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Gene: ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2) Homo sapiens
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Symbol: ENPP2
Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Description: Exhibits calcium ion binding activity; lysophospholipase activity; and zinc ion binding activity. Involved in several processes, including cellular lipid catabolic process; positive regulation of lamellipodium morphogenesis; and positive regulation of peptidyl-tyrosine phosphorylation. Localizes to extracellular space. Biomarker of proliferative diabetic retinopathy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATX; ATX-X; autotaxin; autotaxin-t; E-NPP 2; ectonucleotide pyrophosphatase/phosphodiesterase family member 2; extracellular lysophospholipase D; FLJ26803; LysoPLD; NPP2; PD-IALPHA; PDNP2; phosphodiesterase I/nucleotide pyrophosphatase 2; plasma lysophospholipase D
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl8119,557,086 - 119,673,453 (-)EnsemblGRCh38hg38GRCh38
GRCh388119,557,085 - 119,673,404 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378120,569,317 - 120,685,644 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368120,638,500 - 120,720,287 (-)NCBINCBI36hg18NCBI36
Build 348120,638,506 - 120,720,251NCBI
Celera8116,758,340 - 116,840,155 (-)NCBI
Cytogenetic Map8q24.12NCBI
HuRef8115,890,120 - 115,971,909 (-)NCBIHuRef
CHM1_18120,609,842 - 120,691,629 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on ENPP2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 734409
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.