STARD5 (StAR related lipid transfer domain containing 5) - Rat Genome Database
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Gene: STARD5 (StAR related lipid transfer domain containing 5) Homo sapiens
Analyze
Symbol: STARD5
Name: StAR related lipid transfer domain containing 5
RGD ID: 1317618
HGNC Page HGNC
Description: Exhibits cholesterol binding activity and cholesterol transfer activity. Involved in cholesterol import. Predicted to localize to cytosol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MGC10327; StAR-related lipid transfer (START) domain containing 5; StAR-related lipid transfer domain containing 5; stAR-related lipid transfer protein 5; START domain containing 5; START domain-containing protein 5
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1581,309,053 - 81,324,183 (-)EnsemblGRCh38hg38GRCh38
GRCh381581,309,053 - 81,324,141 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371581,601,394 - 81,616,482 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh371581,605,007 - 81,616,524 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361579,392,062 - 79,403,579 (-)NCBINCBI36hg18NCBI36
Build 341579,392,062 - 79,403,579NCBI
Celera1558,542,985 - 58,554,503 (-)NCBI
Cytogenetic Map15q25.1NCBI
HuRef1558,363,306 - 58,374,824 (-)NCBIHuRef
CHM1_11581,722,973 - 81,734,490 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (TAS)

Molecular Function

References

Additional References at PubMed
PMID:8125298   PMID:11247670   PMID:12011452   PMID:12477932   PMID:12770731   PMID:14702039   PMID:15489334   PMID:15583024   PMID:15760897   PMID:15897605   PMID:16534142   PMID:18403318  
PMID:19474188   PMID:19913121   PMID:20237496   PMID:20628086   PMID:21301993   PMID:23872533   PMID:24440759  


Genomics

Comparative Map Data
STARD5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1581,309,053 - 81,324,183 (-)EnsemblGRCh38hg38GRCh38
GRCh381581,309,053 - 81,324,141 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371581,601,394 - 81,616,482 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh371581,605,007 - 81,616,524 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361579,392,062 - 79,403,579 (-)NCBINCBI36hg18NCBI36
Build 341579,392,062 - 79,403,579NCBI
Celera1558,542,985 - 58,554,503 (-)NCBI
Cytogenetic Map15q25.1NCBI
HuRef1558,363,306 - 58,374,824 (-)NCBIHuRef
CHM1_11581,722,973 - 81,734,490 (-)NCBICHM1_1
Stard5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39783,281,225 - 83,291,536 (+)NCBIGRCm39mm39
GRCm38783,632,017 - 83,642,328 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl783,631,959 - 83,653,127 (+)EnsemblGRCm38mm10GRCm38
MGSCv37790,780,527 - 90,790,838 (+)NCBIGRCm37mm9NCBIm37
MGSCv36783,508,202 - 83,518,513 (+)NCBImm8
Celera781,043,369 - 81,053,681 (+)NCBICelera
Cytogenetic Map7D3NCBI
cM Map747.43NCBI
Stard5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21137,606,151 - 137,616,017 (+)NCBI
Rnor_6.0 Ensembl1145,770,135 - 145,780,001 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01145,770,135 - 145,780,001 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01146,699,154 - 146,709,020 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41139,896,268 - 139,906,134 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1129,627,481 - 129,637,270 (+)NCBICelera
Cytogenetic Map1q31NCBI
Stard5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541611,989,572 - 12,000,226 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541611,989,572 - 12,000,226 (-)NCBIChiLan1.0ChiLan1.0
STARD5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11579,254,417 - 79,265,673 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1579,254,424 - 79,265,673 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01560,299,309 - 60,310,602 (-)NCBIMhudiblu_PPA_v0panPan3
STARD5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl356,461,592 - 56,470,333 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1356,462,153 - 56,472,187 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Stard5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648319,406,273 - 19,416,619 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STARD5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl750,107,035 - 50,118,629 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1750,107,033 - 50,118,652 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2755,706,942 - 55,718,553 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STARD5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1262,067,420 - 2,079,132 (+)NCBI
ChlSab1.1 Ensembl262,067,456 - 2,077,949 (+)Ensembl
Stard5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476820,584,583 - 20,594,842 (+)NCBI

Position Markers
WI-14768  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371581,606,245 - 81,606,335UniSTSGRCh37
Build 361579,393,300 - 79,393,390RGDNCBI36
Celera1558,544,223 - 58,544,313RGD
Cytogenetic Map15q26UniSTS
HuRef1558,364,544 - 58,364,634UniSTS
GeneMap99-GB4 RH Map15285.84UniSTS
Whitehead-RH Map15302.7UniSTS
RH120871  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371581,604,950 - 81,605,089UniSTSGRCh37
Build 361579,392,005 - 79,392,144RGDNCBI36
Celera1558,542,928 - 58,543,067RGD
Cytogenetic Map15q26.3UniSTS
Cytogenetic Map15q26UniSTS
HuRef1558,363,249 - 58,363,388UniSTS
TNG Radiation Hybrid Map1531637.0UniSTS
Whitehead-RH Map15310.2UniSTS
STS-W15415  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371581,605,138 - 81,605,375UniSTSGRCh37
Build 361579,392,193 - 79,392,430RGDNCBI36
Celera1558,543,116 - 58,543,353RGD
Cytogenetic Map15q26.3UniSTS
Cytogenetic Map15q26UniSTS
HuRef1558,363,437 - 58,363,674UniSTS
GeneMap99-GB4 RH Map15288.8UniSTS
D15S1512  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371581,615,974 - 81,616,038UniSTSGRCh37
GRCh371563,363,379 - 63,363,448UniSTSGRCh37
Build 361561,150,432 - 61,150,501RGDNCBI36
Celera1540,243,085 - 40,243,159RGD
Celera1558,553,953 - 58,554,017UniSTS
Cytogenetic Map15q26UniSTS
Cytogenetic Map15q22.1UniSTS
HuRef1558,374,274 - 58,374,338UniSTS
HuRef1540,186,350 - 40,186,429UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2844
Count of miRNA genes:1136
Interacting mature miRNAs:1386
Transcripts:ENST00000302824, ENST00000325346, ENST00000559913, ENST00000560156, ENST00000560723
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 518 102 321 299 449 210 1351 53 195 17 576 224 92 56 717 1
Low 1904 2822 1388 319 1457 249 2641 1742 2849 371 857 1336 82 1 1147 1728 5 2
Below cutoff 16 67 16 6 41 6 353 381 669 31 25 50 1 331

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000302824   ⟹   ENSP00000304032
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1581,309,053 - 81,324,141 (-)Ensembl
RefSeq Acc Id: ENST00000325346   ⟹   ENSP00000317519
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1581,312,668 - 81,324,183 (-)Ensembl
RefSeq Acc Id: ENST00000559913
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1581,319,400 - 81,324,141 (-)Ensembl
RefSeq Acc Id: ENST00000560156   ⟹   ENSP00000453368
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1581,319,351 - 81,324,141 (-)Ensembl
RefSeq Acc Id: ENST00000560723
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1581,312,667 - 81,324,141 (-)Ensembl
RefSeq Acc Id: ENST00000560916
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1581,309,356 - 81,310,139 (-)Ensembl
RefSeq Acc Id: NM_181900   ⟹   NP_871629
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381581,309,053 - 81,324,141 (-)NCBI
GRCh371581,605,007 - 81,616,524 (-)RGD
Build 361579,392,062 - 79,403,579 (-)NCBI Archive
Celera1558,542,985 - 58,554,503 (-)RGD
HuRef1558,363,306 - 58,374,824 (-)RGD
CHM1_11581,722,973 - 81,734,490 (-)NCBI
Sequence:
RefSeq Acc Id: NR_135013
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381581,309,053 - 81,324,141 (-)NCBI
CHM1_11581,722,975 - 81,734,490 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_871629   ⟸   NM_181900
- UniProtKB: Q9NSY2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000453368   ⟸   ENST00000560156
RefSeq Acc Id: ENSP00000317519   ⟸   ENST00000325346
RefSeq Acc Id: ENSP00000304032   ⟸   ENST00000302824
Protein Domains
START

Promoters
RGD ID:6792083
Promoter ID:HG_KWN:22105
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000303950,   UC002BGN.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361579,403,361 - 79,403,861 (-)MPROMDB
RGD ID:7230307
Promoter ID:EPDNEW_H20899
Type:initiation region
Name:STARD5_1
Description:StAR related lipid transfer domain containing 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381581,324,139 - 81,324,199EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q24.2-26.3(chr15:75307767-101723215)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052346]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052346]|See cases [RCV000052346] Chr15:75307767..101723215 [GRCh38]
Chr15:75600108..102263418 [GRCh37]
Chr15:73387161..100080941 [NCBI36]
Chr15:15q24.2-26.3
pathogenic
GRCh38/hg38 15q24.3-26.3(chr15:77543797-101843411)x3 copy number gain See cases [RCV000052347] Chr15:77543797..101843411 [GRCh38]
Chr15:77836139..102383614 [GRCh37]
Chr15:75623194..100201137 [NCBI36]
Chr15:15q24.3-26.3
pathogenic
NM_001172128.1(IL16):c.3886C>A (p.Arg1296=) single nucleotide variant Malignant melanoma [RCV000070916] Chr15:81308688 [GRCh38]
Chr15:81601029 [GRCh37]
Chr15:79388084 [NCBI36]
Chr15:15q25.1
not provided
GRCh38/hg38 15q23-26.3(chr15:72154949-101920998)x3 copy number gain See cases [RCV000143019] Chr15:72154949..101920998 [GRCh38]
Chr15:72447290..102461201 [GRCh37]
Chr15:70234344..100278724 [NCBI36]
Chr15:15q23-26.3
pathogenic
GRCh38/hg38 15q22.2-26.3(chr15:59828460-101920998)x3 copy number gain See cases [RCV000142915] Chr15:59828460..101920998 [GRCh38]
Chr15:60120659..102461201 [GRCh37]
Chr15:57907951..100278724 [NCBI36]
Chr15:15q22.2-26.3
pathogenic
GRCh37/hg19 15q24.2-26.3(chr15:76061144-102429112)x3 copy number gain See cases [RCV000511332] Chr15:76061144..102429112 [GRCh37]
Chr15:15q24.2-26.3
pathogenic
GRCh37/hg19 15q22.31-26.3(chr15:64637227-102509910)x3 copy number gain See cases [RCV000240602] Chr15:64637227..102509910 [GRCh37]
Chr15:15q22.31-26.3
pathogenic
GRCh37/hg19 15q22.1-26.3(chr15:59297293-102480888)x3 copy number gain not provided [RCV000415836] Chr15:59297293..102480888 [GRCh37]
Chr15:15q22.1-26.3
likely pathogenic
GRCh37/hg19 15q25.1-25.2(chr15:80703867-83955596)x1 copy number loss See cases [RCV000446990] Chr15:80703867..83955596 [GRCh37]
Chr15:15q25.1-25.2
pathogenic
GRCh37/hg19 15q15.1-26.3(chr15:41745084-102354798)x4 copy number gain See cases [RCV000447123] Chr15:41745084..102354798 [GRCh37]
Chr15:15q15.1-26.3
pathogenic
GRCh37/hg19 15q25.1-26.3(chr15:80648093-102429112)x3 copy number gain See cases [RCV000445705] Chr15:80648093..102429112 [GRCh37]
Chr15:15q25.1-26.3
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4 copy number gain See cases [RCV000447765] Chr15:20733395..102511616 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)x3 copy number gain See cases [RCV000510717] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112) copy number gain See cases [RCV000512019] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3
pathogenic
Single allele duplication not provided [RCV000677926] Chr15:31115047..102354857 [GRCh37]
Chr15:15q13.2-26.3
pathogenic
GRCh37/hg19 15q25.1-25.2(chr15:80955355-82622366)x4 copy number gain not provided [RCV000683713] Chr15:80955355..82622366 [GRCh37]
Chr15:15q25.1-25.2
uncertain significance
GRCh37/hg19 15q24.3-26.3(chr15:77479244-102429112)x3 copy number gain not provided [RCV000683710] Chr15:77479244..102429112 [GRCh37]
Chr15:15q24.3-26.3
pathogenic
GRCh37/hg19 15q25.1-25.3(chr15:79023343-87158823)x1,2 copy number gain not provided [RCV000683712] Chr15:79023343..87158823 [GRCh37]
Chr15:15q25.1-25.3
pathogenic
GRCh37/hg19 15q23-26.3(chr15:71329220-102270758)x3 copy number gain not provided [RCV000683703] Chr15:71329220..102270758 [GRCh37]
Chr15:15q23-26.3
pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20016811-102493540)x3 copy number gain not provided [RCV000751155] Chr15:20016811..102493540 [GRCh37]
Chr15:15q11.1-26.3
pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20071673-102461162)x3 copy number gain not provided [RCV000751156] Chr15:20071673..102461162 [GRCh37]
Chr15:15q11.1-26.3
pathogenic
GRCh37/hg19 15q25.1-25.2(chr15:80728654-84107646)x1 copy number loss not provided [RCV000849378] Chr15:80728654..84107646 [GRCh37]
Chr15:15q25.1-25.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:18065 AgrOrtholog
COSMIC STARD5 COSMIC
Ensembl Genes ENSG00000172345 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000304032 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000317519 UniProtKB/Swiss-Prot
  ENSP00000453368 UniProtKB/TrEMBL
Ensembl Transcript ENST00000302824 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000325346 UniProtKB/Swiss-Prot
  ENST00000560156 UniProtKB/TrEMBL
Gene3D-CATH 3.30.530.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000172345 GTEx
HGNC ID HGNC:18065 ENTREZGENE
Human Proteome Map STARD5 Human Proteome Map
InterPro StARD5 UniProtKB/Swiss-Prot
  StARD5/6 UniProtKB/Swiss-Prot
  START-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  START_lipid-bd_dom UniProtKB/Swiss-Prot
KEGG Report hsa:80765 UniProtKB/Swiss-Prot
NCBI Gene 80765 ENTREZGENE
OMIM 607050 OMIM
PANTHER PTHR46374 UniProtKB/Swiss-Prot
  PTHR46374:SF3 UniProtKB/Swiss-Prot
Pfam START UniProtKB/Swiss-Prot
PharmGKB PA38286 PharmGKB
PROSITE START UniProtKB/Swiss-Prot
SMART START UniProtKB/Swiss-Prot
UniProt H0YLW4_HUMAN UniProtKB/TrEMBL
  Q9NSY2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P59094 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 STARD5  StAR related lipid transfer domain containing 5    StAR-related lipid transfer domain containing 5  Symbol and/or name change 5135510 APPROVED
2015-11-10 STARD5  StAR-related lipid transfer domain containing 5    StAR-related lipid transfer (START) domain containing 5  Symbol and/or name change 5135510 APPROVED
2011-09-01 STARD5  StAR-related lipid transfer (START) domain containing 5  STARD5  StAR-related lipid transfer (START) domain containing 5  Symbol and/or name change 5135510 APPROVED