI
HuRef	15	58,363,306 - 58,374,824 (-)	NCBI		HuRef
CHM1_1	15	81,722,973 - 81,734,490 (-)	NCBI		CHM1_1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3-isobutyl-1-methyl-7H-xanthine (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (EXP)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (ISO)

aflatoxin B1 (EXP)

amiodarone (EXP)

benzo[a]pyrene (EXP,ISO)

bisphenol A (EXP,ISO)

buspirone (ISO)

butanal (EXP)

carbon nanotube (ISO)

cisplatin (EXP)

copper(II) sulfate (EXP)

crocidolite asbestos (EXP)

cyclosporin A (EXP)

dexamethasone (EXP)

dextran sulfate (ISO)

doxorubicin (EXP)

elemental selenium (EXP)

ethanol (ISO)

ethyl methanesulfonate (EXP)

indometacin (EXP)

isoprenaline (ISO)

methyl methanesulfonate (EXP)

paracetamol (EXP)

perfluorononanoic acid (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

rotenone (ISO)

selenium atom (EXP)

silicon dioxide (ISO)

sunitinib (EXP)

tetrachloromethane (ISO)

titanium dioxide (ISO)

trichostatin A (EXP)

troglitazone (ISO)

trovafloxacin (ISO)

urethane (EXP)

valdecoxib (ISO)

vitamin E (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bile acid and bile salt transport (TAS)

cholesterol import (IDA)

intermembrane lipid transfer (IEA)

Cellular Component

cytosol (TAS)

Molecular Function

bile acid binding (IEA)

cholesterol binding (IDA)

cholesterol transfer activity (IDA)

References

References - curated


1.	GOA_HUMAN data from the GO Consortium
2.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8125298	PMID:11247670	PMID:12011452	PMID:12477932	PMID:12770731	PMID:14702039	PMID:15489334	PMID:15583024	PMID:15760897	PMID:15897605	PMID:16534142	PMID:18403318
PMID:19474188	PMID:19913121	PMID:20237496	PMID:20628086	PMID:21301993	PMID:23872533	PMID:24440759

Genomics

Comparative Map Data

STARD5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	15	81,309,053 - 81,324,183 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	15	81,309,053 - 81,324,141 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	15	81,601,394 - 81,616,482 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	15	81,605,007 - 81,616,524 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	79,392,062 - 79,403,579 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	15	79,392,062 - 79,403,579	NCBI
Celera	15	58,542,985 - 58,554,503 (-)	NCBI
Cytogenetic Map	15	q25.1	NCBI
HuRef	15	58,363,306 - 58,374,824 (-)	NCBI		HuRef
CHM1_1	15	81,722,973 - 81,734,490 (-)	NCBI		CHM1_1

Stard5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	83,281,225 - 83,291,536 (+)	NCBI	GRCm39		mm39
GRCm38	7	83,632,017 - 83,642,328 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	83,631,959 - 83,653,127 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	90,780,527 - 90,790,838 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	7	83,508,202 - 83,518,513 (+)	NCBI			mm8
Celera	7	81,043,369 - 81,053,681 (+)	NCBI		Celera
Cytogenetic Map	7	D3	NCBI
cM Map	7	47.43	NCBI

Stard5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	137,606,151 - 137,616,017 (+)	NCBI
Rnor_6.0 Ensembl	1	145,770,135 - 145,780,001 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	1	145,770,135 - 145,780,001 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	1	146,699,154 - 146,709,020 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	139,896,268 - 139,906,134 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	1	129,627,481 - 129,637,270 (+)	NCBI		Celera
Cytogenetic Map	1	q31	NCBI

Stard5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	11,989,572 - 12,000,226 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955416	11,989,572 - 12,000,226 (-)	NCBI	ChiLan1.0	ChiLan1.0

STARD5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	15	79,254,417 - 79,265,673 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	79,254,424 - 79,265,673 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	15	60,299,309 - 60,310,602 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

STARD5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	3	56,461,592 - 56,470,333 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	3	56,462,153 - 56,472,187 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Stard5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936483	19,406,273 - 19,416,619 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

STARD5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	50,107,035 - 50,118,629 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	50,107,033 - 50,118,652 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	55,706,942 - 55,718,553 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

STARD5
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	2,067,420 - 2,079,132 (+)	NCBI
ChlSab1.1 Ensembl	26	2,067,456 - 2,077,949 (+)	Ensembl

Stard5
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624768	20,584,583 - 20,594,842 (+)	NCBI

Position Markers

WI-14768

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	15	81,606,245 - 81,606,335	UniSTS	GRCh37
Build 36	15	79,393,300 - 79,393,390	RGD	NCBI36
Celera	15	58,544,223 - 58,544,313	RGD
Cytogenetic Map	15	q26	UniSTS
HuRef	15	58,364,544 - 58,364,634	UniSTS
GeneMap99-GB4 RH Map	15	285.84	UniSTS
Whitehead-RH Map	15	302.7	UniSTS

RH120871

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	15	81,604,950 - 81,605,089	UniSTS	GRCh37
Build 36	15	79,392,005 - 79,392,144	RGD	NCBI36
Celera	15	58,542,928 - 58,543,067	RGD
Cytogenetic Map	15	q26.3	UniSTS
Cytogenetic Map	15	q26	UniSTS
HuRef	15	58,363,249 - 58,363,388	UniSTS
TNG Radiation Hybrid Map	15	31637.0	UniSTS
Whitehead-RH Map	15	310.2	UniSTS

STS-W15415

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	15	81,605,138 - 81,605,375	UniSTS	GRCh37
Build 36	15	79,392,193 - 79,392,430	RGD	NCBI36
Celera	15	58,543,116 - 58,543,353	RGD
Cytogenetic Map	15	q26.3	UniSTS
Cytogenetic Map	15	q26	UniSTS
HuRef	15	58,363,437 - 58,363,674	UniSTS
GeneMap99-GB4 RH Map	15	288.8	UniSTS

D15S1512

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	15	81,615,974 - 81,616,038	UniSTS	GRCh37
GRCh37	15	63,363,379 - 63,363,448	UniSTS	GRCh37
Build 36	15	61,150,432 - 61,150,501	RGD	NCBI36
Celera	15	40,243,085 - 40,243,159	RGD
Celera	15	58,553,953 - 58,554,017	UniSTS
Cytogenetic Map	15	q26	UniSTS
Cytogenetic Map	15	q22.1	UniSTS
HuRef	15	58,374,274 - 58,374,338	UniSTS
HuRef	15	40,186,350 - 40,186,429	UniSTS

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	2844
Count of miRNA genes:	1136
Interacting mature miRNAs:	1386
Transcripts:	ENST00000302824, ENST00000325346, ENST00000559913, ENST00000560156, ENST00000560723
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

visual system

adipose tissue

appendage

entire extraembryonic component

pharyngeal arch

High

Medium

518

102

321

299

449

210

1351

195

576

224

717

Low

1904

2822

1388

319

1457

249

2641

1742

2849

371

857

1336

1147

1728

Below cutoff

353

381

669

331

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_181900	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NR_135013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC103858	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF480304	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK026352	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK097024	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK225479	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL137657	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC004365	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471136	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENST00000302824 ⟹ ENSP00000304032

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	15	81,309,053 - 81,324,141 (-)	Ensembl

RefSeq Acc Id:

ENST00000325346 ⟹ ENSP00000317519

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	15	81,312,668 - 81,324,183 (-)	Ensembl

RefSeq Acc Id:

ENST00000559913

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	15	81,319,400 - 81,324,141 (-)	Ensembl

RefSeq Acc Id:

ENST00000560156 ⟹ ENSP00000453368

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	15	81,319,351 - 81,324,141 (-)	Ensembl

RefSeq Acc Id:

ENST00000560723

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	15	81,312,667 - 81,324,141 (-)	Ensembl

RefSeq Acc Id:

ENST00000560916

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	15	81,309,356 - 81,310,139 (-)	Ensembl

RefSeq Acc Id:

NM_181900 ⟹ NP_871629

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	15	81,309,053 - 81,324,141 (-)	NCBI
GRCh37	15	81,605,007 - 81,616,524 (-)	RGD
Build 36	15	79,392,062 - 79,403,579 (-)	NCBI Archive
Celera	15	58,542,985 - 58,554,503 (-)	RGD
HuRef	15	58,363,306 - 58,374,824 (-)	RGD
CHM1_1	15	81,722,973 - 81,734,490 (-)	NCBI

Sequence:

show sequence

GAGCTCCAGCCTCCAGGCACCCGGGATCCAGCGCCGCCGCTCATAACACCCGCGACCCCGCAGC
TAAGCGCAGCTCCCGACGCAATGGACCCGGCGCTGGCAGCCCAGATGAGCGAGGCTGTGGCCGA
GAAGATGCTCCAGTACCGGCGGGACACAGCAGGCTGGAAGATTTGCCGGGAAGGCAATGGAGTT
TCAGTTTCCTGGAGGCCATCTGTGGAGTTTCCAGGGAACCTGTACCGAGGAGAAGGCATTGTAT
ATGGGACACTAGAGGAGGTGTGGGACTGTGTGAAGCCAGCTGTTGGAGGCCTACGAGTGAAGTG
GGATGAGAATGTGACCGGTTTTGAAATTATCCAAAGCATCACTGACACCCTGTGTGTAAGCAGA
ACCTCCACTCCCTCCGCTGCCATGAAGCTCATTTCTCCCAGAGATTTTGTGGACTTGGTGCTAG
TCAAGAGATATGAGGATGGGACCATCAGTTCCAACGCCACCCATGTGGAGCATCCGTTATGTCC
CCCGAAGCCAGGTTTTGTGAGAGGATTTAACCATCCTTGTGGTTGCTTCTGTGAACCTCTTCCA
GGGGAACCCACCAAGACCAACCTGGTCACATTCTTCCATACCGACCTCAGCGGTTACCTCCCAC
AGAACGTGGTGGACTCCTTCTTCCCCCGCAGCATGACCCGGTTTTATGCCAACCTTCAGAAAGC
AGTGAAGCAATTCCATGAGTAATGCTATCGTTACTTCTTGGCAAAGAACTCCCGTGACTCATCG
AGGAGCTCCAGCTGTTGGGACACCAAGGAGCCTGGGAGCACGCAGAGGCCTGTGTTCACTCTTT
GGAACAAGCTGATGGACTGCGCATCTCTGAGAATGCCAACCAGAGGCGGCAGCCCACCCTTCCT
GCCTCCTGCCCCACTCAGGGTTGGCGTGTGATGAGCCATTCATGTGTTCCAAACTCCATCTGCC
TGTTACCCAAACACGCCTCTCCTGGCAGGGTAGACCCAGGCCTCTAACCATCTGACAGAGACTC
GGCCTGGACACCATGCGATGCACTCTGGCACCAAGGCTTTATGTGCCCATCACTCTCAGAGACC
ACGTTTCCCTGACTGTCATAGAGAATCATCATCGCCACTGAAAACCAGGCCCTGTTGCCTTTTA
AGCATGTACCGCTCCCTCAGTCCTGTGCTGCAGCCCCCCAAATATATTTTTCTGATATAGACCT
TGTATATGGCTTTAATGCCGCAAAATATTTATTTTTCCTTAAAAAAGGTGTCAACTTGGAAATA
ATGGTTTAAAAACAGGATAAGCATTAAGGAAAAACAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NR_135013

RefSeq Status:

VALIDATED

Type:

NON-CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	15	81,309,053 - 81,324,141 (-)	NCBI
CHM1_1	15	81,722,975 - 81,734,490 (-)	NCBI

Sequence:

show sequence

GAGCTCCAGCCTCCAGGCACCCGGGATCCAGCGCCGCCGCTCATAACACCCGCGACCCCGCAGC
TAAGCGCAGCTCCCGACGCAATGGACCCGGCGCTGGCAGCCCAGATGAGCGAGGCTGTGGCCGA
GAAGATGCTCCAGTACCGGCGGGACACAGCAGGCTGGAAGATTTGCCGGGAAGGCGTACCGAGG
AGAAGGCATTGTATATGGGACACTAGAGGAGGTGTGGGACTGTGTGAAGCCAGCTGTTGGAGGC
CTACGAGTGAAGTGGGATGAGAATGTGACCGGTTTTGAAATTATCCAAAGCATCACTGACACCC
TGTGTGTAAGCAGAACCTCCACTCCCTCCGCTGCCATGAAGCTCATTTCTCCCAGAGATTTTGT
GGACTTGGTGCTAGTCAAGAGATATGAGGATGGGACCATCAGTTCCAACGCCACCCATGTGGAG
CATCCGTTATGTCCCCCGAAGCCAGGTTTTGTGAGAGGATTTAACCATCCTTGTGGTTGCTTCT
GTGAACCTCTTCCAGGGGAACCCACCAAGACCAACCTGGTCACATTCTTCCATACCGACCTCAG
CGGTTACCTCCCACAGAACGTGGTGGACTCCTTCTTCCCCCGCAGCATGACCCGGTTTTATGCC
AACCTTCAGAAAGCAGTGAAGCAATTCCATGAGTAATGCTATCGTTACTTCTTGGCAAAGAACT
CCCGTGACTCATCGAGGAGCTCCAGCTGTTGGGACACCAAGGAGCCTGGGAGCACGCAGAGGCC
TGTGTTCACTCTTTGGAACAAGCTGATGGACTGCGCATCTCTGAGAATGCCAACCAGAGGCGGC
AGCCCACCCTTCCTGCCTCCTGCCCCACTCAGGGTTGGCGTGTGATGAGCCATTCATGTGTTCC
AAACTCCATCTGCCTGTTACCCAAACACGCCTCTCCTGGCAGGGTAGACCCAGGCCTCTAACCA
TCTGACAGAGACTCGGCCTGGACACCATGCGATGCACTCTGGCACCAAGGCTTTATGTGCCCAT
CACTCTCAGAGACCACGTTTCCCTGACTGTCATAGAGAATCATCATCGCCACTGAAAACCAGGC
CCTGTTGCCTTTTAAGCATGTACCGCTCCCTCAGTCCTGTGCTGCAGCCCCCCAAATATATTTT
TCTGATATAGACCTTGTATATGGCTTTAATGCCGCAAAATATTTATTTTTCCTTAAAAAAGGTG
TCAACTTGGAAATAATGGTTTAAAAACAGGATAAGCATTAAGGAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_871629	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH04365	(Get FASTA)	NCBI Sequence Viewer
	AAL89654	(Get FASTA)	NCBI Sequence Viewer
	CAB70862	(Get FASTA)	NCBI Sequence Viewer
	EAW99095	(Get FASTA)	NCBI Sequence Viewer
	EAW99096	(Get FASTA)	NCBI Sequence Viewer
	EAW99097	(Get FASTA)	NCBI Sequence Viewer
	Q9NSY2	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_871629 ⟸ NM_181900

- UniProtKB:

Q9NSY2 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MDPALAAQMSEAVAEKMLQYRRDTAGWKICREGNGVSVSWRPSVEFPGNLYRGEGIVYGTLEEV
WDCVKPAVGGLRVKWDENVTGFEIIQSITDTLCVSRTSTPSAAMKLISPRDFVDLVLVKRYEDG
TISSNATHVEHPLCPPKPGFVRGFNHPCGCFCEPLPGEPTKTNLVTFFHTDLSGYLPQNVVDSF
FPRSMTRFYANLQKAVKQFHE

hide sequence

RefSeq Acc Id:

ENSP00000453368 ⟸ ENST00000560156

RefSeq Acc Id:

ENSP00000317519 ⟸ ENST00000325346

RefSeq Acc Id:

ENSP00000304032 ⟸ ENST00000302824

Protein Domains

START

Promoters

RGD ID:

6792083

Promoter ID:

HG_KWN:22105

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, Jurkat, K562, Lymphoblastoid, NB4

Transcripts:

OTTHUMT00000303950, UC002BGN.1

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	15	79,403,361 - 79,403,861 (-)	MPROMDB

RGD ID:

7230307

Promoter ID:

EPDNEW_H20899

Type:

initiation region

Name:

STARD5_1

Description:

StAR related lipid transfer domain containing 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	15	81,324,139 - 81,324,199	EPDNEW

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 15q24.2-26.3(chr15:75307767-101723215)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052346]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052346]\|See cases [RCV000052346]	Chr15:75307767..101723215 [GRCh38] Chr15:75600108..102263418 [GRCh37] Chr15:73387161..100080941 [NCBI36] Chr15:15q24.2-26.3	pathogenic
GRCh38/hg38 15q24.3-26.3(chr15:77543797-101843411)x3	copy number gain	See cases [RCV000052347]	Chr15:77543797..101843411 [GRCh38] Chr15:77836139..102383614 [GRCh37] Chr15:75623194..100201137 [NCBI36] Chr15:15q24.3-26.3	pathogenic
NM_001172128.1(IL16):c.3886C>A (p.Arg1296=)	single nucleotide variant	Malignant melanoma [RCV000070916]	Chr15:81308688 [GRCh38] Chr15:81601029 [GRCh37] Chr15:79388084 [NCBI36] Chr15:15q25.1	not provided
GRCh38/hg38 15q23-26.3(chr15:72154949-101920998)x3	copy number gain	See cases [RCV000143019]	Chr15:72154949..101920998 [GRCh38] Chr15:72447290..102461201 [GRCh37] Chr15:70234344..100278724 [NCBI36] Chr15:15q23-26.3	pathogenic
GRCh38/hg38 15q22.2-26.3(chr15:59828460-101920998)x3	copy number gain	See cases [RCV000142915]	Chr15:59828460..101920998 [GRCh38] Chr15:60120659..102461201 [GRCh37] Chr15:57907951..100278724 [NCBI36] Chr15:15q22.2-26.3	pathogenic
GRCh37/hg19 15q24.2-26.3(chr15:76061144-102429112)x3	copy number gain	See cases [RCV000511332]	Chr15:76061144..102429112 [GRCh37] Chr15:15q24.2-26.3	pathogenic
GRCh37/hg19 15q22.31-26.3(chr15:64637227-102509910)x3	copy number gain	See cases [RCV000240602]	Chr15:64637227..102509910 [GRCh37] Chr15:15q22.31-26.3	pathogenic
GRCh37/hg19 15q22.1-26.3(chr15:59297293-102480888)x3	copy number gain	not provided [RCV000415836]	Chr15:59297293..102480888 [GRCh37] Chr15:15q22.1-26.3	likely pathogenic
GRCh37/hg19 15q25.1-25.2(chr15:80703867-83955596)x1	copy number loss	See cases [RCV000446990]	Chr15:80703867..83955596 [GRCh37] Chr15:15q25.1-25.2	pathogenic
GRCh37/hg19 15q15.1-26.3(chr15:41745084-102354798)x4	copy number gain	See cases [RCV000447123]	Chr15:41745084..102354798 [GRCh37] Chr15:15q15.1-26.3	pathogenic
GRCh37/hg19 15q25.1-26.3(chr15:80648093-102429112)x3	copy number gain	See cases [RCV000445705]	Chr15:80648093..102429112 [GRCh37] Chr15:15q25.1-26.3	pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4	copy number gain	See cases [RCV000447765]	Chr15:20733395..102511616 [GRCh37] Chr15:15q11.2-26.3	pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)x3	copy number gain	See cases [RCV000510717]	Chr15:22770422..102429112 [GRCh37] Chr15:15q11.2-26.3	pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)	copy number gain	See cases [RCV000512019]	Chr15:22770422..102429112 [GRCh37] Chr15:15q11.2-26.3	pathogenic
Single allele	duplication	not provided [RCV000677926]	Chr15:31115047..102354857 [GRCh37] Chr15:15q13.2-26.3	pathogenic
GRCh37/hg19 15q25.1-25.2(chr15:80955355-82622366)x4	copy number gain	not provided [RCV000683713]	Chr15:80955355..82622366 [GRCh37] Chr15:15q25.1-25.2	uncertain significance
GRCh37/hg19 15q24.3-26.3(chr15:77479244-102429112)x3	copy number gain	not provided [RCV000683710]	Chr15:77479244..102429112 [GRCh37] Chr15:15q24.3-26.3	pathogenic
GRCh37/hg19 15q25.1-25.3(chr15:79023343-87158823)x1,2	copy number gain	not provided [RCV000683712]	Chr15:79023343..87158823 [GRCh37] Chr15:15q25.1-25.3	pathogenic
GRCh37/hg19 15q23-26.3(chr15:71329220-102270758)x3	copy number gain	not provided [RCV000683703]	Chr15:71329220..102270758 [GRCh37] Chr15:15q23-26.3	pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20016811-102493540)x3	copy number gain	not provided [RCV000751155]	Chr15:20016811..102493540 [GRCh37] Chr15:15q11.1-26.3	pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20071673-102461162)x3	copy number gain	not provided [RCV000751156]	Chr15:20071673..102461162 [GRCh37] Chr15:15q11.1-26.3	pathogenic
GRCh37/hg19 15q25.1-25.2(chr15:80728654-84107646)x1	copy number loss	not provided [RCV000849378]	Chr15:80728654..84107646 [GRCh37] Chr15:15q25.1-25.2	pathogenic

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:18065	AgrOrtholog
COSMIC	STARD5	COSMIC
Ensembl Genes	ENSG00000172345	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSP00000304032	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSP00000317519	UniProtKB/Swiss-Prot
	ENSP00000453368	UniProtKB/TrEMBL
Ensembl Transcript	ENST00000302824	ENTREZGENE, UniProtKB/Swiss-Prot
	ENST00000325346	UniProtKB/Swiss-Prot
	ENST00000560156	UniProtKB/TrEMBL
Gene3D-CATH	3.30.530.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx	ENSG00000172345	GTEx
HGNC ID	HGNC:18065	ENTREZGENE
Human Proteome Map	STARD5	Human Proteome Map
InterPro	StARD5	UniProtKB/Swiss-Prot
	StARD5/6	UniProtKB/Swiss-Prot
	START-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	START_lipid-bd_dom	UniProtKB/Swiss-Prot
KEGG Report	hsa:80765	UniProtKB/Swiss-Prot
NCBI Gene	80765	ENTREZGENE
OMIM	607050	OMIM
PANTHER	PTHR46374	UniProtKB/Swiss-Prot
	PTHR46374:SF3	UniProtKB/Swiss-Prot
Pfam	START	UniProtKB/Swiss-Prot
PharmGKB	PA38286	PharmGKB
PROSITE	START	UniProtKB/Swiss-Prot
SMART	START	UniProtKB/Swiss-Prot
UniProt	H0YLW4_HUMAN	UniProtKB/TrEMBL
	Q9NSY2	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	P59094	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-11-24	STARD5	StAR related lipid transfer domain containing 5		StAR-related lipid transfer domain containing 5	Symbol and/or name change	5135510	APPROVED
2015-11-10	STARD5	StAR-related lipid transfer domain containing 5		StAR-related lipid transfer (START) domain containing 5	Symbol and/or name change	5135510	APPROVED
2011-09-01	STARD5	StAR-related lipid transfer (START) domain containing 5	STARD5	StAR-related lipid transfer (START) domain containing 5	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)