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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69298
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Enpp2
Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Enpp2affects expressionEXP 6480464CTDBenzo(a)pyrene affects the expression of ENPP2 mRNAPMID:25490995
Enpp2affects methylationISOENPP2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of ENPP2 intronPMID:30157460
Enpp2decreases expressionISOENPP2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of ENPP2 mRNAPMID:20106945 PMID:21632981 PMID:21871943
Enpp2decreases expressionISOEnpp2 (Mus musculus)6480464CTDBenzo(a)pyrene metabolite results in decreased expression of ENPP2 mRNA; Benzo(a)pyrene results in decreased expression of ENPP2 mRNAPMID:19770486 PMID:20713471 PMID:22610609 PMID:32553695
Enpp2decreases methylationISOENPP2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of ENPP2 exon; Benzo(a)pyrene results in decreased methylation of ENPP2 promoterPMID:27901495
Enpp2increases expressionISOEnpp2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of ENPP2 mRNAPMID:22228805 PMID:27195522
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